Class 546/282.4 - Plural ring oxygens in the additional hetero ring

Subclass of Class 546 - Organic compounds -- part of the class 532-570 series
Definition: Compounds in which the additional hetero ring contains at
No. of patents: 192
Last issue date: 01/15/2008

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Number	Title	Issue Date
7319101	COMT inhibitors for the treatment of depression and impaired cognition The present invention relates to compounds of formula I wherein R1 is as defined in the specification and to esters thereof which are hydrolyzable under physiological conditions and to the ph...	01/15/2008
7297797	Pyrrolines The invention relates to novel Δ1-pyrrolines of the formula (I) in which R1, R2, R3, R4, A1, A2, R5, R6, R7, R	11/20/2007
7078417	Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines with adenosine receptor-binding activity and their use as cardiovascular preparations This application relates to pyridine derivatives having the general structure in which the several variables are as defined in the specification and claims, and to a process for preparing these compounds, a pharmac...	07/18/2006
7034035	Fungicidal mono-, bi-, and tri-cycloheteroalkyl amides and their compositions, methods of use and preparation The present invention relates to compounds of Formula I: wherein: a) represents a 6-membered heterocyclic aromatic ring in w...	04/25/2006
6858732	Photochromic benzodioxine fused naphthopyran compounds, compositions and articles containing those naphthopyran compounds Benzodioxino-naphtho[1,2-b]pyran compounds having particularly advantageous photochromic properties, such as, high sensitivity/coloration, two distinct absorption bands in the 430-500 nm range and 520-620 nm range of the visible spectrum may be generally described a...	02/22/2005
6656957	Pyridine derivatives A compound of formula I ##STR1## wherein X represents an optionally halo-substituted (C2-4)alkynylene group bonded via vicinal unsaturated carbon atoms....	12/02/2003
6555028	Polymeric matrix compatibilized naphthopyrans Described are polymeric matrix compatibilized naphthopyran compounds, examples of which are certain 2H-naphtho[1,2-b]pyrans, 3H-naphtho[2,1-b]pyrans and indeno[2,1-f]naphtho[1,2-b]pyrans each having at least one substituent containing terminal and/or pend...	04/29/2003
6498172	Prostaglandin agonists and their use to treat bone disorders This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for t...	12/24/2002
6448260	Endothelin receptor antagonists Novel indane and indene derivatives are described which are endothelin receptor antagonists....	09/10/2002
6384045	Tricyclic and tetracyclic pyrones This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxypyrone synthetic method is a simple con...	05/07/2002
6372764	Pyrrolidine modulators of chemokine receptor activity The present invention is directed to pyrrolidine compounds of the formula I: ##STR1## (wherein R1, R2, R3, R4c, R4d, and R4f are defined herein) which are useful as modulators of chemokine ...	04/16/2002
6355653	Amino-triazolopyridine derivatives The invention relates to compounds of formula ##STR1## wherein R1 is a 5 or 6 membered heteroaryl group, containing 1 to 3 heteroatoms, selected from N, O or S, and which groups are optionally substituted by one or two substituents, which are l...	03/12/2002
6281221	Substituted 1,3-dioxan-5-ylamino-hererocyclic compounds, processes for their preparation and their use as pest control compositions The invention relates to novel substituted 1,3-dioxan-5-ylamino-heterocyclic compounds of the formula ##STR1## in which A is CH or N; X is NH, O or S(O)q, where q=0-2; Y is O or S(O)m, where m=0-2, and R1, R2, R...	08/28/2001
6274737	Endothelin receptor antagonists Novel indane and indene derivatives are described which are endothelin receptor antagonists....	08/14/2001
6211202	2-methoxyimino-2-(pyridinyloxymethyl) phenyl acetamides with substituted ketal derivatives on the pyridine ring The present invention provides novel 2-methoxyimino-2-(pyridinyloxymethyl)phenyl acetamide compounds with substituted ketal substituents on the pyridine ring, their use as fungicidal compounds, and their use in fungicidal compositions comprising at l...	04/03/2001
6143751	Pyridine derivatives and pharmaceutical compositions containing them Compounds of the formula (I) wherein X, R1, R2, and Ar1 as defined in the specification. The compounds are useful medicaments, particularly in the treatment of asthma or rhinitis....	11/07/2000
6113814	Polymerizable polyalkoxylated naphthopyrans Described are novel photochromic polymerizable polyalkoxylated naphthopyran compounds, examples of which are certain 2H-naphtho[1,2-b]pyrans, 3H-naphtho[2,1-b]pyrans and indeno[2,1-f]naphtho[1,2-b]pyrans each having at least one polyalkoxylated substituen...	09/05/2000
6060487	Indanol compounds A compound of formula (I): ##STR1## wherein R1, R2, R3, R4, X--Y, A, Z and Z' are as defined in the description, in the form of the cis or trans isomers each in racemic or optically active form, and acid ad...	05/09/2000
6022497	Photochromic six-membered heterocyclic-fused naphthopyrans Described are novel photochromic six-membered heterocyclic-fused naphthopyran compounds, examples of which are naphthopyran compounds having a substituted or unsubstituted six-membered heterocyclic group fused to one side of the naphtho portion of the nap...	02/08/2000
5958970	Tricyclic and tetracyclic pyrones This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxyprone synthetic method is a simple cond...	09/28/1999
5958927	Indanol compounds A compound of formula (I): ##STR1## wherein R1, R2, R3, R4, X-Y, A, Z and Z' are as defined in the description, in the form of the cis or trans isomers each in racemic or optically active form, and acid add...	09/28/1999
5843867	Substituted pyridine compounds Disclosed herein are herbicidal pyridine compounds substituted at the 2- or 6-position with an OR2 moiety where R2 is hydrogen, lower alkyl, halomethyl, lower cyanoalkyl, alkenyl or alkynyl, as well as herbicidal compositions and her...	12/01/1998
5824625	Substituted pyridine compounds Disclosed herein are herbicidal pyridine compounds substituted at the 2- or 6-position with an OR2 moiety where R2 is hydrogen, lower alkyl, halomethyl, lower cyanoalkyl, alkenyl or alkynyl, as well as herbicidal compositions and her...	10/20/1998
5808124	O- or S-substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity....	09/15/1998
5786373	Fibrinogen receptor antagonists Novel fibrinogen receptor antagonists of the formula: X--Y--Z-Aryl-A--B and the pharmaceutically acceptable salts thereof, wherein Aryl is a 5-membered aromatic ring system containing 1 or 2 heteroatoms chosen from N, O or S wherein ring atoms may be unsu...	07/28/1998
5763460	N-(piperidinyl-1-alkyl)-substituted cyclohexane carboxylic acid amides as 5-htia receptor antagonists Compounds of formula (I) and the pharmaceutically acceptable acid addition salts thereof are 5-HT1A binding agents and may be used, for example, as anxiolytics. In the formula a and b each represents 0, 1, 2 or 3 such that the sum of a+b is 0, ...	06/09/1998
5719182	Endothelin receptor anatagonists Novel indane and indene derivatives are described which are endothelin receptor antagonists....	02/17/1998
5710288	1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents Compounds of the formula ##STR1## where the symbols have the meaning defined in the specification, are capable of lowering intraocular pressure in the eye of a mammal....	01/20/1998
5710164	Diheterocyclic styryl nitriles Disclosed herein are compounds of the formula: ##STR1## where Ar1 and Ar2 are, independently, pyridinyl, quinolinyl, 1,4-benzodioxanyl, dihydro-1,4-benzodioxanyl, pyrrolyl, azaindolyl or carbazolyl, or a pharmaceutically accepta...	01/20/1998
5667721	Liquid crystalline di-1,3-dioxane derivatives Liquid crystalline compounds having two dioxane rings, the dipole moments of which are unidirectional. These are compounds of the general formula ##STR1## wherein A and B each independently is cyclic or acyclic hydrophobic residues; and n is 0, 1 or ...	09/16/1997
5656656	Tartronic acids, their acetalic ethers and O-esters Tartronic acid acetalic ethers and esters of the general formula: ##STR1## are provided and are useful in treatment of bone dysmetabolism. As examples, Ra and Rb may be hydrogen, B is a C2 -C12 acyl group, R is phenyl and n is 0...	08/12/1997
5656253	Ligands useful in radiographic imaging The present invention relates particularly to novel pyridine based nitrogen-sulfur ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes, novel aminothiol ligands that are suitable f...	08/12/1997
5629323	Amide derivatives as 5-HT_1A ligands Amide Derivatives of formula (I) wherein R1 is a mono or bicyclic heteroaryl radical, R2 is cycloalkyl, R3 and R4 each represent hydrogen or lower alkyl, and R5 is a group of formula (A) or (B) or (C)...	05/13/1997
5618931	Acetylenes disubstituted with a 5 substituted dihydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity Compounds of the formula ##STR1## wherein the symbols have the meaning described in the specification have retinoid-like biological activity....	04/08/1997
5599820	Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment The present invention is directed to novel taxanes useful as chemotherapeutic agents or their precursors. Processes for preparing the novel taxanes include coupling reactions, in the presence of a base, of baccatin of formula (III) or (IV) ##STR1## ...	02/04/1997
5585374	Amide derivatives Amide derivatives of formula (I) and their pharmaceutically acceptable salts (where a and b each represent 0, 1, 2 or 3 such that a+b=0, 1, 2 or 3, the dotted line represents an optional double bond, A is an optionally substituted C1-2 -alkylen...	12/17/1996
5580868	Pyridyloxy-acrylic acid esters Novel pyridyloxy-acrylic acid esters of the formula ##STR1## in which Ar represents optionally substituted aryl or represents optionally substituted heteroaryl, a process for preparing the novel compounds and their use as agents for combating pests. ...	12/03/1996
5573712	Substituted naphthopyrans Described are novel reversible photochromic naphthopyran compounds, examples of which are compounds having certain substituents at the number 5 and 6 carbon atoms of the naphtho portion of the naphthopyran and at the 2-position of the pyran ring. Certain ...	11/12/1996
5552090	Photochromic naphthopyran compounds Described are novel reversible photochromic naphthopyran compounds, examples of which are compounds substituted at the 3 position of the pyran ring with (i) an aryl substituent and (ii) a phenyl substituent having a 5- or 6-member heterocyclic ring fused ...	09/03/1996
5521179	Heterocyclic amides The present invention relates to certain novel heterocyclic amides which are 1-pyridylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them usef...	05/28/1996

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Class 546/282.4 - Plural ring oxygens in the additional hetero ring