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| Number | Title | Issue Date |
| 7329670 | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas The compounds are aryl and heteroaryl substituted heterocyclic ureas of the formula A—NH—C(O)—NH—B where A is the aryl or hetaryl substituted heterocyclic group and B is an aryl or heteroaryl moiety. The compounds inhibit raf kinase and are useful in the tre... | 02/12/2008 |
| 7321045 | Vitronectin receptor antagonist pharmaceuticals The present invention describes novel compounds of the formula: (Q)d-Ln-Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. Th... | 01/22/2008 |
| 7317104 | Chelants and macrocyclic metal complex radiopharmaceuticals thereof Chelants and macrocyclic metal complexes thereof, methods of preparing the chelants and macrocyclic metal complexes, and radiopharmaceutical compositions comprising the macrocyclic metal complexes are disclosed. Methods of using the macrocyclic metal complexes as ra... | 01/08/2008 |
| 7309800 | Biphenylcarboxylic amide derivatives as p38 kinase inhibitors Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors. ... | 12/18/2007 |
| 7253193 | Cyanoguanidine prodrugs Pyridyl cyanoguanidine compounds of the general formula I wherein A, X1, X2, X3, Y1, Y2, Y3, R1, R2, R5, R6 and n are as indicated in the description are su... | 08/07/2007 |
| 7241780 | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure wherein Q is C or N, A is O or S, Z is O or a bond, X is CH or N and R1, R2, R2a, R2b, R2c, R3, Y,... | 07/10/2007 |
| 7226596 | Compositions and methods for the treatment of tumors The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of an ADAM8 gene that is amplified in the genome of tumor cells. ... | 06/05/2007 |
| 7208629 | 5′-Carbamoyl-1,1-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors Compounds of formula (I): wherein when m is 0 to 4 R1 is selected from C1–6alkyl, C3–7cycloalkyl, C2–6alkenyl, —SO2NR4R5, —CONR4R5 and —COOR4; and when m is 2 to 4 R1 is additionally selected from C1–6alkoxy, hydroxy, NR4R5, —NR4SO2R5, —NR4SOR5, ... | 04/24/2007 |
| 7186737 | Inhibitors of p38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to inhibitors of ZAP70. The invention also relates to methods for producing these... | 03/06/2007 |
| 7183297 | Biphenyl-derivatives as p38-kinase inhibitors Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors. ... | 02/27/2007 |
| 7166623 | 2′-Methyl-5′-(1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors. ... | 01/23/2007 |
| 7151118 | Biphenylcarboxylic amide derivatives as p38-kinase inhibitors Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors. ... | 12/19/2006 |
| 7056925 | Urea kinase inhibitors Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds. | 06/06/2006 |
| 7045512 | Fungicidal phenoxyphenylhydrazine derivatives A fungicidally active compound of the formula: a) wherein Q is —NY—NH—, —N═N—, or X is oxygen... | 05/16/2006 |
| 7022695 | Thioether-substituted benzamides as inhibitors of Factor Xa Thioether-substituted benzamide compounds having the formula: are provided that exhibit exceptionally strong inhibition of Factor Xa in combination with weak hERG binding. ... | 04/04/2006 |
| 6989398 | Benzanilides as potassium channel openers Benzanilides are provided which are voltage-dependent potassium channel openers. Methods of using the benzanilides of the invention are also provided. ... | 01/24/2006 |
| 6936719 | Biaryl compounds as serine protease inhibitors Compounds of formula (I) are useful as inhibitors of trypsin like serine protease enzymes such as thrombin, factor VIIa, factor Xa, TF/FVIIa, and trypsin. These compounds could be useful to treat and/or prevent clotting disorders, and as anticoagulating agents. ... | 08/30/2005 |
| 6897209 | Labelled factor XIIIa substrates A complex of a radiometal or paramagnetic metal ion with a metal chelating agent such as a diaminedioxime has attached thereto a substituent of formula (Y)m-A-NHR)k can function as a substrate for the fibrin-stabilizing Factor XIIIa. The comple... | 05/24/2005 |
| 6875764 | Urea and thiourea compounds useful for treatment of coccidiosis The present invention relates to novel compounds, pharmaceutical compositions containing the same as well as a method for treatment of parasitic disorders, wherein said compounds are administered. The present compounds are especially well suited for treatment of coc... | 04/05/2005 |
| 6838472 | Substituted urea retinoid agonists The current invention provide novel compounds, methods of treating or preventing emphysema, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and dermatological disorders and methods for de... | 01/04/2005 |
| 6803486 | Selective neuronal nitric oxide synthase inhibitors Peptidomimetic compositions for selective inhibition of neuronal nitric oxide synthase. ... | 10/12/2004 |
| 6727265 | Phenoxyethyl-thiourea-pyridine compounds and their use for treatment of HIV-infections The invention provides compounds which inhibit reverse transcriptase (RT) and which inhibit replication of a retrovirus, such as human immunodeficiency virus-1 (HIV-1). The compound of the invention are phenoxyethyl-thiourea-pyridines. The invention additionally pro... | 04/27/2004 |
| 6699994 | Biaryl compounds as serine protease inhibitors Compounds of formula (I) are useful as inhibitors of trypsin like serine protease enzymes such as thrombin, factor VIIa, factor Xa, TF/FVIIa, and trypsin. These compounds could be useful to treat and/or prevent clotting disorders, and as anticoagulating a... | 03/02/2004 |
| 6693122 | Nitrosated and nitrosylated potassium channel activators, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated potassium channel activators, and novel compositions comprising at least one nitrosated and/or nitrosylated potassium channel activator, and, optionally, at least one compound that donat... | 02/17/2004 |
| 6677353 | Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating... | 01/13/2004 |
| 6653299 | Labelled factor XIIIa substrates A complex of a radiometal or paramagnetic metal ion with a metal chelating agent such as a diaminedioxime has attached thereto a substituent of formula --(Y)m --A--NHR, can function as a substrate for the fibrin-stabilizing Factor XIIIa. The co... | 11/25/2003 |
| 6649613 | Diacylhydrazine derivatives Diacylhydrazine derivatives of general formula (I) ##STR1## wherein X, Y, Z, R1, 2 and R3 are as defined herein, and their physiologically acceptable salts or solvates thereof, are integrin inhibitors and can be used to co... | 11/18/2003 |
| 6645968 | Potassium channel openers Compounds of formula I: ##STR1## are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.... | 11/11/2003 |
| 6646129 | Cyanoguanidines as cell proliferation inhibitors The present invention relates to hitherto unknown compounds of formula (I) or their tautomeric forms, ##STR1## the attachment to the pyridine ring being in the 3- or 4-position, in which formula R stands for one or more substituents which can be the same ... | 11/11/2003 |
| 6632823 | Substituted pyridine compounds useful as modulators of acetylcholine receptors In accordance with the present invention, a novel class of substituted pyridine compounds (optionally containing ether, ester, amide, ketone or thioether substitutions) that promote the release of ligands involved in neurotransmission have been discovered... | 10/14/2003 |
| 6608077 | Il-8 receptor antagonists This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8). ##STR1##... | 08/19/2003 |
| 6596863 | Medical composition containing nitroetheneamine Derivative or salt there of as active constituent Process for producing a nitroetheneamine derivative ##STR1## or its stereoisomer, its tautomer or a salt thereof comprising reacting a compound of the formula ##STR2## with a compound of the formula R6 --CH2 NO2 to obtain ... | 07/22/2003 |
| 6583162 | 2-pyridinylguanidine urokinase inhibitors Compounds of formula (I): ##STR1## or a pharmaceutically acceptable salt thereof, or solvate of either entity, wherein R4 is a guanidinyl moiety and the other substituents are as defined in the text, are urokinase inhibitors.... | 06/24/2003 |
| 6555561 | Diaminopyridine-containing thiourea inhibitors of herpes viruses This invention provides compounds of formula I having the structure ##STR1## Wherein substitutions at X, G, R1, R2, R3, R4, R5 are set forth in the specification.... | 04/29/2003 |
| 6525077 | Cyanoguanidine prodrugs A compound of the formula ##STR1## is disclosed, the compound being suited for therapeutical uses. The invention also discloses compositions comprising said compound, methods of treatment involving administering said compound to a patient, and the use ... | 02/25/2003 |
| 6472393 | Serine protease inhibitors Compounds having the structure shown below wherein A, B, N1, N2, X, Y, Q, R2, R5 and R6 are as defined herein are useful to inhibit serine protease enzymes, such as TF/factor VIIa factor Xa, thrombin ... | 10/29/2002 |
| 6458803 | Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating... | 10/01/2002 |
| 6458816 | Modified prodrug forms of AP/AMP The present invention relates to compounds according to the structure: ##STR1## Where R is H or CH3 ; R2 is phosphate which can be free acid or salt; R3 is H, F, Cl, Br, I, OCH3, OCF3 , CF3 or a C | 10/01/2002 |
| 6451792 | Medical composition containing nitroetheneamine derivative or salt thereof as active constituent A medical composition containing, as an active constituent, a nitroetheneamine derivative represented by the formula (I): ##STR1## wherein the substituents are as defined in the disclosure, its stereoisomers, its tautomers or a salt thereof.... | 09/17/2002 |
| 6444691 | 1,3-disubstituted ureas as ACAT inhibitors, and method of preparing thereof The invention relates to 1,3-disubstituted ureas of general formula (I) where R1 is an aryl, R2 is nitro and/or amino, and X is oxygen and/or sulfur, and the method of preparing thereof which consists in treating aromatic amines with... | 09/03/2002 |
