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| Number | Title | Issue Date |
| 7342115 | 3-substituted-6-aryl pyridines 3-substituted-6-aryl pyridines of Formula I are provided: wherein R1, R2, R3, R8, R9, A and Ar are defined herein. Such compounds are ligands of C5a receptor. Preferred... | 03/11/2008 |
| 7314873 | (Halo-benzo carbonyl)heterobi cyclic p38 linase inhibiting agents Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (I) are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty ar... | 01/01/2008 |
| 7223778 | 5-substituted-2-arylpyridines Novel 5-substituted-2-arylpyridine compounds are provided. Such compounds can act as selective modulators of CRF receptors. The 5-substituted-2-arylpyridine compounds provided herein are useful in the treatment of a number of CNS and periphereal disorders, particula... | 05/29/2007 |
| 7195719 | High polarization ferroelectric liquid crystal compositions The invention relates to chiral nonracemic liquid crystal compounds having achiral tails comprising a perfluoroalkyl terminal portion which are useful as components in liquid crystal to impart high polarization to the mixture. The materials of this invention can be ... | 03/27/2007 |
| 7186839 | Chemical process for the extraction of 2-hydroxy pyridine derivatives, 2-hydroxyquinoline, and 2-hydroxybenzothiazole A process for extracting from aqueous solution the alkali metal or calcium salt of a halo or haloalkyl substituted 2-hydroxypyridine, or a 2-hydroxyquinoline or 2-hydroxybenzothiazole which comprises contacting an aqueous alkaline or neutral solution of the alkali m... | 03/06/2007 |
| 7041852 | Perfluoroalkylanilines The present invention relates to a process for preparing perfluoroalkylanilines and to their use for preparing active ingredients, in particular for agrochemicals. ... | 05/09/2006 |
| 7015320 | Process for the manufacture of optically active 3-substituted lactams by asymmetric hydrogenation of 3-alkylidenelactams The present invention relates generally to processes for the efficient production optically active 3-substituted lactams of formula (I) process, comprising: contacting a compound of formula (II): ... | 03/21/2006 |
| 6916933 | 4-pyridinyl-n-acyl-l-phenylalanines Compounds of Formula I have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4 and are useful for treating disease whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4. ... | 07/12/2005 |
| 6858742 | DNA labeling reagents, acridinium-9-carboxamide derivatives and process of preparing DNA labeling compounds The present invention relates to DNA labeling reagents comprising a furocoumarin derivative and a detectable group with or without bound via a binding enhancer, and acridinium-9-carboxamide derivatives for use as chemiluminescent labels. The present invention also r... | 02/22/2005 |
| 6844032 | Liquid crystal compounds having bis(trifluoromethyl) phenyl rings, liquid crystal compositions and liquid crystal display devices The compound (1) having 2,3-bis(trifluoromethyl)-1,4-phenylene is stable chemically and has excellent miscibility with other liquid crystal compounds, large and negative dielectric anisotropy and proper optical anisotropy. A liquid crystal composition comprising the... | 01/18/2005 |
| 6828466 | Process for the synthesis of phenols from arenes A process to synthesize substituted phenols such as those of the general formula RR′R″Ar(OH) wherein R, R′, and R″ are each independently hydrogen or any group which does not interfere in the process for synthesizing the substituted phenol including, but not... | 12/07/2004 |
| 6765095 | 2,3-disubstituted pyridine derivative, process for the preparation thereof, pharmaceutical composition containing the same, and intermediate therefor A compound of the formula (I) wherein A is O, S, CHR1 or NR2, R1 and R2 are H, lower alkyl, X1 and X2 are H, halogen, nitro, cyano, etc., Y1 is... | 07/20/2004 |
| 6710045 | Heterocyclic fluoroalkenyl thioethers and the use thereof as pesticides (IV) The present invention relates to novel heterocyclic fluoroalkenyl thioethers of the formula (I) in which m represents integers from 3 to 10, n represents 0, 1 or 2 and Het represents the following, i... | 03/23/2004 |
| 6673745 | Herbicidal 3,5-difluoropyridines The invention relates to novel compounds of formula I: ##STR1## wherein R, A, B and X have the meaning given in claim 1; and the agronomically acceptable salts or N-oxides thereof, and to herbicidal compositions containing such compounds as active ingredi... | 01/06/2004 |
| 6670380 | Pyridone inhibitors of fatty acid binding protein and method Compounds are provided having the formula: ##STR1## wherein A, Q, and X are as described herein. A method is also provided for treating diabetes and related diseases, especially Type II diabetes, employing such compounds alone or in combination with other... | 12/30/2003 |
| 6632823 | Substituted pyridine compounds useful as modulators of acetylcholine receptors In accordance with the present invention, a novel class of substituted pyridine compounds (optionally containing ether, ester, amide, ketone or thioether substitutions) that promote the release of ligands involved in neurotransmission have been discovered... | 10/14/2003 |
| 6509471 | 3-substituted pyridine compounds and related synthesis The present invention relates to 3-substituted and 2,3-disubstituted pyridine compounds which are useful as intermediates in the synthesis of pyridylsulfonylurea herbicides. The invention also relates to arylation of alcohols using a pyridinediazonium sal... | 01/21/2003 |
| 6472348 | Pyridone derivatives and herbicides The present invention relates to pyridone derivatives and herbicidal compositions containing the pyridone derivatives as active ingredients.... | 10/29/2002 |
| 6441007 | Pharmaceutical compositions and methods for use Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof aryloxyalkylamines, including pyridyloxylalkylamines and phenoxyalkylamines, such as ... | 08/27/2002 |
| 6437139 | Synthesis of pharmaceutically useful pyridine derivatives A process is provided for the preparation of compounds of formula I, ##STR1## useful in the preparation of compounds such as Omeprazole, Lansoprazole and Pantoprazole, wherein R1 =H or CH3, R2 =H or CH3, R3... | 08/20/2002 |
| 6420565 | Process for making 2, 5-substituted pyridine 2-lithio-5-halopyridine is formed as a predominant component of a reaction mixture by reacting BuLi with 2,5-dihalopyridine in a non-coordinating solvent.... | 07/16/2002 |
| 6420564 | Process for preparing tribromomethylsulfonylpyridine The present invention provides a process for preparing a tribromomethylsulfonylpyridine, which comprises reacting a methylthiopyridine and a hypobromite in the presence of a base and water in a heterogeneous system. According to the present invention, it ... | 07/16/2002 |
| 6407245 | Substituted thiopyridines Substituted thiopyridines of the general formula I ##STR1## where n is 1 or 2; R1 is chlorine, C1 -C3 -fluoroalkyl, nitro or methylsulfonyl; R2 is a C1 -C10 -alkyl, C2 -C10... | 06/18/2002 |
| 6323222 | 1-aza-2-alkyl-6-aryl-cycloalkane compounds Compound of formula (I): ##STR1## wherein: {character pullout} n represents 0 or 1, {character pullout} R1 represents hydrogen, arylalkyl, alkyl, acyl, alkoxycarbonyl, arylalkoxycarbonyl or trifluoroacetyl, {character pullout} R2 represen... | 11/27/2001 |
| 6316631 | Process for converting 2,4-dichloropyridines into 2-aryloxy-4-chloropyridines This invention relates to a process for converting 2,4-dichloropyridines into 2-aryloxy-4-chloropyridines, comprising reacting a compound of formula (I), wherein R1 is (C1 -C4)alkyl; R2 is methyl or ethyl; and R... | 11/13/2001 |
| 6310006 | Herbicidal 3,5-difluoropyridines The invention relates to novel compounds of formula I: ##STR1## wherein R, A, B and X have the meaning given in claim 1; and the agronomically acceptable salts or N-oxides thereof, and to herbicidal compositions containing such compounds as active ingredients.... | 10/30/2001 |
| 6306839 | 2-methoxyimino-2-(pyridinyloxymethyl) phenyl acetamides with (derivatised) hydroxyalkyl derivatives on the pyridine ring The present invention provides novel 2-methoxyimino-2-(pyridinyloxymethyl)phenyl acetamide compounds with (derivatised) hydroxyalkyl substituents on the pyridine ring, their use as fungicidal compounds, and their use in fungicidal compositions comprising ... | 10/23/2001 |
| 6271379 | Intermediates useful for the synthesis of huperzine A Intermediates useful for the synthesis of huperzine A represented by the structures below, ##STR1## and methods for their synthesis, wherein: R1 is lower alkyl, benzyl, or substituted benzyl; X is a suitable leaving group; Y is an electron withdrawi... | 08/07/2001 |
| 6248892 | Process for preparing arylpyridines 2-, 3- or 4-arylpyridines are prepared by reacting a halopyridine with an aryl Grignard compound, where the halogen is chlorine or bromine, in the presence of a palladium catalyst of the formula (IV) ##STR1##... | 06/19/2001 |
| 6175011 | Process for the preparation of arylamides of heteroaromatic carboxylic acids A process for the preparation of arylamides of heteroaromatic carboxylic acids of the formula: ##STR1## in which each An is nitrogen or CRn (n=1-5), with the proviso that at least one of the ring members is nitrogen and that two nitr... | 01/16/2001 |
| 6143899 | Chemical process A process for the preparation of 2-hydroxy-6-trifluoromethylpyridine which comprises reacting 2-fluoro-6-trifluomethylpyridine or a mixture of 2-fluoro-6-trifluoromethylpyridine and 2-chloro-6-trifluoromethylpyridine with an alkali metal hydroxide at a te... | 11/07/2000 |
| 6133447 | Process for the preparation of substituted pyridines 2-chloro-3-hydroxypyridine is prepared by reacting 3-hydroxypyridine with aqueous sodium hypochlorite.... | 10/17/2000 |
| 6121454 | Synthesis of pharmaceutically useful pyridine derivatives A process is provided for the preparation of compounds of formula I, ##STR1## useful in the preparation of compounds such as Omeprazole, Lansoprazole and Pantoprazole, wherein R1 =H or CH3, R2 =H or CH3, R | 09/19/2000 |
| 6090817 | Phenylpyridine derivatives useful as phosphodiesterase inhibitors (4-oxy-3-(aryl)phenyl)pyridine compounds, in free or acid addition salt form, are useful as pharmaceuticals for treatment and prophylaxis of inflammation, particularly inflammatory or obstructive diseases of the airways, e.g. for asthma therapy. Preferred... | 07/18/2000 |
| 6054583 | Preparation of 2-substituted pyridines This invention relates to a process for preparing 2-substituted pyridines via metal halogen exchange with sec-butyllithium on optionally substituted 2-bromo or 2-iodopyridines. The resulting lithopyridine intermediate is reacted with an electrophile to pr... | 04/25/2000 |
| 6048823 | Pyridone derivatives and herbicides A pyridone derivative represented by the general formula: ##STR1## {wherein R is an alkyl group or a haloalkyl group, R1 is a hydrogen atom, an alkyl group, a haloalkyl group, an acetyl group, an amino group, an alkoxycarbonylamino group, ... | 04/11/2000 |
| 6020524 | Process for the preparation of 2-(pyrid-2-yloxymethyl)phenylacetates as pesticide intermediates A compound of the following formula ##STR1## wherein M is an alkali metal or alkaline earth metal atom and a process for the preparation of the compound is provided.... | 02/01/2000 |
| 6015569 | Polycyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## and are useful for the treatment of a wide variety of disease... | 01/18/2000 |
| 6008161 | Herbicidal 2-(hetero)aryloxy-6-arylpyridines and 2-aryl-4-(hetero) aryloxypyrimidines Herbicidal 2-(hetero)aryloxy-6-arylpyridines and 2-Aryl-4-(hetero)aryloxypyrimidines New herbicidal pyridine and pyrimidine derivatives of general formula (1), ##STR1## wherein Z represents a nitrogen atom or a C--H group; A represents an optionally ... | 12/28/1999 |
| 5973159 | Chemical process 2-Hydroxy-6-trifluoromethylpyridine is prepared by reacting 2-chloro-6-trifluoromethylpyridine with an aqueous alkali metal hydroxide in a sealed vessel at a temperature of at least 140° C. under autogenous pressure.... | 10/26/1999 |
