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Class 546/339 - Chalcogen attached indirectly to the six-membered hetero ring by nonionic bonding (e.g., sulfato betaines, etc.)


Subclass of Class 546 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein chalcogen (i.e., oxygen, sulfur, selenium,
No. of patents: 457
Last issue date: 03/06/2012


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NumberTitleIssue Date
8129539Process for the preparation of 2-substituted-5-(1-alkylthio)alkylpyridines
2-Substituted-5-(1-alkylthio)alkylpyridines are produced efficiently and in high yield from a non-pyridine source by cyclization. ...
03/06/2012
8067609Methods for oligomerizing olefins with chromium pyridine thioether catalysts
The present invention provides a method of producing oligomers of olefins, comprising reacting olefins with a chromium based catalyst under oligomerization conditions. The catalyst can be the product of the combination of a chromium compound and a pyridyl thioether ...
11/29/2011
7709650Process for the preparation of 2-substituted-5-(1-alkylthio)alkylpyridines
2-Substituted-5-(1-alkylthio)alkylpyridines are produced efficiently and in high yield from a non-pyridine source by cyclization. ...
05/04/2010
7456292Hydroxamic acid-containing amino acid derivatives
Novel hydroxamic acid containing amino acid derivatives are provided that are useful for treatment of inflammation, inflammatory and immunological diseases; lowering blood glucose, serum insulin, free fatty acids, cholesterol and triglyceride levels; and for treatme...
11/25/2008
74140644-(3,3-dihalo-allyloxy) phenoxy alkyl derivatives
Compounds of formula wherein A1, A2 and A3 are each independently of the others a bond or a C1-C6alkylene bridge; ...
08/19/2008
7399775β-amyloid protein production/secretion inhibitor
Provided are novel compounds having an inhibitory activity against production or secretion of β-amyloid protein. They embrace compounds represented by the following formula (1): and capable of being replaced with a variety...
07/15/2008
7390433Benzene derivative having long, linear conjugated structure, process for producing benzene derivative, and liquid-crystal material
The present invention provides, in a method for transporting charge using the molecular orientation in a liquid-crystalline state, a novel benzene derivative having a long, linear conjugated structure expected to have satisfactory charge-transport properties without...
06/24/2008
7378446Compound having anti-HCV activity and process for producing the same
The object of the present invention is to provide a compound useful for the prevention and treatment of viral infectious diseases, and particularly liver diseases caused by HCV infection due to its having a high degree of replication inhibitory activity against HCV,...
05/27/2008
7375121Chemical compounds
The present invention concerns compounds of formula (I), and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts, which compounds inhibit carboxypeptidase U and thus can be used in the preventio...
05/20/2008
7354942Benzylether and benzylamino beta-secretase inhibitors for the treatment of Alzheimer's disease
The present invention is directed to benzylether and benzylamino derivative compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secre...
04/08/2008
7345202Use of sulfamic acids as resolving agent
The invention relates to the use of chiral sulfamic acids as resolving agents, the sulfamic acid having the formula (R1,R2)N—SO3H, wherein: R1 and R2, being the same or different, represent a hydrogen atom or a C1
03/18/2008
73421153-substituted-6-aryl pyridines
3-substituted-6-aryl pyridines of Formula I are provided: wherein R1, R2, R3, R8, R9, A and Ar are defined herein. Such compounds are ligands of C5a receptor. Preferred...
03/11/2008
7338960Phenylalkanoic acid and phenyloxyalkanoic acid derivatives as hPPAR activators
A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, wherein: ...
03/04/2008
7332623Aryl-substituted acyclic enediyne compounds
This invention provides aryl-substituted acyclic enediyne compounds of formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein
02/19/2008
7321044Synthesis of oxygen-substituted benzocycloheptenes as valuable intermediate products for the production of tissue-selective estrogens
The invention relates to intermediate products and a new process for the production of benzocycloheptene C. The process for the production of its new intermediate products according to the invention starts from eco...
01/22/2008
7291753Transfer hydrogenation processes and catalysts
The invention relates to a process for the reduction of compounds comprising a carbon-carbon (C═C), carbon-oxygen (C═O), or carbon-nitrogen (C═N) double bond, to a corresponding hydrogenated alkane, alcohol or amine, comprising contacting a compound comprising...
11/06/2007
7256297Methods of preparing sulfinamides and sulfoxides
This invention encompasses novel methods of preparing sulfinamides and sulfoxides, particularly stereomerically pure sulfinamides and sulfoxides. The invention further encompasses novel compounds from which sulfinamides and sulfoxides can be prepared. ...
08/14/2007
7256186Gamma secretase inhibitors
This invention discloses novel gamma secretase inhibitors of the formula: wherein: R1 is a substituted aryl or substituted heteroaryl group; R2 ...
08/14/2007
7253178Carboxylic acids
The present invention provides a novel carboxylic acid derivative, a salt thereof or a hydrate of them which is useful as an insulin sensitizer, and a medicament comprising the derivative as the effective ingredient. More specifically, it provides a carboxylic acid ...
08/07/2007
7253194Compounds and inhibitors of phospholipases
The present invention relates generally to amino acid derivatives and to methods of making the same. In particular, the invention relates to compounds bearing a stereochemical identity, that is, the same stereochemistry, with the chiral α-carbon of D-α-amino acids...
08/07/2007
7247731Ligands for metals and improved metal-catalyzed processes based thereon
One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming react...
07/24/2007
7235576Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy. ...
06/26/2007
7208602Gamma secretase inhibitors
This invention discloses novel gamma secretase inhibitors of the formula: wherein: R1 is a substituted aryl or substituted heteroaryl group; R2 ...
04/24/2007
7169325Liquid crystalline compound, liquid crystalline composition and retardation film
To provide a liquid crystalline compound capable of exhibiting a biaxial liquid crystal phase, provide a trifunctional or greater functional polymerizable liquid crystalline compound having polymerizable groups, and also to provide a liquid crystalline composition a...
01/30/2007
7166593Glucocorticoid receptor modulators
The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonist and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions conta...
01/23/2007
7148238Phenyl-piperazine derivatives as serotonin reuptake inhibitors
The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depress...
12/12/2006
7144884Phenyl-piperazine derivatives as serotonin reuptake inhibitors
The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disor...
12/05/2006
7138407Phenyl-piperazine derivatives as serotonin reuptake inhibitors
The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depress...
11/21/2006
7129247Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents
The present invention relates to novel heterocyclyl-containing diaryl sulfide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing...
10/31/2006
7125880Corticotropin releasing factor antagonists
Corticotropin-releasing factor (CRF) antagonists having the formulae wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 an...
10/24/2006
7105549Aryl substituted pyridines and the use thereof
This invention relates aryl substituted pyridines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1–R4 are set in the specification. The in...
09/12/2006
7074936Cleavable surfactants and methods of use thereof
Cleavable compositions and methods of use especially in MALDI MS analysis of hydrophobic proteins. ...
07/11/2006
7067538MCP-1 receptor antagonists and methods of use thereof
The present invention relates to sulfones that are useful in the treatment of chemokine-mediated disorders. In certain embodiments, the present invention concerns the compounds that are MCP-1 receptor antagonists. ...
06/27/2006
7064214Methods of preparing sulfinamides and sulfoxides
This invention encompasses novel methods of preparing sulfinamides and sulfoxides, particularly stereomerically pure sulfinamides and sulfoxides. The invention further encompasses novel compounds from which sulfinamides and sulfoxides can be prepared. ...
06/20/2006
7022857Preparation of substituted aromatic compounds
A process for preparing compounds of the formula (II), where the substituents R1 to R5 are each independently H, CH3, straight-chain or branched C1–C8-alkyl, CH(O...
04/04/2006
70086362,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
This invention provides compounds of Formula I having the structure or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia. ...
03/07/2006
6962994Process for the synthesis of 1,3-diols
An improved process for the preparation of cis-1,3-diols is described where a beta hydroxy ketone is treated with a trialkylborane or dialkylalkoxyborane or a mixture of a trialkylborane and a dialkylalkoxyborane followed by recovery and reuse of the alkylborane spe...
11/08/2005
6949656Cyclic amine derivatives and use thereof
A composition for use as an antiobestic agent and preventive or therapeutic agent for diabetes, containing a compound of the formula (I): wherein, A is substituted aryl or substituted heteroaryl with one or more group(...
09/27/2005
6946560Ligands for metals and improved metal-catalyzed processes based thereon
One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming react...
09/20/2005
6909003Process for the manufacture of organic compounds
The invention relates to a process for the manufacture of a compound of formula or a salt, especially a pharmaceutically acceptable salt with a base, thereof or a lactone thereof wherein the element represents —CH
06/21/2005
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