Class 546/282.7 - Polycyclo ring system having the additional hetero ring as one of the cyclos

Subclass of Class 546 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the additional hetero ring is one of the
No. of patents: 227
Last issue date: 01/13/2009

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Number	Title	Issue Date
7476741	Substituted 4H-chromens, 2H-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to substituted 4H-chromenes, 2H-chromenes, chromans and analogs thereof, represented by the general Formula (I) wherein R5, A, B, X, Y, Z and dotted lines are defined herein. The present invention also relates to the disc...	01/13/2009
7425568	Compounds, which are potent inhibitors of Na /Ca exchange mechanism and are useful in the treatment of arrhythmias Therapeutically active compounds of formula (I): wherein the variables shown in formula (I) are defined in the disclosure; and pharmaceutically acceptable salts and esters thereof. The compounds are potent inhibitors of the...	09/16/2008
7371874	6-Alkylamino-2-methyl-2′-(N-methyl substituted sulfonamido)methyl-2H-1-benzopyran derivative as anti-inflammatory inhibitor The present invention relates to a noble 6-alkylamino-2-methyl-2′-(N-methyl substituted sulfonamido)methyl-2H-1-benzopyran derivative, a method for preparing the same with high efficiency using a parallel synthetic method, one of combinatorial chemical synthetic t...	05/13/2008
7365095	Chromane and chromene derivatives and uses thereof Compounds of formula I or pharmaceutically acceptable salts thereof are provided: wherein each of R1, R2, R3, R4, y, m, n, and Ar are as defined, and described in classes and subc...	04/29/2008
7358377	Schweinfurthin analogues Methods and intermediates for preparing enantiomerically enriched Schweinfurthin analogs which are useful for the treatment of cancer, as well as novel Schweinfurthin analogs having anti-cancer activity, compositions comprising such analogs and therapeutic methods c...	04/15/2008
7288567	Inhibitors of histone deacetylase The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and cond...	10/30/2007
7244763	Compounds that modulate PPAR activity and methods of preparation This invention relates to compounds that alter PPAR activity. The invention also relates to pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic...	07/17/2007
7034035	Fungicidal mono-, bi-, and tri-cycloheteroalkyl amides and their compositions, methods of use and preparation The present invention relates to compounds of Formula I: wherein: a) represents a 6-membered heterocyclic aromatic ring in w...	04/25/2006
7026487	Amines substituted with a dihydronaphthalenyl, chromenyl, or thiochromenyl group, a pyridyl group and an alkyl group, having retinoid-like biological activity Compounds of the formula where the symbols are as defined in the specification, have retinoid agonist, antagonist or negative hormone-like biological activity. ...	04/11/2006
6995162	Substituted alkylamine derivatives and methods of use Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical composit...	02/07/2006
6951952	Dyes There are described novel rhodol dye compounds The dye compounds exhibit a first color when in the crystalline form and a second color, different from the first color, when in the liquid, amorphous form. ...	10/04/2005
6939007	Photochromic bis-naphthopyran compounds and methods for their manufacture The invention provides photochromic bis-naphthopyran compounds as well as methods for their manufacture and their use. The bis-naphthopyran compounds of the invention exhibit a wide range of color, i.e., from pink to purple to blue gray, upon activation by a source ...	09/06/2005
6933305	Amide compounds and use thereof The present invention relates to an amide compound of the formula wherein R1 is a hydrogen and the like, R2 is a hydrogen and the like, X is SO2 and the like, Y is the formula (III) and...	08/23/2005
6919371	2,6-substituted chroman derivatives useful as beta-3 adrenoreceptor agonists This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions. ...	07/19/2005
6903218	Sulfonamide substituted chroman derivatives This invention related to novel sulfonamide substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions. ...	06/07/2005
6878714	Substituted alkylamine derivatives and methods of use Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for p...	04/12/2005
6858732	Photochromic benzodioxine fused naphthopyran compounds, compositions and articles containing those naphthopyran compounds Benzodioxino-naphtho[1,2-b]pyran compounds having particularly advantageous photochromic properties, such as, high sensitivity/coloration, two distinct absorption bands in the 430-500 nm range and 520-620 nm range of the visible spectrum may be generally described a...	02/22/2005
6846817	Nicotine receptor ligands The invention provides nicotine receptor agonists of formula I: wherein R1, x, y, and n have any of the values given in the specification, or a pharmaceutically acceptable salt thereof, as well as pharmaceut...	01/25/2005
6822093	Synthesis of heteroarylamine intermediate compounds Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines. ...	11/23/2004
6809113	Antagonists of MCP-1 function and methods of use thereof Compounds which are antagonists of MCP-1 function and are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases, especially those associated with aberrant lymphocyte or monocyte accumulation such as arthritis, asthma, atherosc...	10/26/2004
6747145	Photochromic bis-naphthopyran compounds and methods for their manufacture The invention provides photochromic bis-naphthopyran compounds as well as methods for their manufacture and their use. The bis-naphthopyran compounds of the invention exhibit a wide range of color, i.e., from pink to purple to blue gray, upon activation by a source ...	06/08/2004
6727239	Derivatives of 2-aminopyridines, their use as medicaments and pharmaceutical compositions containing them A compound of the formula wherein the substituents are defined as in the specification and their pharmaceutically acceptable salts having NOS and ROS activity. ...	04/27/2004
6716850	Non-nucleoside reverse transcriptase inhibitors Compounds of the formula I: where; R1 is O, S; R2 is an optionally substituted nitrogen-containing heterocycle, wherein the nitrogen is located at the 2 position relative to the (thio)...	04/06/2004
6699860	Di-substituted aminomethyl-chroman derivative beta-3 adrenoreceptor agonists This invention is related to novel di-substituted aminomethyl chroman derivatives which are useful in the treatment of beta-3 receptor-mediated conditions....	03/02/2004
6673937	Syntheses and methods of use of new antimitotic agents Oxidative cyclization of bis-naphthyl ethers allows concise total syntheses of palmarumycin CP1 and deoxypreussomerin A in 8-9 steps and 15-35% overall yield from 5-hydroxy-8-methoxy-1-tetralone. A small library of palmarumycin analogs was crea...	01/06/2004
6660752	2,6-Substituted chroman derivatives useful as beta-3 adrenoreceptor agonists This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions....	12/09/2003
6645951	Benzopyran or thiobenzopyran derivatives The present invention provides novel benzopyran compounds, pharmaceutically acceptable salts thereof and stereoisomers thereof where the benzopyran compounds of the invention are compounds according to Formula I: ##STR1## The present invention further pro...	11/11/2003
6638972	Chroman and benzofuran derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor. ##STR1##...	10/28/2003
6593471	Synthesis of heteroarylamine intermediate compounds Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines....	07/15/2003
6590099	Synthesis of heteroarylamine intermediate compounds Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines....	07/08/2003
6555028	Polymeric matrix compatibilized naphthopyrans Described are polymeric matrix compatibilized naphthopyran compounds, examples of which are certain 2H-naphtho[1,2-b]pyrans, 3H-naphtho[2,1-b]pyrans and indeno[2,1-f]naphtho[1,2-b]pyrans each having at least one substituent containing terminal and/or pend...	04/29/2003
6545164	Fluorochromes labelling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer The present invention provides low molecular weight fluorescent labeling complexes with large wavelength shifts between absorption of one dye in the complex and emission from another dye in the complex. These complexes can be used, for example, for multip...	04/08/2003
6544986	Pyridones and their use as modulators of serine hydrolase enzymes This invention relates to a compound of formula I: ##STR1## or a pharmaceutically acceptable salt thereof; in which preferably R3, R4 and R6 are each hydrogen; X is C.dbd.O or CH2 ; and R7 and R8 are...	04/08/2003
6472414	Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure ##STR1## including pharmaceutically acceptable salts thereof or prodrug esters...	10/29/2002
6469031	Carboxyl substituted chroman derivatives useful as beta 3 adrenoreceptor agonists This invention is related to novel carboxyl substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions....	10/22/2002
6433179	Process for producing paroxetine A process for producing a paroxetine represented by the following formula (4), which comprises reacting an N-alkylpiperidine represented by the following general formula (1) with a haloformic acid ester represented by the general formula (2) to prepare an...	08/13/2002
6423847	Synthesis and clinical uses of D,଱-tocopherol nicotinate compounds A process of synthesis of D,଱-tocopherol nicotinate compounds is presented. Therapeutic uses for this compound are described. The active agents are demonstrated to be complementary in their physiological functions especially as these relate to cellu...	07/23/2002
6420375	Fused ring compounds, process for producing the same and use thereof To provide a novel compound of the formula: ##STR1## [wherein A1 ix a 5 or 6-membered ring which may be substituted by a group not containing a cyclic group, A2 is an aromatic ring which may be substituted, X is a divalent group, Y i...	07/16/2002
6384045	Tricyclic and tetracyclic pyrones This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxypyrone synthetic method is a simple con...	05/07/2002
6369225	Compounds having activity as inhibitors of cytochrome P450RAI Compounds having Formula 8 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. ##STR1##...	04/09/2002

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Class 546/282.7 - Polycyclo ring system having the additional hetero ring as one of the cyclos