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| Number | Title | Issue Date |
| 8178683 | Antimicrobial ortho-fluorophenyl oxazolidinones for treatment of bacterial infections The present invention provides certain ortho-fluorophenyl oxazolidinones of the following formula I: or pharmaceutically acceptable salts or prodrugs thereof that are antibacterial agents, pharmaceutical compositions contai... | 05/15/2012 |
| 8158801 | Violet laser excitable dyes and their method of use The present invention provides dye compounds optimally excited at about 400 nm and have a Stokes shift of at least about 80 nm. These dyes find use in detection of analyte in a sample and the preparation of dye-conjugates. ... | 04/17/2012 |
| 8124778 | Tricyclic inhibitors of fatty acid amide hydrolase A series of substituted oxazole compounds having an alpha keto side chain at the 2 position and an aromatic, heteroaromatic or heterocycle substituent at the 5 position are disclosed. These compounds exhibit inhibition of fatty acid amid hydrolase and arc useful for... | 02/28/2012 |
| 7994331 | Heterocycle-substituted benzimidazole derivative A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: (I) wherein X1 to X4 independently represent a carbon atom or the like; the ring A represents a 5- to 6-membered heteroaryl having 1 to 4 heteroatoms indep... | 08/09/2011 |
| 7449583 | Process for the preparation of 4-(8-chloro-5 6-dihydro-11h-benzo-(5 6)-cyclohepta-(1 2b)-pyridin-11-ylidene-1-piperidiniecarboxylic acid ethyl ester (loratadine) A process and new oxazolinic intermediates for the preparation of 4-(8-chloro-5,6-dihydro-11H-benzo-[5,6]-cyclohepta-[1,2-b]-pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester (loratadine) is described. The process starts from 2-(4,4-dimethyl-4,5-dihydrooxa... | 11/11/2008 |
| 7442486 | Radiation-sensitive compositions comprising oxazole derivatives and imageable elements based thereon Radiation-sensitive element comprising: (a) one or more types of monomers each comprising at least one ethylenically unsaturated group accessible to a free-radical polymerization, (b) at least one sensitizer, (c) at least one coinitiator capable of forming free radi... | 10/28/2008 |
| 7420055 | Aryl sulfonamides Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful... | 09/02/2008 |
| 7390907 | Vanilloid receptor ligands and their use in treatments Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascu... | 06/24/2008 |
| 7282501 | Modulators of peroxisome proliferator activated receptors (PPAR) The present invention is directed to a compound of formula I, and pharmaceutically acceptable salts, solvates, hydrates or stereoisomer thereof, which are useful in treating Syndrome X, Type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hyperte... | 10/16/2007 |
| 7273936 | Oxazole and thiazole compounds as transforming growth factor (TGF) inhibitors Novel oxazole and thiazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of tran... | 09/25/2007 |
| 7253187 | Heterocyclic inhibitors of ERK2 and uses thereof Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein Z1 and Z2 are each independently nitrogen or CH and Ring A, TmR1... | 08/07/2007 |
| 7238716 | Alkanoic acid derivatives process for their production and use thereof An alkanoic acid derivative useful as a prophylactic or therapeutic agent of diabetes mellitus, hyperlipidemia, impaired glucose tolerance and the like can be provided by a compound represented by the formula whe... | 07/03/2007 |
| 7226940 | Substituted heterocycles for the treatment of diabetes and other diseases The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymph... | 06/05/2007 |
| 7214678 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain According to the invention there is provided a compound the formula I; wherein A, X, B, R1, R2, R3 and R4 are as defined in the specification. | 05/08/2007 |
| 7214693 | Heterocyclic selective androgen receptor modulators and methods of use thereof This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and a... | 05/08/2007 |
| 7211591 | Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate there... | 05/01/2007 |
| 7199124 | JNK inhibitor The present invention relates to a c-Jun N-terminal kinase inhibitor containing an azole compound (I) substituted by a nitrogen-containing aromatic group having substituent(s)(except a compound represented by the formula: ... | 04/03/2007 |
| 7192974 | Hydroxymethyl substituted dihydroisoxazole derivatives useful as antibiotic agents Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, (I) R1a is NH(C═W)R5 or (a); W is O or S; R2 and R3 are for example H or F; R1 is for example hydrogen, or ha... | 03/20/2007 |
| 7189712 | 1,3-Oxazole compounds for the treatment of cancer Oxazole derivatives, which are useful as VEGFR2, CDK2, and CDK4 inhibitors are described herein. The described invention also includes methods of making such oxazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases. | 03/13/2007 |
| 7186738 | Antibacterial oxalidinones Compounds of the formula (I), or a pharmaceutically-acceptable salts, or in-vivo-hydrolysable esters thereo Formula (I): wherein N-HeT is for example triazolyl; Q is for example phenyl or pyridyl, substituted with: T is for example selected from (TAa1 to TAa12) such... | 03/06/2007 |
| 7183278 | Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component Disclosed are novel compounds useful for the control of harmful organisms, harmful organism control agents using the same, and processes for producing the novel compounds. The useful novel compounds according to the present invention include compounds represented by... | 02/27/2007 |
| 7173048 | Indolyl derivatives as liver-X-receptor (LXR) modulators The invention relates to compounds of formula (I): and pharmaceutically acceptable salts and pharmaceutically acceptable esters thereof, wherein R1, R2, R3, R4, R5... | 02/06/2007 |
| 7157456 | Substituted oxazolidinones and their use in the field of blood coagulation The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxi... | 01/02/2007 |
| 7148219 | Biaryl heterocyclic compounds and methods of making and using the same The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety th... | 12/12/2006 |
| 7144900 | Pharmaceutical composition Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for prophylaxis ... | 12/05/2006 |
| 7141583 | Oxazolidinone derivatives with antibiotic activity Compounds of the formula (I), or a pharmaceutically acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein HET is an N-linked 5-membered heteroaryl ring, optionally substituted on a C atom by an ox... | 11/28/2006 |
| 7129259 | Halogenated biaryl heterocyclic compounds and methods of making and using the same The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having at least one halogenated hydrocarbon moiety, a biaryl moiet... | 10/31/2006 |
| 7122666 | Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses Compounds having activity against production of an inflammatory cytokine of formula (I)′: A′ is pyrrole; R1′ is phenyl or naphthyl; R2′ is pyridyl or pyrimidinyl; R3′ is... | 10/17/2006 |
| 7119104 | Activator of peroxisome proliferator-activated receptor delta A compound represented by the formula (I) or a salt of the compound, and a PPAR-δ activator which contains the compound or salt as the active ingredient: (wherein A represents O or S; B | 10/10/2006 |
| 7112599 | Oxazole compounds for the treatment of neurodegenerative disorders The present invention relates to compounds of the Formula wherein R3, R5, R6, R7, and Z, and other variables enumerated under one or more of R3, R5 | 09/26/2006 |
| 7105547 | Antimicrobial 1-aryl dihydropyridone compounds The present invention provides antibacterial agents of formula I, or a pharmaceutically acceptable salt thereof. ... | 09/12/2006 |
| 7105556 | Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure wherein Q is C or N, X1 is C or N, and R1, R2, R2a, R2b, R2c, R3, Y, A, m, n, X2 | 09/12/2006 |
| 7091360 | Process for preparing heteroaryl and unsaturated heterocycloalkylmagnesium reagents and uses thereof The present invention is directed to a novel process for preparing heteroaryl and unsaturated heterocycloalkylmagnesium reagents that are useful in the synthesis of a variety of pharmaceuticals, in particular certain cysteine protease inhibitors. ... | 08/15/2006 |
| RE39140 | Heterocyclic compounds Novel heterocyclic compounds of the formula wherein, R1 represents a hydrogen atom or an alkyl group, A represents an ethylene group which may be substituted by alkyl or a trimethylene group which may be substituted by... | 06/20/2006 |
| RE39131 | Heterocyclic compounds Novel heterocyclic compounds of the formula wherein, R1 represents a hydrogen atoms or an alkyl group, A represents an ethylene group which may be substituted by alkyl or a trimethylene group which may be substituted b... | 06/13/2006 |
| RE39130 | Heterocyclic compounds Novel heterocyclic compounds of the formula wherein, R1 represents a hydrogen atom or an alkyl group, A represents an ethylene group which may be substituted by alkyl or a trimethylene group which may be substituted by... | 06/13/2006 |
| RE39129 | Heterocyclic compounds Novel heterocyclic compounds of the formula wherein, R1 represents a hydrogen atom or an alkyl group, A represents an ethylene group which may be substituted by alkyl or a trimethylene group which may be substituted by... | 06/13/2006 |
| RE39127 | Heterocyclic compounds Novel heterocyclic compounds of the formula wherein, R1 represents a hydrogen atom or an alkyl group, A represents an ethylene group which may be substituted by alkyl or a trimethylene group which may be substituted by... | 06/13/2006 |
| 7056933 | Heterocyclo-alkylsulfonyl pyrazoles The present invention relates to heterocyclo alkylsulfonyl pyrazoles of the formula I: wherein the ring of the formula (R5)—A—(SOmR4), m, X, R1 through R5 | 06/06/2006 |
| 7049271 | Phenyl-substituted 2-enamino-ketonitriles The present invention relates to novel phenyl-substituted 2-enamino-ketonitriles of the formula (I): in which Ar, X, Z, Y and K are each as defined in the description, to a plurality of pro... | 05/23/2006 |
