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| Number | Title | Issue Date |
| 8124783 | Process for producing 1-benzyl-4-[5,6-dimethoxy-1-indanon-2-yl)methyl] piperidine or its salt thereof via novel intermediate Disclosed herein the process for producing 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2yl)methyl]piperidine or its salt thereof employing novel intermediates. ... | 02/28/2012 |
| 7968725 | Pyridinyl modulators of γ-secretase The present invention relates to compounds of Formula I as shown below, wherein the definitions of A, X, R1 R2, R3, R4, R5, R6, R7, R8, and R9 are provided in the spec... | 06/28/2011 |
| 7829721 | Specific caspase-10 inhibitors The invention relates to compounds of the general formula (I), and to their use as caspase-10 inhibitors, especially for the treatment of diabetic retinopathy. ... | 11/09/2010 |
| 7807838 | Methods for the preparation of HCV polymerase inhibitors The present invention relates to methods and compounds useful in the preparation of compounds of the formula (I). ... | 10/05/2010 |
| 7541472 | 3-Aryl-3-hydroxy-2-methylenepropionic acid esters as fungicides Compounds of formula I are described: along with compositions thereof, methods of use thereof (particularly as fungicides), and methods of making the same. ... | 06/02/2009 |
| 7423030 | 1-amino-phthalazine derivatives, the preparation and the therapeutic use thereof A 1-amino-phthalazine derivative of general formula (I) wherein the substituents are as defined herein. Also disclosed are a method for preparing such compounds, intermediates for use in such method and medical treatments u... | 09/09/2008 |
| 7300946 | N-(substituted arylmethyl)-4-(disubstituted methyl) piperidines and pyridines It has now been found that certain novel N-(substituted aryl)-4(disubstituted methyl)piperidine and pyridine derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): wherein m, n, q, r, and s are independently selec... | 11/27/2007 |
| RE39916 | Compounds that modulate PPAR activity and methods for their preparation This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds of their salts, and methods of using them as therapeutic a... | 11/06/2007 |
| RE39754 | Benzamide derivatives and pharmaceutical compositions containing same The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune... | 07/31/2007 |
| 7220752 | Compounds active at the glucocorticoid receptor II This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in therapy and in the regulation of metabolism, especially lowering blood glucose ... | 05/22/2007 |
| 7199239 | Chemical compounds A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, Wherein: R1 and R2 are independently hydrogen or C... | 04/03/2007 |
| 7166726 | Aryl substituted 3,4-dihydroanthracene derivatives having retinoid antagonist or retinoid inverse agonist type biological activity Disclosed herein are compounds of the formula wherein R1 is independently H or alkyl of 1 to 6 carbons; R2 is optional and is defined as lower alkyl of 1 to 6 carbons, F, Cl, Br... | 01/23/2007 |
| 7125442 | Lightfast additive having UV-absorbing moiety and ink composition including the same A lightfast additive and an ink composition including the same include a benzophenone moiety for lightfastness and a moiety for wettability and the ability to stabilize a colorant, wherein the two moieties are covalently bonded. The lightfast additive may exhibit ef... | 10/24/2006 |
| 7012146 | Ion channel modulating agents The present invention relates to ion channel modulating agents. More particularly, the present invention relates to a particular class of chemical compounds that has proven useful as modulators of SK Ca, IK Ca and BK Ca channels. In further aspects, the present inve... | 03/14/2006 |
| 6984645 | Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein Compounds that are dual aP2/k-FABP inhibitors are provided having the formula wherein A, B, X, Y, R1, R2 and R3 are as described herein. A method is also provided for treating diabetes ... | 01/10/2006 |
| 6962994 | Process for the synthesis of 1,3-diols An improved process for the preparation of cis-1,3-diols is described where a beta hydroxy ketone is treated with a trialkylborane or dialkylalkoxyborane or a mixture of a trialkylborane and a dialkylalkoxyborane followed by recovery and reuse of the alkylborane spe... | 11/08/2005 |
| 6951877 | Materials and methods for treating hypercholesterolemia The subject invention provides novel HMG-CoA-reductase inhibitors. In a preferred embodiment, the HMG-CoA reductase inhibitors of the subject invention can be deactivated to a primary inactive metabolite by hydrolytic enzymes. Compounds of the present invention can ... | 10/04/2005 |
| 6949656 | Cyclic amine derivatives and use thereof A composition for use as an antiobestic agent and preventive or therapeutic agent for diabetes, containing a compound of the formula (I): wherein, A is substituted aryl or substituted heteroaryl with one or more group(... | 09/27/2005 |
| 6949650 | Process for the racemization of 1-benzyl-4-(4-fluorophenyl)-3-hydroxymethyl-1,2-3,6-tetrahydropyridine to be used as intermediate in the synthesis of paroxetine A process for the racemization of enantiomerically enriched 1-benzyl-4-(4-fluorophenyl)-3-hydroxymethyl-1,2,3,6-tetrahydropyridine which is a useful intermediate in the preparation of paroxetine. Formula (A) means that the compound (I) has an enantiomeric excess of ... | 09/27/2005 |
| 6942980 | Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities Methods of characterizing and identifying negative hormones of nuclear receptors. Also disclosed are methods of making modulators of retinoid nuclear receptor transactivation activity, assays for agonists, antagonists, and negative hormones of the RAR receptor, and ... | 09/13/2005 |
| 6939875 | Compounds that modulate PPAR activity and methods for their preparation This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic a... | 09/06/2005 |
| 6921454 | Elastomer toughened radiation curable adhesives A radiation curable adhesive composition which includes: a) an α,β-olefinically unsaturated ether monomer component consisting of one or more compounds having the formula: R[O—CH═CHR1]n (I) where R is... | 07/26/2005 |
| 6906046 | Pharmaceutical uses and synthesis of benzobicyclooctanes Benzobicyclooctane compounds, their use in inhibiting cellular events involving TNF-α and IL-8, and in the treatment of inflammation events in general; a combinatorial library of diverse bicyclooctanes and process for their synthesis as a library and as individual ... | 06/14/2005 |
| 6881741 | Compounds and methods for the treatment or prevention of Flavivirus infections The present invention provides novel compounds represented by formula I: or pharmaceutically acceptable salts thereof useful for treating flaviviridae viral infection. ... | 04/19/2005 |
| 6875867 | Process for preparing chiral diol sulfones and dihydroxy acid HMG CoA reductase inhibitors A process is provided for preparing chiral diol sulfones of the structure where R3 is preferably where R4a is preferably aryl such as phenyl, and R | 04/05/2005 |
| 6867218 | Compounds, their preparation and use The present invention relates to compounds of the general formula (I) The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Act... | 03/15/2005 |
| 6749988 | Amine compounds, resist compositions and patterning process Novel amine compounds having a nitrogen-containing cyclic structure and a hydrating group such as a hydroxy, ether, ester, carbonyl, carbonate group or lactone ring are useful for use in resist compositions for preventing a resist film from thinning and also for enh... | 06/15/2004 |
| 6737530 | Process A new process for the preparation of 4-(4-pyridinyl)benzoic acid, or a salt thereof. ... | 05/18/2004 |
| 6649623 | Cyclic amine derivatives and use thereof A composition for use as an antiobestic agent and preventive or therapeutic agent for diabetes, containing a compound of the formula (I): ##STR1## wherein, A is optionally substituted aryl or optionally substituted heteroaryl; X is O, S, NR wherei... | 11/18/2003 |
| 6642273 | Unsaturated derivatives at the 4-position of 6-tert-butyl-1,1-dimethylindane and their use in human and veterinary medicine and in cosmetics An unsaturated derivative at the 4-position of 6-tert-butyl-1,1-dimethylindane corresponding to the following formula: ##STR1## in which: X represents: a divalent radical of formula: ##STR2## and Y represents a divalent radical of following formul... | 11/04/2003 |
| 6638940 | Tetrahydropyridines as pesticides Compounds of formula ##STR1## are described, wherein R1 and R2 are for example, independently of each other, halogen, C1 -C6 -alkyl, C3 -C6 -cycloalkyl, halogen-C1 -C6 | 10/28/2003 |
| 6603012 | RAR selective retinoid agonists New compounds containing bicyclic fused rings, one of which being a phenyl moiety connected by an aliphatic chain to a cycloalkyl or aryl moiety, and pharmaceutically active salts thereof are useful as RAR selective retinoid agonists. Furthermore, such re... | 08/05/2003 |
| 6596193 | Electrooptical liquid crystal system To improve switching times, especially at low temperatures, one or more reactive liquid crystalline compounds is added to a liquid crystal mixture used in an electrooptical system. The electrooptical system comprises a PDLC film comprising a liquid crysta... | 07/22/2003 |
| 6579881 | Indoles A 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: ##STR1## wherein A, B, C, D, T, Y, and Z each represent a methine or a nitrogen linkage; R1, R2, R3 | 06/17/2003 |
| 6565769 | Electrooptical liquid crystal system To improve switching times, especially at low temperatures, one or more reactive liquid crystalline compounds is added to a liquid crystal mixture used in an electrooptical system. The electrooptical system comprises a PDLC film comprising a liquid crystal mix... | 05/20/2003 |
| 6492522 | Process and intermediates for production of donepezil and related compounds The present invention relates to a new process for the preparation of acetylcholinesterase inhibitors of formula (I) or a salt thereof, wherein: R1 is N-acyl-4-piperidyl; N-alkoxycarbonyl-4-piperidyl; N-alkyl-4-piperidyl; N-benzyl-4-piperidyl; ... | 12/10/2002 |
| 6448243 | 1,4-substituted cyclic amine derivatives A novel 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: ##STR1## (wherein A, B, C, D, T, Y and Z represent each methine or nitrogen; R1, R2, R3, ... | 09/10/2002 |
| 6444688 | Compounds and compositions with nitrogen-containing non-basic side chains The instant invention provides compounds of formula I ##STR1## wherein R1 is OH, O--C(O)--(C1 -C6 alkyl), O--C(O)--O(C1 -C6 alkyl), O--C(O)--Ar, or O--C(O)--O--Ar; R2 is H, OH, O(C1 -... | 09/03/2002 |
| 6420314 | Substituted 2-phenyl pyridines, their manufacture and use as herbicides Substituted 2-phenylpyridines of the formula I ##STR1## in which the substituents and the index m are defined in the specification.... | 07/16/2002 |
| 6391899 | Compounds and compositions for treating tissue ischemia There is disclosed a genus of compounds and pharmaceutical compositions that are protective for mitigating damage associated with tissue ischemia, particularly stroke (CNS ischemia), and ischemia of the myocardium. The present invention further provides a... | 05/21/2002 |
