"That the automobile has practically reached the limit of its development is suggested by the fact that during the past year no improvements of a radical nature have been introduced."
|8344150||Pyrrole end-capped bipyridine assay powder for selective detection of zinc ions and a process for the preparation thereof|
The present invention provides pyrrole end-capped bipyridine derivative having a general formula (1) useful for the detection of zinc ions in solution. The present invention also provides a process for the preparation of pyrrole end-capped bipyridine derivative havi...
|8247570||Process for preparing 2-amino-5-cyanobenzoic acid derivatives|
Disclosed is a method for preparing a compound of Formula 1 comprising contacting a compound of Formula 2 with a metal cyanide reagent, a copper(I) salt reagent, an iodide salt reagent and at least one compound of Formula 3 ...
This invention provides compounds of Formula 1, their N-oxides and agriculturally suitable salts wherein R1, R2, R3, R4a, R4b and R
|8076487||Pyridone derivative and herbicide|
A pyridone derivative represented by Formula  or an agriculturally acceptable salt thereof: wherein R1 is a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, or the...
|8026368||Hydrazide compounds and thrombopoietin receptor activators|
Compounds effective for preventing, treatment or improving diseases against which activation of the thrombopoietin receptor is effective are provided. A compound represented by the formula (I) (wherein R1, R2, R3, L1
|7514561||Pesticidal 5-(acylamino) pyrazole derivatives|
Substituted-acylaminopyrazole derivatives of formula (I): or salts thereof, wherein the various symbols are as defined in the description, processes for their preparation, compositions thereof and m...
|7442799||Preparation and use of 2-substituted-5-oxo-3-pyrazolidinecarboxylates|
A method is disclosed for preparing a 2-substituted-5-oxo-3-pyrazolidinecarboxylate compound of Formula I. The method comprises contacting a succinic acid derivative of the formula R1OC(O)C(H)(X)C(R2a)(R2b)C(O)Y (i.e. Formula II)wher...
This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for the treatmen...
|7390907||Vanilloid receptor ligands and their use in treatments|
Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascu...
Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comp...
|7253290||Pyrazole derivatives as GnRH inhibitors|
The invention relates to a group of novel thieno-pyrrole compounds of Formula (I): wherein: R1, R2, R5, R6, R6a, R7, R8, A, B and M are...
This invention provides compounds of Formula 1, their N-oxides and agriculturally suitable salts wherein R1, R2, R3, R4a, R4b
|7223777||Compounds for the management of aging-related and diabetic vascular complications, process for their preparation, therapeutic and cosmetic uses thereof|
The invention discloses a new clause of a five membered heterocylic ring compounds of general formula I and its pharmaceutically or cosmetically acceptable salts, wherein R1, R2, R3, R4, R5, A, B, X and Y are as ...
|7214678||Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain|
According to the invention there is provided a compound the formula I; wherein A, X, B, R1, R2, R3 and R4 are as defined in the specification.
|7199138||Substituted anthranilamides for controlling invertebrate pests|
This invention provides compounds of Formula I, N-oxides and salts thereof wherein A, B, R1 through R5, R7 through R9, X and Y are as defined in the disclosure.
|7199246||Process for the preparation of pesticidal compounds|
A process for the preparation of a compound of general formula (I), wherein R1 is CN or CSNH2; R2 is hydrogen or chloride; and R3 is halogen or haloalkyl or haloalkoxy or SF5 which process comprises reacting a c...
|7183296||Anti-HIV pyrazole derivatives|
The present invention comprises novel and known pyrazole derivatives having anti-HIV activity, a process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine. In particular, the compounds of formula I are inhibitors of the hum...
|7179823||5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity|
A compound of formula (I) F wherein R1 represents a hydrocarbon group which may be substituted or a heterocyclic group which may be substituted; x represents a bond, an oxygen atom, a sulfur atom, or a group of the formula: —CO—, —CS—, —CR4...
This invention pertains to a compound of Formula I, its N-oxide or an agriculturally suitable salt of the compound (Formula I) wherein R1, R2, R3, R4, and R5 are as defined in the disclosure. Also disclosed are ...
This invention relates to nicotinamide derivatives of general formula (I): in which R1, X, Y, Z and R2 have the meanings defined herein, and to processes for the preparation of, intermediate...
|7115749||Substituted 5-oxo pyrazoles and [1,2,4]triazoles as antiviral agents|
The present invention provides compounds of formula I wherein X and R1–R7 are as defined herein. Compositions containing these compounds, and methods for inhibiting HCV RNA-dependent RNA polymerase and treating hepatitis C and related disorde...
|7105556||Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method|
Compounds are provided which have the structure wherein Q is C or N, X1 is C or N, and R1, R2, R2a, R2b, R2c, R3, Y, A, m, n, X2
|6967254||Substituted heterocyclic compounds and methods of use|
The present invention relates to compounds having the general formula or a pharmaceutically acceptable salt thereof. Also included is a method of prophylaxis or treatment of inflammation, rheumatoid arthritis, Pagets d...
|6965032||Substituted dihydro 3-halo-1h-pyrazole-5-carboxylates and their preparation and use|
This invention relates to a compound of Formula I, a method for its preparation and its use in the preparation of a compound of Formula II wherein R1, R2, R3, X and n are as defined in the disclosure. This invention also discloses pr...
|6958354||Pyrazole compounds as transforming growth factor (TGF) inhibitors|
Novel pyrazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming gro...
|6951876||Sulfamoylheteroaryl pyrazole compounds as anti-inflammatory/analgesic agents|
This invention relates to a compound of the formula: or a pharmaceutically acceptable salt thereof, wherein A and R1 are each an optionally substituted 5 to 6-membered heteroaryl, wherein the heteroaryl is o...
|6900230||Heterocyclo-alkylsulfonyl pyrazoles as anti-inflammatory/analgesic agents|
The present invention relates to compounds of the formula wherein R1, R3, R5, R6, and A are defined as in the specification, to pharmaceutical compositions containing them an...
|6872690||Herbicidal 2-alkynyl-pyri (mi) dines|
The invention relates method of combating undesired plant growth at a locus, comprising application to the locus of an effective amount of at least one compound of formula (I): wherein R1
|6864252||Hydrazinyl and nitrogen oxide pyrazoles|
The present invention relates to hydrazinyl and nitrogen oxide pyrazoles of the formula I: wherein the ring of the formula (R5)-A-(SOmR4), m, X, R1 through R5 are ...
|6852740||Pyrazole derivatives as p38 kinase inhibitors|
A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula I wherein Q, R1, R2, R3 and R
The present invention relates to 5-(alkylidene-cycloalkyl)-pyrazoles and 5-(alkylidene-heterocyclyl)-pyrazoles of the formula I: wherein the ring of the formula (R5)-A-(SOmR4), m, B, ri...
|6812347||Processes for the preparation of pesticidal compounds and novel intermediates thereof|
A process for the preparation of a compound of the formula (I): wherein R1 is CN or CSNH2; X is N or CR4; R2 and R4 are each independently hydrogen or chloro; R
|6794512||Efficient synthesis of 5-heteroatom-containing -pyrazoles|
An efficient synthesis of sulfonyl pyrazoles of formula I: wherein the ring of the formula (R5)-A-(SOmR4), m, R1 through R9 are as defined in the specification, comp...
|6794336||Herbicidal substituted pyridines, their preparation, and their use as herbicides and plant growth regulators|
The present invention relates to a compound of the formula (I) or salt thereof in which R1 is identical or different at each occurrence and is H, halogen, CN, nitro, SF5, (C1-C
|6756373||Pharmaceutically active compounds|
There is provided a compound of formula I: wherein X represents O or NR5 R4 represents H, halo, cyano, nitro, halo(loweralkyl), OR6, OC(O)R7, C(O)R8, ...
|6750338||Process for making 5-substituted pyrazoles|
This invention relates to a novel process of preparing selected 5-substituted pyrazoles useful as p38 kinase and COX-2 inhibitors. ...
|6699887||Anti-HIV pyrazole derivatives|
The present invention comprises novel and known pyrazole derivatives having anti-HIV activity, a process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine. In particular, the compounds of formula I are inhibitors...
|6664277||Prenylation inhibitors containing dimethylcyclobutane and methods of their synthesis and use|
The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein...
|6620943||Process for preparing 4-trifluoromethylsulfinylpyrazole derivative|
A process for the preparation of a compound of formula (I) ##STR1## comprising oxidizing a compound of formula (II) ##STR2## with trifluoroperacetic acid in the presence of a corrosion inhibiting compound such as boric acid. Also, a process for preparing ...
|6613776||Pyrazole compounds useful as protein kinase inhibitors|
This invention describes novel pyrazole compositions comprising a pharmaceutically acceptable carrier and a compound of formula V: ##STR1## wherein Z1 is N, CRa, or CH, and Z2 is N or CH, provided one of Z1 and ...