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| Number | Title | Issue Date |
| 7795441 | Process for preparing imino compounds Process for preparing imine compounds, in which a carbonyl compound is reacted with a primary amine. The imine compound obtained in this way can be reacted further with a metalalkyl and subsequently a carbonyl compound to form an imine compound. ... | 09/14/2010 |
| 7358264 | Statine derivatives for the treatment of Alzheimer's disease The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment ... | 04/15/2008 |
| 7354943 | Statine derivatives for the treatment of Alzheimer's disease The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment ... | 04/08/2008 |
| 7320993 | Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group, ... | 01/22/2008 |
| 6949655 | Acyclic piperidine derivatives A compound having the formula (I): wherein: each R1, R2, R3 and R4 are independently selected from (C1-C10)-straight ... | 09/27/2005 |
| 6632823 | Substituted pyridine compounds useful as modulators of acetylcholine receptors In accordance with the present invention, a novel class of substituted pyridine compounds (optionally containing ether, ester, amide, ketone or thioether substitutions) that promote the release of ligands involved in neurotransmission have been discovered... | 10/14/2003 |
| 6566375 | Elevation of HDL cholesterol by 4-[(aminothioxomethyl)-hydrazono]-N-(substituted)-4-arylbutanamides Compounds of this invention increase plasma levels of high density lipoprotein or HDL, the "good" cholesterol and as such may be useful for treating diseases such as atherosclerosis. These compounds are represented by the formula ##STR1## wherein: R | 05/20/2003 |
| 6506780 | Benzophenones and sulfones as inhibitors of glycine uptake This invention relates to a series of substituted benzophenone and sulfone compounds of the formula I ##STR1## wherein ring A, Z, Y, R and X are defined as in the specification, that exhibit activity as glycine transport inhibitors, their pharmaceutically... | 01/14/2003 |
| 6214818 | Cephem compounds and pharmaceutical compositions containing the same A cephem compound, wherein the cephem ring has a substituent at the 3-position, which substituent is shown by the formula II, wherein Het is a mono- or polycyclic heterocyclic group comprising one or more hetero atoms selected from the group consisting of... | 04/10/2001 |
| 6204387 | Process for making diaryl pyridines useful as COX-2 inhibitors The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1##... | 03/20/2001 |
| 6121268 | Benzyloxy substituted aromatics and their use as fungicides Compounds with fungicidal properties having formula I ##STR1## where m and n are 0 or 1 provided that m+n is 1; X is hydrogen, halo, (C1 -C4)alkyl, or (C1 -C4)alkoxy; R is an optionally-substituted alkyl, c... | 09/19/2000 |
| 6096893 | Process and intermediates for 3-heteroaryl-4(3H) quinazolines A new pyridine carbaldehyde is useful for the synthesis of compounds which are effective for treating neurodegeneration conditions and CNS trauma.... | 08/01/2000 |
| 5922710 | Iminooxybenzylcrotonate esters, their preparation and their use Iminooxybenzylcrotonate esters of the formula I ##STR1## where the index and the substituents have the following meanings: n is 0, 1, 2, 3 or 4; R is nitro, cyano, halogen, unsubst. or subst. alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy o... | 07/13/1999 |
| 5919792 | Integrin antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are v댣 antagonists, ... | 07/06/1999 |
| 5731332 | Substituted benzamidine compounds which have useful pharmaceutical activity Compounds of formula ##STR1## and their therapeutic use, inter alia, as LTB4 -antagonists. Exemplary compounds are: (Methoxycarbonyl-imino-{4'-2-(2-propylphenoxy)-ethoxy!-biphenyl-4-yl}-meth yl)-amine; (Benzyloxycarbonyl-imino-{4'-2-(2-... | 03/24/1998 |
| 5705513 | Fungicides for the control of take-all disease of plants A compound, composition, and method for controlling Take-all disease of plants by applying to the seed prior to planting, a fungicide of the formula: ##STR1## wherein Z1 and Z2 are C and are part of an aromatic ring which i... | 01/06/1998 |
| 5605915 | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity Compounds of the formula ##STR1## wherein the symbols have the meaning defined in the specification.... | 02/25/1997 |
| 5565488 | Oxalylamino-benzofuran- and benzothienyl-derivatives The inventive Oxalylamino-benzofuran- and benzothienyl-derivatives are prepared by reacting the appropriate amino substituted benzofuranes and benzothiophenes with oxalic acid derivatives. The inventive compounds are suitable for the prevention and treatm... | 10/15/1996 |
| 5552418 | Trisubstituted Naphthylalkylamides The invention relates to a compound selected from those of formula (I): ##STR1## in which R, R1, R2 and R3 are as defined in the specification, and a medicinal product containing said compound for treating a disorder of ... | 09/03/1996 |
| 5536723 | S-nitroso derivatives of hydrazinoacetic acids, 1-[(acylthio and (mercapto)-1-oxoalkyl]-1,2,34-Tetrahydroquinoline-2-carboxylic acids and alanyl prolines and isoquinolines The invention relates to novel S-nitroso derivatives of ACE inhibitors and to pharmaceutical compositions comprising the S-nitrosothiol derivatives of the invention together with a pharmaceutically acceptable carrier. The invention also relates to methods for ... | 07/16/1996 |
| 5453509 | Functionalization of acyl pyridinium salts This invention relates to a method of preparation of 1,2-dihydropyridine compounds having the structure: ##STR1## which comprises reacting a compound having the structure: ##STR2## The reaction is performed under suitable reaction conditions and... | 09/26/1995 |
| 5411973 | Therapeutic alcohols Compounds of formula I ##STR1## wherein X, A, B, R1 and R2 have the meanings given in the specification, and pharmaceutically acceptable salts and pharmaceutically acceptable in vivo hydrolysable ester thereof, processes for pre... | 05/02/1995 |
| 5389653 | Catechol derivatives Catechol derivatives of the formula ##STR1## wherein Ra, Rb and Rc have the significance given herein, the ester and ether derivatives thereof which are hydrolyzable under physiological conditions and the pharmaceutically acceptable salts thereof are... | 02/14/1995 |
| 5380858 | Process for the preparation of intermediates useful for the synthesis of histamine receptor antagonists The present invention relates to a novel process for the preparation of highly potent histamine receptor antagonists, in particular histamine H3 receptor antagonists. Also disclosed is a novel process for the preparation of intermediates useful... | 01/10/1995 |
| 5356890 | S-nitroso derivatives of ace inhibitors and the use thereof The invention relates to novel S-nitroso derivatives of ACE inhibitors and to pharmaceutical compositions comprising the S-nitrosothiol derivatives of the invention together with a pharmaceutically acceptable carrier. The invention also relates to methods for ... | 10/18/1994 |
| 5231182 | Method of making certain aryl containing amides Methods of preparing bis-aryl amide and urea compounds of the general formula: ##STR1## wherein x is a divalent amide or urea substituent and Y is a nitrogen containing heterocycle, which compounds are inhibitors of platelet activating factor.... | 07/27/1993 |
| 5204479 | Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime The subject of the invention is the compounds of formula (I): ##STR1## in which: R represents a hydrogen atom, a saturated or unsaturated, linear, branched or cyclic alkyl radical containing up to 8 carbon atoms, R' represents an amine-containing moiety o... | 04/20/1993 |
| 5142056 | Retroviral protease inhibiting compounds A retroviral protease inhibiting compound of the formula A--X--B or a pharmaceutically acceptable salt, prodrug or ester thereof, wherein X is a linking group; A is (1) substituted amino, (2) substituted carbonyl, (3) functionalized imino, (4) functionalized alkyl,... | 08/25/1992 |
| 5100460 | Herbicidal compounds and compositions containing them Herbicides of formula: ##STR1## in which: n=0,1, 2 f=0,1 A is chosen from the groups ##STR2## in which: Ar is chosen from the groups ##STR3## B is chosen from optionally substituted C1 -C10 alkyl and C3... | 03/31/1992 |
| 5079366 | Quarternary pyridinium salts The invention provides novel amino acids and peptides containing them which comprise a dihydropyridine.revreaction.pyridinium salt-type redox system and which provide site-specific and sustained delivery of pharmacologically active peptides to the brain. ... | 01/07/1992 |
| 5077409 | Method of preparing bis-aryl amide and urea antagonists of platelet activating factor Methods of preparing bis-aryl amide and urea compounds of the general formula: ##STR1## wherein x is a divalent amide or urea substituent and Y is a nitrogen containing heterocycle, which compounds are inhibitors of platelet activating factor.... | 12/31/1991 |
| 5055471 | Fungicides This invention relates to derivatives of propanoic acid of the formula ##STR1## Useful as fungicides, insecticides and miticides, to processes for preparing them, to compositions containing them, and to methods of using them to combat fungi, especial... | 10/08/1991 |
| 5053504 | Process for benzazepine intermediates A process is disclosed for providing benzazepine intermediates of the formulae ##STR1## wherein R3, R4 and Y are as defined herein, which intermediates are useful in a process for the preparation of pharmaceutically useful ... | 10/01/1991 |
| 5008276 | Methyl -(2-substituted)pyrid-3-yl-ଲ-methoxyacrylates, compositions containing them and their use as fungicides Fungicidal compounds of the formula (I): ##STR1## and stereoisomers thereof, wherein K is oxygen or sulphur; Z is optionally substituted aryl or optionally substituted heteroaryl; X is O, S(O)n, NR4, CR1 R2... | 04/16/1991 |
| 4996218 | Chloroaniline derivatives Compounds of the general formula (I) ##STR1## and physiologically acceptable salts and solvates thereof, which have 댢 -adrenoreceptor stimulant activity. They may be used in the treatment of diseases associated with reversible airwa... | 02/26/1991 |
| 4968796 | Preparation of sulphonylisothioureas Disclosed is a process for the preparation of a sulphonylisothiourea of the formula ##STR1## wherein R1, R2, R3, X, Y, and Z are as defined herein, which comprises reacting a sulphonic acid amide of the formula R... | 11/06/1990 |
| 4963682 | Novel radiopharmaceuticals and chelating agents useful in their preparation A dihydropyridine.rarw..fwdarw. pyridinium salt type of redox, or chemical, delivery system for the site-specific and/or site-enhanced delivery of a radionuclide to the brain is provided. A chelating agent capable of chelating with a radionuclide and havi... | 10/16/1990 |
| 4960890 | Methine dyes which have at least one heterocycle containing two nitrogen atoms and preparation thereof Methine dyes (I) which conform in one of their tautomeric forms to the general formula ##STR1## where Y1 is in both or either case an electron-attracting group and the other Y1 is hydrogen, Y2 is in each case, indepen... | 10/02/1990 |
| 4945177 | Antimicrobially active nitriles and the production thereof Novel 2,2-dibromo-3-oxonitriles of Formula I, R--CO--CBr2 --CN (I) in which R represents in each case a possibly substituted or unsubstituted aliphatic, cycloaliphatic, aromatic or heterocyclic group, with the ex... | 07/31/1990 |
| 4913837 | Heterocyclic compounds Heterocyclic compounds of the formula I R1 -A1 -Z1 -A2 -[Z2 -A3 ]n -R2I wherein R1, R2, A1, A2, A3, Z1, Z2 | 04/03/1990 |
