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Class 546/345 - Halogen attached directly to the six-membered hetero ring by nonionic bonding


Subclass of Class 546 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein halogen is attached directly to the six-membered
No. of patents: 328
Last issue date: 05/26/2009


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NumberTitleIssue Date
7538227Process for stabilizing 4-halopyridines
The present invention relates to a process for stabilizing 4-halopyridines of the formula (I) by adding a secondary and/or aliphatic or mixed aliphatic-aromatic tertiary amine, and mixtures comprising a compound of the form...
05/26/2009
75249682-pyridinylcycloalkylbenzamide derivatives and their use as fungicides
A compound of general formula (I): A process for preparing this compound. A fungicidal composition comprising a compound of general formula (I). A method for treating plants by applying a compound of general for...
04/28/2009
7365204Process for the production of pyridine and picolines
An process for the preparation of pyridine and/or picolines is disclosed. The process comprises contacting a mixture of carbonyl compound with ammonia in the presence of surface-passivated titanium-silicate catalyst in gas phase at a temperature ranging between 300-...
04/29/2008
7345177Vapor phase catalytic chlorination of β-picoline
2-Chloro-5-trichloromethylpyridine is obtained by chlorinating β-picoline in the vapor phase using a Mordenite zeolite or a supported palladium catalyst. ...
03/18/2008
7321043Processes for the preparation of 2-aminomethylpyridines and the 2-cyanopyridines used in their preparation
Disclosed herein is a process for the preparation of a compound of the formula (II): or a salt thereof, wherein X is halogen; each Y, which may be the same or different, is halogen, haloalkyl, alkoxycarbonyl or a...
01/22/2008
7304159Ligands and catalyst systems thereof for ethylene oligomerisation to linear alpha olefins
Mixed bis-imine pyridine ligands of formula (I), wherein Z1, which is different from Z2, is an optionally substituted aryl group; and Z2 comprises an optionally substituted heterohydrocarbyl moiety, or an optionally substituted aryl ...
12/04/2007
7273938Preparation of novel substituted haloarene compounds
This invention relates to a new process for the preparation of novel substituted haloarene compounds of the formula I or IV: respectively, wherein R1, R2, R3, R4, R
09/25/2007
7238764Process for the co-oligomerisation of ethylene and alpha olefins
A process for production of higher linear alpha olefins and/or alkyl-branched alpha olefins, which comprises the co-oligomerisation of one or more alpha olefins with ethylene in the presence of a metal catalyst system employing one or more bis-aryliminepyridine MX
07/03/2007
7232926Method for the production of sulphamic acid halogenides
The present invention relates to a process for preparing sulfamoyl halides of primary or secondary amines, comprising the following steps: i) reacting a primary or secondary amine A1 with at least equimolar amounts of SO3
06/19/2007
7217827Halogen-containing aromatic compound
The present invention relates to halogen-containing aromatic compounds and methods thereof. The present invention relates a halogen-containing aromatic acid dianhydride, halogen-containing aromatic tetranitrile compound, halogen-containing m-phenylenediamine compoun...
05/15/2007
7179871Non-symmetrical ligands and catalyst systems thereof for ethylene oligomerization to linear alpha olefins
Non-symmetrical ligands of formula (I); bis-aryliminepyridine MXn complexes comprising a non-symmetrical ligand of formula (I), wherein M is a metal selected from Fe or Co, n is 2 or 3, and X is halide...
02/20/2007
7125880Corticotropin releasing factor antagonists
Corticotropin-releasing factor (CRF) antagonists having the formulae wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 an...
10/24/2006
7101868Substituted arylamine derivatives and methods of use
Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and meth...
09/05/2006
7053020Catalyst systems for ethylene oligomerisation to linear alpha olefins
A catalyst system comprising: (a) one or more bisarylimino pyridine iron or cobalt catalysts; (b) a first co-catalyst compound which is selected from aluminium alkyls, aluminoxanes, and mixtures thereof; and ...
05/30/2006
7049442Ligands and catalyst systems thereof for ethylene oligomerisation to linear alpha olefins
Mixed bis-imine pyridine ligands of formula (I), wherein Z1, which is different from Z2, is an optionally substituted aryl group; and Z2 comprises an optionally substituted heterohydrocarbyl moiety, or an optionally substituted aryl ...
05/23/2006
7041691Compounds for the modulation of PPARγ activity
Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity. ...
05/09/2006
7037988Process for the co-oligomerisation of ethylene and alpha olefins
A process for production of higher linear alpha olefins and/or alkyl-branched alpha olefins, which comprises the co-oligomerisation of one or more alpha olefins with ethylene in the presence of a metal catalyst system employing one or more bis-aryliminepyridine MX
05/02/2006
7022857Preparation of substituted aromatic compounds
A process for preparing compounds of the formula (II), where the substituents R1 to R5 are each independently H, CH3, straight-chain or branched C1–C8-alkyl, CH(O...
04/04/2006
7012165Oxidative fluorination of aromatic and chloroaromatic derivatives
The subject invention provides methods of fluorinating an aromatic or chloroaromatic compound comprising combining an aromatic compound, a chloroaromatic compound, a mixture of aromatic compounds, a mixture of chloroaromatic compounds, or a mixture of chloroaromatic...
03/14/2006
6943257Process for preparation of aromatic halides from aromatic amines
The present invention provides a process for preparing an aromatic bromide or aromatic iodide from an aromatic amine derivative using nitrite anion and halodimethylsulfonium halide generated in situ from hydrobromic acid/DMSO or hydriodic acid/DMSO. The process for ...
09/13/2005
6921828Processes for the preparation of 2-aminomethlpyridines and the 2-cyanopyridines used in their preparation
The invention relates to a process for the preparation of a compound of formula (V), according to the following scheme: wherein the various substituants are as defined in the description ...
07/26/2005
6916959Halogen-containing aromatic compound
The present invention relates to halogen-containing aromatic compounds and methods thereof. The present invention relates a halogen-containing aromatic acid dianhydride, halogen-containing aromatic tetranitrile compound, halogen-containing m-phenylenediamine compoun...
07/12/2005
6903088Compounds which inhibit leukocyte adhesion mediated by VLA-4
Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, su...
06/07/2005
6844441Process for preparing substituted pyridines
A process for preparing a compound of the formula: wherein n, R1, R2, R3 and X are as defined above, used as an intermediate in the synthesis of β-adrenergic receptor agonists. ...
01/18/2005
6806371Preparation of substituted pyridine N-oxide compounds
A process for preparing substituted pyridine N-oxide compounds of the formula in which R1, R2, R3 and R4 are each H, a carboxyl group or a C1-C12-alkyl radical which may contain atoms from the gro...
10/19/2004
6794513Preparation of 3,6-dichloro-2-trichloromethylpyridine by vapor phase chlorination of 6-chloro-2-trichloromethylpyridine
A mixture containing 5,6-dichloro-2-trichloromethylpyridine and 3,6-dichloro-2-trichloromethylpyridine enriched in 3,6-dichloro-2-trichloro-methylpyridine is obtained by chlorinating 6-chloro-2-trichloromethylpyridine in the vapor phase using a Type L zeolite cataly...
09/21/2004
6706021Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors
Aminoguanidine and alkoxyguanidine compounds are described, including compounds of the Formula VII: wherein X is O or NR9 and Het, R1, R7, R8, R12-R15, R
03/16/2004
6683187Ligands and catalyst systems thereof for ethylene oligomerization to linear alpha olefins
Ligands of formula (V); ##STR1## bis-aryliminepyridine MXn complexes comprising a ligand of formula (V), wherein M is a metal selected from Fe and Co, n is 2 or 3, and X is halide, optionally substituted hydrocarbyl, alkoxide, amide, or hydride...
01/27/2004
6670480Process for preparing substituted pyridines
A process for preparing a compound of the formula ##STR1## wherein n, R1, R2, R3 and X are as defined above, used as an intermediate in the synthesis of ଲ-adrenergic receptor agonists....
12/30/2003
6667401Method for producing heterocyclic compounds
The present invention relates to a process for the preparation of compounds of the formula (I) ##STR1## in which R1, A, D, X and Z have the meanings given in the description, by reacting compounds of the formula (II) ##STR2## in wh...
12/23/2003
6653512Perfluoroalkyl haloalkyl ethers and compositions and applications thereof
Described are compositions comprising perfluoroalkyl haloalkyl ethers and, optionally, surfactant; uses for perfluoroalkyl haloalkyl ether compounds and compositions thereof, optionally comprising surfactant; and perfluoroalkyl haloalkyl ethers....
11/25/2003
6645904Aminophosphonium compounds
The present invention relates to compounds of the formula ##STR1## in which one, two or three of the radicals R1, R2, R3 and R4 are ##STR2## where m and n are an integer from 1 to 10, R5, R6
11/11/2003
6639079Chemical process
A process for the preparation of 3,5-dichloropyridine comprising reacting a trichloropyridine, a tetrachloropyridine or pentachloropyridine with zinc metal, in the presence of an acidic compound and at a temperature in the range 50-120° C....
10/28/2003
6635641Amide compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
Amide compounds represented by the formula: ##STR1## wherein: R1 is a moiety represented by the formula ##STR2## where X is selected from the group consisting of CH2, O, S, and NH; and Y is selected from the group consisting...
10/21/2003
6635767Synthesis of heteroarylamine intermediate compounds
Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines....
10/21/2003
6613909Synthesis of heteroarylamine intermediate compounds
Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines....
09/02/2003
6586601Method for producing 2-halopyridine-n-oxide
The present invention concerns a process for the preparation of 2-halopyridine N-oxide by reaction of 2-halopyridine with hydrogen peroxide in aqueous solution in the presence of an acid anhydride as catalyst in which, according to the invention, as catal...
07/01/2003
65831622-pyridinylguanidine urokinase inhibitors
Compounds of formula (I): ##STR1## or a pharmaceutically acceptable salt thereof, or solvate of either entity, wherein R4 is a guanidinyl moiety and the other substituents are as defined in the text, are urokinase inhibitors....
06/24/2003
64857975-Arylindane derivatives and ferroelectric liquid crystal mixture containing same
A ferroelectric liquid crystal mixture, especially useful for operation in the ͌Vmin -mode, comprises a 5-Arylindane derivative of the formula (I), ##STR1## wherein Y is CH, CF or N and R1 (--A1 --M1)a
11/26/2002
6469224Process for preparation of substituted aromatic compound
A substituted aromatic compound substituted with Q is obtained by reacting a phosphazenium compound represented by formula (1) ##STR1## (in the formula, Q- represents an anion in a form derived by elimination of a proton from an inorganic acid,...
10/22/2002
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