Did You Know...
...that Robert Adler has the dubious distinction of being the Father of the Couch Potato? Back in 1955 Adler was employed by what was then Zenith Radio Corp., where he was charged to invent something that would allow viewers to turn down the TV volume without leaving their chairs. After a series of flops (such as a wired contraption that people tripped over), Adler hit on the idea of using sound waves. Thus the Remote Control was born...
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| Number | Title | Issue Date |
| 7342115 | 3-substituted-6-aryl pyridines 3-substituted-6-aryl pyridines of Formula I are provided: wherein R1, R2, R3, R8, R9, A and Ar are defined herein. Such compounds are ligands of C5a receptor. Preferred... | 03/11/2008 |
| 7332498 | Modulation of KSP kinesin activity with heterocyclic-fused pyrimidinone derivatives A method of modulating KSP kinesin activity in vitro comprising contacting KSP kinesin with at least one chemical entity chosen from compounds represented by Formula I: and pharmaceutically acceptable salts there... | 02/19/2008 |
| 7320993 | Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group, ... | 01/22/2008 |
| 7220861 | Processes for preparing quinolonecarboxylate derivatives Provided is a process for preparing quinolonecarboxylate derivatives under a mild condition in high yield, so as to be favorably applied to a large-scale mass production thereof. ... | 05/22/2007 |
| 7151182 | Intermediates for N-substituted carbamoyloxyalkyl-azolium derivatives N-substituted carbamoyloxyalkyl-azolium derivatives which have antifungal activity and are useful for the treatment of fungal diseases. ... | 12/19/2006 |
| 7135486 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and the use thereof This application relates to compounds of formula (I), wherein R1, R2, R3, and R4 are defined as recited in the claims, or a tautomer, salt, hyd... | 11/14/2006 |
| 7129255 | Substituted 2-carba-3,5-dicyano-4-aryl-6-aminopyridines and the use of the same as selective ligands of the adenosine receptor This application relates to compounds of the formula wherein the groups R1–R6 are as defined in the specification and claims, and to a pharmaceutical composition containing the same, and t... | 10/31/2006 |
| 7109218 | Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same Compounds of the formula (I) a process for their preparation and their use as medicaments are described. ... | 09/19/2006 |
| 7074813 | Substituted N′-(arylcarbonyl)-benzhydrazides, N′-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to substituted N′-(arylcarbonyl)-benzhydrazides, N′-(arylcarbonyl)-benzylidene-hydrazides and analogs thereof, represented by the Formulae I and II: wherein Ar1, A... | 07/11/2006 |
| 7015337 | Process for preparing 5-aminomethyl-2-thiophenecarbonitrile HCl by one-pot reaction The present invention provides a novel process for preparing a compound represented by the above formula 7, which is an important intermediate for an oral thrombin inhibitor, by one-pot reaction. In accordance with the present invention, the above intermediate for t... | 03/21/2006 |
| 7015237 | Pyridine matrix metalloproteinase inhibitors Selective MMP-13 inhibitors are pyridine derivatives of the formula or a pharmaceutically acceptable salt thereof, wherein: R1 and R2 independently are hydrogen, halo, hydrox... | 03/21/2006 |
| 6911451 | Phenylalanine derivatives Phenylalanine derivatives of formula (1) are described: wherein L1 is a linker atom or group; X1 is a group selected from —N(R3)CO—, —N(R3)SO | 06/28/2005 |
| 6649767 | Process for preparing 1,4-dihydropyridine compounds A process for preparing a 1,4-dihydropyridine compound comprising contacting an enamine compound ##STR1## and a compound having a structure of ##STR2## in the presence of a base; and treating the reaction mixture thus obtained in the presence of an a... | 11/18/2003 |
| 6503933 | 2-pyridylmethylamine derivatives useful as fungicides Compounds of formula (I) and salts thereof as phytopathogenic fungicides wherein A1 is substituted 2-pyridyl; A2 is optionally substituted phenyl; L is --(C.dbd.O)--, --SO2 -- or --(C.dbd.S)--; R1 is hydrogen, o... | 01/07/2003 |
| 6432960 | Squarate derivatives of dihydropyridine NPY antagonists A series of antagonists of NPY have been synthesized and are comprised of squarate derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). ##STR1## As antagonists of NPY-induced behavior, these compounds are expected to act as effective anorexiant ag... | 08/13/2002 |
| 6392048 | Process for preparing carbocyclic or heterocyclic nitriles by vapor phase ammoxidation The present invention provides a process for preparing carbocyclic or heterocyclic nitrites by the vapor phase contact ammoxidation of carbocyclic compounds or heterocyclic compounds, in which the reaction is carried out effectively without the increase o... | 05/21/2002 |
| 6392050 | Process for preparing substituted pyridines The invention relates to a process for preparing substituted pyridines in a simple and cost-effective manner in good yields by reacting substituted 1,4-dihydropyridines with methyl nitrite in the presence of an acid that contains less than 20% by weight o... | 05/21/2002 |
| 6130334 | Process for making 2-aryl-3-aryl-5-halo pyridines useful as COX-2 inhibitors The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases.... | 10/10/2000 |
| 6046221 | Immunotherapeutic aryl amides Novel aryl amides are inhibitors of tumor necrosis factor and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is N-benzoyl-3-amino-3-(3',4'-dimethoxyphenyl)propanamide.... | 04/04/2000 |
| 6002012 | Process for the preparation of [(5,6-dicarboxy-3-pyridyl) methyl] ammonium halides There is provided a process for the preparation of [(5,6-dicarboxy-3-pyridyl)methyl]ammonium halides having the structural formula I ##STR1## The [(5,6-dicarboxy-3-pyridyl)methyl]ammonium halides are useful as intermediates in the preparation of... | 12/14/1999 |
| 5959116 | Pyridine-2, 3-dicarboximides their preparation and their use for controlling undesired plant growth A pyridine-2,3-dicarboxylic acid diester of the formula Va ##STR1## where the radicals R2 and R4 have the meanings set out in the specification and where R8 is a C1 -C4 -alkyl, C3 -C | 09/28/1999 |
| 5955615 | Pyridone-methide azo dyestuffs Dyestuffs of the formula wherein D is the radical of a carbo- or heterocyclic diazo component, X represents O, NH, NT, NCOT, NCCH2 T or NSO2 T, and the other substituents have the meaning given in the description, are preferably suitable, if m... | 09/21/1999 |
| 5861419 | Substituted pyridines as selective cyclooxygenase-2 inhibitors The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ... | 01/19/1999 |
| 5808015 | Pyridone-methide azo dyestuffs with improved dyeing and printing properties for hydrophobic synethic fiber materials Dyestuffs of the formula ##STR1## wherein D is the radical of a carbo- or heterocyclic diazo component, X represents O, NH, NT, NCOT, NCCH2 T or NSO2 T, are preferably suitable, if m=n=l=o, for dyeing and printing hydrophobic synthet... | 09/15/1998 |
| 5763638 | Preparation of aromatic nitriles A process for the preparation of nitriles of formula ##STR1## wherein X is CH or N, and R1 and R2 are each independently of the other hydrogen, chloro, bromo, C1 -C6 alkyl, C1 -C6 alko... | 06/09/1998 |
| 5760063 | Arylhydrazone derivatives useful as antibacterial agents The subject invention, provides arylhydrazone compounds having the Formula 1: ##STR1## wherein A and B are independently aryl or heteroaryl and A and B independently are substituted with at least one group selected from alkyl, halogen, CN, COOR | 06/02/1998 |
| 5716971 | Pyridine derivatives, their production and use Pyridine derivatives of the formula ##STR1## wherein the ring A stands for an optionally further substituted benzene ring; the ring B stands for an optionally substituted pyridine ring; Q stands for hydroxyl group, or OQ1 or Q1 ... | 02/10/1998 |
| 5708180 | Process for the preparation of 2-halogenopyridinealdehydes and novel 2-halogenopyridinealdehydes The reaction of cyanoolefins, aminocarbonylolefins or hydroxyiminoolefins with a Vilsmeier reagent leads to 2-halogenopyridines which bear aldehyde groups in the 3 and/or 5 position. These pyridinealdehydes are valuable intermediates for the preparation o... | 01/13/1998 |
| 5696140 | N-cyano-N'-pyridylguanidines as serotonin antagonists The present invention relates to hitherto unknown compounds of formula or their tautomeric forms, the attachment to the pyridine ring being in the 3- or 4-position, in which R', R" are the same or different and stand for hydrogen, halogen, or trifluoromet... | 12/09/1997 |
| 5648496 | Process for producing aminonitropyridines A process for producing an aminonitropyridine represented by the general formula [1], which comprises reacting a nitropyridine represented by the general formula [2] (wherein X1, X2 and X3 indicate a hydrogen atom, a halog... | 07/15/1997 |
| 5587387 | Heterocycle-substituted benzenemethanamine derivatives The present invention is concerned with antiretroviral (e.g. anti-HIV-1)compounds having the formula ##STR1## wherein R1 and R2 each independently are halo or methyl; R3 is hydrogen, halo, nitro or trifiuoromethyl; R | 12/24/1996 |
| 5569765 | 2-anilinopyridine pesticides A process for controlling pests in which the pests or the plants threatened by attack with pests are treated with a 2-anilinopyridine of the formula I ##STR1## where the substituents have the following meanings: R1 is alkyl, alkenyl, alkyn... | 10/29/1996 |
| 5563160 | N-cyano-N'-pyridylguanidines as serotonin antagonists The present invention relates to hitherto unknown compounds of formula or their tautomeric forms, the attachment to the pyridine ring being in the 3- or 4-position, in which R', R" are the same or different and stand for hydrogen, halogen, or trifluoromet... | 10/08/1996 |
| 5554578 | Oxime ether derivatives, their preparation and fungicides containing these derivatives Oxime ether derivatives of the formula I ##STR1## where R1 and R2 are each hydrogen or alkyl, Het is pyridyl, quinolyl, pyrimidinyl, pyrazinyl, pyridazinyl, thienyl, quinoxalinyl, isoxazolyl, benzoxazolyl or benzothiazolyl bedeu... | 09/10/1996 |
| 5550135 | Heterocycle-substituted benzenemethanamine derivatives The present invention is concerned with antiretroviral (e.g. anti-HIV-1) compounds having the formula ##STR1## wherein R1 and R2 each independently are halo or methyl; R3 is hydrogen, halo, nitro or trifluoromethyl; R... | 08/27/1996 |
| 5539117 | 2-acetyl-6-cyanopyridines and their use as intermediates in the synthesis of oligo-2,6-pyridines The present invention is directed to 2-acetyl-6-cyanopyridine compounds that are useful as intermediates in the synthesis of oligo-2,6-pyridines. The present invention is also directed to new, simpler, less expensive methods for synthesizing such oligopyr... | 07/23/1996 |
| 5532245 | Substituted N-heteroaryl-1,2-diaminocyclobutene-3,4-dione compounds The compounds of the formula: ##STR1## wherein R1 is hydrogen, straight or branched chain alkyl, cyclic or bicyclic alkyl, alkanoyl, alkylsulfonyl, aroyl, arylalkenoyl, arylsulfonyl, arylalkanoyl or arylalkylsulfonyl; R2 is hydr... | 07/02/1996 |
| 5516776 | Enantioselective synthesis of antifolates A process and intermediates for the enantioselective synthesis of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid are disclosed.... | 05/14/1996 |
| 5516786 | Fungicidal substituted amino acid amides Combating fungi with substituted amine acid derivatives of the formula ##STR1## in which R1 represents alkyl, alkenyl, alkinyl, halogenoalkyl, halogenoalkenyl, halogenoalkinyl, cycloalkyl or cycloalkenyl, R2, R3, R4 | 05/14/1996 |
| 5468863 | Process for the preparation of substituted 2,3-difluoropyridines The invention relates to a novel process for the preparation of substituted 2,3-difluoropyridines by reaction of substituted 2,3-halopyridines with fluoride salts in the presence of phase transfer catalysts, preferably in polar aprotic solvents, without r... | 11/21/1995 |
