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| Number | Title | Issue Date |
| 7456291 | Use of a vitamin combination for the treatment of primary headaches Use of a combination of two vitamin compounds, i.e. riboflavin (also known as vitamin B2) and nicotinic acid (also referred to as niacin) or, as an alternative thereto, the corresponding amide, i.e. niacinamide or nicotinamide (also known as vitamin PP) f... | 11/25/2008 |
| 7378412 | Pharmaceutical compounds Compounds or their salts having general formula: A-B—C—NO2 wherein: A is a drug radical; B is a linker; and C is a bivalent radical. ... | 05/27/2008 |
| 7345176 | Process for conversion of cyanopyridines to nicotinamides and catalyst therefor, process for preparing said catalyst The present invention relates to an improved process for conversion of cyanopyridines to nicotinamides. More particularly the present invention relates to preparation of nicotinamides and isonicotinamides which finds its usage in the preparation of anti-TB drug i.e.... | 03/18/2008 |
| 7317105 | Preparation of 4-haloalkylnicotinamides The invention relates to a method for producing 4-haloalkylnicotinamides having the formula (I): wherein R1 is (C1-C4)haloalky, comprising subjecting one or more 3-((C1... | 01/08/2008 |
| 7297796 | Sulfamoyl benzamide derivatives and methods of their use Novel sulfamoyl benzamide compounds, pharmaceutical compositions containing the sulfamoyl benzamide compounds, and methods of their pharmaceutical use are disclosed. In certain embodiments, the sulfamoyl benzamide compounds are agonists and/or modulating ligands of ... | 11/20/2007 |
| 7288658 | Process for preparation of pyridine derivatives The present invention relates to a process for the manufacture of compounds of formula wherein the substituents are as described herein which comprises the steps of a) reacting a compound o... | 10/30/2007 |
| 7125898 | Nicotinamide derivatives useful as p38 inhibitors. Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38. | 10/24/2006 |
| 7122539 | Nitric esters and nitrate salts of specific drugs Nitric acid salts with medicines active in the respiratory system pathology treatment. ... | 10/17/2006 |
| 6566403 | N-acetonylbenzamide fungicides This invention relates to new compositions comprising predominantly one enantiomer of an N-acetonylbenzamide fungicide, methods of preparing N-acetonylbenzamides, and their use as fungicides.... | 05/20/2003 |
| 6380218 | Nicotinamide derivatives A compound of formula (I) wherein m, n, o, p, q, r, A, B, D, E, R1, R2,R3, R4, R5, R6, R7 and R8 are as defined in the description, useful in the treatment of respiratory, ... | 04/30/2002 |
| 6271372 | Process for the preparation of arylamides of heteroaromatic carboxylic acids A process for the preparation of arylamides of heteroaromatic carboxylic acids of the formula: ##STR1## in which each An is nitrogen or CRn (n=1 to 5), with the proviso that at least one of the ring members is nitrogen and that two n... | 08/07/2001 |
| 6251827 | Acylsulfamoylbenzamides, crop protection compositions comprising them, and processes for their preparation Acylsulfamoylbenzamides of the formula I and crop protection compositions comprising them are described. In this formula I, R1, R2, R3, R4 and R5 are various organic radicals and X is CH or N. ##... | 06/26/2001 |
| 6218543 | Processes for producing highly pure nicotinamide Described are processes for the large, commercial scale production of USP grade nicotinamide, wherein the USP grade product is isolated using novel strategies which minimize product waste, and avoid the need for crystallizations and/or ameliorate complica... | 04/17/2001 |
| 6133478 | Catalyst and process for preparing amides A platinum complex useful as a catalyst for converting nitrites into amides comprises a platinum complex of dialkyl phosphine of stoichiometric formula: PtX(R2 POHOPR2)(PR2 OH) where R is an alkyl, alicyclic, chiral, alkyl... | 10/17/2000 |
| 5900484 | Process for the preparation of arylamides of heteroaromatic carboxylic acids A process for the preparation of arylamides of heteroaromatic carboxylic acids of the formula: ##STR1## in which each An is nitrogen or CRn (n=1 to 5), with the proviso that at least one of the ring members is nitrogen and that ... | 05/04/1999 |
| 5863950 | HIV protease inhibitors HIV protease inhibitors, obtainable by chemical synthesis, block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compound... | 01/26/1999 |
| 5763614 | 1,4-dihydropyridine derivatives and methods of producing the same 1,4-dihydropyridine derivatives and optically active 1,4-dihydropyridine derivatives with the following formula, having vasodilating activity based on calcium antagonism, and PAF antagonism, and methods of producing the same are disclosed: ##STR1## ... | 06/09/1998 |
| 5756750 | Continuous processes for the hydrolysis of cyanopyridines under substantially adiabatic conditions Described are preferred processes for hydrolyzing substituted and unsubstituted cyanopyridines in the presence of a base and under substantially adiabatic conditions to produce pyridine substituted amides and/or pyridine substituted carboxylic acids. Pref... | 05/26/1998 |
| 5714518 | HIV protease inhibitors and methods of making the same HIV protease inhibitors, obtainable by chemical synthesis, block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compound... | 02/03/1998 |
| 5614636 | Process for the preparation of 2,4-pyridine dicarboxylic acid A process for the preparation of carboxamides of nitrogen-containing aromatic heterocyclic compounds from the corresponding N-heterocyclic compounds by reaction thereof with formamide in the presence of peroxodisulfuric acid or a peroxodisulfate.... | 03/25/1997 |
| 5206372 | Preparation of 2-chloropyridine derivatives Certain 2-chloropyridine derivatives, which are useful as starting materials for the preparation of various herbicides and fungicides, are prepared by cyclization of 1,3-butadiene derivatives in the presence of hydrogen chloride.... | 04/27/1993 |
| 5142057 | Process for producing carboxylic acid amides A process for producing a carboxylic acid amide or ester, which comprises reacting an organic chloride having at least one chlorine atom on its ring of a substituted or unsubstituted, aromatic or heterocyclic hydrocarbon with carbon monoxide and an amine ... | 08/25/1992 |
| 5107057 | Cyano-dienes, halopyridines, intermediates and a process for their preparation This invention relates to certain cyano-dienes and halopyridines and the processes for their preparation from a protected 1,3-dialdehyde and a cyano-diene.... | 04/21/1992 |
| 5008276 | Methyl -(2-substituted)pyrid-3-yl-ଲ-methoxyacrylates, compositions containing them and their use as fungicides Fungicidal compounds of the formula (I): ##STR1## and stereoisomers thereof, wherein K is oxygen or sulphur; Z is optionally substituted aryl or optionally substituted heteroaryl; X is O, S(O)n, NR4, CR1 R2... | 04/16/1991 |
| 4929613 | Antibacterial agents The novel series of quinoline-, naphthyridine- and benzoxazine-carboxylic acids useful as antibacterial agents is described. Novel methods for preparing the compounds as well as novel intermediates are also described as are methods for their formulation a... | 05/29/1990 |
| 4681946 | Preparation of nicotinamide A process for the preparation of nicotinamide by amidation of a nicotinic acid/nicotinamide melt, vacuum distillation of the amidation mixture, removal of the nicotinamide as the bottom product and recycling of the top product, depleted with respect to ni... | 07/21/1987 |
| 4503231 | Hydrolysis of nitriles to amides with quaternary ammonium hydroxide Hydrolysis of nitrile to amide by use of a quaternary ammonium hydroxide at 60° to 95° C.... | 03/05/1985 |
| 4447615 | Process for the purification of nicotinic acid amide I Crude nicotinamide is purified by a recrystallization and in this way freed especially from nicotinic acid and salts of nicotinic acid. As solvent there is used a 2-methylpropanol-1 containing water. The recrystallization takes place at a pH between about... | 05/08/1984 |
| 4327219 | Nicotinamide production In the hydrolysis of nicontinonitrile to nicotinamide, the hydrolysis effluent, containing nicotinamide, unconverted nicotinonitrile, ammonia and some ammonium nicotinate is stripped with gaseous ammonia to produce a molten nicontinamide bottoms, essentia... | 04/27/1982 |
| 4314064 | Process for the production of nicotinamide Nicotinamide is prepared from nicotinonitrile by hydrolysis at 120° to 200° C. employing alkali hydroxide.... | 02/02/1982 |
| 4304937 | Process of preparing carboxylic acid amides A process of preparing a carboxylic acid amide which comprises reacting (a) an aldehyde with (b) at least one compound selected from the group consisting of ammonia, a primary amine and a secondary amine in the presence of a molecular oxygen-containing ga... | 12/08/1981 |
| 4304917 | Crystallization process In the crystallization of a material from a liquid solution thereof wherein normal rapid cooling produces a non-filterable solid, the mixture of material and liquid is subjected to a high shear force field to produce a filterable slurry of the material, w... | 12/08/1981 |
| 4139536 | Process for the recovery of nicotinamide Nicotinamide is recovered from the reaction mixture resulting from the hydrolysis of nicotinonitrile at elevated temperature by converting the nicotinamide into a melt while removing the solvent.... | 02/13/1979 |
| 4128554 | Process for the preparation of carboxylic acid amides from organic halides Carboxylic acid amides are obtained from aryl, heterocyclic, and vinylic halides and substituted derivates thereof, by reacting same with a primary or secondary amine and carbon monoxide, in the presence of a palladium catalyst and if necessry a tertiary ... | 12/05/1978 |
| 4096149 | Hydrolysis of nitriles Nitriles, such as acrylonitrile, are converted to the corresponding amides by a catalytic hydrolysis employing as the heterogeneous catalyst, the reaction product of a rhodium compound and a thiophosphite supported on a solid support.... | 06/20/1978 |
| 4096184 | Process for preparing acid amides A process for preparing acid amides by hydration of the corresponding nitrile compounds with water in the presence of a catalyst, characterized in that the catalyst is the one prepared by treating a vanadate with a cuprous salt or with at least two of met... | 06/20/1978 |
| 4008241 | Nicotinamide production Nicotinamide is produced by aqueous ammonia hydrolysis of nicotinonitrile wherein the conversion is limited to at least 30% and no greater than 70%, with the nicotinonitrile concentration, expressed as weight product amide per 100 pounds of water, being a... | 02/15/1977 |
| 3989466 | Liquid-liquid extraction apparatus including fibrous strand packing Apparatus is provided for use in carrying out liquid-liquid extraction techniques, which apparatus includes an extraction column containing a unique solvent sorbing packing material, namely a plurality or bundle of elongated fibrous strands having first a... | 11/02/1976 |
| 3980661 | Hydrolysis of nitriles Nitriles, such as acrylonitrile, are converted to the corresponding amides by a catalytic liquid phase hydrolysis employing as the homogeneous catalyst, the reaction product of a rhodium compound and a thiophosphite.... | 09/14/1976 |
| 3957804 | Method for the production of nicotinamide and isonicotinamide A method for the production of nicotinamide or isonicotinamide by catalytically hydrating 3- or 4-cyanopyridine which is characterized in that the hydration reaction is carried out in the presence of a nickel oxide/iron oxide combined catalyst.... | 05/18/1976 |
