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| Number | Title | Issue Date |
| 8378112 | Glycyrrhetinic acid derivative and use thereof Disclosed is a gap junction inhibitor which is more practically useful compared with carbenoxolone. Also disclosed is a novel glycyrrhetinic acid derivative. The glycyrrhetinic acid derivative is represented by general formula (1) or (2). | 02/19/2013 |
| 8324391 | Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors Compounds of the formula Ia***** in which the substituents have the definitions provided in the specification, are novel, effective PDE4 inhibitors. ... | 12/04/2012 |
| 8318944 | Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors Compounds of the formula Ia***** in which the substituents have the definitions provided in the specification, are novel, effective PDE4 inhibitors. ... | 11/27/2012 |
| 8003798 | Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors Compounds of the formula I in which the substituents have the definitions provided in the specification, are novel, effective PDE4 inhibitors. ... | 08/23/2011 |
| 7994333 | Methods and compositions for selectin inhibition The present invention relates to the field of anti-inflammatory substances, and more particularly to novel compounds that act as antagonists of the mammalian adhesion proteins known as selectins. In some embodiments, methods for treating selectin mediated disorders ... | 08/09/2011 |
| 7667043 | Molecular structures with controllable electron conducting properties Aromatic and heteroaromatic molecular structures with controllable electron conducting properties are derived from the incorporation of electron active substituents in selective positions. Such compounds can form self-assembled layers on metal or other substrates, a... | 02/23/2010 |
| 7365196 | Sulphonamido-substituted bridged bicycloalkyl derivatives A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease. ... | 04/29/2008 |
| 7338961 | Sphingosine kinase inhibitors The invention relates to substituted adamantane compounds, pharmaceutical compositions thereof, processes for their preparation, and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferative disease, inflammatory disease, or angioge... | 03/04/2008 |
| 7335659 | Substituted 10-aryl-11-benzo[]fluorenes and 7-aryl-5, 6-dihydro-benzo[]anthracenes for selective effects on estrogen receptors This invention provides a compound, or its possible salt, having the formula, wherein: Re and ′Re are OH, optionally independently etherified or esterified; Z is —CH2CH2— or... | 02/26/2008 |
| 7326696 | Amino-methyl substituted tetracycline compounds Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed. ... | 02/05/2008 |
| 7320993 | Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group, ... | 01/22/2008 |
| 7317024 | Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof The invention relates to a class of novel non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have th... | 01/08/2008 |
| 7220783 | Para-terphenyl compounds The present invention provides a selective suppressor of the IgE production comprising a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody and which do... | 05/22/2007 |
| 7202093 | Method for labeling phosphorylated peptides, method for selectively adsorbing phosphorylated peptides, complex compounds used in the methods, process for producing the complex compounds, and raw material compounds for the complex compounds Provided are a method for easily detecting phosphorylated peptides, namely, proteins, in samples derived from living organisms or the like, a method for selectively adsorbing the phosphorylated peptides, and compounds that are highly coordinated to the phosphorylate... | 04/10/2007 |
| 7173131 | Anthryl derivative group substituted compound, and organic luminescent device making use of same An anthryl derivative group substituted compound having a specific chemical structure is provided. This compound is used for producing an organic luminescent device which can emit luminescent hues with a very high purity and effect light emission with a high lumines... | 02/06/2007 |
| 7160907 | Pleuromutilin derivatives Pleuromutilin compounds of the formula: are of use in anti-bacterial therapy. ... | 01/09/2007 |
| 7157477 | Aliphatic amino-substituted demethoxylated hypocrellins and their synthesis The invention involves a methods and compositions for use in photodynamic therapy. Novel perylenequinone derivatives, conjugates comprising perylenequinone derivatives and a binding agent, and methods of treatment using these compositions are disclosed. The present ... | 01/02/2007 |
| 7138406 | Modulators of the glucocorticoid receptor The present invention provides compounds of the formula wherein A is of the formula and X, Y, n, R1–R25 are as described in the speci... | 11/21/2006 |
| 7101915 | P-terphenyl compounds The present invention provides a selective suppressor of the IgE production comprising a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody and which do... | 09/05/2006 |
| 7087599 | Estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a v... | 08/08/2006 |
| 7074536 | Alkylenebisnaphtol derivative and charge control agent which consists of the same The present invention provides an alkylenebisnaphthol derivative represented by formula [I]: and a salt thereof. The compound of the present invention has an excellent triboelectric charge property and useful as ... | 07/11/2006 |
| 7074836 | Para-terphenyl compounds The present invention provides a selective suppressor of the IgE production comprising a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody and which do... | 07/11/2006 |
| 7067179 | Fused ring compound A novel compound represented by the general formula (I), and a nematic liquid crystal composition incorporating the same. A compound represented by the general formula (I) can be produced industrially extremely e... | 06/27/2006 |
| 7037632 | Organophotoreceptor with charge transport material with fluorenone azine groups Improved organophotoreceptor comprises an electrically conductive substrate and a photoconductive element on the electrically conductive substrate, the photoconductive element comprising: (a) a charge transport material having the ... | 05/02/2006 |
| 7011917 | Organophotoreceptor with charge transport material having bis(9-fluorenone) azine groups Improved organophotoreceptor comprises an electrically conductive substrate and a photoconductive element on the electrically conductive substrate, the photoconductive element comprising: (a) a charge transport material having the ... | 03/14/2006 |
| 7001708 | Photosensitive polymeric material for worm optical data storage with two-photon fluorescent readout Image formation via photoinduced fluorescence changes in a polymeric medium with two-photon fluorescence readout of a multi-layer structure. Fluorophore-containing polymers, possessing one or more basic functional groups, underwent protonation in the presence of a p... | 02/21/2006 |
| 6995181 | Modulators of the glucocorticoid receptor and method Novel non-steroidal compounds are provided which are glucocorticoid receptor modulators which are useful in treating diseases requiring glucocorticoid receptor agonist or antagonist therapy such as obesity, diabetes, inflammatory and immune disorders, and have the s... | 02/07/2006 |
| 6972297 | 2-Hydroxy-mutilin carbamate derivatives for antibacterial use 2-(S)-hydroxymutilin carbamate derivatives of formula (I), in which R1 is a 5- or 6-membered optionally substituted heteroaryl group; and R2 is vinyl or ethyl, are useful in the treatment of bacterial infections | 12/06/2005 |
| 6906046 | Pharmaceutical uses and synthesis of benzobicyclooctanes Benzobicyclooctane compounds, their use in inhibiting cellular events involving TNF-α and IL-8, and in the treatment of inflammation events in general; a combinatorial library of diverse bicyclooctanes and process for their synthesis as a library and as individual ... | 06/14/2005 |
| 6756375 | 10-Aryl-11h-benzo[b]fluorene derivatives and analogs for medicinal use The invention provides for a non-steroidal compound having the formula wherein Re and ′Re are OH, optionally independently etherified or esterified; Z is —CH2— or —CH2C... | 06/29/2004 |
| 6737423 | Substituted heterocyclo-norbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostics, and medicaments comprising them Substituted heterocyclo-norbornylaminoderivatives having: a) an exo-configuration nitrogen and an endo-fused five-membered ring or six-membered ring of the formula (I) or b) an exo-configuration nitrogen and an exo-fused five-membered ring or six-membered ring of th... | 05/18/2004 |
| 6677330 | Fluorides of 4-substituted piperidine derivatives The present invention provides a novel compound having an excellent acetylcholinesterase inhibitory effect. That is, it provides a 4-substituted piperidine compound fluoride represented by the following formula, a pharmaceutically acceptable salt thereof ... | 01/13/2004 |
| 6673625 | Saccharide sensing molecules having enhanced fluorescent properties The present invention provides formulae for fluorescent compounds that have a number of properties which make them uniquely suited for use in sensors of analytes such as saccharides. The advantageous fluorescent properties include favorable excitation wav... | 01/06/2004 |
| 6630492 | Lymphocyte function antigen-1 antagonists Mevinolin compounds for use in the treatment or prevention of autoimmune diseases, inflammation, ischemia/reperfusion injury and graft rejection. Such compounds bind to the LFA-1 I-domain and thereby inhibit LFA-1/ICAM-1 or LFA-1/ICAM-3 interactions.... | 10/07/2003 |
| 6620963 | TRICYCLO[6.2.202,7]DODECA-2(7),3,5-TRIEN-4-CARBONYLAMINO-PHENYL AND TRICYCLO[6.2.202,7]DODECA-2(7),3,5-TRIEN-4-CARBONYLAMINO-HETEROARYL AND RELATED COMPOUNDS HAVING RAR RECEPTOR SELECTIVE BIOLOGICAL ACTIVITY Compounds of the formula ##STR1## where the variables have the meaning defined in the specification, which bind specifically or selectively to to RAR retinoid receptors.... | 09/16/2003 |
| 6521646 | Dibenzoazulene derivatives for treating thrombosis, osteoporosis, arteriosclerosis Compounds of the formula (I) and their physiologically acceptable salts and solvates are useful as integrin-inhibiting substances. They are especially useful in the prophylaxis and treatment of cardiovascular disorders, of thrombosis, cardiac infarction, ... | 02/18/2003 |
| 6492355 | Adamantane derivatives The invention provides compounds of general formula ##STR1## in which m, A, R1 and Ar have the meanings defined in the specification; a process for their preparation; pharmaceutical compositions containing them; a process for preparing the phar... | 12/10/2002 |
| 6399606 | Neuroprotective agents and methods related thereto Neuroprotective agents are disclosed having the following structure: ##STR1## wherein R1, R2, R3, R4 and R5 are as defined herein. Such compounds have utility in the treatment of conditions which bene... | 06/04/2002 |
| 6319948 | Retinoid antagonists and uses thereof Retinoid antagonist compounds have been found to be useful in the prevention and/or minimization of surgical adhesion formation. Also provided by the invention are certain novel substituted (5,6)-dihydronaphthalenyl compounds which are retinoid antagonists and... | 11/20/2001 |
| 6268362 | Amino anthracyclinone derivatives and their use in the treatment of amyloidosis A compound of formula (1), wherein R1 represents hydrogen, hydroxy, a group of formula OR7, wherein R7 is C1 -C6 alkyl, C2 -C6 alkenyl; R2 represents hydrogen, hydroxy, ... | 07/31/2001 |
