Class 546/277.1 - Bicyclo ring system which is isoindole (including hydrogenated)

Subclass of Class 546 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the polycyclo ring system is bicyclo and
No. of patents: 214
Last issue date: 03/02/2010

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Number	Title	Issue Date
7671208	Acetone solvate of phthaloyl amlodipine An acetone solvate of phthaloyl amlodipine, as well as a process for its preparation including dissolving phthaloyl amlodipine in acetone and cooling the mixture. The present invention also comprises a method for the synthesis of amlodipine, its salts or solvates, w...	03/02/2010
7423058	Inhibitors of hepatitis C virus NS3 protease The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of us...	09/09/2008
7390907	Vanilloid receptor ligands and their use in treatments Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascu...	06/24/2008
7375100	2-amino-pyridine derivatives useful for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the ...	05/20/2008
7365081	Indole derivatives and their use as medicaments The invention relates to novel indole derivatives of the general formula 1, to their preparation and to their use as medicaments, in particular for treating tumors ...	04/29/2008
7345062	Substituted acylhydroxamic acids and method of reducing TNFαlevels Imido and amido substituted acylhydroxamidic acids which reduce the levels of TNFα and inhibit phosphodiesterase in a mammal. A typical embodiment is (3-(1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propandylamino)propanoate. ...	03/18/2008
7342041	3,4-(cyclopentyl)-fused proline compounds as inhibitors of hepatitis C virus NS3 serine protease The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of us...	03/11/2008
7320992	Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods fo...	01/22/2008
7317027	Azaindole-derivatives as factor Xa inhibitors The present invention relates to compounds of the formula I wherein R0, R1, R2, R3, Q, V, G and M are as defined herein. The compounds of the formula I are valuable pha...	01/08/2008
7276516	CB1 antagonist compounds Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. As such, compounds of the present invention ...	10/02/2007
7276500	Substituted amides, their preparation and use An amide of the formula I and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the following meanings:...	10/02/2007
7205328	Oxindoles with anti-HIV activity The present invention relates to inhibition of viruses, e.g., HIV using oxindoles and compounds related to oxindoles. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in a cell...	04/17/2007
7205330	Inhibitors of hepatitis C virus NS3 protease The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of us...	04/17/2007
7192957	Compounds as inhibitors of hepatitis C virus NS3 serine protease The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of us...	03/20/2007
7157585	Serine protease inhibitors Compounds of formula (I) where R5, R6a, each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as antiinflammatory agents. ...	01/02/2007
7105682	Substituted amine derivatives and methods of use Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for p...	09/12/2006
7102009	Substituted amine derivatives and methods of use Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for p...	09/05/2006
7091356	Substituted alkanohydroxamic acids and method of reducing TNFα levels Imido and Amido substituted alkanohydroxamic acids reduce the levels of TNFa and inhibit phosphodiesterase in a mammal. A typical embodiment is 3-(3-cyclopentyloxy-4-methoxyphenyl)-N-hydroxy-3-phthalimidopropionamide. ...	08/15/2006
6933295	Substituted isoindoles and the use thereof The invention relates to the field of blood clotting, to novel compounds of formula (I), to a method for their production and to the use of these compounds as active ingredients in medicaments for preventing and/or tre...	08/23/2005
6903095	Phthalimido derivatives and a process for their preparation This invention relates to phthalimido derivatives of the formula wherein X is —N═ or —CH═, and R1 to R4 and m are as defined in the specification, as well as their pharmaceutically accepta...	06/07/2005
6900319	Thrombin inhibitors The invention relates to a compound of the formula I: or a salt thereof with a physiologically tolerated acid, or stereoisomers thereof, wherein R1, R2, A, B, C and D have the meanings described i...	05/31/2005
6716856	4,5,6,7-tetrahydroindazole derivatives as antitumor agents Compounds which are 4,5,6,7-tetrahydroindazole derivative formula (1), wherein the dotted line (x) represents a single or double bond; n is 0 or 1; R1, R2 and R3 have the meanings reported in the description; Ra, R′a, Rb, R′b, Rc...	04/06/2004
6699899	Substituted acylhydroxamic acids and method of reducing TNF଱ levels Imido and amido substituted acylhydroxamic acids which reduce the levels of TNF଱ and inhibit phosphodiesterase in a mammal. A typical embodiment is (3-(1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propanoylamino)p ropanoate....	03/02/2004
6660742	Compositions and methods of the use thereof achiral analogues of CC-1065 and the duocarmycins The present invention relates to novel achiral seco-analogues of DNA minor groove and sequence-selective alkylating agents (+)-CC1065 and the duocarmycins, depicted as general class I, II, III, IV and V: ##STR1## wherein X is a good leaving group, such as...	12/09/2003
6610692	Thrombin inhibitors Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: ##STR1## or a pharmaceutically acceptable salt thereof, wherein b is NY or O; c is CY2 or N; d is CY3...	08/26/2003
6559174	N-arylsulfonyl aryl aza-bicyclic derivatives as potent cell adhesion inhibitors Compounds of Formula I are antagonists of VLA-4 and/or alpha4/beta7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are...	05/06/2003
6552065	Deacetylase inhibitors The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties....	04/22/2003
6541503	Substituted oxindole derivatives as protein tyrosine kinase and as protein serine/threonine kinase inhibitors Compounds of formula (I): wherein X is N, CH, CCF3, or C(C1-12 aliphatic); R4 is sulfonic acid, C1-12 aliphatic-sulfonyl, sulfonyl-C1-12 aliphatic, C1-12 aliphatic-sulfonyl-C1-6 ...	04/01/2003
6521638	2,3-dihydro-1H-isoindole derivatives useful as modulators of dopamine D3 receptors (antipsychotic agents) Compounds of formula (I) wherein R1, R2, A, q are as defined herein, and salts thereof, have affinity for dopamine receptors, in particular the D3 receptor, and thus have potential in the treatment of conditions wherein modulation of...	02/18/2003
6492374	Benzofuran derivatives, their preparation and use The present invention relates to benzofuran derivatives having general Formula (I) ##STR1## wherein A is selected from (1), (2), (3), (4) ##STR2## wherein Z is O or S; s is 0 or 1; q is 0 or 1; R4 is hydrogen, C1-6 -alkyl, C	12/10/2002
6482951	Isoindolin-1-one glucokinase activators Isoindolin-1-one-substituted propionamide glucokinase activators which increase insulin secretion in the treatment of type II diabetes....	11/19/2002
6476028	Compounds and methods A method of treating a CCR5-mediated disease state in mammals which comprises administering to a mammal in need of such treatment, an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof. ##STR1##...	11/05/2002
6391896	3-Tetrahydropyridin-4-yl indoles for treatment of psychotic disorders The invention is related to the following compounds: ##STR1## wherein all variables are as defined in the specification. The compounds are useful for treating psychotic disorders....	05/21/2002
6365617	Indole and indazole urea-peptoids as thrombin receptor antagonists The invention is directed to novel indole and indazole urea-peptoid compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, an...	04/02/2002
6365606	6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity Novel compounds which are effective PDE IV inhibitors are disclosed. The compounds possess improved PDE IV inhibition compared to theophylline or rolipram, with improved selectivity with regard to, e.g., PDE V inhibition. The present invention includes co...	04/02/2002
6344468	Substituted isoindolones and their use as cyclic GMP modulators in medicaments The present invention relates to substituted isoindolone derivatives of the formula I, ##STR1## in which R1, R2, R3, R4, R5, R6 and R7 are as defined in the claims, which are use...	02/05/2002
6337344	Indole derivatives as inhibitors or factor Xa The present invention relates to the inhibition of blood clotting proteins, and more particularly, to indole derivatives of formula (I), in which R1a, R1b, R1c R1d, R2, R3, R4 and A a...	01/08/2002
6262080	3-(thio-substitutedamido)-lactams useful as inhibitors of matrix metalloproteinase The present invention provides novel thio-substitutedamido lactam derivatives of the formula ##STR1## useful in as inhibitors of matrix metallo-proteinases (MMPs)....	07/17/2001
6262268	Process and intermediates to a tetrahydro-[1,8]-naphthyridine A novel process is provided for the preparation of 3-(5,6,7,8-tetrahydro-[1,8]-naphthyridin-2-yl)-propylamine which is useful in the synthesis of ଱v integrin receptor antagonists. Also provided are useful intermediates obtained from the process....	07/17/2001
6245774	Tri-substituted phenyl or pyridine derivatives Compounds of general formula (1) are described: ##STR1## wherein .dbd.W-- is (1) .dbd.C(Y)-- where Y is a halogen atom, or an alkyl or --XRa group where X is --O--, --S(O)m -- [where m is zero or an integer of value 1 or 2], or --N(R...	06/12/2001

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Class 546/277.1 - Bicyclo ring system which is isoindole (including hydrogenated)