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| Number | Title | Issue Date |
| 7629469 | Intermediate for the preparation of paliperidone A new compound of formula (IV) R represents a protecting group which is removable by hydrogenation, and use thereof as an intermediate for preparing paliperidone. ... | 12/08/2009 |
| 7214678 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain According to the invention there is provided a compound the formula I; wherein A, X, B, R1, R2, R3 and R4 are as defined in the specification. | 05/08/2007 |
| 6956055 | Substituted γ-lactone compounds as NMDA-antagonists The invention relates to substituted γ-lactone compounds, to methods for the production thereof, to medicaments containing these compounds and to the use of these compounds for producing medicaments. ... | 10/18/2005 |
| 6927217 | HIV protease inhibitors The present invention relates to novel dihydropyrones of Formula I wherein X is NH or NR8, which inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development o... | 08/09/2005 |
| 6858632 | Derivatives of isosorbide mononitrate and its use as vasodilating agents with reduced tolerance Novel derivatives of isosorbide mononitrate and its pharmaceutically acceptable salts, which have vasodilating activity with a reduced effect of tolerance, of the general formula (I) in which A and B independently repr... | 02/22/2005 |
| 6794336 | Herbicidal substituted pyridines, their preparation, and their use as herbicides and plant growth regulators The present invention relates to a compound of the formula (I) or salt thereof in which R1 is identical or different at each occurrence and is H, halogen, CN, nitro, SF5, (C1-C | 09/21/2004 |
| 6756390 | Organic acid salt of amlodipine Disclosed are a novel organic acid salt of amlodipine with superb physicochemical properties, its preparation method, and a pharmaceutical composition containing the same as a therapeutically active ingredient. ... | 06/29/2004 |
| 6716987 | Derivatives of benzofuran or benzodioxazole compounds An oxygen-containing heterocyclic compound represented by following Formula (I): wherein R1 and R2 independently represent hydrogen, lower alkyl, cyano, —(CH2)n—E1 | 04/06/2004 |
| 6566375 | Elevation of HDL cholesterol by 4-[(aminothioxomethyl)-hydrazono]-N-(substituted)-4-arylbutanamides Compounds of this invention increase plasma levels of high density lipoprotein or HDL, the "good" cholesterol and as such may be useful for treating diseases such as atherosclerosis. These compounds are represented by the formula ##STR1## wherein: R | 05/20/2003 |
| 6492374 | Benzofuran derivatives, their preparation and use The present invention relates to benzofuran derivatives having general Formula (I) ##STR1## wherein A is selected from (1), (2), (3), (4) ##STR2## wherein Z is O or S; s is 0 or 1; q is 0 or 1; R4 is hydrogen, C1-6 -alkyl, C | 12/10/2002 |
| 6492416 | 4,5-diaryl-3(2H)-furanone derivatives as cyclooxygenase-2 inhibitors The present invention provides a novel class of 4,5-diaryl-3(2H)-furanone derivatives, which inhibit strongly and selectively COX-2 over COX-1. They are useful to treat inflammation, inflammation-associated disorders, and COX-2 mediated diseases.... | 12/10/2002 |
| 6303789 | Benzamides with tetrahydrofuranyloxy substitutents as phosphodiesterase 4 inhibitors Compounds of the formula I ##STR1## in which R1, R2, R3, R4, R5, m and n have the meanings cited in the description, are novel effective PDE-inhibitors.... | 10/16/2001 |
| 6265436 | Substituted 5-biphenyl-3,4-dihydroxy-2(5H)-furanones and method of use therefor The present invention broadly relates to racemic or optically active 5-substituted 3,4-dihydroxy-2(5H)-furanone compounds and their pharmaceutically acceptable salts, useful for treating a pathology in which reactive oxygen species and inflammatory mediat... | 07/24/2001 |
| 6222048 | Diaryl-2-(5H)-furanones as Cox-2 inhibitors The invention encompasses the novel compound of Formula (I) as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound o... | 04/24/2001 |
| 6180651 | Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics The present invention relates to derivatives of the formula ##STR1## the process for their preparation, and to their uses in therapeutics, especially as drugs with anti-inflammatory, analgesic and chemopreventive properties.... | 01/30/2001 |
| 6172057 | N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenase... | 01/09/2001 |
| 6156761 | Substituted tetralone derivatives for enhancing cognition The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein A, B, R2, R3 and q are as defined in the disclosure, pharmaceutical compositions containing them; methods for their production; ... | 12/05/2000 |
| 6143780 | N-arylmethylthioanilide compounds useful for the inhibition of the replication of HIV Compounds of the formula ##STR1## wherein A and X are independently oxygen or sulphur; R6 is H, halogen, alkyl, alkoxy, alkylthio, cyano, or nitro; Y is --CH2 O--, --OCH2 --, --CH2 S--, or --CH2 SO2 | 11/07/2000 |
| 6124457 | Process and intermediates for a ଲ3 -adrenergic receptor agonist The instant invention relates to intermediates of Formula II, ##STR1## wherein R1, R2 and R3 are as defined in the specification, and to processes for preparing such intermediates. This invention also relates to proce... | 09/26/2000 |
| 6124333 | Metalloproteinase inhibitors Therapeutically active hydroxamic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, and the use of such compounds in medicine. The compounds are inhibitors of metalloproteinases involved in tissue degradation.... | 09/26/2000 |
| 6124332 | Metalloproteinase inhibitors Therapeutically active hydroxamic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, and the use of such compounds in medicine. The compounds are inhibitors of metalloproteinases involved in tissue degradation.... | 09/26/2000 |
| 6121202 | Thienyloxypyridines and-pyrimidines useful as herbicidal agents The present invention provides a herbicidal compound of formula I, methods for the preparation thereof and intermediates useful therefor. ##STR1## wherein X and Y are each independently O or S; Z is N or CR4.... | 09/19/2000 |
| 6090942 | Process and intermediates for a ଲ3 -adrenergic receptor agonist The instant invention relates to intermediates of Formula II, ##STR1## wherein R1, R2 and R3 are as defined in the specification, and to processes for preparing such intermediates. This invention also relates to proce... | 07/18/2000 |
| 6020343 | (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases c... | 02/01/2000 |
| 6013811 | Preparation process of benzodifuranone dyes A process for the preparation of a polycyclic dye of Formula (1) which comprises steps: i) reaction of a compound of formula (2) with a compound of formula (3) or a derivative thereof to form an intermediate of formula (4) and ii) reaction of the intermed... | 01/11/2000 |
| 5994540 | Di-and trisubstituted pyridines and their preparation Substituted pyridines of the general formula: ##STR1## wherein R1 is hydroxyl or chlorine, and a) X is hydrogen or chlorine, R2 and R3 together are .dbd.O, R4 is a group of the formula --OR5 and ... | 11/30/1999 |
| 5977169 | Substituted tetronic acids useful for treating HIV and other retroviruses This invention comprises novel substituted tetronic acid type compounds, 2, 4(3H, 5H)-furandiones, that are useful for the inhibition of the HIV protease enzyme. The compounds may be useful for the treatment of a person with AIDS or AIDS related diseases.... | 11/02/1999 |
| 5889027 | 3(2H)-furanone derivatives The present invention relates to 3(2H)-furanone compounds possessing fungicidal activity to plant fungi and a process for preparing them.... | 03/30/1999 |
| 5843867 | Substituted pyridine compounds Disclosed herein are herbicidal pyridine compounds substituted at the 2- or 6-position with an OR2 moiety where R2 is hydrogen, lower alkyl, halomethyl, lower cyanoalkyl, alkenyl or alkynyl, as well as herbicidal compositions and her... | 12/01/1998 |
| 5824625 | Substituted pyridine compounds Disclosed herein are herbicidal pyridine compounds substituted at the 2- or 6-position with an OR2 moiety where R2 is hydrogen, lower alkyl, halomethyl, lower cyanoalkyl, alkenyl or alkynyl, as well as herbicidal compositions and her... | 10/20/1998 |
| 5807873 | Diarylmethylidenefuran derivatives and their uses in therapeutics The present invention relates to the derivatives of the formula ##STR1## and to their use in therapeutics, especially as drugs with anti-inflammatory and analgesic properties.... | 09/15/1998 |
| 5760236 | Di and trisubstituted pyridines Substituted pyridines of the general formula: ##STR1## wherein R1 is hydroxyl or chlorine, and a) X is hydrogen or chlorine, R2 and R3 together are .dbd.O, R4 is a group of the formula --OR5 and ... | 06/02/1998 |
| 5747422 | Substituted 2-phenylpiridines Substituted 2-phenylpyridines I ##STR1## where substituents have the meaning described in the specification and their use as herbicides; for the desiccation/defoliation of plants.... | 05/05/1998 |
| 5733850 | Substituted 2-phenylpyridines Substituted 2-phenylpyridines I ##STR1## where the substituents have the meaning given in the specification and their use.... | 03/31/1998 |
| 5723620 | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity A compound of the formula ##STR1## wherein all variables are as defined in the specification having retinoid-like activity.... | 03/03/1998 |
| 5705513 | Fungicides for the control of take-all disease of plants A compound, composition, and method for controlling Take-all disease of plants by applying to the seed prior to planting, a fungicide of the formula: ##STR1## wherein Z1 and Z2 are C and are part of an aromatic ring which i... | 01/06/1998 |
| 5703093 | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders Tetrahydrofurans, tetrahydrothiophenes, pyrrolidines and cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammatory or immune res... | 12/30/1997 |
| 5691373 | Nonpeptide endothelin antagonists I Novel nonpeptide antagonists of endothelin I are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myoc... | 11/25/1997 |
| 5684198 | Method of preparing therapeutic amides Amides having formula I: ##STR1## wherein E, X, R2 and R3 have the meanings given in the specification, and pharmaceutically acceptable salts and pharmaceutically acceptable in vivo hydrolysable esters thereof, which are useful ... | 11/04/1997 |
| 5672615 | Arylsulfonamido-substituted hydrodxamic acids Disclosed are the compounds of formula I ##STR1## wherein R and R1 together with the chain to which they are attached or R1 and R2 together with the carbon atom to which they are attached form a ring; pharmaceutically... | 09/30/1997 |
