Did You Know...
...that after Parker Brothers executives turned down the game of Monopoly because it had "52 fundamental errors" (including taking too long to play), a copy of the game wound up in the home of the company president who stayed up until 1 a.m. to finish playing it? He was so impressed by the game that the next day he wrote to inventor Charles Darrow and offered to buy it!
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| Number | Title | Issue Date |
| RE41008 | Method for producing 5-aryl nicotinaldehydes The invention relates to a process for the preparation of 5-arylnicotinaldehydes by reduction of the corresponding 5-arylnicotinic acids by catalytic hydrogenation in the presence of carboxylic anhydrides in which the catalyst used is a palladium/ligand complex, cha... | 11/24/2009 |
| 7553970 | Process for preparing 3-heteroaryl-3-hydroxypropanoic acid derivatives The invention relates to a process for preparing enantiomer-enriched 3-heteroaryl-3-hydroxypropanoic acid derivatives and 3-heteroaryl-1-aminopropan-3-ols, and to their use. ... | 06/30/2009 |
| 7528256 | Process for the preparation of nicotinaldehydes The invention relates to a process for the preparation of nicotinaldehydes by reduction of the corresponding nicotinic acid morpholinamides. ... | 05/05/2009 |
| 7459563 | Process for the preparation of isonicotinic acid derivatives The present invention relates to a process for the manufacture of compounds of formula Ia or Ib and pharmaceutically acceptable additional salts thereof, wherein R is lower alkyl. The compounds of formula Ia or Ib are valua... | 12/02/2008 |
| 7439207 | 2,6 substituted pyridine-3-carbonyl derivatives serving as plant protection agents having herbicidal action The invention relates to novel substituted pyridyl ketones of the formula in which A, R, X, Y, Z and n are as defined in the disclosure, to processes for preparing these novel subst... | 10/21/2008 |
| 7378375 | Substituted pyridine herbicides Compounds of the formula I in which the substituents are as defined in claim 1 are suitable for use as herbicides. ... | 05/27/2008 |
| 7355048 | Process for preparing 1-(6-methylpyridin-3-yl)-2-[4- (methylsulphonyl)phenyl]ethanone A four-step process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone of the formula: starting from 2-methyl-5-ethylpyridine. 1-(6-Methylpyridin-3yl)-2-[4-(methylsulfonyl)phenyl]ethanone is an inte... | 04/08/2008 |
| 7342116 | Process for producing heterocyclic aldehyde A process is disclosed for preparing a heterocyclic aldehyde by oxidizing a heterocyclic alcohol with high selectivity and high yield. Specifically, the heterocyclic aldehyde is prepared by reacting a heterocyclic compound having at least one hydroxymethyl group bon... | 03/11/2008 |
| 7332498 | Modulation of KSP kinesin activity with heterocyclic-fused pyrimidinone derivatives A method of modulating KSP kinesin activity in vitro comprising contacting KSP kinesin with at least one chemical entity chosen from compounds represented by Formula I: and pharmaceutically acceptable salts there... | 02/19/2008 |
| 7320993 | Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group, ... | 01/22/2008 |
| 7273946 | Prostaglandin derivatives Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension. ... | 09/25/2007 |
| 7241896 | Method for producing 2-halogen-pyridine-carboxylic acid amides The invention relates to a process for preparing 2-halopyridinecarboxamides of primary aromatic monoamines I which have a substituent other than hydrogen in the ortho-position to the amino group by reaction of 2-halopyridinecarbonyl chloride II with the aromatic mon... | 07/10/2007 |
| 7238714 | Aryl or heteroaryl amide compounds This invention provides a compound of the formula (I): wherein A represents a phenyl group or the like: B represents an aryl or the like: E represents a 1,4-phenylene group; R1 and R2 indepe... | 07/03/2007 |
| 7238717 | CCR9 inhibitors and methods of use thereof The invention relates to compounds represented by Structural Formula I, which can bind to CCR9 receptors and block the binding of a ligand (e.g., TECK) to the receptors. The invention also relates to a method of inhibiting a function of CCR9, and to the use compound... | 07/03/2007 |
| 7235570 | 1,4-dihydropyridine and pyridine compounds as calcium channel blockers The present invention is directed in part towards methods of modulating the function of calcium channels with pyridine- or 1,4-dihydropyridine-based compounds. In addition, the invention describes methods of preventing and treating protein kinase-related abnormal co... | 06/26/2007 |
| 7199136 | 1,4-dihydro-1,4-diphenylpyridine derivatives The invention relates to novel 1,4-dihydro-1,4-diphenylpyridine derivatives of formula (I) wherein the variable groups are as defined in the text and claims. Processes for their preparation, pharmaceutical compos... | 04/03/2007 |
| 7175834 | Sunscreen composition with enhanced SPF and water resistant properties The present invention relates to a sunscreen formulation which exhibits superior ultraviolet protection and water resistance than prior art sunscreen compositions. The sunscreen formulation comprises (a) a dispersion comprising a sunscreen active agent and (b) a bas... | 02/13/2007 |
| 7141673 | 1-(6-methylpyridine-3-yl)-2-[4-(methylsulphonyl) phenyl] ethanone and method for its preparation A starting product for the preparation of COX-2 inhibitors, notably the compound 1-(6-methylpyridine-3-yl)-2-[(4-(methylsulfonyl)phenyl]ethanone of the formula (I): A method for making the compound. ... | 11/28/2006 |
| 7126001 | Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof The present invention provides the compound having the formula: wherein each of R1 and R2 is, substituted or unsubstituted, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino, piperid... | 10/24/2006 |
| 7101868 | Substituted arylamine derivatives and methods of use Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and meth... | 09/05/2006 |
| 7067673 | Process and catalyst for the preparation of acetylpyridines A process for the production of acetylopyridines of the formula (1): by reacting a pyridinecarboxylic ester of the formula (II): wherein R1 is C | 06/27/2006 |
| 6998411 | 2-Methylheptylisonicotinate and process for production thereof The present invention relates to a novel antifungal antibacterial compound 2-methylheptylisonicotinate of formula 1 below obtained from natural sources and to a process for the isolation thereof. ... | 02/14/2006 |
| 6987199 | Process for preparing beta-ketoester compound The present invention relates to a new process for preparing beta-ketoester compound of the following formula (1), which is a useful intermediate for the synthesis of such quinoline antibiotics as Ciprofloxacin, Levofloxacin, Gemifloxacin, Trovafloxacin, etc. The qu... | 01/17/2006 |
| 6984735 | Process for making an aldehyde A process for making an aromatic aldehyde in which a sulfoxide is reacted with a dihalogenated aromatic compound in the absence of an effective amount of an activating reagent. The aldehyde may then be used to make other compounds, such as a compound that acts as a ... | 01/10/2006 |
| 6919460 | Processes and intermediates useful in preparing β3-adrenergic receptor agonists The present invention provides processes useful in the preparation of certain β3-adrenergic receptor agonists of the structural formula the pharmaceutically acceptable salts thereof, and the hydrates of sai... | 07/19/2005 |
| 6881845 | Process for preparing (±)trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidine The present invention relates to a process for preparing (±)-trans-4-p-fluorophenyl-3-hyroxymethyl-1-methylpiperdine of formula (I). The present invention also relates to novel intermediates of the formula (IX) and (IX′) methods for preparing said intermediates a... | 04/19/2005 |
| 6864267 | Calcilytic compounds Novel calcilytic compounds and methods of using them are provided. ... | 03/08/2005 |
| 6852742 | 1,4-dihydropyridine and pyridine compounds as calcium channel blockers The present invention is directed in part towards methods of modulating the function of calcium channels with pyridine- or 1,4-dihydropyridine-based compounds. In addition, the invention describes methods of preventing and treating protein kinase-related abnormal co... | 02/08/2005 |
| 6814951 | Acetaldehyde and malondialdehyde protein adducts as markers for alcohol liver disease A novel protein adduct is disclosed which is associated with the presence of alcohol liver disease. The adduct is a hybrid product of malondialdehyde and acetaldehyde which act synergistically to bind hepatic proteins. The adduct is highly immunogenic and fluorescen... | 11/09/2004 |
| 6812226 | P2X7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular disease The invention provides piperidine compounds of general formula (I) in which A, B, X, Y, Z, R, R1 and R2 are as defined in the specification, their use as medicaments, compositions containing them and processes for their for their preparation. ... | 11/02/2004 |
| 6794377 | Ortho, ortho-substituted nitrogen-containing bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparation comprising them Ortho, ortho-substituted nitrogen-containing bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations including their use as antiarrhythmic active compounds, for example, for the treatment and prophylaxis of atria... | 09/21/2004 |
| 6770662 | Benzoylpyridine derivative or its salt, fungicide containing it as an active ingredient, its production process and intermediate for producing it The present invention relates to a fungicide containing a novel benzoylpyridine derivative or its salt. The present invention provides a fungicide containing a benzoylpyridine derivative represented by the formula (I) or its salt: | 08/03/2004 |
| 6737529 | Process for the preparation of 2-chloro-5-methylpyridine-3-carbaldehyde The present invention relates to an improved process for the preparation of 2-chloro-5-methylpyridine-3-carbaldehyde which is a useful intermediate in the preparation of a variety of pharmaceutical and pesticide products. ... | 05/18/2004 |
| 6713467 | Acid derivatives useful as serine protease inhibitors Compounds of formula I and II, or pharmaceutically-acceptable salts thereof, are useful as inhibitors of Factor VIIa, Factor IXa, Factor Xa, Factor FXIa, tryptase, and urokinase, wherein ring B is phenyl or pyridyl, L is... | 03/30/2004 |
| 6703509 | Method for producing 5-aryl nicotinaldehydes The invention relates to a process for the preparation of 5-arylnicotinaldehydes by reduction of the corresponding 5-arylnicotinic acids by catalytic hydrogenation in the presence of carboxylic anhydrides in which the catalyst used is a palladium/ligand c... | 03/09/2004 |
| 6699853 | 4-HALOALKYL-3-HETEROCYCLYLPYRIDINES, 4-HALOALKYL-5-HETEROCYCLYL-PYRIMIDINES AND 4-TRIFLUOROMETHYL-3-OXADIAZOLYLPYRIDINES, PROCESSES FOR THEIR PREPARATION, COMPOSITIONS COMPRISING THEM, AND THEIR USE AS PESTICIDES The present invention relates to 4-Haloalkyl-3-heterocyclylpyridines, 4-haloalkyl-5-heterocyclyl-pyrimidines and 4-trifluoromethyl-3-oxadiazolylpyridines, Processes for Their Preparation, Compositions Comprising Them, and Their Use as Pesticides More part... | 03/02/2004 |
| 6673938 | Substituted pyridine herbicides ##STR1## Compounds of formula (I), in which the substituents are as defined in claim 1 and the agrochemically tolerated salts M+ and all stereoisomers and tautomers of the compounds of formula (I) are suitable for use as herbicides.... | 01/06/2004 |
| 6649768 | Production methods of imidazole compound and salt thereof and intermediates therefor A production method including a step for converting a halogen compound of the formula (6) or a salt thereof to a glyoxal compound of the formula (2) or a salt thereof in dimethyl sulfoxide, and a step for reacting the glyoxal compound of the formula (2) o... | 11/18/2003 |
| 6642387 | Substituted acetylpyridine derivatives and process for the preparation of intermediates for optically active 댣 agonist by the use of the same It is an objective to produce intermediates of optically active beta-3 adrenaline receptor agonists from readily available raw materials in a safe, efficient and industrially advantageous manner. A substituted acetylpyridine derivative represented by the ... | 11/04/2003 |
| 6642273 | Unsaturated derivatives at the 4-position of 6-tert-butyl-1,1-dimethylindane and their use in human and veterinary medicine and in cosmetics An unsaturated derivative at the 4-position of 6-tert-butyl-1,1-dimethylindane corresponding to the following formula: ##STR1## in which: X represents: a divalent radical of formula: ##STR2## and Y represents a divalent radical of following formul... | 11/04/2003 |
