Class 546/35 - At least three ring hetero atoms in the heptacyclo ring system

Subclass of Class 546 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the heptacyclo ring system includes at
No. of patents: 39
Last issue date: 03/04/2008

Number	Title	Issue Date
7338962	Spirocyclic heterocyclic derivatives and methods of their use Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be us...	03/04/2008
7232829	Therapeutic compounds and methods The invention provides kappa receptor agonists of formula (I) and delta receptor antagonists of formula (II), wherein R1–R6 X and n have any of the meanings given in the specification, as well as compositions comprising them, methods for thei...	06/19/2007
7172767	Opioid agonist / antagonist combinations The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide ...	02/06/2007
7164021	Opiate analogs selective for the δ-opioid receptor Novel compounds which selectively bind to the δ-opioid receptor have been designed. These compounds have greater selectivity, improved water (blood) solubility, and enhanced therapeutic value as analgesics. Because agonists with selectivity for the δ-opioid recept...	01/16/2007
6939892	Compositions for treating or preventing malaria and method of treating malaria An antibiotic SF2487 substance having the formula (I) or a salt thereof possesses an antimalarial activity against the proliferation of malarial parasites and is therefore useful as an antimalarial drug. ...	09/06/2005
6770654	Indole derivatives and use thereof in medicines This invention relates to: an indole derivative or a pharmaceutically acceptable salt thereof represented by formula (I): wherein R1 is, for example, hydrogen or C1-5 alkyl; R2 is, for ex...	08/03/2004
6534514	Kappa opioid receptor antagonists Compounds of the formula: ##STR1## are provided, which are selective kappa opioid receptor antagonists, wherein R1 is (C1 -C5)alkyl, C3 -C6 (cycloalkyl)alkyl, C5 -C7 (cycloalkeny...	03/18/2003
6500824	Kappa (OP2) opioid receptor antagonists The invention provides kappa receptor antagonists of formula (I), wherein R1 -R6 X and Y have any of the meanings given in the specification, as well as compositions comprising them, and methods for their use....	12/31/2002
6399166	Liquid crystal display and method A liquid crystal display has a first substrate plate and a second substrate plate, and a liquid crystal layer disposed between the plates. A polarizing coating, having molecules of one or more organic dyes capable of forming a lyotropic liquid crystalline...	06/04/2002
6395900	Methods of O-demethylation and N-deprotection The present invention provides a method for N-deprotecting an opioid compound, a method for N-deprotecting and O-demethylating an opioid compound, a method for O-demethylating an opioid compound, and a method for O-demethylating a nonpeptidic delta agonis...	05/28/2002
6359111	Opioid receptor targeting A compound comprising a ligand portion which has binding affinity for an opioid receptor, and a therapeutically or diagnostically effective group selected from radionuclide chelating agents, fluorochromes, toxins, drugs, polyboron moieties, proteins, biol...	03/19/2002
6291675	Methods of o-demethylation and n-deprotection The present invention provides a method for N-deprotecting an opioid compound, a method for N-deprotecting and O-demethylating an opioid compound, a method for O-demethylating an opioid compound, and a method for O-demethylating a nonpeptidic delta agonis...	09/18/2001
6218541	Method for extracting bisbenzylisoquinolines A method for obtaining purified bisbenzylisoquinoline alkaloids from the roots of Stephania Tetrandra involves obtaining, from the roots of Stephania Tetrandra, a precipitate comprising tetrandrine, fangchinoline and compounds which constitute impurities,...	04/17/2001
6156762	Indolomorphinan derivative and agent for curing and preventing cerebral disorder The present invention provides an indolomorphinan derivative or a pharmacologically acceptable acid addition salt thereof, and an agent for curing and preventing cerebral disorders composed of the derivative and salt thereof, which is represented by the f...	12/05/2000
6136817	Opioid receptor antagonist compounds New morphinane derivatives of the formula ##STR1## their pharmaceutically acceptable salts, a process for their preparation and their use in the manufacture of pharmaceutical preparations....	10/24/2000
6048867	Biologically active rupununines A method of therapy wherein there is administered to a person in need of such therapy a pharmacologically effective amount of a rupununine having the formula: ##STR1##...	04/11/2000
6049428	Dichroic light polarizers The present invention provides dyes of formula I-XXXIV, described in detail below, and dichroic light polarizers based on the dyes. In the dichroic light polarizers of this invention the dye molecules are aggregated into particles oriented in a predetermi...	04/11/2000
5994327	Process for the preparation of morphinans A process for the preparation of 14-alkoxyindolomorphinans and 14-alkoxybenzofuranomorphinans is disclosed. The process facilitates the preparation of a large variety of 14-alkoxy substituted indolomorphinans and benzofuranomorphinans in which a 3-hydroxy...	11/30/1999
5886001	Agonist compounds New morphinane derivatives of the formula (I) ##STR1## their pharmaceutically acceptable salts, a process for their preparation and their use in therapy. The variables in the above structure are as follows: R1 is selected from the group co...	03/23/1999
5869668	Processes for preparing L!- or D!-homoalanin-4-yl-(methyl) phosphinic acid and salts thereof by racemate resolution The title compounds are obtained by racemate resolution of D,L-homoalanin-4-yl(methyl)phosphinic acid via precipitation of one of the diastereomeric salts using chiral bases such as quinine or cinchonine. It is possible to increase the yield of desired en...	02/09/1999
5861411	4-Acylaminopyridine derivative A novel 4-acylaminopyridine derivative represented by the following formula (I) is disclosed. ##STR1## The 4-acylaminopyridine derivative of the present invention is useful as a medicine for treating disturbances of memory such as senile dementia and...	01/19/1999
5849731	Indole derivatives and medical application thereof The present invention relates to indole derivatives represented by the following compound 1 and the pharmacologically acceptable acid addition salt thereof. ##STR1## The compounds of the present invention were found to exhibit strong antitussive...	12/15/1998
5631264	Substituted 6,11-ethano-6,11-dihydrobenzo[B]quinolizinium salts and compositions and methods of use thereof Substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts, pharmaceutical compositions containing them, and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries utilizing them....	05/20/1997
5578725	Delta opioid receptor antagonists Compounds are provided of the formula: ##STR1## wherein R1 is (C1 -C5)alkyl, C3 -C6 (cycloalkyl)alkyl, C5 -C7 (cycloalkenyl)alkyl, (C6 -C12)aryl, (C	11/26/1996
5554620	Substituted 6,11-ethano-6,11-dihydrobenzo[b] quinolizinium salts and compositions and methods of use thereof Substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts, pharmaceutical compositions containing them, and methods for the treatment of neurodegenerative disorders or neurotoxic injuries utilizing them, wherein the substituted 6,11-ethano-6,11-dihy...	09/10/1996
5536728	4-acylaminopyridine derivative A novel 4-acylaminopyridine derivative represented by the following formula (I) is disclosed. ##STR1## The 4-acylaminopyridine derivative of the present invention is useful as a medicine for treating disturbances of memory such as senile dementia and...	07/16/1996
5457208	Kappa opioid receptor antagonists Compounds of the formula: ##STR1## are provided, which are selective kappa opioid receptor antagonists, wherein R1 is (C1 -C5)alkyl, C3 -C6 (cycloalkyl)alkyl, C5 -C7 (cycloa...	10/10/1995
5436249	Opioid agonist compounds The present invention provides novel substituted opioid analgesic compounds of Formula I: ##STR1## which are opioid agonists, and which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeuti...	07/25/1995
5397785	4-acylaminopyridine derivative A novel 4-acylaminopyridine derivative represented by the following formula (I) is disclosed. ##STR1## The 4-acylaminopyridine derivative of the present invention is useful as a medicine for treating disturbances of memory such as senile dementia and...	03/14/1995
5354863	Opioid agonist compounds The present invention provides novel substituted opioid analgesic compounds of Formula I: ##STR1## which are opioid agonists, and which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeuti...	10/11/1994
5225417	Opioid agonist compounds The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are opioid agonists which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effect...	07/06/1993
5126350	Polycyclic aromatic antifungal compounds A compound represented by the formula I: ##STR1## wherein R1 and R2 are independently hydrogen or (C2 -C10) alkanoyl in substantially chemically pure form, and pharmaceutical compositions thereof are disclo...	06/30/1992
5091535	Organic photochromic compound, a dimer of pyrido quinoline An organic photochromic compound with improved long term preservability, thermal stability, the repetition character of the record and the like and useful as recording-memory materials or photosensitizers, comprising dimers of the compounds selected from ...	02/25/1992
4578468	Antibiotic LL-D42067ଲ Antibiotic LL-D42067ଲ derived by aerobic fermentation of the microorganism Actinomadura madurae subspecies simaoensis NRRL 15734, useful as an antibacterial and antiparasitic agent....	03/25/1986
4551533	Antibiotic LL-D42067଱ Antibiotic LL-D42067଱ derived by aerobic fermentation of the microorganism Actinomadura madurae subspecies simaoensis NRRL 15734, useful as an antibacterial and antiparasitic agent....	11/05/1985
4424355	Resolution of substituted dibenzo[b,f]thiepin-3-carboxylic acid-5-oxides with brucine or ephedrine The present invention is concerned with an improved process for the production of highly active optical isomers of (-) 7 or 8 fluorodibenzo[b,f]thiepin-3-carboxylic acid-5-oxide having the structural formula ##STR1## in which the fluoro substitu...	01/03/1984
4386205	Resolution of racemic 5-phenyl-2-pentanol Resolution of racemic 5-phenyl-2-pentanol via the hemiphthalate ester, followed by diastereomer salt formation with (+)-brucine, separation of the brucine salt of (S)-5-phenyl-2-pentanol hemiphthalate and recovery of the (S)-alcohol therefrom. The (S)-5-p...	05/31/1983
4335057	4-(2',2,2'-Trihalogenoethyl)-cyclobutane-1-sulfonic acid salts with optically active bases There is described a new process for the preparation of optically active 2-(2',2'-dihalogenovinyl)-cyclopropane-1-carboxylic acids substituted in the 3 position, and derivatives thereof. A racemate of certain cyclobutanones is reacted with a sulfurous aci...	06/15/1982
3968141	Processes for stereospecifically preparing chiral 2-substituted-4-hydroxy-2-cyclopenten-1-one A method for stereospecifically preparing chiral 2-substituted-4-hydroxy-2-cyclopenten-1-one which comprises asymmetrically reducing 2-substituted cyclopentane-1,3,4-trione to the corresponding 2-substituted-4(R)-hydroxy-cyclopentane-1,3-dione, enolizing ...	07/06/1976

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Class 546/35 - At least three ring hetero atoms in the heptacyclo ring system