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| Number | Title | Issue Date |
| 8143412 | Inhibitors of proliferation and activation of signal transducer and activator of transcription (STATs) Pyridine compounds effective in modulation STAT3 and/or STAT5 activation are provided that are useful in the prevention and treatment of proliferative disease and conditions including cancer, inflammation and proliferative skin disorders. ... | 03/27/2012 |
| 7700780 | Zwitterionic chromophores and macromolecules containing such chromophores The invention disclosed relates to functionalized zwitterionic chromophores of structural formula III and III′. Wherein A is a linear or branched alkyl group having up to 20 carbon atoms... | 04/20/2010 |
| 7687634 | Insecticidal N-substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximines N-Substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximines are effective at controlling insects. ... | 03/30/2010 |
| 7405229 | Cathepsin cysteine protease inhibitors This invention relates to a class of compounds having the general formula (I) which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone r... | 07/29/2008 |
| 7375134 | Cathepsin cysteine protease inhibitors This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, s... | 05/20/2008 |
| 7348456 | Substituted amides Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are... | 03/25/2008 |
| 7342115 | 3-substituted-6-aryl pyridines 3-substituted-6-aryl pyridines of Formula I are provided: wherein R1, R2, R3, R8, R9, A and Ar are defined herein. Such compounds are ligands of C5a receptor. Preferred... | 03/11/2008 |
| 7320993 | Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group, ... | 01/22/2008 |
| 7279478 | Cathepsin cysteine protease inhibitors This invention relates to class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as o... | 10/09/2007 |
| 7268152 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof Compounds of Formula (IA) and Formula (IB) wherein R1, R2, R3, R4, R5, and R6 are as defined herein for Formula (IA) or Formula (IB), or a tautome... | 09/11/2007 |
| 7262209 | Carbonyloxy-cyanomethyl compounds as antiparasitic agents The invention relates to compounds of the general formula wherein Ar1, Ar2, R4, R5, R6, R7, R8, W, X, a and b have the significances gi... | 08/28/2007 |
| 7258924 | Polar ordering of reactive chromophores in layer-by-layer nonlinear optical materials Thin films exhibiting second-order nonlinear optical (NLO) properties, as well as materials and methods for producing such films, are provided. The films are formed by depositing, on a substrate, alternate layers of a polyelectrolyte and a low molecular weight chrom... | 08/21/2007 |
| 7157454 | Derivatives of n-(arylsulfonyl)beta-aminoacids comprising a substituted aminomethyl group, the preparation method thereof and the pharmaceutical compositions containing same The invention relates to compounds of formula: These compounds show affinity for the bradykinin receptors with selectivity towards the B1 receptors; they may be used for the preparation of medicinal pr... | 01/02/2007 |
| 7081468 | Ortho-substituted anthranilic acid amides and their use as medicaments Ortho-substituted anthranilic acid amides and use thereof as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis are described. ... | 07/25/2006 |
| 7019166 | Method for the production of 2,4,5-trimethylphenyl acetic acid The present invention relates to a novel process for preparing 2,4,5-trimethylphenyl-acetic acid by reacting pseudocumene with dichloroacetyl chloride in a Friedel-Crafts reaction to give 2,2-dichloro-1-(2,4,5-trimethylphenyl)ethanone, converting the 2,2-dichloro-1-... | 03/28/2006 |
| 6953811 | N-substituted tetrahydropyridines and their use as pesticides A description is given of compounds of the formula in which R1 and R2 independently of one another are halogen, C1-C6alkyl, halo-C1-C6alkyl... | 10/11/2005 |
| 6946269 | Alkyl esters of 3-(3,4-dihalophenyl)-2,6-dioxopiperidine-3-propionic acid of use as intermediates The invention relates to lower-alkyl esters of 3-(3,4-dihalophenyl)-2,6-dioxopiperidine-3-propionic acid derivatives, and to processes for preparing the same. ... | 09/20/2005 |
| 6894169 | Zwitterionic chromophores and polymers containing such chromophores A non-linear chromophore is obtained by reacting a picolinium halide having a desired functional group (preferably —OH) with a lithium TCNQ adduct. If desired, the chromophore can be graft polymerized onto a polymer which has complementary functional groups (prefe... | 05/17/2005 |
| 6812229 | Carbamate derivative and agricultural/horticultural fungicide It is to provide a novel fungicide having high controlling effects on plant diseases particularly on wheat powdery mildew and cucumber gray mold, without ill effects on crops. A carbamate derivative represented by the general formula [I] | 11/02/2004 |
| 6747146 | Method of producing nitroguanidine- and nitroenamine derivatives Method of producing compounds of formula wherein R1 is hydrogen or C1-C4-alkyl; R2 is hydrogen, C1-C8-alkyl, C3-C6-cyc... | 06/08/2004 |
| 6743564 | Amine compounds, resist compositions and patterning process Amine compounds having a cyano group are useful in resist compositions for preventing a resist film from thinning and also for enhancing the resolution and focus margin of resist. ... | 06/01/2004 |
| 6716981 | Process for the preparation of N-(amino-4, 6-dihalo-pyrimidine) formamides A process for the preparation of a 2,5-diamino-4,6-dihalopyrimidine of the formula: in which X is a halogen atom, comprising reacting 2,5-diamino-4,6-dihydroxypyrimidine or its salt of the formula: | 04/06/2004 |
| 6699884 | Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation Methods of treating cyclooxygenase-2 mediated disorders comprising administering to a subject a therapeutically effective amount of one or more fluoro-substituted benzenesulfonyl compounds corresponding to Formula I: ##STR1## wherein A, X, n, R1... | 03/02/2004 |
| 6638962 | Cycloheptene compounds Compound of formula (I): ##STR1## wherein: X represents a bond or alkylene, CO, S(O)n, --S(O)n --A1 --, --CO--A1 --, --A--S(O)n --A'1 -- or --A1 --CO--A'1 --, ... | 10/28/2003 |
| 6638940 | Tetrahydropyridines as pesticides Compounds of formula ##STR1## are described, wherein R1 and R2 are for example, independently of each other, halogen, C1 -C6 -alkyl, C3 -C6 -cycloalkyl, halogen-C1 -C6 | 10/28/2003 |
| 6635645 | 2,5,-diazabicyclo[2.2.1]heptane derivatives, their preparation and therapeutic uses The invention relates to 2,5-diazabicyclo[2.2.1]heptane derivatives, to pharmaceutical compositions containing them, and to methods for the treatment or prevention of disorders associated with a dysfunction of the nicotinic receptors utilizing them.... | 10/21/2003 |
| 6630495 | Fungicides Compounds of formula (I) or (II): ##STR1## or salts therefor are used as phytopathogenic fungicides wherein the various radicals and substitutents are as defined in the description. Pesticidal compositions contain these compounds together with an agr... | 10/07/2003 |
| 6624179 | Geometrical isomers of acrylonitrile compounds, mixture thereof, and process for producing these A geometrical isomer of an acrylonitrile compound represented by the formula (I) or of its salt, or a mixture thereof: ##STR1## [wherein T is phenyl or pyridyl, which is substituted by R2, Q is phenyl, thienyl, pyridyl or benzyl, which may be s... | 09/23/2003 |
| 6566527 | Process for preparing 1-(6-methylpyridin-3-yl)-2-[4-methylsulphonyl)-phenyl]ethanone A five-step process for preparing 1-(6-methylpyridin-3-yl)-2-[4-methylsulfonyl)phenyl]ethanone of formula (I): ##STR1## The process involves the following steps: (a) 4-(methylthio)benzyl alcohol is converted into 4-(methylthio)benzyl chloride; (b) 4-... | 05/20/2003 |
| 6555562 | Phenylalanine derivatives Phenylalanine derivatives of formula (1) are described: ##STR1## wherein R is a carboxylic acid or a derivative thereof; L1 is a linker atom or group; Ar is an optionally substituted aromatic group; and the salts, solvates, hydrates and N-oxides thereof.... | 04/29/2003 |
| 6525036 | Compounds and compositions as protease inhibitors The present invention relates to novel cysteine protease inhibitors of Formula I: ##STR1## the pharmaceutically acceptable salts and N-oxide derivatives thereof, their use as therapeutic agents and methods of making them.... | 02/25/2003 |
| 6503933 | 2-pyridylmethylamine derivatives useful as fungicides Compounds of formula (I) and salts thereof as phytopathogenic fungicides wherein A1 is substituted 2-pyridyl; A2 is optionally substituted phenyl; L is --(C.dbd.O)--, --SO2 -- or --(C.dbd.S)--; R1 is hydrogen, o... | 01/07/2003 |
| 6437122 | Method for producing a heterocyclic nitrile A method for producing a heterocyclic nitrile in high yield by a gas-phase catalytic reaction of a heterocyclic carboxylic acid or an ester thereof with ammonia in the presence of a catalyst comprising an oxide of at least one element selected from copper... | 08/20/2002 |
| 6417207 | Nitrosated and nitrosylated potassium channel activators, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated potassium channel activators, and novel compositions comprising at least one nitrosated and/or nitrosylated potassium channel activator, and, optionally, at least one compound that donat... | 07/09/2002 |
| 6392050 | Process for preparing substituted pyridines The invention relates to a process for preparing substituted pyridines in a simple and cost-effective manner in good yields by reacting substituted 1,4-dihydropyridines with methyl nitrite in the presence of an acid that contains less than 20% by weight o... | 05/21/2002 |
| 6387934 | 2-Cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives 2-Cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of diseases or disorders whose course involves increased connective tissue or cartilage degradation.... | 05/14/2002 |
| 6376671 | 2-sulfamoylbenzoic acid derivatives 2-Sulfamoylbenzoic acid derivatives of general formula (I): ##STR1## which have both an antagonistic effect on the leukotriene D4 receptor and an antagonistic effect on the thromboxane A2 receptor and salts thereof, pharmaceuticals, ... | 04/23/2002 |
| 6335352 | IL-8 receptor antagonists Novel compounds useful in the treatment of Interleukin-8 mediated diseases, and methods of using them are disclosed.... | 01/01/2002 |
| 6335446 | Quinolinium- and pyridinium-based fluorescent dye compounds The present invention relates to quinolinium- and pyridinium-based fluorescent dyes. The dyes are useful for staining proteins in solution, in gels and on solid supports. The dyes of the invention exhibit higher fluorescence emission than known compounds ... | 01/01/2002 |
| 6303641 | Cyanoamidines as cell proliferation inhibitors Compounds of the following formula are used for inhibiting cell proliferation: ##STR1## wherein R, R1, Q, X are as defined in the specification.... | 10/16/2001 |
