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| Number | Title | Issue Date |
| 8058446 | Certain substituted amides, method of making, and method of use thereof At least one chemical entity chosen from compounds of Formula 1 and pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, and mixtures thereof is described herein. Pharmaceutical c... | 11/15/2011 |
| 7419986 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, pre... | 09/02/2008 |
| 7410982 | Propanamine derivatives as serotonin and norepinephrine reuptake inhibitors There is provided a heretoaryloxy/thio 3-substituted propanamine compound of formula (I) wherein A is selected from —O— and —S—; X is selected from phenyl optionally substituted with up to 5 substituents each independently selected from halo, C1-C... | 08/12/2008 |
| 7393846 | Heterocyclic compounds useful for the treatment of inflammatory and allergic disorders The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs, their pharmaceutically acceptable salts, their appropriate N-oxides, the... | 07/01/2008 |
| 7393865 | Sleep inducing compounds and methods relating thereto Compounds having the following structure (I): including stereoisomers, prodrugs, and pharmaceutically acceptable salts, esters and solvates thereof, wherein R1, R2, R3a, R3b, L | 07/01/2008 |
| 7390907 | Vanilloid receptor ligands and their use in treatments Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascu... | 06/24/2008 |
| 7335666 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, pre... | 02/26/2008 |
| 7288567 | Inhibitors of histone deacetylase The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and cond... | 10/30/2007 |
| 7238725 | Tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel tricyclic compounds useful for the treatment of inflammatory conditions, diseases of the central nervous and insulin resistant diabetes. ... | 07/03/2007 |
| 7223789 | Heterocyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs, their pharmaceutically acceptable salts, their appropriate N-oxides, the... | 05/29/2007 |
| 7217723 | Heterocyclic compound having oxime group The present invention provides a compound that has an excellent inhibitory activity on STAT6 activation and is effective against allergic diseases, and a medicinal composition thereof. According to the present invention, disclosed is the compound represented by the ... | 05/15/2007 |
| 7208491 | N-monoacylated o-phenylenediamines Mono-acylated o-phenylendiamines derivatives of formula I wherein X and R are as described herein, have been found useful for the treatment of diseases mediated by the inhibition of histone deacetylase, such as c... | 04/24/2007 |
| 7205305 | Inhibitors of p38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceut... | 04/17/2007 |
| 7183293 | Ether derivatives useful as inhibitors of PDE4 isozymes This application is directed to compounds of the formula wherein j is 1; k is 0 or 1; m is 1, 2 or 3; n is 1 or 2; W1 and W2 are independently —O— or —S(═O)t—, where t i... | 02/27/2007 |
| 7135479 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress di... | 11/14/2006 |
| 7129234 | Phenyl heterocyclyl ethers The invention relates to compounds of formula I ... | 10/31/2006 |
| 7105513 | Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals The present invention relates to acylated, heteroaryl-condensed cycloalkenylamines, to pharmaceutical compositions comprising such compounds, to methods for the stimulation of the expression of endothelial NO synthase, and methods of treatment comprising administeri... | 09/12/2006 |
| 7034044 | Conjugated aromatic compounds with a pyridine substituent The present invention relates to compounds of formulae The compounds of the present invention are NMDA (N-methyl-D-aspartate)-receptor subtype blockers and are used in the treatment of diseases related to this receptor. | 04/25/2006 |
| 6921827 | Process for preparing 3-aryl-benzo{b} thiophenes The present invention relates to a process for preparing a compound of formula (I): which includes cyclodehydrating a compound of formula (II): in the presence of an acid activated clay or acid activated zeolite catalyst and in the presence of a suitable solvent | 07/26/2005 |
| 6897226 | NK-1 receptor active amine oxide prodrugs Compounds of the invention are amine oxide prodrugs showing activity on the NK1 receptor. ... | 05/24/2005 |
| 6872730 | Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists The present invention relates to novel substituted benzofurans and benzothiophenes compounds that are antagonists of alpha V (αv) integrins, for example αvβ3 and αvβ5 integrins, their pharmaceutically acceptable salts... | 03/29/2005 |
| 6846819 | Fab I inhibitors Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections. ... | 01/25/2005 |
| 6828333 | Ether derivatives useful as inhibitors of PDE4 isozymes This application is directed to compounds of the formula wherein j is 1; k is 0 or 1; m is 1, 2 or 3; n is 1 or 2; W1 and W2 are independently —O— or —S(═O)t—, where t is 0, 1... | 12/07/2004 |
| 6822093 | Synthesis of heteroarylamine intermediate compounds Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines. ... | 11/23/2004 |
| 6720423 | Dihydrobenzofuran and dihydrobenzothiophene 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors Compounds of the formula where the variables have the meaning defined in the specification, are specific or selective agonists of RXR retinoid receptors. ... | 04/13/2004 |
| 6696470 | Pyridylthiophene compounds A compound of the formula: ##STR1## and its pharmaceutically effective salts, wherein R1 and R2 are independently selected from the following: (a) hydrogen, halo, R5 --, C2-6 alkenyl, C2-6 alkynyl, ... | 02/24/2004 |
| 6689797 | Tetrahydropyridines, preparation method and pharmaceutical compositions containing same The present invention relates to compounds of formula (I): ##STR1## in which R1 represents a hydrogen or halogen atom, or a group CF3 ; R2 and R3 represent, independently, a hydrogen atom or a methyl group; n and n' ... | 02/10/2004 |
| 6683192 | Small organic molecule regulators of cell proliferation A compound represented in general formula (X) and (XI): ##STR1##... | 01/27/2004 |
| 6664274 | Piperidine derivatives as serotonine reuptake inhibitors The present invention provides compounds of formula I ##STR1## and a method of inhibiting the reuptake of serotonin, antagonizing the 5-HT1A receptor and antagonizing the 5-HT2A receptor which comprises administering to a subject in ... | 12/16/2003 |
| 6608060 | Inhibitors of p38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides... | 08/19/2003 |
| 6608090 | Benzothiophenes with novel basic side chains The instant invention provides novel benzothiophene compounds for use in treating skeletal diseases.... | 08/19/2003 |
| 6593471 | Synthesis of heteroarylamine intermediate compounds Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines.... | 07/15/2003 |
| 6590099 | Synthesis of heteroarylamine intermediate compounds Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines.... | 07/08/2003 |
| 6559167 | Prodrugs of proton pump inhibitors Prodrugs of the pyridyl methyl sulfinyl benzimidazole type proton pump inhibitor drugs have a hydrolyzable arylsulfonyl or heteroarylsulfonyl group attached to the benzimidazole nitrogen. The prodrugs of the invention hydrolyze under physiological conditi... | 05/06/2003 |
| 6555028 | Polymeric matrix compatibilized naphthopyrans Described are polymeric matrix compatibilized naphthopyran compounds, examples of which are certain 2H-naphtho[1,2-b]pyrans, 3H-naphtho[2,1-b]pyrans and indeno[2,1-f]naphtho[1,2-b]pyrans each having at least one substituent containing terminal and/or pend... | 04/29/2003 |
| 6544986 | Pyridones and their use as modulators of serine hydrolase enzymes This invention relates to a compound of formula I: ##STR1## or a pharmaceutically acceptable salt thereof; in which preferably R3, R4 and R6 are each hydrogen; X is C.dbd.O or CH2 ; and R7 and R8 are... | 04/08/2003 |
| 6458787 | Cyclic AMP-specific phosphodiesterase inhibitors Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, a... | 10/01/2002 |
| 6429312 | N-aminoalkyldibenzothiopencarboxamide receptor subtype specific ligands Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof, wherein: R1, R2, R3, R4 are the same or different and represent hydrogen, C1 -C6 ... | 08/06/2002 |
| 6423717 | Sulphonamide derivatives, process for their preparation, and their use as medicaments Novel sulphonamide derivatives having CNS activity, processes for their preparation and their use as medicaments are disclosed. The present compounds are of formula (I) or a salt thereof: ##STR1## wherein: P isbenzothiophene, benzothiadiazole, quinoline, ... | 07/23/2002 |
| 6388105 | Benzofuran, indole or benzothiophene 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors Compounds of the formula ##STR1## Where the variables are defined as in the specification, are selective agonists of RXR retinoid receptors.... | 05/14/2002 |
