Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 8093395 | Sphingosine compound, method for producing the same, and sphingomyelinase inhibitor An object of the invention is to provide a novel sphingosine compound with an inhibitory activity against sphingomyelinase, and a method for producing the sphingosine compound. The novel sphingosine compound or a salt thereof according to the invention is rep... | 01/10/2012 |
| 8013165 | Ethanamine compounds and methods of using the same 545 The present invention is directed to ethanamine compounds, pharmaceutical compositions comprising the same, and methods of treating depression by administering the ethanamine compound. ... | 09/06/2011 |
| 7553972 | Benzamide inhibitors of the P2Xreceptor The present invention provides benzamide inhibitors of the P2X7 receptor of the formula: wherein R1-R3 are as defined herein. The compounds of the invention are useful in the treatment of IL... | 06/30/2009 |
| 7541473 | Monocyclopentadienyl complexes Monocyclopentadienyl complexes in which the cyclopentadienyl system bears at least one unsubstituted, substituted or fused, heteroaromatic ring system bound via a specific bridge, a catalyst system comprising at least one of the monocyclopentadienyl complexes, the u... | 06/02/2009 |
| 7384905 | Pyridine derivates useful as fragrance materials A novel compound is having the structure, Formula (I): exhibits interesting odor characteristics, generally green in nature, particularly of a tomato leaf character, and so find use in perfumes and perfumed products. ... | 06/10/2008 |
| 7332623 | Aryl-substituted acyclic enediyne compounds This invention provides aryl-substituted acyclic enediyne compounds of formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein | 02/19/2008 |
| 7125880 | Corticotropin releasing factor antagonists Corticotropin-releasing factor (CRF) antagonists having the formulae wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 an... | 10/24/2006 |
| 7122294 | Photoacid generators with perfluorinated multifunctional anions Photoacid generators (PAGs) comprising photoactive moieties and perfluorinated, multifunctional anionic moieties (or incipient anionic moieties) are disclosed which provide photoacids with high acid strength, low volatility and low diffusivity. The present invention... | 10/17/2006 |
| 7083814 | Antiviral substances from plant cuticular and epicuticular material Substances having antiviral activity against one or more human disease-causing viruses are disclosed. These antiviral substances are obtained from the cuticular and extracuticular layers of plants. Pharmaceutical and nutraceutical formulations comprising the antivir... | 08/01/2006 |
| 7081543 | Bridged biscyclopentadienyl ligands and method of preparation The present invention relates to ligands and the synthesis of those ligands for use in metallocene complexes. More particularly, the present invention relates to the synthesis of diarylsilyl bridged biscyclopentadienes using diarylsilyldisulfonates. Even more partic... | 07/25/2006 |
| 7078403 | Antiviral agents Disclosed herein are compounds of formula II: wherein Alk, Z, X1, X2, R1, —R10 and R11 are defined herein, and their salts and pharmaceutically acceptable deriva... | 07/18/2006 |
| 7060716 | Tryptase inhibitors Compounds of the formula (I), in which M is a central building block selected from the group below in which A1, A2, K1 and K2 are as defined in the description, are novel effective tryptase inhibitors. ... | 06/13/2006 |
| 7045159 | Antiviral substances from plant cuticular and epiciticular material Substances having antiviral activity against one or more human disease-causing viruses are disclosed. These antiviral substances are obtained from the cuticular and extracuticular layers of plants. Pharmaceutical and nutraceutical formulations comprising the antivir... | 05/16/2006 |
| 7041856 | Coupling catalyst and process using the same There are disclosed a process for producing a coupling compound of formula (1): (Y—)(n−1)R1—R2—(R1)(n′−1), (1) wherein R1 and R2 | 05/09/2006 |
| 7029707 | Method of producing a processed kava product having an altered kavalactone distribution and processed kava products produced using the same A method of producing a processed kava product involves using an extraction solvent, such as liquid CO2, to preferentially extract different kavalactones from the source material at different rates. By controlling the extraction parameters and stopping th... | 04/18/2006 |
| 7022857 | Preparation of substituted aromatic compounds A process for preparing compounds of the formula (II), where the substituents R1 to R5 are each independently H, CH3, straight-chain or branched C1–C8-alkyl, CH(O... | 04/04/2006 |
| 7018987 | Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof The present invention relates to novel water-soluble, stable derivatives of combretastatin A-4, and novel synthesis methods therefore. The combretastatin A-4 prodrugs described herein appear to be useful in the treatment of neoplastic disease. ... | 03/28/2006 |
| 6960676 | Method of preparing group 14 bridged biscyclopentadienyl ligands The present invention relates to ligands and the synthesis of those ligands for use in metallocene complexes. More particularly, the present invention relates to the synthesis of diarylsilyl bridged biscyclopentadienes using diarylsilyldisulfonates. Even more partic... | 11/01/2005 |
| 6774240 | Process for preparing ambient temperature ionic liquids A process for preparing an ionic liquid or salt, formed by reaction between an organic base and an alkylating agent, wherein the alkylating agent is a fluorinated ester or an alkyl sulfonate, is described. Suitable organic bases include imidazoles, substituted imida... | 08/10/2004 |
| 6743947 | Electrochemically stable onium salts and electrolytes containing such for electrochemical capacitors Based on the discovery that the melting point and solubility of onium salts are affected by the asymmetry of the substitution on cation, and that the branched substituents effectively shield onium cations from electrochemical reduction, new onium salts are synthesiz... | 06/01/2004 |
| 6657093 | Preparation of substituted aromatic compounds A process for preparing compounds of the formula (II), ##STR1## where the substituents R1 to R5 are each independently H, CH3, straight-chain or branched C1 -C8 -alkyl, CH(OC1 -C5 | 12/02/2003 |
| 6642273 | Unsaturated derivatives at the 4-position of 6-tert-butyl-1,1-dimethylindane and their use in human and veterinary medicine and in cosmetics An unsaturated derivative at the 4-position of 6-tert-butyl-1,1-dimethylindane corresponding to the following formula: ##STR1## in which: X represents: a divalent radical of formula: ##STR2## and Y represents a divalent radical of following formul... | 11/04/2003 |
| 6552044 | Indane or dihydroindole derivatives The present invention relates to substituted indane or dihydroindole compounds of Formula (I) ##STR1## wherein A is an indole. These compounds have high affinity for D4 receptors.... | 04/22/2003 |
| 6545159 | Vinyl-phenyl pyridine monomers and polymers prepared therefrom The present invention relates to vinyl-phenyl monomers and polymers prepared therefrom. More particularly, the present invention is to provide the vinyl-phenyl monomers expressed by formula (1) which are capable of various polymerization such as radical p... | 04/08/2003 |
| 6495695 | Process for the preparation of a collidine and 2,3,5,6-tetramethyl pyridine The present invention provides a process for synthesis of tri- and tetra-alkylated pyridines (i.e. collidines) in high yields by reacting methyl ethyl ketone with formaldehyde in presence of ammonia in gas phase in the presence of a zeolite catalyst which... | 12/17/2002 |
| 6492524 | Process for the synthesis of an aryl pyridine base using a zeolite catalyst The present invention provides an improved process for the synthesis of aryl pyridine bases by reacting an aromatic aldehyde or ketone and allylic alcohol or aldehyde in presence of ammonia in gas phase, in high yield and selectivity with catalyst obtaine... | 12/10/2002 |
| 6465646 | 1-alkoxy and 1-acyloxy substituted cyclohex-1-ene compounds and sulfur and 1-alkoxycarbonyl analogs having retinoid-like biological activity Compounds of Formula 1 and of Formula 2 ##STR1## where the symbols have the meaning defined in the specification, have retinoid, retinoid antagonist or retinoid negative hormone like biological activity.... | 10/15/2002 |
| 6465647 | Oxygen, sulfur and nitrogen substituted cyclohexene and cyclohexane derivatives having retinoid-like biological activity Compounds of the Formula 1, Formula 2, Formula 3 and Formula 4 wherein the symbols have the meaning assigned to them in the disclosure have retinoid-like biological activity. ##STR1##... | 10/15/2002 |
| 6452016 | Process for the preparation of 1,2,3,6-tetrahydro-2,2,6,6-tetramethylpyridine N-oxide The invention relates to a process for the preparation of 1,2,3,6-tetrahydro 2,2,6,6-tetramethylpyridine N-oxide by the catalytic oxidation of 1,2,3,6-tetrahydro-2,2,6,6-tetramethylpyridine, wherein 1,2,3,6-tetrahydro-2,2,6,6-tetramethylpyridine is oxidiz... | 09/17/2002 |
| 6403800 | Synthesis of 1-(2-sulfoethyl)-pyridinium betaine Described is a process for preparing 1-(2-sulfoethyl)pyridinium betaine wherein pyridine is reacted with a sulfoethylating agent from the group consisting of carbyl sulfate, ethionic acid and its salt and vinylsulfonic acid and vinylsulfonate, the reactio... | 06/11/2002 |
| 6399821 | Process for the synthesis of perfluorosulphonamides, of perfluorosulphonimides and of their salts, and a sulphonylation reagent The invention concerns a method of sulphonation characterised in that it consists in contacting a nucleophile whose nucleophilic atom is a nitrogen atom with a reagent comprising by successive or simultaneous addition: a heavy sulphonyl halide (i.e. whose... | 06/04/2002 |
| 6399820 | Process and reagent useful for the synthesis of sulphanilide which is perhalogenated on the carbon borne by the sulphur atom of the sulphanilide function The present invention relates to a process and a reagent useful for the synthesis of sulphanilide which is perhalogenated on the carbon borne by the sulphur atom of the sulphanilide function. This persulphonylation process is characterized in that it comp... | 06/04/2002 |
| 6392050 | Process for preparing substituted pyridines The invention relates to a process for preparing substituted pyridines in a simple and cost-effective manner in good yields by reacting substituted 1,4-dihydropyridines with methyl nitrite in the presence of an acid that contains less than 20% by weight o... | 05/21/2002 |
| 6365744 | Process for producing pyridine derivative through reaction of azametallacyclopentadiene with alkyne A process for producing a pyridine derivative, which comprises reacting an azametallacyclopentadiene represented by formula (1) with an alkyne in an organic solvent containing a complex of a transition metal such as Ni(II). ##STR1## (In formula (1), M rep... | 04/02/2002 |
| 6362193 | Cycloalkenyl substituted compounds Novel pyridyl or pyrimidinyl substituted cycloalkenyl compounds and compositions for use in therapy.... | 03/26/2002 |
| 6362009 | Solid phase synthesis of heterocycles Methods for solid phase and combinatorial synthesis using a resin activation/capture approach are provided. In particular, methods for the production of dihydropyridones, N-acyidihydropyridones, tetrahydropyridones, pyridines, aminopyridines, N-acyltetrah... | 03/26/2002 |
| 6355806 | ACETYLENES DISUBSTITUTED WITH A 5 ALKYL, ARYL OR HETEROARYL SUBSTITUTED DIHYDRONAPHTHYL GROUP AND WITH AN ARYL OR HETEROARYL GROUP HAVING RETINOID-LIKE WITH AN ARYL OR HETEROARYL GROUP HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY Compounds of the formula ##STR1## wherein the symbols have the meaning described in the specification, have retinoid-like biological activity.... | 03/12/2002 |
| 6352566 | Ethers of polyalkyl or polyalkenyl N-hydroxyalkyl succinimides and fuel compositions containing the same Ethers of polyalkyl or polyalkenyl N-hydroxyalkyl succinimides having the formula: ##STR1## or a fuel soluble salt thereof; wherein R is a polyalkyl or polyalkenyl group having an average molecular weight in the range of about 450 to about 5,000; n is an ... | 03/05/2002 |
| 6313132 | Therapeutically active diarylpropylamines; their pharmaceutically acceptable salts; a method for their preparation and method for their use The invention relates to novel compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and Ar are as defined in claim 1, their salts with physiologically acceptable acids and, whe... | 11/06/2001 |
| 6288009 | Plant growth regulator compositions The invention provides novel mepiquat plant growth regulator compositions which have improved hygroscopicity and corrosion characteristics. The novel mepiquat plant growth regulator compositions of the invention can be readily prepared from technical mepi... | 09/11/2001 |
