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| Number | Title | Issue Date |
| 7872142 | Coumarin derivatives useful as TNFα inhibitors Novel compounds composition capable of inhibiting TNFα and having antiimmunoinflammatory and autoimmune properties useful in a pharmaceutical composition, such as for a drug containing this as an active ingredient; and a therapeutic method with the use of these nov... | 01/18/2011 |
| 7572919 | Heteroaryl-containing isoflavones as aromatase inhibitors Compounds and methods useful for treating and prevention of cancer, particularly hormone-dependent breast cancer. Provided are compounds of formula I: wherein X is selected from O, N, S, SO, SO2, and S(CH2 | 08/11/2009 |
| 7432263 | Amino-phthalazinone derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them Compounds which are amino-phthalazinone derivatives according to formula 1 and pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed; these compounds or compostions are useful in the treatment of diseases ... | 10/07/2008 |
| 7378421 | Chromenone derivatives Novel compounds of the formula I in which R1, R2, R3 and Het are as defined herein, which are inhibitors of tyrosine kinases and/or Raf kinases and can be employed for... | 05/27/2008 |
| 7371874 | 6-Alkylamino-2-methyl-2′-(N-methyl substituted sulfonamido)methyl-2H-1-benzopyran derivative as anti-inflammatory inhibitor The present invention relates to a noble 6-alkylamino-2-methyl-2′-(N-methyl substituted sulfonamido)methyl-2H-1-benzopyran derivative, a method for preparing the same with high efficiency using a parallel synthetic method, one of combinatorial chemical synthetic t... | 05/13/2008 |
| RE39663 | Electron-deficient nitrogen heterocycle-substituted fluorescein dyes The invention provides compositions electron-deficient nitrogen heterocycle-substituted fluorescein dyes and methods in which the dyes are conjugated to substrates and used as detection labels in molecular biology experiments. The electron-deficient nitrogen heteroc... | 05/29/2007 |
| 7175872 | Pyridinium-Betain compounds for use as taste modulators Pyridinium-Betain compounds of the general formula (A): wherein R1 is H or a primary amino acids that is attached to the structure, X is OH or its ionized form O−, | 02/13/2007 |
| 7109316 | Oligonucleotide tagged nucleoside triphosphates (OTNTPs) for genetic analysis Oligonucleotide tagged nucleoside triphosphates, OTNTPs, which are substrates for polymerases and or terminal nucleotidyl transferases are provided as well as methods of making these OTNTPs. Further provided are OTNTPs with fluorescent dyes including energy transfer... | 09/19/2006 |
| 7081468 | Ortho-substituted anthranilic acid amides and their use as medicaments Ortho-substituted anthranilic acid amides and use thereof as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis are described. ... | 07/25/2006 |
| 7038063 | Atropisomers of asymmetric xanthene fluorescent dyes and methods of DNA sequencing and fragment analysis Atropisomeric energy-transfer dye compounds are disclosed. A variety of molecular biology applications utilize atropisomeric xanthene fluorescent dyes as labels for substrates such as nucleotides, nucleosides, polynucleotides, polypeptides and carbohydrates. Methods... | 05/02/2006 |
| 7015328 | Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to substituted coumarins and quinolines and analogs thereof, represented by the general Formula I: wherein A, B, X, Y, and Z are defined herein. The present invention also relates to t... | 03/21/2006 |
| 6903218 | Sulfonamide substituted chroman derivatives This invention related to novel sulfonamide substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions. ... | 06/07/2005 |
| 6900325 | Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to substituted coumarins and quinolines and analogs thereof, represented by the general Formula I: wherein A, B, X, Y, and Z are defined herein. The present invention also relates to t... | 05/31/2005 |
| 6767916 | Chalcone coumarins Disclosed are novel chalcone derivatives having the formula (I). These compounds possess antiproliferative activity, and are useful for the manufacture of a medicament for the treatment or prevention of neoplasms, partic... | 07/27/2004 |
| 6716850 | Non-nucleoside reverse transcriptase inhibitors Compounds of the formula I: where; R1 is O, S; R2 is an optionally substituted nitrogen-containing heterocycle, wherein the nitrogen is located at the 2 position relative to the (thio)... | 04/06/2004 |
| 6706757 | Chroman derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor. ... | 03/16/2004 |
| 6699860 | Di-substituted aminomethyl-chroman derivative beta-3 adrenoreceptor agonists This invention is related to novel di-substituted aminomethyl chroman derivatives which are useful in the treatment of beta-3 receptor-mediated conditions.... | 03/02/2004 |
| 6689799 | 1,4-dihydropyridine-5-carboxylic acid ester derivatives and method for the preparation thereof The present invention relates to ester derivatives of 1,4-dihydropyridine-5-carboxylic acid of formula (I) wherein R1, R2 and R3 may be a coumarin group. These compounds possess an anti-viral activity. Most of the anti-vir... | 02/10/2004 |
| 6683095 | CDK inhibitors having 3-hydroxychromen-4-one structure A novel 3-hydroxychromen-4-one derivative, pharmaceutically acceptable salt, hydrate, solvate or isomer thereof which is useful as an inhibitor for Cyclin Dependent Kinase ("CDK") is disclosed. Further, a process for preparing the compound and a compositi... | 01/27/2004 |
| 6649769 | Atropisomers of asymmetric xanthene fluorescent dyes and methods of DNA sequencing and fragment analysis Atropisomeric energy-transfer dye compounds are disclosed. A variety of molecular biology applications utilize atropisomeric xanthene fluorescent dyes as labels for substrates such as nucleotides, nucleosides, polynucleotides, polypeptides and carbohydrat... | 11/18/2003 |
| 6605725 | Benzanilides as potassium channel openers Benzanilides are provided which are voltage-dependent potassium channel openers. Methods of using the benzanilides of the invention are also provided.... | 08/12/2003 |
| 6518431 | Process for preparing substituted pyridines A process for preparing a compound of the formula ##STR1## wherein n, R1, R2, R3 and X are as defined above, used as an intermediate in the synthesis of ଲ-adrenergic receptor agonists.... | 02/11/2003 |
| 6448407 | Atropisomers of asymmetric xanthene fluorescent dyes and methods of DNA sequencing and fragment analysis Substantially pure atropisomers of xanthene compounds are disclosed. A variety of molecular biology applications utilize atropisomeric xanthene fluorescent dyes as labels for substrates such as nucleotides, nucleosides, polynucleotides, polypeptides and c... | 09/10/2002 |
| 6384045 | Tricyclic and tetracyclic pyrones This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxypyrone synthetic method is a simple con... | 05/07/2002 |
| 6372907 | Water-soluble rhodamine dye peptide conjugates The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the same and methods for their use. The dyes, energy-transfer dye... | 04/16/2002 |
| 6340694 | Diarylbenzopyran derivatives as cyclooxygenase-2 inhibitors The diarylbenzopyran derivatives represented by formula I, and the pharmaceutically acceptable salts thereof, are disclosed. The composition comprising the compound of formula I, or a pharmaceutically acceptable salt thereof, shows an excellent selective ... | 01/22/2002 |
| 6329534 | Glucocorticoid receptor antagonists for treatment of diabetes Compounds of formula I ##STR1## are useful for treating type II diabetes, obesity, hyperglycemia, inadequate glucose clearance, hyperinsulinemia, hypertriglyceridemia, and high-circulating glucocorticoid levels, preparations of the compounds, composi... | 12/11/2001 |
| 6303789 | Benzamides with tetrahydrofuranyloxy substitutents as phosphodiesterase 4 inhibitors Compounds of the formula I ##STR1## in which R1, R2, R3, R4, R5, m and n have the meanings cited in the description, are novel effective PDE-inhibitors.... | 10/16/2001 |
| 6255324 | Amino-and mercurio-substituted 4',5'-dihydropsoralens and therapeutical uses thereof 5'-substituted, 4',5'-dihydropsoralen compounds (5) bearing tertiary amines (and salts thereof), quaternary ammonium moieties or organomercurial moieties are described. ##STR1## Also described are 2-substituted mercurimethyl-2-3-dihydro-benzofurans of ... | 07/03/2001 |
| 6232450 | Inhibition of human fucosyltransferases with N-linked Lewis-x and LacNAc analogs A new class of N-linked Lewis and LacNAc analogs of are synthesized and shown to be effective inhibitors of human fucosyltransferases. In a high yielding reaction sequence the glucosamine derivative 1 was transformed to the 3-azido-2,3-dideoxy sugar 2e un... | 05/15/2001 |
| 6221604 | Electron-deficient nitrogen heterocycle-substituted fluorescein dyes The invention provides compositions electron-deficient nitrogen heterocycle-substituted fluorescein dyes and methods in which the dyes are conjugated to substrates and used as detection labels in molecular biology experiments. The electron-deficient nitro... | 04/24/2001 |
| 6191278 | Water-soluble rhodamine dyes and conjugates thereof The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the same and methods for their use. The dyes, energy-transfer dye... | 02/20/2001 |
| 6177424 | 4'-Substituted-4',5'-dihydropsoralens and therapeutical uses thereof The invention relates to 4'-substituted-4',5'-dihydropsoralen compounds of formula(V): ##STR1## In the formula R is hydrogen, a halogen, CN or an acyl group; T is a halogen, CN, a carboalkoxy group NR1 R2, or (N+ R1 | 01/23/2001 |
| 6153627 | Chroman derivatives Chroman derivatives of the formula I ##STR1## wherein R1 to R8 have the meanings defined herein, and their salts have an effect on the cardiovascular system.... | 11/28/2000 |
| 6150356 | Potassium channel inhibitors and method Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure ##STR1## where A, B, D, Q, X1, R, R1, X2 and R2 are as defined herein. These compounds... | 11/21/2000 |
| 6140331 | Fused benzo compounds for the treatment of central nervous system disorders | 10/31/2000 |
| 6071938 | Benzopyrans A compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein X, O R, R1, R2, R3, and R4 are defined in the specification; compositions containing such compounds; intermediates ... | 06/06/2000 |
| 6060487 | Indanol compounds A compound of formula (I): ##STR1## wherein R1, R2, R3, R4, X--Y, A, Z and Z' are as defined in the description, in the form of the cis or trans isomers each in racemic or optically active form, and acid ad... | 05/09/2000 |
| 6051586 | Sulfonamide substituted chroman derivatives useful as beta 3 adrenoreceptor agonists This invention related to novel sulfonamide substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions.... | 04/18/2000 |
| 6022497 | Photochromic six-membered heterocyclic-fused naphthopyrans Described are novel photochromic six-membered heterocyclic-fused naphthopyran compounds, examples of which are naphthopyran compounds having a substituted or unsubstituted six-membered heterocyclic group fused to one side of the naphtho portion of the nap... | 02/08/2000 |
