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| Number | Title | Issue Date |
| 8124781 | Processes for producing cycloalkylcarboxamido-pyridine benzoic acids The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid in substantially free form (Compound 1). ... | 02/28/2012 |
| 7678919 | Method for producing pentacyclic taxans Taxan derivatives are produced efficiently and inexpensively, which are useful as oral-administrable antitumor compounds. A compound of formula (1) (wherein R1 is an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group... | 03/16/2010 |
| 7410980 | Crystals of taxane derivative and process for their production A crystal of (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-9,10-[(1S)-2-(dimethylamino)ethylidenedioxy]-5,20-epoxy-1-hydroxytax-11-en-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-3-(3-fluoro-2-pyridyl)-2-hydroxypropionate, which has characteristic peaks at dif... | 08/12/2008 |
| 7297797 | Pyrrolines The invention relates to novel Δ1-pyrrolines of the formula (I) in which R1, R2, R3, R4, A1, A2, R5, R6, R7, R | 11/20/2007 |
| 7205305 | Inhibitors of p38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceut... | 04/17/2007 |
| 7157454 | Derivatives of n-(arylsulfonyl)beta-aminoacids comprising a substituted aminomethyl group, the preparation method thereof and the pharmaceutical compositions containing same The invention relates to compounds of formula: These compounds show affinity for the bradykinin receptors with selectivity towards the B1 receptors; they may be used for the preparation of medicinal pr... | 01/02/2007 |
| 7119208 | Anti-sickling agents Compounds for the treatment of sickle-cell disease, and methods for their use are provided. The compounds have a dual mode of action. First, binding of the compounds to hemoglobin increases the oxygen affinity of both normal and sickle hemoglobin. Secondly, binding ... | 10/10/2006 |
| 7026476 | Intermediate arylamine compounds Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are and pharmaceutical compositions containing, intermediate compounds and processes... | 04/11/2006 |
| 6900231 | Aminopyridyl-substituted phenyl acetamides as protease inhibitors Phenyl acetamide compounds are described, including compounds of or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R3-R6, R11, B, Y and W are set forth in the s... | 05/31/2005 |
| 6867230 | Hygromycin A derivatives This invention relates to compounds of the formula and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R2, R3 and R10 | 03/15/2005 |
| 6689798 | Benzofuran derivatives The present invention provides novel benzofuran derivatives represented by the following formula (I) or salts thereof: ##STR1## wherein Py is a 2-, 3-, or 4-pyridyl group and R is a substituted or unsubstituted phenyl group or a substituted or unsubstitut... | 02/10/2004 |
| 6677330 | Fluorides of 4-substituted piperidine derivatives The present invention provides a novel compound having an excellent acetylcholinesterase inhibitory effect. That is, it provides a 4-substituted piperidine compound fluoride represented by the following formula, a pharmaceutically acceptable salt thereof ... | 01/13/2004 |
| 6649633 | Nicotinamide biaryl derivatives useful as inhibitors of PDE4 isozymes This application is directed to compounds useful as inhibitors at PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis and chronic obstructuive pulmonary disease, of the form... | 11/18/2003 |
| 6646123 | Pentacyclic Compound The present invention relates to a novel taxol derivative having an antitumor activity which is represented by formula (1). ##STR1## [In the formula (I), R1 : a phenyl group, R2 : an alkyl group, an alkenyl group, an alkynyl group, a... | 11/11/2003 |
| 6608060 | Inhibitors of p38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides... | 08/19/2003 |
| 6545151 | Pentacyclic compound The present invention relates to a novel taxol derivative having an antitumor-activity which is represented by formula (1). ##STR1## [In the formula (I), R1 : a phenyl group, R2 : an alkyl group, an alkenyl group, an alkynyl group, a... | 04/08/2003 |
| 6511995 | Pyridine derivative and pharmaceutical containing the same A pyridine derivative represented by formula (1) wherein all the variables have been defined in the specification. The compounds are used for inhibiting collagen production and are useful for preventing or treating fibrosis. ##STR1##... | 01/28/2003 |
| 6498172 | Prostaglandin agonists and their use to treat bone disorders This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for t... | 12/24/2002 |
| 6441173 | Process for preparing indane carboxylate and cyclopentano [6] pyridine derivatives This invention relates to an improved process for preparing (+) (1S,2R,3S)-3-[2-(2-hydroxyeth-1-yloxy)-4-methoxyphenyl]-1-(3,4-methylenedi oxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof, preferably the eth... | 08/27/2002 |
| 6417161 | Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines as protease inhibitors The present invention is directed to aminoguanidine and alkoxyguanidine compounds, including compounds of Formula I: ##STR1## wherein X is O or NR19 and A1, A2, R7 -R10, R18, Ra,... | 07/09/2002 |
| 6413979 | Substituted 5-(2,2-difluoro-1,3-benzodioxol-5-yl) cyclopentenopyridine derivative The present invention relates to a cyclopentenopyridine derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, wherein Ar is a phenyl group or the like. R1 is a mono- or di-C1 -C6 alky... | 07/02/2002 |
| 6376538 | Cell adhesion inhibitors The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of us... | 04/23/2002 |
| 6369083 | 2-methoxyimino-2 (pyrinyloxymethyl) phenyl acetamides with polyether derivatives on the pyridine ring The present invention provides novel 2-methoxyimino-2-(pyridinyloxymethyl) phenyl acetamide compounds with polyether substituents on the pyridine ring, their use as fungicidal compounds, and their use in fungicidal compositions comprising at least one of ... | 04/09/2002 |
| 6353110 | Asymmetric conjugate addition reaction This invention relates to a key intermediate in the synthesis of an endothelin antagonist the synthesis of this key intermediate via an asymmetric conjugate addition reaction.... | 03/05/2002 |
| 6342497 | 2"-deoxy hygromycin derivatives This invention relates to compounds of the formula ##STR1## and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1 and R2 are as defined herein. The compounds of formula 1 are antibacterial and antiprotoz... | 01/29/2002 |
| 6340704 | Cell differentiation inducing amide derivatives, their production and use The present invention provides a compound represented by the formula: ##STR1## wherein R1 is an amino group which may be substituted; R2 is a hydrogen atom or a lower alkyl group which may be substituted; X is a methyne group which m... | 01/22/2002 |
| 6262084 | Compounds that inhibit the binding of integrins to their receptors A method for the inhibition of the binding of 댔ଲ.sub.1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions the... | 07/17/2001 |
| 6262083 | Genipin derivative having liver protection activity The present invention relates to novel genipin derivatives which have an excellent liver protection activity with little cytotoxicity, and these compounds are so stable in vivo that they do not induce any side effects.... | 07/17/2001 |
| 6232319 | Substituted tetrahydropyridin derivatives, method of preparation and pharmaceutical compositions containing them The invention relates to compounds of general formula (I): ##STR1## in which R, R1, R2, X and Y are as defined in the description, their geometrical and/or optical isomers, and their addition salts with a pharmaceutically-acceptable ... | 05/15/2001 |
| 6211363 | Pentacyclic compound The present invention relates to a novel taxol derivative having an antitumor-activity which is represented by formula (1). ##STR1## [In the formula (I), R1 : a phenyl group, R2 : an alkyl group, an alkenyl group, an alkynyl group, a... | 04/03/2001 |
| 6211202 | 2-methoxyimino-2-(pyridinyloxymethyl) phenyl acetamides with substituted ketal derivatives on the pyridine ring The present invention provides novel 2-methoxyimino-2-(pyridinyloxymethyl)phenyl acetamide compounds with substituted ketal substituents on the pyridine ring, their use as fungicidal compounds, and their use in fungicidal compositions comprising at l... | 04/03/2001 |
| 6194448 | N, N-disubstituted amides that inhibit the binding of integrins to their receptors A method for the inhibition of the binding of 댔ଲ.sub.1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions com... | 02/27/2001 |
| 6172235 | Asymmetric conjugate addition reaction This invention relates to a key intermediate in the synthesis of an endothelin antagonist and the synthesis of this key intermediate using an asymmetric conjugate addition reaction.... | 01/09/2001 |
| 6133442 | Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antagonists Compounds of formula I ##STR1## wherein R1 signifies phenyl, substituted phenyl or heterocyclyl; R2 signifies phenyl or substituted phenyl; R3 signifies hydrogen, lower-alkyl, cyano, carboxy, esterified carboxy, phenyl, su... | 10/17/2000 |
| 6130335 | N-([1,2,4]triazoloazinyl) benzenesulfonamide and pyridinesulfonamide compounds and their use as herbicides N-(Triazoloazinyl)arylsulfonamide compounds, such as 2,6-dimethoxy-N-(8-chloro-5-methoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)be nzenesulfonamide, 2-methoxy-4-(trifluoromethyl)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimi din-2-yl)pyridine-3-sulfonamide... | 10/10/2000 |
| 6121451 | Intermediates and process for the manufacture of camptothecin derivatives (CPT-11) and related compounds This invention relates to intermediates and processes for the synthesis of camtothecin derivatives, such as irinotecan. Related procedures and compounds are disclosed, such as a method of making mappicine.... | 09/19/2000 |
| 6075140 | Pentacyclic compound The present invention relates to a novel taxol derivative having an antitumor activity which is represented by formula (1). ##STR1## [In the formula (I), R1 : a phenyl group, R2 : an alkyl group, an alkenyl group, an alkynyl gro... | 06/13/2000 |
| 6060487 | Indanol compounds A compound of formula (I): ##STR1## wherein R1, R2, R3, R4, X--Y, A, Z and Z' are as defined in the description, in the form of the cis or trans isomers each in racemic or optically active form, and acid ad... | 05/09/2000 |
| 6037356 | Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors Aminoguanidine and alkoxyguanidine compounds are described, including compounds of the Formula VII: ##STR1## wherein X is O or NR9 and Het, R1, R7, R8, R12 -R15, Ra, Rb... | 03/14/2000 |
| 6028033 | N-aminopyridone derivatives and their use as herbicides There are described N-aminopyridone derivatives of the formula I: ##STR1## where the substituents R1 to R12 have the meanings given in claim 1, a process for their preparation, and their use for controlling undesirable vegetatio... | 02/22/2000 |
