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| Number | Title | Issue Date |
| 8143411 | Substituted 6-phenylnicotinic acids and their use The present application relates to novel substituted 6-phenylnicotinic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis... | 03/27/2012 |
| 8017786 | Substituted β-phenyl-α-hydroxy-propanoic acid, synthesis method and use thereof The present invention relates to a compound of the formula (I), wherein R1, R2 and R3 are each independently selected from H, OH, F, Cl, Br, methoxy and ethoxy; or alternatively, R1 and R2 together form —OCH | 09/13/2011 |
| 7414136 | Method for producing 3-substituted 2-chloro-5-fluoro-pyridine or its salt To provide a method for producing a 3-substituted 2-chloro-5-fluoro-pyridine or its salt in high yield from a readily available material through a short process under mild reaction conditions using a reagent which is easy for handling and simple in the reaction oper... | 08/19/2008 |
| 7320993 | Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group, ... | 01/22/2008 |
| 7247645 | Dihydropyridine derivatives Compounds having a selective N-type calcium channel antagonistic activity are provided. Dihydropyridine derivatives represented by the following formula: analogs thereof and pharmaceutically acceptable salts ther... | 07/24/2007 |
| 7199140 | Vinyl phenyl derivatives as GLK activators The invention relates to novel compounds of Formula (I) or a salt, solvate or prodrug thereof, wherein A, R1, R2, R3, n and m are described in the specification, useful in the treatment of ... | 04/03/2007 |
| 7166726 | Aryl substituted 3,4-dihydroanthracene derivatives having retinoid antagonist or retinoid inverse agonist type biological activity Disclosed herein are compounds of the formula wherein R1 is independently H or alkyl of 1 to 6 carbons; R2 is optional and is defined as lower alkyl of 1 to 6 carbons, F, Cl, Br... | 01/23/2007 |
| 6995179 | Dihydropyridine derivative Dihydropyridine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel. They are used as remedies for various diseases relating to the N-type... | 02/07/2006 |
| 6992095 | Stilbene compounds comprising an adamantyl group, compositions and methods thereof The invention relates to novel stilbene compounds having the general formula (I): as well as to pharmaceutical compositions for use in human or veterinary medicine, including dermatological, rheumatic, respiratory, card... | 01/31/2006 |
| 6951877 | Materials and methods for treating hypercholesterolemia The subject invention provides novel HMG-CoA-reductase inhibitors. In a preferred embodiment, the HMG-CoA reductase inhibitors of the subject invention can be deactivated to a primary inactive metabolite by hydrolytic enzymes. Compounds of the present invention can ... | 10/04/2005 |
| 6942980 | Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities Methods of characterizing and identifying negative hormones of nuclear receptors. Also disclosed are methods of making modulators of retinoid nuclear receptor transactivation activity, assays for agonists, antagonists, and negative hormones of the RAR receptor, and ... | 09/13/2005 |
| 6900232 | Cycloalkyl alkanoic acids as integrin receptor antagonists The present invention relates to a class of compounds represented by the Formula I Wherein A1 is a pyridinyl of the formula optionally substituted by one or mo... | 05/31/2005 |
| 6727237 | Inhibitors of bacterial NAD synthetase The present invention provides methods of synthesizing and screening inhibitors of bacterial NAD synthetase enzyme, compounds thereof, and methods of treating bacterial and microbial infections with inhibitors of bacterial NAD synthetase enzyme. ... | 04/27/2004 |
| 6713467 | Acid derivatives useful as serine protease inhibitors Compounds of formula I and II, or pharmaceutically-acceptable salts thereof, are useful as inhibitors of Factor VIIa, Factor IXa, Factor Xa, Factor FXIa, tryptase, and urokinase, wherein ring B is phenyl or pyridyl, L is... | 03/30/2004 |
| 6703509 | Method for producing 5-aryl nicotinaldehydes The invention relates to a process for the preparation of 5-arylnicotinaldehydes by reduction of the corresponding 5-arylnicotinic acids by catalytic hydrogenation in the presence of carboxylic anhydrides in which the catalyst used is a palladium/ligand c... | 03/09/2004 |
| 6673938 | Substituted pyridine herbicides ##STR1## Compounds of formula (I), in which the substituents are as defined in claim 1 and the agrochemically tolerated salts M+ and all stereoisomers and tautomers of the compounds of formula (I) are suitable for use as herbicides.... | 01/06/2004 |
| 6649767 | Process for preparing 1,4-dihydropyridine compounds A process for preparing a 1,4-dihydropyridine compound comprising contacting an enamine compound ##STR1## and a compound having a structure of ##STR2## in the presence of a base; and treating the reaction mixture thus obtained in the presence of an a... | 11/18/2003 |
| 6541640 | Process for the preparation of 4-haloalkylnicotinonitriles 4-Haloalkylnicotinonitriles having the formula (I) ##STR1## which are suitable as intermediates in the preparation of pesticides, are obtained by: (a) reacting a 3-amino-1-haloalkyl-2-propen-1-one RF --C(O)--CH.dbd.CH--NH2 (II) in a con... | 04/01/2003 |
| 6515023 | Thrombin receptor antagonists A thrombin receptor antagonist having the formula ##STR1## useful for inhibiting the aggregation of blood platelets. The compounds can be used in a method of acting upon a thrombin receptor which comprises administering a therapeutically effective but non... | 02/04/2003 |
| 6500852 | Inhibitors of bacterial NAD synthetase The present invention provides methods of synthesizing and screening inhibitors of bacterial NAD synthetase enzyme, compounds thereof, and methods of treating bacterial and microbial infections with inhibitors of bacterial NAD synthetase enzyme.... | 12/31/2002 |
| 6489347 | Process ##STR1## Compounds of structure (1) are obtained by reduction of compounds of the structures ##STR2## ##STR3## Compounds of structure (1), especially where Z is a hydrogen atom or a 3,4-methylenedioxyphenyl group, are important intermediates for inte... | 12/03/2002 |
| 6441182 | Method for the production of 2,6-dichloro-5-fluoro-nicotinic acid and coarse and particularly pure 2,6-dichloro-5-fluoro-nicotinic acid The invention relates to a method for the production of 2,6-dichloro-5-fluoronicotinic acid by hydrolyzing 2,6-dichloro-5-fluoro-3-cyanopyridine by (a) dissolving 2,6-dichloro-5-fluoro-3-cyanopyridine at 70 to 90° C. in sulfuric acid having a concentrati... | 08/27/2002 |
| 6441010 | Bi-aromatic compounds linked via a heteroethynylene radical, and pharmaceutical and cosmetic compositions containing them Bi-aromatic compounds linked via a heteroethynylene radical are provided along with pharmaceutical and cosmetic compositions containing these compounds and methods for their use.... | 08/27/2002 |
| 6432960 | Squarate derivatives of dihydropyridine NPY antagonists A series of antagonists of NPY have been synthesized and are comprised of squarate derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). ##STR1## As antagonists of NPY-induced behavior, these compounds are expected to act as effective anorexiant ag... | 08/13/2002 |
| 6392050 | Process for preparing substituted pyridines The invention relates to a process for preparing substituted pyridines in a simple and cost-effective manner in good yields by reacting substituted 1,4-dihydropyridines with methyl nitrite in the presence of an acid that contains less than 20% by weight o... | 05/21/2002 |
| 6391881 | Thiourea derivatives of dihydropyridine NPY antagonists A series of antagonists of NPY have been synthesized and are comprised of thiourea linked piperazine and piperidine derivatives of 4-phenyl-1,4-dihydropyridines of Formula 1. ##STR1## where Z is NR7 R8 or ##STR2## and X is CH or... | 05/21/2002 |
| 6376521 | A3 adenosine receptor antagonists Disclosed are pyridine and dihydropyridine derivatives, pharmaceutical compositions comprising one or more of these derivatives, and a method of selectively blocking an A3 adenosine receptor of a mammal by the use of one or more of these deriva... | 04/23/2002 |
| 6344561 | O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.... | 02/05/2002 |
| 6310214 | Process for the preparation of chloropyridine sulphonic acid chlorides A process is disclosed for preparing chlorinated pyridinesulphonic acid chlorides of the general formula I ##STR1## from hydroxypyridine-sulphonic acids of the general formula II ##STR2## The process generally entails a) passing chlorine gas into a mixtur... | 10/30/2001 |
| 6214878 | Stilbene compounds comprising an adamantyl group, compositions and methods thereof The invention relates to novel stilbene compounds having the general formula (I): ##STR1## as well as to pharmaceutical compositions for use in human or veterinary medicine, including dermatological, rheumatic, respiratory, cardiovascular and ophthal... | 04/10/2001 |
| 6165236 | Poly(oxyalkylene) pyridyl and piperidyl esters and fuel compositions containing the same A poly(oxyalkylene)pyridyl or piperidyl ester having the formula: ##STR1## or a fuel-soluble salt thereof; wherein A is a nitrogen-containing ring selected from the group consisting of 3-pyridyl, 4-pyridyl, 3-piperidyl and 4-piperidyl; R1 ... | 12/26/2000 |
| 6110970 | Nitrogen-containing oxyalkylene esters and uses thereof This invention relates to nitrogen-containing oxyalkylene diester compositions for treating disease conditions including cancer and other proliferative diseases. The nitrogen-containing oxyalkylene diesters are represented by the formula ##STR1## ... | 08/29/2000 |
| 6090824 | Therapeutic neurokinin receptor antagonist compounds Compounds of formula I ##STR1## wherein Q1, Q2, Q3, and Q4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists Substan... | 07/18/2000 |
| 6045720 | Pyridine compound and liquid crystalline composition A compound expressed by the following formula (1) and a liquid crystalline composition with using it are provided: ##STR1## wherein, either one of rings A, B and C denotes ##STR2## remaining two of them denote each independently ##STR3## ... | 04/04/2000 |
| 6022974 | Process for the production of 2-chloro-5-chloromethyl-pyridine A process for the production of 2-chloro-5-chloromethylpyridine of the formula: ##STR1## starting from 6-hydroxynicotinic acid of the formula: ##STR2## In this way 6-hydroxynicotinic acid is reacted with an acid chloride to 6-hydroxynicotin... | 02/08/2000 |
| 5919792 | Integrin antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are v댣 antagonists, ... | 07/06/1999 |
| 5892050 | Process for the preparation of pyridine dicarboxylate derivatives There is provided a single vessel process for the preparation of a pyridine dicarboxylate compound of formula I ##STR1## via the sequential condensation of an alkyl vinyl ether with Vilsmeier reagent, oxalacetate and an ammonia source.... | 04/06/1999 |
| 5869676 | Process for the synthesis of ribonucleotide reductase inhibitors 3-AP and 3-AMP The present invention relates to improved, efficient chemical syntheses of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) and 3-amino-4-methylpyridine-2-carboxaldehyde thiosemicarbazone (3-AMP).... | 02/09/1999 |
| 5861419 | Substituted pyridines as selective cyclooxygenase-2 inhibitors The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ... | 01/19/1999 |
| 5747422 | Substituted 2-phenylpiridines Substituted 2-phenylpyridines I ##STR1## where substituents have the meaning described in the specification and their use as herbicides; for the desiccation/defoliation of plants.... | 05/05/1998 |
