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Pet Toilet-Like Water Disk and Food Storage
One pet-friendly inventor patented "a device for watering pets, e.g., a dog or cat." The device, he helpfully noted, "has the general shape of a toilet."
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| Number | Title | Issue Date |
| 7390907 | Vanilloid receptor ligands and their use in treatments Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascu... | 06/24/2008 |
| 7338966 | Substituted oxindole derivatives as tyrosine kinase inhibitors The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alt... | 03/04/2008 |
| 7282511 | Isatine derivatives with neurotrophic activity The present invention relates to novel isatin derivatives, pharmaceutical compositions comprising the isatin derivatives of the invention, methods of preparing the isatin derivatives of the invention, their use in the treatment of neurodegenerative diseases and for ... | 10/16/2007 |
| 7253203 | Indoline derivatives This invention relates to substituted indoline derivative compounds which are antagonists of the progesterone receptor, their preparation and pharmaceutical utility, particularly including contraception and treatment of benign or malignant neoplastic diseases, havin... | 08/07/2007 |
| 7189755 | Pyrrolidine melanocortin-specific compounds Melanocortin receptor-specific pyrrolidine compounds having the structure: and stereoisomer and pharmaceutically acceptable salts thereof, where R1, R2, and R3 are as described in... | 03/13/2007 |
| 7148249 | Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments The present invention relates to heterocyclically substituted indolinones of general formula wherein R1 to R5 and X are defined as in claim 1, the tautomers, the diastereomers, ... | 12/12/2006 |
| 7109231 | Cyclohept[b]indole derivatives A novel class of tricyclic compounds of the following formula (I): (formula I); is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of inflammatory diseases such as septic shock | 09/19/2006 |
| 7105543 | 4-, 5-, 6- and 7-indole derivatives useful for the treatment of CNS disorders The present invention relates to 4-, 5-, 6- or 7-methylene substituted indolyl derivatives of formula I wherein R is aryl or heteroaryl, where said aryl or heteroaryl groups may be substituted one or more times w... | 09/12/2006 |
| 7071332 | Indolinone derivatives as protein kinase/phosphatase inhibitors The present invention relates to certain 2-indolinone compounds which modulate the activity of protein kinases (“PKs”) and phosphatases. The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical co... | 07/04/2006 |
| 7071217 | Substituted oxindole derivatives as tyrosine kinase inhibitors The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alt... | 07/04/2006 |
| 6969729 | Use of isatin derivatives as ion channel activating agents The present invention relates to ion channel activating agents. More particularly, the present invention relates to a particular class of chemical compounds that has proven useful as openers of SKCa and IKCa channels. In further aspects, the present invention relate... | 11/29/2005 |
| 6962942 | Azacycloalkanone serine protease inhibitors The present invention is directed to non-peptidic factor Xa inhibitors which are useful for the treatment of arterial and venous thrombotic occlusive disorders, inflammation, cancer, and neurodegenerative diseases. The factor Xa inhibitors provide compounds having F... | 11/08/2005 |
| 6958338 | 4-,5-,6-and 7-indole derivatives useful for the treatment of CNS disorders The present invention relates to 4-, 5-, 6- or 7-methylene substituted indolyl derivatives of formula I wherein R is aryl or heteroaryl, where said aryl or heteroaryl groups may be substituted one or more times with a ... | 10/25/2005 |
| 6911463 | 3-substituted oxindole β-3 agonists The present invention relates to a β3 adrenergic receptor agonist of formula (I); or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful for treating Type 2 diabetes and/or obesity. ... | 06/28/2005 |
| 6846819 | Fab I inhibitors Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections. ... | 01/25/2005 |
| 6727263 | Indole and 2,3-dihydroindole derivatives, their preparation and use The present invention relates to indole and 2,3-dihydroindole derivatives having formula (I) or any of its any of its enantiometers or any mixture thereof, or an acid addition salt thereof, wherein A, R1, R | 04/27/2004 |
| 6689792 | Antipsychotic indolyl derivatives Compounds of formula (1) are provided: ##STR1## wherein R1 and R2 are H, OH, F, Cl, Br, I, 1 to 6 carbon alkyl or alkenyl, 1 to 6 carbon alkoxy, aryl, OR5, nitro, amino, CF3 or R1 and R2 ar... | 02/10/2004 |
| 6673790 | Indolin-2-one derivatives, preparation and their use as ocytocin receptor ligands The present invention relates to novel indolin-2-one derivatives of formula: ##STR1## to the preparation and to the pharmaceutical compositions comprising them. These compounds have an affinity for oxytocin receptors.... | 01/06/2004 |
| 6613781 | Heterocyclylaklylindole or -azaindole compounds as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor ##STR1##... | 09/02/2003 |
| 6603006 | Intermediate for the synthesis of amlodipine, a process for the preparation thereof and corresponding use An intermediate for the synthesis of amlodipine, a process for the preparation thereof and the corresponding use are disclosed. The intermediate is ethyl 3-amino-4-(2-(phthalimido)ethoxy)crotonate and is of formula III: ##STR1## The process for the p... | 08/05/2003 |
| 6573293 | Pyrrole substituted 2-indolinone protein kinase inhibitors The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinas... | 06/03/2003 |
| 6566375 | Elevation of HDL cholesterol by 4-[(aminothioxomethyl)-hydrazono]-N-(substituted)-4-arylbutanamides Compounds of this invention increase plasma levels of high density lipoprotein or HDL, the "good" cholesterol and as such may be useful for treating diseases such as atherosclerosis. These compounds are represented by the formula ##STR1## wherein: R | 05/20/2003 |
| 6534651 | 7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof The invention provides a novel class of substituted isoindolinone derivatives, useful for the treatment of inflammation and reperfusion injuries. Pharmaceutical compositions, and methods of making and using the compounds, or pharmaceutically acceptable sa... | 03/18/2003 |
| 6506763 | 3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity The present invention relates to novel 3-(substituted)-2-indolinones compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment... | 01/14/2003 |
| 6476035 | Indole and 2,3-dihydroindole derivatives, their preparation and use The present invention relates to indole and 2,3-dihydroindole derivatives having formula (I) ##STR1## or any of its any of its enantiometers or any mixture thereof, or an acid addition salt thereof, wherein A, R1, R2, R3, ... | 11/05/2002 |
| 6476028 | Compounds and methods A method of treating a CCR5-mediated disease state in mammals which comprises administering to a mammal in need of such treatment, an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof. ##STR1##... | 11/05/2002 |
| 6436965 | PDE IV inhibiting amides, compositions and methods of treatment Compounds represented by formula I: ##STR1## as well as pharmaceutically acceptable salts and hydrates thereof are disclosed as useful for treating or preventing diseases and conditions mediated by PDE-IV. Pharmaceutical compositions and methods of treatm... | 08/20/2002 |
| 6353109 | Certain fused pyrrolecarboxamides; a new class of GABA brain receptor Disclosed are compounds of the formula ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein: W represents substituted or unsubstituted aryl or heteroaryl; T is hydrogen, halogen, hydroxyl, amino or alkyl; X is hydrogen, hydroxy, or lower alky... | 03/05/2002 |
| 6350747 | 3-(anilinomethylene) oxindoles The present invention relates generally to novel amine substituted oxindole compounds and compositions. Such compounds and compositions have utility as pharmacological agents in treating diseases or conditions alleviated by the inhibition or antagonism of... | 02/26/2002 |
| 6302837 | Benzothiophene, benzofuran and indole compounds A compound selected from those of formula (I): ##STR1## wherein: X represents oxygen, sulphur, or NR3 wherein R3 is as defined in the description, Y represents oxygen, sulphur, NR3, or may represent single bond in certain ... | 10/16/2001 |
| 6268391 | Benzylidene-1,3-dihydro-indol-2-one derivatives a receptor tyrosine kinase inhibitors, particularly of Raf kinases Compounds of general formula (I) wherein: R1 is H or optionally joined with R2 to form a fused ring selected from the group consisting of five to ten membered aryl, heteroaryl or heterocyclyl rings, R2 and R3 ar... | 07/31/2001 |
| 6214858 | Caspases and apoptosis A compound of formula ##STR1## wherein R1 is hydrogen, or C1-4 alkyl; R2 is C1-10 alkyl, optionally substituted arylC1-4 alkyl, optionally substituted heteroaryl C1-4 alkyl optionally substitute... | 04/10/2001 |
| 6207836 | Indolin-2-one derivatives A compound represented by formula (I): ##STR1## wherein R1 represents a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a nitro group, a trifluoromethyl group, a lower alkylthio group, an acyl group, a carboxyl group,... | 03/27/2001 |
| 6159995 | Substituted diaminocarboxylic acids Compounds of formula (I) ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading metalloproteinases is involved.... | 12/12/2000 |
| 6130239 | 4-Alkenyl- and 4-alkynyloxindoles Disclosed are novel 4-alkenyl- and 4-alkynyl oxindoles having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R1, R2, R3, a, b, and X are as defined herein. These compounds inhibit cycl... | 10/10/2000 |
| 6127549 | Fluorescent indigo pigments Compounds of formula: A(B)x, (I), wherein x is an integer from 1 to 4, A is the radical of a chromophore of the quinacridone, anthraquinone, perylene, indigo, quinophthalone, isoindolinone, isoindoline, diox... | 10/03/2000 |
| 6127544 | Indolin-2-one derivatives A compound represented by formula (I): wherein R1 represents a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a nitro group, a trifluoromethyl group, a lower alkylthio group, an acyl group, a carboxyl group, a mercap... | 10/03/2000 |
| 6114536 | Indolin-2-one derivatives A compound represented by formula (I): ##STR1## wherein R1 represents a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a nitro group, a trifluoromethyl group, a lower alkylthio group, an acyl group, a carboxyl g... | 09/05/2000 |
| 6100276 | Isatin derivatives as acetylcholinesterase inhibitors and analgesics This application relates to compounds of the formula ##STR1## wherein R, X and Y are defined within, which compounds are useful for the treatment of memory dysfunction characterized by decreased cholinergic function, and for analgesia, pharmaceutical... | 08/08/2000 |
| 6096887 | Certain fused pyrrolecarboxamides; a new class of GABA brain receptor ligands The present invention encompasses structures of the formula I: ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein: ##STR2## W represents substituted or unsubstituted heteroaryl; X is hydrogen, hydroxy or lower alkyl; T i... | 08/01/2000 |
