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| Number | Title | Issue Date |
| 7977488 | 1-heterocyclylsulfonyl, 2-aminomethyl, 5-(hetero-) aryl substituted 1-H-pyrrole derivatives as acid secretion inhibitors The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monoc... | 07/12/2011 |
| 7888512 | Synthesis of nicotine derivatives from nicotine Methods of synthesizing nicotine analogs and derivatives are described. In some embodiments the methods utilize an alkyl or aryl silyl-substituted nicotine analog intermediate. Intermediates useful for the synthesis of nicotine and nicotine analogs are also describe... | 02/15/2011 |
| 7820826 | Synthesis and regioselective substitution of 6-halo-and 6-alkoxy nicotine derivatives The present invention provides active compounds for modulating nicotinic acetylcholine receptors and methods of making the same. The methods of preparing the active compounds utilize different intermediate compounds. ... | 10/26/2010 |
| 7553968 | Synthesis of nicotine derivatives from nicotine Methods of synthesizing nicotine analogs and derivatives are described. In some embodiments the methods utilize an alkyl or aryl silyl-substituted nicotine analog intermediate. Intermediates useful for the synthesis of nicotine and nicotine analogs are also describe... | 06/30/2009 |
| 7514562 | Urea derivatives and their use as vanilloid receptor antagonists in the treatment of pain Compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein P, P′, W, R1, R2, n, p, q, r, s and t are as defined in the specification, processes for preparing such compo... | 04/07/2009 |
| 7501520 | Regioselective halogenation of nicotine and substituted nicotines A first aspect of the present invention is a method for of making a compound of Formula Ia or Formula Ib: wherein X is halo, by (a) metalating a precursor compound to form an organometallic intermediate, and then reacting t... | 03/10/2009 |
| 7446205 | Method for making nicotine hapten A high yielding and short process for preparing the 3′-aminomethylnicotine hapten of general formula I permits the isolation of the hapten in very pure quantities. The process can be adapted for the synthesis of a single ... | 11/04/2008 |
| RE40525 | Hepatitis C inhibitor tri-peptides A racemate diastereoisomer and optical isomer of a compound of formula (I): wherein B is H, a C6 or C10 aryl, C7-16 aralkyl; Het or (lower alkyl)-Het, all of which may be optionally substituted wi... | 09/30/2008 |
| 7399765 | Substituted diazabicycloalkane derivatives Compounds of formula (I) Z-Ar1—Ar2 (I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substitute... | 07/15/2008 |
| 7396843 | 5′-carbamoyl-1,1′-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors. ... | 07/08/2008 |
| 7390907 | Vanilloid receptor ligands and their use in treatments Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascu... | 06/24/2008 |
| 7371768 | Pyrazol derivatives, pest control agent comprising the same as active ingredient, and process for producing the same The present invention relates to pest control agent having systemic activity and a high safety along with a wide insecticidal spectrum and excellent insecticidal activity, which are 1-aryl-3-cyano-5-pyridylalkylaminopyrazole derivatives represented by formula (1): | 05/13/2008 |
| 7368470 | Substituted 3-pyrrolidine-indole derivatives Substituted 3-pyrrolidine-indole derivatives and methods for their production. Also pharmaceutical compositions containing these compounds and the use of these substances in methods of treatment, in particular treatment of pain and/or depression. ... | 05/06/2008 |
| 7365092 | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease The present invention relates to compounds of formula I: or pharmaceutically acceptable salts thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they ac... | 04/29/2008 |
| 7361768 | Synthesis of nicotine derivatives from nicotine Methods of synthesizing nicotine analogs and derivatives are described. In some embodiments the methods utilize an alkyl or aryl silyl-substituted nicotine analog intermediate. Intermediates useful for the synthesis of nicotine and nicotine analogs are also describe... | 04/22/2008 |
| 7358263 | Fused bicyclic-substituted amines as histamine-3 receptor ligands Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands... | 04/15/2008 |
| 7323462 | Morpholine dopamine agonists Compounds of formula (I), (Ia) and (Ib) useful as a medicament. ... | 01/29/2008 |
| 7317010 | Thieno-pyrrole compounds as antagonists of gonadotropin releasing hormone The invention relates to a group of novel thieno-pyrrole compounds of Formula (I), wherein: R1, R2, R4, R5, R6, R6a, R7, R8, A and ... | 01/08/2008 |
| 7304159 | Ligands and catalyst systems thereof for ethylene oligomerisation to linear alpha olefins Mixed bis-imine pyridine ligands of formula (I), wherein Z1, which is different from Z2, is an optionally substituted aryl group; and Z2 comprises an optionally substituted heterohydrocarbyl moiety, or an optionally substituted aryl ... | 12/04/2007 |
| 7297694 | Pyridylfurans and pyrroles as Raf kinase inhibitors Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy. ... | 11/20/2007 |
| 7294647 | Kappa agonist compounds and pharmaceutical formulations thereof Compounds having kappa opioid agonist activity, compositions containing them and 5 method of using them as analgesics and pruritic agents are provided. The compounds of formulae I, II, III and IV have the structure: ... | 11/13/2007 |
| 7279470 | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The present compounds are inhibitors of hormone-sensitive lipase and may... | 10/09/2007 |
| 7276524 | Pyridyl alkane acid amides as cytostatics and immunosuppressives The invention relates to new pyridyl alkane acid amides according to general formula (I) as well as methods for their production, medicaments containing these compounds as well as their medical use, especially in the treatment of tumors or for immunosuppression ... | 10/02/2007 |
| 7276500 | Substituted amides, their preparation and use An amide of the formula I and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the following meanings:... | 10/02/2007 |
| 7262207 | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and v... | 08/28/2007 |
| 7256203 | Dicationic 2,5-diarylfuran aza-analogs as anti-protozoan agents A compound of Formula (I): wherein: X is selected from the group consisting of O, S, and NR17, where R17 is hydrogen or lower alkyl; A and... | 08/14/2007 |
| 7256188 | 3-aminoalkyl-2-aryl-indole derivatives and their use as GnRH antagonists The present invention relates to compounds of formula I which are antagonists of gonadotropin releasing hormone (GnRH) activity. The invention also relates to pharmaceutical formulations, the use of a compound of the present invention in the manufacture of a medicam... | 08/14/2007 |
| 7247735 | Octupolar molecules used as organic semiconductors In the case of the materials according to the invention, the charge carrier mobility in the correspondingly prepared films is achieved if the molecules are composed in such a way that side chains—consisting of conjugated aromatic or heteroaromatic systems—are at... | 07/24/2007 |
| 7247648 | N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones Compounds of Formula (I) are effective in the treatment of a microbial infection. ... | 07/24/2007 |
| 7241745 | Pyridyl alkene and pyridyl alkine acid amides as cytostatics and immunosupressives The invention relates to a new pyridyl alkene and pyridyl alkine acid amides according to the general formula (I) as well as methods for their production, medicaments containing these compounds as well as their m... | 07/10/2007 |
| 7235566 | Pyridinone derivatives for treatment of atherosclerosis Compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis. ... | 06/26/2007 |
| 7220761 | Compounds and methods for controlling fungi, bacteria and insects The present invention includes compounds of pyridinium salts and methods of their use for industrial uses. The present invention also relates to methods of controlling fungi and/or bacteria. The present invention may also be used to control insects. ... | 05/22/2007 |
| 7214678 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain According to the invention there is provided a compound the formula I; wherein A, X, B, R1, R2, R3 and R4 are as defined in the specification. | 05/08/2007 |
| 7205305 | Inhibitors of p38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceut... | 04/17/2007 |
| 7189755 | Pyrrolidine melanocortin-specific compounds Melanocortin receptor-specific pyrrolidine compounds having the structure: and stereoisomer and pharmaceutically acceptable salts thereof, where R1, R2, and R3 are as described in... | 03/13/2007 |
| 7186843 | Aminomethylpyrrolidine derivatives having aromatic substituents This invention provides a quinolone derivative having potent antibacterial activity against various bacteria including drug-resistant strains which is a compound of the following formula wherein R1 is an optionally substituted aromatic group, a salt of th... | 03/06/2007 |
| 7186722 | 2-heteroaryl-3,4-dihydro-2h-pyrrole derivatives and the use thereof as pesticides Novel Δ1-pyrrolines of the Formula (I) in which R1, R2, R3 and Het have the meanings given in the description, a plurality of processes for prep... | 03/06/2007 |
| 7183297 | Biphenyl-derivatives as p38-kinase inhibitors Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors. ... | 02/27/2007 |
| 7179806 | Δ1-pyrrolines used as pesticides The invention relates to novel Δ1-pyrrolines of the formula (I) in which R1, R2, R3, m, and Q have the meanings given in the disclosure, to a plurality of processes fo... | 02/20/2007 |
| 7173129 | Sulfonamide-substituted chalcone derivatives and their use to treat diseases The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula or its pharmaceutically acceptable salt or ester, wherein the substituents are defined in the ... | 02/06/2007 |
