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| Number | Title | Issue Date |
| 8168795 | Selective sphingosine-1-phosphate receptor antagonists Described herein are compounds useful as antagonists of sphingosine-1-phosphate receptors. Further described herein is the use of these compounds and related pharmaceutical compositions to treat disorders associated with sphingosine-1-phosphate-3 (S1P3) receptor mod... | 05/01/2012 |
| 7989634 | Melanocortin receptor agonists The present invention relates a compound of formula 1, and pharmaceutically acceptable salt, hydrate, solvate, or isomer thereof effective as agonist of melanocortin receptor, and an agonistic composition of melanocortin receptor comprising the same as active ingred... | 08/02/2011 |
| 7674910 | Process for preparing diimine compounds Process for preparing diimine compounds, in which a discarbonyl compound is reacted with primary amines in the presence of phosphorus pentoxide. ... | 03/09/2010 |
| 7378409 | Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis. | 05/27/2008 |
| 7342115 | 3-substituted-6-aryl pyridines 3-substituted-6-aryl pyridines of Formula I are provided: wherein R1, R2, R3, R8, R9, A and Ar are defined herein. Such compounds are ligands of C5a receptor. Preferred... | 03/11/2008 |
| 7342116 | Process for producing heterocyclic aldehyde A process is disclosed for preparing a heterocyclic aldehyde by oxidizing a heterocyclic alcohol with high selectivity and high yield. Specifically, the heterocyclic aldehyde is prepared by reacting a heterocyclic compound having at least one hydroxymethyl group bon... | 03/11/2008 |
| 7332498 | Modulation of KSP kinesin activity with heterocyclic-fused pyrimidinone derivatives A method of modulating KSP kinesin activity in vitro comprising contacting KSP kinesin with at least one chemical entity chosen from compounds represented by Formula I: and pharmaceutically acceptable salts there... | 02/19/2008 |
| 7332607 | Processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol The present invention provides various processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol. These processes may be characterized by the following scheme: ... | 02/19/2008 |
| 7320983 | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ... | 01/22/2008 |
| RE39991 | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation A compound having the following formula: wherein R3 and M are defined herein, and processes therewith. ... | 01/01/2008 |
| 7312181 | Acylated thiosemicarbazides as herbicides The present invention provides compounds of Formula I: wherein Ar1 is aryl or heteroaryl, Ar2 is aryl or heteroaryl, and R is a suitable organic group. Herbicidal composition comprising such... | 12/25/2007 |
| 7294642 | 1,3-Diamino-2-hydroxypropane pro-drug derivatives The present invention relates to compounds of formula (AA) (I) and (X): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are ... | 11/13/2007 |
| 7282502 | CCR9 inhibitors and methods of use thereof The invention relates to compounds represented by Structural Formula I, which can bind to CCR9 receptors and block the binding of a ligand (e.g., TECK) to the receptors. The invention also relates to a method of inhibiting a function of CCR9, and to the use compound... | 10/16/2007 |
| 7256192 | Aromatic diamide derivatives, chemicals for agricultural or horticultural use and usage thereof The present invention relates to an aromatic diamide derivative represented by the general formula (I): [A1 is optionally substituted (C1-C8)alkylene grou... | 08/14/2007 |
| 7238717 | CCR9 inhibitors and methods of use thereof The invention relates to compounds represented by Structural Formula I, which can bind to CCR9 receptors and block the binding of a ligand (e.g., TECK) to the receptors. The invention also relates to a method of inhibiting a function of CCR9, and to the use compound... | 07/03/2007 |
| 7217706 | Propanolamine derivatives This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which have gut selective sympatho... | 05/15/2007 |
| 7202381 | Compounds as opioid receptor modulators This invention is directed towards novel compounds as opioid receptor modulators, antagonists, and agonists useful for the treatment of opioid modulated disorders such as pain and gastrointestinal disorders. ... | 04/10/2007 |
| 7141673 | 1-(6-methylpyridine-3-yl)-2-[4-(methylsulphonyl) phenyl] ethanone and method for its preparation A starting product for the preparation of COX-2 inhibitors, notably the compound 1-(6-methylpyridine-3-yl)-2-[(4-(methylsulfonyl)phenyl]ethanone of the formula (I): A method for making the compound. ... | 11/28/2006 |
| 7126001 | Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof The present invention provides the compound having the formula: wherein each of R1 and R2 is, substituted or unsubstituted, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino, piperid... | 10/24/2006 |
| 7125880 | Corticotropin releasing factor antagonists Corticotropin-releasing factor (CRF) antagonists having the formulae wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 an... | 10/24/2006 |
| 7115618 | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ... | 10/03/2006 |
| 7105549 | Aryl substituted pyridines and the use thereof This invention relates aryl substituted pyridines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1–R4 are set in the specification. The in... | 09/12/2006 |
| 7067542 | Diaminediols for the treatment of Alzheimer's disease The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the... | 06/27/2006 |
| 7067673 | Process and catalyst for the preparation of acetylpyridines A process for the production of acetylopyridines of the formula (1): by reacting a pyridinecarboxylic ester of the formula (II): wherein R1 is C | 06/27/2006 |
| 7064124 | NF-κB inhibitor containing substituted benzoic acid derivative as active ingredient A NF-κB inhibitor represented by the following formula (I) is provided: ... | 06/20/2006 |
| 7053109 | Aminediols for the treatment of Alzheimer's disease The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the... | 05/30/2006 |
| 6998411 | 2-Methylheptylisonicotinate and process for production thereof The present invention relates to a novel antifungal antibacterial compound 2-methylheptylisonicotinate of formula 1 below obtained from natural sources and to a process for the isolation thereof. ... | 02/14/2006 |
| 6962934 | Substituted amino carboxamides for the treatment of Alzheimer's disease The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treat... | 11/08/2005 |
| 6949655 | Acyclic piperidine derivatives A compound having the formula (I): wherein: each R1, R2, R3 and R4 are independently selected from (C1-C10)-straight ... | 09/27/2005 |
| 6946559 | Method of converting functional group through halogen-metal exchange reaction A method by which a halogen atom of a halogen compound can be efficiently replaced with an electrophilic group. Also provided are: a reagent for converting a functional group through a halogen-metal exchange reaction, characterized by comprising either a mixt... | 09/20/2005 |
| 6890932 | Anthranilic acid derivative The present invention relates to an anthranilic acid derivative expressed by the following formula (1) or the following formula (2), or its pharmacologically permissible salt or solvate. ... | 05/10/2005 |
| 6861531 | Synthesis of 2,6-dicarbonylpyridines Synthesis of 2,6-dicarbonylpyridines in solution in a hydrocarbon medium is described. The solutions of 2,6-dicarbonylpyridines may be used directly in further syntheses. ... | 03/01/2005 |
| 6849634 | Potassium channel inhibitors Compounds useful as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described. ... | 02/01/2005 |
| 6770662 | Benzoylpyridine derivative or its salt, fungicide containing it as an active ingredient, its production process and intermediate for producing it The present invention relates to a fungicide containing a novel benzoylpyridine derivative or its salt. The present invention provides a fungicide containing a benzoylpyridine derivative represented by the formula (I) or its salt: | 08/03/2004 |
| 6762303 | Method for producing pyridine compounds A method for producing a pyridine compound of formula (II), comprising oxidizing a dihydropyridine compound of formula (I) in the presence of (i) at least one acid and at least one nitrous acid or a nitrite, or (ii) at least one base, and a hydrogen peroxide solutio... | 07/13/2004 |
| 6713467 | Acid derivatives useful as serine protease inhibitors Compounds of formula I and II, or pharmaceutically-acceptable salts thereof, are useful as inhibitors of Factor VIIa, Factor IXa, Factor Xa, Factor FXIa, tryptase, and urokinase, wherein ring B is phenyl or pyridyl, L is... | 03/30/2004 |
| 6706740 | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation Heterocyclic aromatic amides (HAA) according to Formula I: wherein X1-X4, M, Z, and A are herein defined. The invention also encompasses hydrates, salts and complexes thereof. These compounds are us... | 03/16/2004 |
| 6706725 | Vitamin D analogues The invention relates to novel bicyclic compounds having the general formula (I): as well as to a method for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine... | 03/16/2004 |
| 6673784 | Electrophilic ketones for the treatment of herpesvirus infections A class of compounds is described which can be used for the treatment of viral infections. Compounds of particular interest are defined by Formula II ##STR1## wherein each of R1, R2, and R3 is independently selected f... | 01/06/2004 |
| 6664397 | Use of (+)mefloquine for the treatment of malaria Use of (+)-(11R,2'S)--2-piperidinyl-2,8-bis(trifluoromethyl)-4-quinolineme thanol or a pharmaceutically acceptable salt thereof substantially free of its (-)-enantiomer in the manufacture of a medicament having reduced side-effect compared to t... | 12/16/2003 |
