Class 546/324 - Acyclic nitrogen single bonded directly to acyclic nitrogen

Subclass of Class 546 - Organic compounds -- part of the class 532-570 series
Definition: Compounds in which acyclic nitrogen is single bonded directly
No. of patents: 40
Last issue date: 02/19/2008

Number	Title	Issue Date
7332498	Modulation of KSP kinesin activity with heterocyclic-fused pyrimidinone derivatives A method of modulating KSP kinesin activity in vitro comprising contacting KSP kinesin with at least one chemical entity chosen from compounds represented by Formula I: and pharmaceutically acceptable salts there...	02/19/2008
7217706	Propanolamine derivatives This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which have gut selective sympatho...	05/15/2007
7148245	Biphenyl derivatives substituted with an aromatic or heteroaromatic radical, and pharmaceutical and cosmetic compositions containing them Compounds of formula (I): in which: Ar represents an aromatic or a heteroaromatic radical optionally substituted, in particular, with an alkyl or a carboxyl group, ...	12/12/2006
7148354	Process for preparation of donepezil An efficient process for preparation of donepezil is provided. In one embodiment, the process for preparation of donepezil includes suspending a catalyst, which is palladium metal on carbon and the compound of the structure	12/12/2006
7087239	Crystalline hydrates of anilide derivatives The present invention relates to crystalline hydrates of substituted anilide derivatives, to their preparation, and to their use for controlling phytopathogenic fungi or undesired attack by insects or mites and/or for regulating the growth of plants. ...	08/08/2006
7084171	Compounds and therapies for the prevention of vascular and non-vascular pathologies The invention provides a method of treating a mammal having, or at risk of, an indication associated with a TGF-beta deficiency comprising administering one or more agents that is effective to elevate the level of TGF-beta. The invention also provides novel compound...	08/01/2006
7030115	N-sulfonylurea apoptosis promoters Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds. ...	04/18/2006
6780995	Activated iododerivatives for the treatment of cancer and aids A series of activated iodo-benzamide derivatives are described as antineoplastic and antiviral drug compounds. The compounds generally possess a chelating group, a thiol trapping group and an activating group. The presumptive mechanism of action in preventing cancer...	08/24/2004
6624178	Compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses thereof The invention discloses novel compounds of the pyridinium series useful for the management of diabetes and aging-related vascular complications, including kidney disease, nerve damage, atherosclerosis, retinopathy, dermatological disorders and discolorati...	09/23/2003
6608094	Compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses thereof Novel compounds of the pyridinium series useful for the management of diabetes and aging-related vascular and neurovascular complications, including kidney disease, nerve damage, atherosclerosis, retinopathy, inflammatory disorders, immunological disorder...	08/19/2003
6511988	Activated iododerivatives for the treatment of cancer and aids A series of activated iodo-benzamide derivatives are described as antineoplastic and antiviral drug compounds. The compounds generally possess a chelating group, a thiol trapping group and an activating group. The presumptive mechanism of action in preven...	01/28/2003
6462057	Compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses thereof The invention discloses novel compounds of the pyridinium series useful for the management of diabetes and aging-related vascular complications, including kidney disease, nerve damage, atherosclerosis, retinopathy, dermatological disorders and discolorati...	10/08/2002
6376665	Amide derivatives as inhibitors of matrix metalloproteinases, TNF-଱, and aggrecanase The present application describes novel amides and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein these compounds are useful as inhibitors of matrix metalloproteinases, TNF-଱, and aggrecana...	04/23/2002
6306871	Activated iododerivatives for the treatment of cancer and AIDS A series of activated iodo-benzamide derivatives are described as antineoplastic and antiviral drug compounds. The compounds generally possess a chelating group, a thiol trapping group and an activating group. The presumptive mechanism of action in preven...	10/23/2001
6271245	Hydroxamic acid derivatives The present invention relates to hydroxamic acid derivatives that inhibit N-Acetylated ଱-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit...	08/07/2001
6133442	Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antagonists Compounds of formula I ##STR1## wherein R1 signifies phenyl, substituted phenyl or heterocyclyl; R2 signifies phenyl or substituted phenyl; R3 signifies hydrogen, lower-alkyl, cyano, carboxy, esterified carboxy, phenyl, su...	10/17/2000
6090824	Therapeutic neurokinin receptor antagonist compounds Compounds of formula I ##STR1## wherein Q1, Q2, Q3, and Q4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists Substan...	07/18/2000
5962682	Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antagonists Compounds of formula (I) ##STR1## wherein R1 signifies phenyl, substituted phenyl or heterocyclyl; R2 signifies phenyl or substituted phenyl; R3 signifies hydrogen, lower-alkyl, cyano, carboxy, esterified carboxy, phe...	10/05/1999
5919792	Integrin antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are ଱v댣 antagonists, ଱...	07/06/1999
5789422	Substituted arylalkylamines as neurokinin antagonists Compounds represented by the structural formula ##STR1## or a pharmaceutically acceptable salt thereof are disclosed, wherein: A1 is --CH2 R6, --OR6, --N(R6)(R7), --S(O)e R	08/04/1998
5596095	Formation and utility of sulfonic acid protecting groups The present invention is a method of protecting a sulfonic acid functional group in an organic molecule as a substituted or unsubstituted neopentyl sulfonate ester. The method allows the conversion of R--SO3 --H to R'--SO3 --H, where...	01/21/1997
5498720	Certain triazole compounds and their pharmaceutical uses In the invention of novel nonsteroidal antiinflammatory compounds the title novel triazole compounds, were synthesized from carboxylic acids, 2,5-acetonylacetone, or isoniazid, respectively. To give 4H-1,2,4-triazol-3-thiols. Treatment of 4H-1,2,4-tri-azo...	03/12/1996
5455234	Inhibition of hair growth Mammalian hair growth is reduced by applying to the skin an inhibitor of a cysteine synthetic pathway enzyme....	10/03/1995
5354762	Six-membered heterocyclic derivatives of N'-substituted N,N'-diacylhydrazines This invention relates to insecticidal compositions containing six-membered heterocyclic derivatives of N'-substituted-N,N'-diacylhydrazines, methods of using such compositions and novel six-membered heterocyclic derivatives of N'-substituted-N,N'-diacylh...	10/11/1994
5276147	Compounds and complexes useful in medical imaging The subject of the present invention is compounds which correspond to the following general formula: ##STR1## in which R1 and R3 independently of one another represent H, an alkyl, alkenyl, cycloalkyl, aryl, arylalkyl or an alky...	01/04/1994
5231104	1-arylethyl-3-substituted piperidines A series of novel 1-(phenethyl) and 1-(2-heteroarylethyl)-3-substituted piperidine derivatives have been prepared, including their pharmaceutically acceptable salts and various novel key intermediates therefor. The 3-substituent present in these compounds...	07/27/1993
5055471	Fungicides This invention relates to derivatives of propanoic acid of the formula ##STR1## Useful as fungicides, insecticides and miticides, to processes for preparing them, to compositions containing them, and to methods of using them to combat fungi, especial...	10/08/1991
4971986	Arylhydrazones useful as SAMDC inhibitors Compounds of formula I ##STR1## wherein A, X1, X2, X3, X4, Y, Z and R1 to R6 have the meanings given in the description, have valuable pharmaceutical properties and are effective espec...	11/20/1990
4450274	Preparation of ethambutol-diisoniazide methane sulfonic acid salt This invention pertains to a new process for preparing an ethambutol-sulfonic acid derivative which is widely used as an antituberculosis agent. In the known process, there are many defects which include: side reactions, impurities, low yield, high cost p...	05/22/1984
4405791	Arylthioureido pyridinecarbamino compounds and use as plant growth regulants A method of regulating the growth of plants, including combating unwanted vegetation, comprises applying to the plants, either on seed, the soil or directly on the plants an effective amount of a novel compound of the class having the general structural f...	09/20/1983
4378239	N-Methylcarbamoyloxy benzaldehyde imine herbicide extenders Herbicidally active thiolcarbamates are employed in combination with certain N-methylcarbamoyloxy benzaldehyde imines having the formula ##STR1## in which R4 is selected from the group consisting of chlorophenyl, chlorophenylthiomethylphen...	03/29/1983
4323362	Dyed paper Compounds of the general formula where A1 and A2 are the radical of a quaternized methylene-active compound and B is a bridge member. The compounds according to the invention are very suitable for coloring ligneous and lignin-free paper s...	04/06/1982
4276297	Pyridylaminotriazole therapeutic agents A series of novel 3-amino-5-(4-pyridyl)-1,2,4-triazole derivatives has been prepared, including their pharmaceutically acceptable acid addition salts. These particular compounds are useful in therapy as anti-ulcer agents. Preferred member compounds includ...	06/30/1981
4197302	2-Pyridinecarboxylic acids 5-Etherified 2-pyridinecarboxylic acids, e.g. those of the formula ##STR1## or functional derivatives thereof, are hypotensive agents....	04/08/1980
4163784	Heterocyclylcarbonyl derivatives of urea, agents for dissolution of gallstones Heterocyclylcarbonyl derivatives of urea having the formula ##STR1## wherein R is a heterocyclyl group; R1 is hydrogen, alkyl having up to ten carbon atoms or phenyl; R2 is R1, 1-naphthyl and phenylalkyl having 1 to 4...	08/07/1979
4154835	Anthelmintic imidazo [1,2-a] pyridines Novel substituted imidazo [1,2-a] pyridine compounds are disclosed which have a high degree of anthelmintic activity. The compounds are substituted with a carbamate and a halogenated alkene group. Processes for the preparation of such compounds are also d...	05/15/1979
4137067	Pyridine-4-carboxylic acid hydrazides for combatting phytopathogenic microorganisms and for regulating plant growth Compounds of formula I ##STR1## WHEREIN R1 represents C1 -C4 -alkyl, alkyl(C1 -C4)-carbonyl or halogenoalkyl(C1 -C3)-carbonyl as well as salts thereof with organic and inorg...	01/30/1979
4060550	Novel n'-acylated phenyl-hydrazine and -hydrazone derivatives Indolylacetic acid derivatives, which have excellent anti-inflammatory, antipyretic and analgesic activities, represented by the formula, ##STR1## wherein X1 and X2 are each methylene; A is an unsubstituted ethylenically unsatur...	11/29/1977
3951996	Process for making nicotinic acid hydrazides A process for condensing a carboxylic acid with ammonia, hydrazine or a substituted hydrazine or a primary or secondary amine to give a compound containing the group --CO--NR'-- where R' is a hydrogen atom, an organic radical, an NH2 group or a...	04/20/1976

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Class 546/324 - Acyclic nitrogen single bonded directly to acyclic nitrogen