Quotables
"The production of too many useful things results in too many useless people."
Karl Marx
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8034950 | Processes for the facile synthesis of diaryl amines and analogues thereof The present invention relates to processes for the facile synthesis of diaryl amines and analogues thereof. The processes of the present invention produce diaryl amines in high yield and purity. The present invention also relates to intermediates useful in the proce... | 10/11/2011 |
| 7956191 | 3-arylamino pyridine derivatives The invention provides novel, substituted 3-arylamino pyridine compounds (I) pharmaceutically acceptable salts, solvates and prodrug compounds thereof, wherein W, R1, R2, R9, R10, R11, R12, R13, R14 are as defined in the specification. Such compounds are MEK inhibit... | 06/07/2011 |
| 7435743 | Pyridine derivatives Pyrimidine compounds of general formula: wherein —R1 represents in which R11 is hydrogen, C1-6 alkyl, halogen, hydroxy, C1-12 alkoxy,... | 10/14/2008 |
| 7432289 | 5-Acylamino-1,1′-biphenyl-4-carboxamide derivatives and their use as P38 kinase inhibitors Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors. ... | 10/07/2008 |
| 7342115 | 3-substituted-6-aryl pyridines 3-substituted-6-aryl pyridines of Formula I are provided: wherein R1, R2, R3, R8, R9, A and Ar are defined herein. Such compounds are ligands of C5a receptor. Preferred... | 03/11/2008 |
| 7320993 | Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group, ... | 01/22/2008 |
| 7282583 | Process for making 5,11-Dihydro-11-ethyl-5-methyl-8{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-di pyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one An improved process for making 5,11-dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-di pyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one. ... | 10/16/2007 |
| 7232926 | Method for the production of sulphamic acid halogenides The present invention relates to a process for preparing sulfamoyl halides of primary or secondary amines, comprising the following steps: i) reacting a primary or secondary amine A1 with at least equimolar amounts of SO3 | 06/19/2007 |
| 7223868 | Heteroaromatic glucokinase activators 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the ... | 05/29/2007 |
| 7157583 | Process for producing high-purity 2,3-pyridinedicarboxylic acid A process for producing 2,3-pyridinedicarboxylic acid having a significantly decreased heavy metal content and capable of satisfying the purity level required for medicinal and agricultural chemicals comprising the steps of: adding at least one sulfur-containing sub... | 01/02/2007 |
| 7115746 | Processes for the facile synthesis of diaryl amines and analogues thereof The present invention relates to processes for the facile synthesis of diaryl amines and analogues thereof. The processes of the present invention produce diaryl amines in high yield and purity. The present invention also relates to intermediates useful in the proce... | 10/03/2006 |
| 6987199 | Process for preparing beta-ketoester compound The present invention relates to a new process for preparing beta-ketoester compound of the following formula (1), which is a useful intermediate for the synthesis of such quinoline antibiotics as Ciprofloxacin, Levofloxacin, Gemifloxacin, Trovafloxacin, etc. The qu... | 01/17/2006 |
| 6962994 | Process for the synthesis of 1,3-diols An improved process for the preparation of cis-1,3-diols is described where a beta hydroxy ketone is treated with a trialkylborane or dialkylalkoxyborane or a mixture of a trialkylborane and a dialkylalkoxyborane followed by recovery and reuse of the alkylborane spe... | 11/08/2005 |
| 6949556 | Acylated 1,2,3,4-tetrahydronaphthyl amines and their use as pharmaceutical agents The present invention relates to compounds of general formula (I), wherein R1-R4 have the meanings given in the specification, A is CH2, CHOH or CH—(C1-C3-alkyl), B and C a... | 09/27/2005 |
| 6919336 | Hallogenated aminobenzophenones and aminobenzoylpyridines as inhibitors of IL-1 and TNF Compounds of formula I and pharmaceutically-acceptable and -cleavable esters thereof and acid addition salts thereof wherein the symbols are as defined are MAP kinase inhibitors, useful pharmaceutically for treating TNFα and IL-1 mediated diseases such as rheumatoi... | 07/19/2005 |
| 6914160 | Oxytocin inhibitors This invention relates to compounds of formula (I) ... | 07/05/2005 |
| 6825221 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain According to the invention there is provided a compound the formula I; wherein A, X, B, R1, R2, R3 and R4 are as defined in the specification. ... | 11/30/2004 |
| 6800650 | Pyridine and quinoline derivatives The present invention provides compounds of formula (I) wherein R1, R2, R3 and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compou... | 10/05/2004 |
| 6794397 | Substituted nicotinamides and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to substituted nicotinamides and analogs thereof, represented by Formula V: or a pharmaceutically acceptable salt or prodrug thereof, wherein: Ar′ and Ar are independently optio... | 09/21/2004 |
| 6750232 | 2-aminopyridine compounds and use thereof as drugs A class of substituted compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by formula (II), wherein R1 is selected from hydrido, halo, alkoxy, aryl, alkylthio, alkylamino... | 06/15/2004 |
| 6680383 | Method for making nevirapine A process for making nevirapine, comprising the following steps: (a) reacting a 2-halo-3-pyridinecarbonitrile of the formula ##STR1## wherein X is a fluorine, chlorine, bromine or iodine atom, preferably chlorine or bromine, with cyclopropylamine, to y... | 01/20/2004 |
| 6632823 | Substituted pyridine compounds useful as modulators of acetylcholine receptors In accordance with the present invention, a novel class of substituted pyridine compounds (optionally containing ether, ester, amide, ketone or thioether substitutions) that promote the release of ligands involved in neurotransmission have been discovered... | 10/14/2003 |
| 6420438 | 1-amino-7-isoquinoline derivatives as serine protease inhibitors The invention relates to serine protease inhibitor compounds of formula (I) ##STR1## where R1 is hydrogen, halo, cyano, nitro or hydroxyl, amino, alkoxy, alkyl, aminoalkyl, hydroxyalkyl, thiol, alkylthio, aminosulphonyl, alkoxyalkyl, alkoxycarb... | 07/16/2002 |
| 6365603 | Aromatic compounds and pharmaceutical compositions containing them Compounds of formula I useful for inhibiting the pain enhancing effects of E-type prostaglandins are disclosed ##STR1## wherein A is a ring system in which the --CH(R.sup.3)N(R.sup.2)B--R.sup.1 and --OR.sup.4 groups are positioned in a 1,2 relationship to... | 04/02/2002 |
| 6362009 | Solid phase synthesis of heterocycles Methods for solid phase and combinatorial synthesis using a resin activation/capture approach are provided. In particular, methods for the production of dihydropyridones, N-acyidihydropyridones, tetrahydropyridones, pyridines, aminopyridines, N-acyltetrah... | 03/26/2002 |
| 6350762 | Dihydropyridine derivative Dihydropyridine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel. They are used as remedies for various diseases relating to... | 02/26/2002 |
| 6316503 | LXR modulators The invention provides compounds, compositions and methods for modulating the effects of LXR in a cell. The compounds and compositions are useful both as diagnostic indicators of LXR function and as pharmacologically active agents. The compounds and compo... | 11/13/2001 |
| 6313302 | Pyrrolidinyl and pyrrolinyl ethylamine compounds as kappa agonists A compound of the following formula: ##STR1## and the salts thereof, wherein A is hydrogen, halo, or hydroxy; the broken line represents an optional double bond with proviso that if the broken line is a double bond, then A is absent; Ar1 is opt... | 11/06/2001 |
| 6313148 | Aromatic amine compounds that antagnoize the pain enhancing effects of prostaglandins Compounds antagonistic of the pain enhancing effects of prostaglandins are disclosed. The compounds comprise an optionally-substituted A ring with a --CH(R3)N(R2)B--R1 and --OD groups positioned in a 1,2 relationship to on... | 11/06/2001 |
| 6197795 | Preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors The present invention relates to the discovery of novel, low molecular weight, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF- converting enzyme (TACE, tumor necrosis factor- con... | 03/06/2001 |
| 6127392 | Anthranilic acid analogs Compounds of the formula: wherein: R1, R2, R3, R4,R5, R6, R7 and R8 are, independently, hydrogen, COOR15, halogen, nitro, cyano, C1-10 alkoxy, C1... | 10/03/2000 |
| 6124457 | Process and intermediates for a ଲ3 -adrenergic receptor agonist The instant invention relates to intermediates of Formula II, ##STR1## wherein R1, R2 and R3 are as defined in the specification, and to processes for preparing such intermediates. This invention also relates to proce... | 09/26/2000 |
| 6121454 | Synthesis of pharmaceutically useful pyridine derivatives A process is provided for the preparation of compounds of formula I, ##STR1## useful in the preparation of compounds such as Omeprazole, Lansoprazole and Pantoprazole, wherein R1 =H or CH3, R2 =H or CH3, R | 09/19/2000 |
| 6034244 | Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity Compounds of the formula ##STR1## wherein the symbols have the meaning defined in the specification, have retinoid-like biological activity.... | 03/07/2000 |
| 6015569 | Polycyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## and are useful for the treatment of a wide variety of disease... | 01/18/2000 |
| 6002012 | Process for the preparation of [(5,6-dicarboxy-3-pyridyl) methyl] ammonium halides There is provided a process for the preparation of [(5,6-dicarboxy-3-pyridyl)methyl]ammonium halides having the structural formula I ##STR1## The [(5,6-dicarboxy-3-pyridyl)methyl]ammonium halides are useful as intermediates in the preparation of... | 12/14/1999 |
| 5965735 | Process for preparing flunixin and intermediates thereof Process for preparing a key intermediate, 2-methyl-3-trifluoromethylaniline (MTA) of Flunixin, as well as novel intermediates thereof are described.... | 10/12/1999 |
| 5962481 | Preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors The present invention relates to the discovery of novel, low molecular weight, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF- converting enzyme (TACE, tumor necrosis factor- con... | 10/05/1999 |
| 5959116 | Pyridine-2, 3-dicarboximides their preparation and their use for controlling undesired plant growth A pyridine-2,3-dicarboxylic acid diester of the formula Va ##STR1## where the radicals R2 and R4 have the meanings set out in the specification and where R8 is a C1 -C4 -alkyl, C3 -C | 09/28/1999 |
| 5929098 | Fungicidically active N-acetonylbenzamide compounds Novel N-acetonylbenzamides are disclosed. These compounds are useful in controlling phytopathogenic fungi.... | 07/27/1999 |
