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| Number | Title | Issue Date |
| 7579475 | S-(-)-amlodipine nicotinate and process for the preparation thereof The present invention provides a novel salt of S-(−)-amlodipine, i.e., a nicotinic acid salt of S-(−)-amlodipine, a process for preparing the same, and a pharmaceutical composition comprising the same as an active ingredient. ... | 08/25/2009 |
| 7291580 | 6-(1,1-difluoroalkyl)-4-aminopicolinates and their use as herbicides 4-Aminopicolinic acids having (1,1-difluoroalkyl) substituents in the 6-position and their amine and acid derivatives are potent herbicides demonstrating a broad spectrum of weed control. ... | 11/06/2007 |
| 7232817 | α- and β-amino acid hydroxyethlamino sulfonyl urea derivatives useful as retroviral protease inhibitors α- and β-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ... | 06/19/2007 |
| 6916800 | Combination therapy including a matrix metalloproteinase inhibitor and an antineoplastic agent The present invention provides methods to treat or prevent neoplasia disorders in a mammal using a combination of a matrix metalloproteinase inhibitor and an antineoplastic agent. ... | 07/12/2005 |
| 6858598 | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia A method of using an MMP inhibitor and optionally radiation therapy, and one or more antineoplastic agents of the topoisomerase class selected from the group consisting of irinotecan and topotecan, as a combination therapy for the treatment of neoplasia is disclosed... | 02/22/2005 |
| 6833378 | Corticotropin releasing factor antagonists Corticotropin-releasing factor (CRF) antagonists having the formulae wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 and R17 are as defined... | 12/21/2004 |
| 6818200 | Method of using deuterated calcium channel blockers A method of enhancing the efficiency and increasing the duration of action of drugs (e.g. dihydropyridines and anti-bacterials) and particularly of nifedipine and penicillins wherein one or more hydrogen atoms are deuterated and wherein the deuterated drug has unexp... | 11/16/2004 |
| 6726894 | Transport vehicles for macromolecules The invention relates to new compounds with the general formula I for use as a tool to introduce macromolecules into cells. The invention further relates to compositions for introducing macromolecules into cells, comprising vesicles formed by at least one compound i... | 04/27/2004 |
| 6699892 | Pharmaceutically acceptable salt of amlodipine and method of preparing the same The present invention discloses a novel and improved pharmaceutical salt, nicotinate, of amlodipine having the following formula: ##STR1## The present invention also discloses methods for preparing and using the same.... | 03/02/2004 |
| 6624178 | Compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses thereof The invention discloses novel compounds of the pyridinium series useful for the management of diabetes and aging-related vascular complications, including kidney disease, nerve damage, atherosclerosis, retinopathy, dermatological disorders and discolorati... | 09/23/2003 |
| 6608060 | Inhibitors of p38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides... | 08/19/2003 |
| 6569860 | Alkoxycarbonylamino heteroaryl carboxylic acid derivatives as IP antagonists This invention relates to compounds which are IP receptor antagonists and which are represented by Formula (I): ##STR1## wherein G2 is a heteroaryl group containing one or two nitrogen atoms substituted with a carboxylic acid group, said hetero... | 05/27/2003 |
| 6503928 | Arylpiperidine and aryl-1,2,5,6-tetrahydropyridine amide derivatives Compounds of the formula ##STR1## wherein R1, R2, R3, R4, X and n are defined in the specification, are useful for the treatment of anxiety, depression and related CNS disorders, and other related conditions suc... | 01/07/2003 |
| 6495576 | Aminal diones as potassium channel openers Compounds of formula (I) ##STR1## may be useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal... | 12/17/2002 |
| 6350766 | Dihydropyridine derivative Dihydropyridine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel. They are used as remedies for various diseases relating to... | 02/26/2002 |
| 6313148 | Aromatic amine compounds that antagnoize the pain enhancing effects of prostaglandins Compounds antagonistic of the pain enhancing effects of prostaglandins are disclosed. The compounds comprise an optionally-substituted A ring with a --CH(R3)N(R2)B--R1 and --OD groups positioned in a 1,2 relationship to on... | 11/06/2001 |
| 6143770 | Tocotrienols and tocotrienol-like compounds and methods for their use The present invention relates to novel tocotrienols and tocotrienol-like compounds displaying biological activity. The tocotrienols and tocotrienol-like compounds of this invention may be conveniently obtained from biological sources or by chemical synthe... | 11/07/2000 |
| 6133443 | Optically active 1,4-dihydropyridine derivatives and process for the preparation thereof Optically active 1,4-dihydropyridine derivatives represented by general formula (I) and anion salts thereof and a production method therefor: ##STR1## (wherein R1 represents a C1-6 alkyl group, R2 represents a nitroge... | 10/17/2000 |
| 6066655 | 4-phenyl-3-substituted 1,4-dihydropyridine esters 4-Phenyl-3-substituted 1,4-dihydropyridine esters are prepared by reaction of benzaldehydes with ketoesters and enamines, if appropriate with isolation of the ylidene intermediate products, or by esterification of corresponding dihydropyridinecarboxylic a... | 05/23/2000 |
| 6022872 | - and ଲ-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors - and ଲ-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 02/08/2000 |
| 6020335 | (N-(pyridinylmethyl)-heterocyclic)ylideneamine compounds as nicotinic acetylcholine receptor binding agents An (N-(pyridinylmethyl)-heterocyclic)ylideneamine compound of the formula ##STR1## wherein R3, A, and B are as described below, and its pharmaceutically acceptable salts and prodrugs. Compounds of the formula I and their pharmaceutically a... | 02/01/2000 |
| 6001836 | Dihydropyridine NPY antagonists: cyanoguanidine derivatives A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of cyanoguanidine derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). ##STR1## As antagonists of NPY-induced feeding behavior, these compounds are ex... | 12/14/1999 |
| 5962479 | Corticotropin releasing factor antagonists Corticotropin-releasing factor (CRF) antagonists having formulae (I), (II) or (III) wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 and R17 are as defined in the description, a... | 10/05/1999 |
| 5955632 | Seco-d steroids active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing them New seco-D steroid derivatives, processes for their preparation and pharmaceutical compositions are provided, which are active on the cardiovascular system. The seco-D steroid derivatives have the following general formula (I): ##STR1##... | 09/21/1999 |
| 5843950 | 1,4-dihydropyridine compound and pharmaceutical composition containing the same A 1,4-dihydropyridine compound having the formula (I): ##STR1## wherein, R1 indicates --COO--A--(3-pyridyl), A indicates a C3 -C6 straight chain alkylene group in which one piperazine may be interposed; R2 ... | 12/01/1998 |
| 5801175 | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the above formula to a biological system.... | 09/01/1998 |
| 5789592 | Phosphonated polypyridyl compounds and their complexes A compound in metal-free or metal complex form of formula (1) to (3) in which R is hydrogen or C1-30 alkyl; X is hydrogen, halogen (preferably Cl or Br) or C1-30 alkyl. ##STR1##... | 08/04/1998 |
| 5736274 | Conjugated N-fluoropyridinium salt-containing polymer and use of the same A polymer containing a recurring unit of a conjugated N-fluoropyridinium salt and an active material for a positive electrode, an electrolyte, a battery material for the positive electrode and a battery which use such a polymer. That polymer provides a ba... | 04/07/1998 |
| 5677461 | Method for producing chromium picolinate complex A method for producing chromium picolinate complex by the reaction of picolinic acid with chromium, wherein the reaction is carried out under the conditions of temperature of 70° C. and pH of 3.5 to 4.2.... | 10/14/1997 |
| 5670645 | Metal ion-ligand coordination complexes, antibodies directed thereto, and assays using such antibodies The present invention relates to the field of immunoassays for metal ions. The invention presents: metal ion-ligand coordination complexes ("MLC"), novel ligands, antibodies specific for MLC, immunoassays utiliizing the foregoing, and methods for selectin... | 09/23/1997 |
| 5668151 | Dihydropyridine NPY antagonists: piperidine derivatives A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of piperidine and tetrahydropyridine derivatives of 4-phenyl-1,4-dihydropyridines of Formula I. ##STR1## As antagonists of NPY-induced feeding behavior, these comp... | 09/16/1997 |
| 5614634 | Leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents Leukotriene-B4 analogs of formula I ##STR1## in which R1 means radical COOR2 with R2 meaning a hydrogen atom or a (C1 -C4)-alkyl group or R1 means radical CH2 OH,... | 03/25/1997 |
| 5576439 | Dihydropyridinecarboxylic acid anhydrides The invention relates to the compounds of formula I ##STR1## wherein R is lower alkyl or hydrogen; R1 is hydrogen, lower alkyl or aryl-lower alkyl; R2 is hydrogen, nitro, cyano trifluoromethyl, halo, lower alkoxy, lower alkyl, l... | 11/19/1996 |
| 5514693 | Imidazolyl and pyridyl derivatives of phenyl substituted 1,4-dihydropyridines and process for their preparation Imidazolyl and pyridyl derivatives of phenyl substituted 1,4-dihydropyridines of formula (I) ##STR1## wherein Het is ##STR2## A represents a direct linkage, --CH2 --, CH2 --CH2 -- or, when Het is ##STR3... | 05/07/1996 |
| 5512564 | Tricyclic thiazole and oxazole derivatives and pharmaceutical agents containing them The present invention concerns thiazolo- 2,3-a!pyrrole and oxazolo- 1,2-a!pyrrole derivatives of formula I ##STR1## in which HET represents a heterocyclic ring with 3-7 ring atoms which can be substituted by one, two or three residues R1 w... | 04/30/1996 |
| 5393730 | Nicotinic acid hydrazone compounds which have useful herbicidal compositions The invention relates to nicotinic acid hydrazone derivatives of formula I: ##STR1## in which the various symbols are as defined in the description, and their use as herbicides or as intermediates in the synthesis of herbicides.... | 02/28/1995 |
| 5389644 | 1,4-dihydropyridine compounds The compounds are 2,4-disubstituted 3-ethoxycarbonyl 5-methoxycarbonyl 6-methyl 1,4-dihydropyridines in their dextrorotatory form, useful to potentiate the activity of cytotoxic agents and to increase the sensitivity of tumor cells to antitumor agents. A ... | 02/14/1995 |
| 5380846 | Addition-curable silicone adhesive compositions and N-heterocyclic silane adhesion promoters Addition-curable platinum group metal catalyzed silicone compositions are provided which utilize an N-heterocyclic adhesion promoter, such as bis(trimethoxysilyltrimethylene) 2,6 pyridine dicarboxylate. Cohesive bonding is effected on both plastic and met... | 01/10/1995 |
| 5356909 | Substituted pyridine-2,4-dicarboxylic acid compounds and the use thereof and medicaments The invention relates to substituted pyridine-2,4-dicarboxylic acid derivatives of the formula I ##STR1## in which R1 and R2 have the meanings given. The invention also relates to a process for the preparation of the abovementio... | 10/18/1994 |
| 5354500 | Optically active carboxylic esters of oxygen-containing heterocycles as doping substances in liquid crystal mixtures and liquid crystal mixtures containing them Use of optically active carboxylic esters of oxygen-containing heterocycles as doping substances in liquid crystal mixtures and liquid crystal mixtures containing them. Optically active 1,3-dioxolane-4-carboxylic esters and oxirane-2-carboxylic esters of ... | 10/11/1994 |
