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Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 7923565 | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme. ... | 04/12/2011 |
| 7705155 | Processes for the production of useful intermediates The present application relates to a new process for the asymmetric production of 3-(pyridin-4-yl)-3-hydroxy-pentanoic acid derivatives, which are useful intermediates in the manufacture of compounds that are known to show antiproliferative activity. ... | 04/27/2010 |
| 7342115 | 3-substituted-6-aryl pyridines 3-substituted-6-aryl pyridines of Formula I are provided: wherein R1, R2, R3, R8, R9, A and Ar are defined herein. Such compounds are ligands of C5a receptor. Preferred... | 03/11/2008 |
| 7335753 | Bifunctional heterocyclic compounds and methods of making and using same The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using... | 02/26/2008 |
| RE39916 | Compounds that modulate PPAR activity and methods for their preparation This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds of their salts, and methods of using them as therapeutic a... | 11/06/2007 |
| 7253178 | Carboxylic acids The present invention provides a novel carboxylic acid derivative, a salt thereof or a hydrate of them which is useful as an insulin sensitizer, and a medicament comprising the derivative as the effective ingredient. More specifically, it provides a carboxylic acid ... | 08/07/2007 |
| 7232821 | (2-((2-alkoxy)-phenyl) -cyclopent-1enyl) aromatic carbo and heterocyclic acid and derivatives Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, R1, R2, Rx, R8, R9 and n are as defined in the specification, a proc... | 06/19/2007 |
| 7214710 | Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids The present invention relates to the field of prodrugs of chemotherapeutic agents and method of use thereof. ... | 05/08/2007 |
| 7211591 | Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate there... | 05/01/2007 |
| 7208183 | Methods and preparations of the latex from the croton species The invention herein describes a procedure for organically extracting the lipophilic components from plants of the Family Euphorbaciae, specifically but not limited to the genus Croton. The extraction (CGO 110), is deplete of the normal proanthocyanidin conte... | 04/24/2007 |
| 7208500 | Thienopyridine-phenylacetamides and their derivatives useful as new anti-angiogenic agents The invention relates to compounds represented by Formula (I): and to prodrugs thereof, pharmaceutically acceptable salts or solvates of said compounds or said prodrugs, wherein each of X1–X5 | 04/24/2007 |
| 7205302 | Heterocyclic compound derivatives and medicines The present invention provides a compound which is useful as a PGI2 receptor agonist, and a pharmaceutical composition. The present invention is directed to a pharmaceutical composition comprising a compound represented by the following formula [1]... | 04/17/2007 |
| 7129246 | N-adamantlmethyl derivatives and intermediates as pharmaceutical compositions and processes for their preparation The invention provides compounds of general formula (I) in which m, A, R1 and Ar have the meanings defined in the specification; a process for, and intermediates used in, their preparation; pharmaceutical compositions containing them; a process for prepar... | 10/31/2006 |
| 7115608 | Pyridinone and pyridinethione derivatives having HIV inhibiting properties The present invention is concerned among others with compounds of formula (1), the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and stereochemically isomeric forms thereof, wherein Q is halo, C1-6 alkyl or C2-6 | 10/03/2006 |
| 7091196 | Bifunctional heterocyclic compounds and methods of making and using same The invention provides a family of compounds useful as anti-infective agents and/or anti-proliferative agents, for example, chemotherapeutic agents, anti-fungal agents, anti-bacterial agents, anti-parasitic agents, anti-viral agents, and/or anti-inflammatory agents,... | 08/15/2006 |
| 7071175 | Pyridine mercapto carboxylic acids as carboxypeptidase U inhibitors The present invention relates to compounds of Formula I, and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts, which compounds inhibit carboxypeptidase U and thus can be used in the prev... | 07/04/2006 |
| 7038058 | Continuous preparation of substituted oxazoles The present invention relates to a process for continuously preparing 5-alkoxy-substituted oxazoles, in particular for continuously preparing 4-methyl-5-alkoxy-substituted oxazoles and also a process for preparing pyridoxine derivatives. ... | 05/02/2006 |
| 7015320 | Process for the manufacture of optically active 3-substituted lactams by asymmetric hydrogenation of 3-alkylidenelactams The present invention relates generally to processes for the efficient production optically active 3-substituted lactams of formula (I) process, comprising: contacting a compound of formula (II): ... | 03/21/2006 |
| 6987189 | Short synthesis of pyridine-based pharmaceutical intermediates A method of making a compound of Formula VI: wherein Tr is a triphenyl group; R1, R2 and R3 are each independently selected from the group consisting of H, C1–C4 alkyl, C1–C4 alkoxy,... | 01/17/2006 |
| 6972294 | Compounds, their preparation and use Disclosed are novel compounds of formula (I) wherein A1, A2, Ar, R5, R6, R8, M, Q, Y, Z, k, m and n are as defined in the specification. These compounds are useful ... | 12/06/2005 |
| 6949680 | Ketones as precursors of active compounds A compound of formula wherein Y represents a pyridyl group, or a phenyl group of formula wherein R3 represents a hydrogen atom, a CF3 group or an al... | 09/27/2005 |
| 6939875 | Compounds that modulate PPAR activity and methods for their preparation This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic a... | 09/06/2005 |
| 6936597 | Prodrugs of anticancer agents employing substituted aromatic acids Polymeric prodrugs of the formula: wherein B is selected from the group consisting of OH, leaving groups, residues of amine-containing moieties and a residues of hydroxyl-containing m... | 08/30/2005 |
| 6916933 | 4-pyridinyl-n-acyl-l-phenylalanines Compounds of Formula I have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4 and are useful for treating disease whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4. ... | 07/12/2005 |
| 6911451 | Phenylalanine derivatives Phenylalanine derivatives of formula (1) are described: wherein L1 is a linker atom or group; X1 is a group selected from —N(R3)CO—, —N(R3)SO | 06/28/2005 |
| 6881845 | Process for preparing (±)trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidine The present invention relates to a process for preparing (±)-trans-4-p-fluorophenyl-3-hyroxymethyl-1-methylpiperdine of formula (I). The present invention also relates to novel intermediates of the formula (IX) and (IX′) methods for preparing said intermediates a... | 04/19/2005 |
| 6878704 | Heterocyclic mutilin esters and their use as antibacterials Pleuromutilin compounds of the formula: are of use in anti-bacterial therapy. ... | 04/12/2005 |
| 6875780 | Compounds that modulate PPAR activity and methods for their preparation This invention relates to compounds that alter PPAR activity. The invention also relates to pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic... | 04/05/2005 |
| 6872690 | Herbicidal 2-alkynyl-pyri (mi) dines The invention relates method of combating undesired plant growth at a locus, comprising application to the locus of an effective amount of at least one compound of formula (I): wherein R1 | 03/29/2005 |
| 6846830 | Naphtalene derivatives and their pharmaceutical use Use of compounds of the formula (I) where A, E, R1, R2, p and q have the meanings given in the specification are GluR6 antagonists useful for the treatment of disorders of the central nervous system. ... | 01/25/2005 |
| 6806371 | Preparation of substituted pyridine N-oxide compounds A process for preparing substituted pyridine N-oxide compounds of the formula in which R1, R2, R3 and R4 are each H, a carboxyl group or a C1-C12-alkyl radical which may contain atoms from the gro... | 10/19/2004 |
| 6794396 | Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity A class of substituted pyridines that are useful for inhibiting the activity of cholesteryl ester transfer protein, and have the structural formula (IA), wherein R2, R3, R4, R5... | 09/21/2004 |
| 6787562 | Substituted aryl and heteroaryl compounds as E-type prostaglandin antagonists Compounds of the formula I; useful for the treatment of pain wherein A, Z, B, R1, X and D are as defined in the specification, methods of making such compounds, methods of using such compounds and pharmaceutical c... | 09/07/2004 |
| 6765019 | Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids The present invention relates to the field of prodrugs of chemotherapeutic agents and method of use thereof. ... | 07/20/2004 |
| 6765095 | 2,3-disubstituted pyridine derivative, process for the preparation thereof, pharmaceutical composition containing the same, and intermediate therefor A compound of the formula (I) wherein A is O, S, CHR1 or NR2, R1 and R2 are H, lower alkyl, X1 and X2 are H, halogen, nitro, cyano, etc., Y1 is... | 07/20/2004 |
| 6723853 | Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins A method of synthesizing a compound having the formula: from a compound having the formula: wherein R1 is hydrogen, fluorine, chlorine or SiR5R6 | 04/20/2004 |
| 6653258 | Hetero-aryl compounds having herbicidal, fungicidal and insecticidal activity Fungicidal compounds of the formula (I): ##STR1## and stereoisomers thereof, wherein R1 is optionally substituted aryl or optionally substituted heteroaryl; Y is oxygen, sulphur or NR4 ; R2, R3 and R4... | 11/25/2003 |
| 6646130 | Process to chiral integrin antagonist beta-amino acid intermediate The invention discloses a novel process for the preparation of enantiomerically enriched mixtures of compounds of structural formula I which are useful intermediates in the synthesis of v댣 integrin receptor antagonists ##STR1##... | 11/11/2003 |
| 6635766 | Process for the preparation of arylamides of heteroaromatic carboxylic acids A process for the preparation of arylamides of heteroaromatic carboxylic acids of the formula: ##STR1## in which each An is nitrogen or CRn (n=1 to 5), with the proviso that at least one of the ring members is nitrogen and that two n... | 10/21/2003 |
| 6632946 | Tetracyclic analogues of camptothecins, their preparation processes, their use as medicaments and the pharmaceutical compositions containing them The invention relates to new tetracyclic analogues of camptothecin, their preparation processes, their use as medicaments and the pharmaceutical compositions containing them. Said analogues, which include in particular 3-hydroxy-3-(4-oxo-4,6-dihydroindoli... | 10/14/2003 |
