Class 546/289 - Nitrogen attached directly to the six-membered hetero ring by nonionic bonding

Subclass of Class 546 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein nitrogen is attached directly to the six-membered
No. of patents: 181
Last issue date: 10/14/2008

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Number	Title	Issue Date
7435743	Pyridine derivatives Pyrimidine compounds of general formula: wherein —R1 represents in which R11 is hydrogen, C1-6 alkyl, halogen, hydroxy, C1-12 alkoxy,...	10/14/2008
7342115	3-substituted-6-aryl pyridines 3-substituted-6-aryl pyridines of Formula I are provided: wherein R1, R2, R3, R8, R9, A and Ar are defined herein. Such compounds are ligands of C5a receptor. Preferred...	03/11/2008
7332498	Modulation of KSP kinesin activity with heterocyclic-fused pyrimidinone derivatives A method of modulating KSP kinesin activity in vitro comprising contacting KSP kinesin with at least one chemical entity chosen from compounds represented by Formula I: and pharmaceutically acceptable salts there...	02/19/2008
7320993	Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group, ...	01/22/2008
7262252	Nonlinear optical materials comprising fluorine-containing polymer There is provided a fluorine-containing resin composition which is used for nonlinear optical material and comprises (I) a fluorine-containing prepolymer and (II) an organic compound exhibiting a second- or higher-order nonlinear optical effect, in which the fluorin...	08/28/2007
7223868	Heteroaromatic glucokinase activators 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the ...	05/29/2007
7151182	Intermediates for N-substituted carbamoyloxyalkyl-azolium derivatives N-substituted carbamoyloxyalkyl-azolium derivatives which have antifungal activity and are useful for the treatment of fungal diseases. ...	12/19/2006
7115637	Inhibitors of p38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceut...	10/03/2006
7071207	Preparation and use of 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives for treatment of obesity This invention relates to 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds...	07/04/2006
7064124	NF-κB inhibitor containing substituted benzoic acid derivative as active ingredient A NF-κB inhibitor represented by the following formula (I) is provided: ...	06/20/2006
7056925	Urea kinase inhibitors Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.	06/06/2006
7015237	Pyridine matrix metalloproteinase inhibitors Selective MMP-13 inhibitors are pyridine derivatives of the formula or a pharmaceutically acceptable salt thereof, wherein: R1 and R2 independently are hydrogen, halo, hydrox...	03/21/2006
6984649	Pyridine derivatives Pyridine compounds of general formula: wherein —R1 represents in which R11 is hydrogen, C1-6 alkyl, halogen, hydroxy, C1-12 ...	01/10/2006
6881845	Process for preparing (±)trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidine The present invention relates to a process for preparing (±)-trans-4-p-fluorophenyl-3-hyroxymethyl-1-methylpiperdine of formula (I). The present invention also relates to novel intermediates of the formula (IX) and (IX′) methods for preparing said intermediates a...	04/19/2005
6809109	2, 4-disubstituted-pyridine N-oxides useful as HIV reverse transcriptase inhibitors The present invention relates to 2,4-disubstituted pyridine-N-oxide compounds of formula (I): or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhib...	10/26/2004
6794377	Ortho, ortho-substituted nitrogen-containing bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparation comprising them Ortho, ortho-substituted nitrogen-containing bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations including their use as antiarrhythmic active compounds, for example, for the treatment and prophylaxis of atria...	09/21/2004
6750232	2-aminopyridine compounds and use thereof as drugs A class of substituted compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by formula (II), wherein R1 is selected from hydrido, halo, alkoxy, aryl, alkylthio, alkylamino...	06/15/2004
6750211	Diimino compounds for use as modulators of cell regulation Compositions, methods of use, isolation and biosynthesis of diimino-piperazine derivatives useful for the modification of sphingolipid metabolism and other biological functions are described. The preferred derivative is 2,6-bis-(ω-aminobutyl)-3,5-diimino-piperazine...	06/15/2004
6632823	Substituted pyridine compounds useful as modulators of acetylcholine receptors In accordance with the present invention, a novel class of substituted pyridine compounds (optionally containing ether, ester, amide, ketone or thioether substitutions) that promote the release of ligands involved in neurotransmission have been discovered...	10/14/2003
6632945	Inhibitors of P38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides...	10/14/2003
6583161	Benzenesulfonamides and benzamides as therapeutic agents The invention provides compounds, compositions and methods relating to novel aromatic derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particul...	06/24/2003
6537999	Pyrimidine derivatives and methods of making and using these derivatives This invention discloses pyrimidine derivatives, and pharmaceutically acceptable salts and prodrugs thereof, of the following formula: ##STR1## wherein L and M are selected from the group consisting of carbon and CH, the chemical bond between L and M is s...	03/25/2003
6486183	Antivirals Compounds of formula (I): wherein Rx is cyano or bromo; R1 is halo; R2 is C1 -C3 alkyl, and pharmaceutically acceptable salts and prodrugs thereof have activity as antiretrovirals....	11/26/2002
6372907	Water-soluble rhodamine dye peptide conjugates The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the same and methods for their use. The dyes, energy-transfer dye...	04/16/2002
6191278	Water-soluble rhodamine dyes and conjugates thereof The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the same and methods for their use. The dyes, energy-transfer dye...	02/20/2001
6130226	Immunotherapeutic agents Cyano and carboxy derivatives of substituted styrenes are inhibitors of tumor necrosis factor ଱, nuclear factor .kappa.B, and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory con...	10/10/2000
6107299	Substituted pyridine and pyrimidine, processes for their preparation and their use as pesticides Compounds of formula I, N-oxides or salts, thereof ##STR1## in which q is 0, 1 or 2 A is CH and D is N+ R×1/n Qn- or A is N and D is N+ R×1/n Qn- or A is CH or N and D is N or A is N+ R×1/n Q	08/22/2000
6022884	Substituted pyridine compounds and methods of use Selected novel substituted pyridine compounds are effective for prophylaxis and treatment of diseases, such as TNF-଱, IL-1ଲ, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel com...	02/08/2000
5972975	Substituted 2-aminopyridines as inhibitors of nitric oxide synthase Substituted 2-aminopyridine compounds of Formula (I) and pharmaceutically acceptable salts which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders. ##STR1##...	10/26/1999
5925596	Substituted aminomethylphenylsulfonylureas their preparation and their use as herbicides and plant growth regulators Substituted aminomethylphenylsulfonylureas, their preparation, and their use as herbicides and plant growth regulators Compounds of the formula (I) and salts thereof ##STR1## where R1 to R7 and A are as defined in claim 1 and, inter ...	07/20/1999
5852042	Substituted pyridines, processes for their preparation and their use as pesticides and fungicides The invention relates to novel substituted N-(4-pyridyl)carboxamides of the formula ##STR1## in which Q is substituted 4-pyridyl, A is hydrogen, alkyl, acyl or aralkyl and Y-Z is an optionally modified hydrocarbon radical or Y is a bond or a biv...	12/22/1998
5763638	Preparation of aromatic nitriles A process for the preparation of nitriles of formula ##STR1## wherein X is CH or N, and R1 and R2 are each independently of the other hydrogen, chloro, bromo, C1 -C6 alkyl, C1 -C6 alko...	06/09/1998
5760063	Arylhydrazone derivatives useful as antibacterial agents The subject invention, provides arylhydrazone compounds having the Formula 1: ##STR1## wherein A and B are independently aryl or heteroaryl and A and B independently are substituted with at least one group selected from alkyl, halogen, CN, COOR	06/02/1998
5756524	Anilide derivatives as fungicides A compound of formula I ##STR1## X is O or S; A is 6-alkoxy-3-pyridyl optionally substituted by halogen; Y is hydrogen or alkyl; R3 is alkyl or a metal salt complex thereof. This invention contains fungicidal compositions and are used to combat...	05/26/1998
5716971	Pyridine derivatives, their production and use Pyridine derivatives of the formula ##STR1## wherein the ring A stands for an optionally further substituted benzene ring; the ring B stands for an optionally substituted pyridine ring; Q stands for hydroxyl group, or OQ1 or Q1 ...	02/10/1998
5696140	N-cyano-N'-pyridylguanidines as serotonin antagonists The present invention relates to hitherto unknown compounds of formula or their tautomeric forms, the attachment to the pyridine ring being in the 3- or 4-position, in which R', R" are the same or different and stand for hydrogen, halogen, or trifluoromet...	12/09/1997
5670525	Substituted 4-phenyl-6-amino-nicotinic acid compounds useful in the treatment of CNS disorders The application relates to substituted 4-phenyl-6-amino-nicotinic acid derivatives for therapeutic use, to novel active compounds and to their use as cerebrally active agents. The active compounds are prepared by oxidizing appropriately substituted dihydr...	09/23/1997
5654321	2-chloro-3-arylamino-1,4-naphthoquinone derivatives, process for preparation thereof and use thereof as an agent for inhibiting platelet aggregation The present invention relates to a novel 2-chloro-3-arylamino-1,4-naphthoquinone derivative represented by the following formula (I), which has a potent inhibitory activity against platelet aggregation: ##STR1## in which X represents nitrogen (N...	08/05/1997
5654429	Method for the preparation of 3-amino-2-chloro-4-alkylpyridines A process for the preparation of a 3-amino-2-chloro-4-alkylpyridine of the formula: ##STR1## wherein R1 is a linear, branched or cyclic hydrocarbon of from one to eight carbon atoms, optionally substituted with one or more electron stabilizing g...	08/05/1997
5652251	6-amino-1,4-dihydropyridine compounds as medicaments for treatment of the central nervous system, and processes for their preparation The present invention relates to the new use of 6-amino-5-nitro- and -5-cyano-1,4-dihydropyridines of the general formula (I) ##STR1## in which A, D and R1 -R4 have the meaning given in the description, new 6-acylamino-dihydropy...	07/29/1997

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Class 546/289 - Nitrogen attached directly to the six-membered hetero ring by nonionic bonding