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| Number | Title | Issue Date |
| 7442702 | Prostaglandin agonists This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for the treatmen... | 10/28/2008 |
| 7399735 | Perfluoropolyether additives Compounds formed of (per)fluoropolyether chains and end groups having a pyridine structure, with structural formula: T1-CW1—O—Rf—CW2-T2 (I) wherein T1, T | 07/15/2008 |
| 7358397 | Preparation of halogenated 4-aminophenols The present invention relates to halogenated 4-aminophenols and to halogenated 4-(phenyidiazenyl)phenols, to a process for their preparation and to the use of the halogenated 4-hydroxyphenols for preparing active ingredients, especially in pharmaceuticals and agroch... | 04/15/2008 |
| 7291580 | 6-(1,1-difluoroalkyl)-4-aminopicolinates and their use as herbicides 4-Aminopicolinic acids having (1,1-difluoroalkyl) substituents in the 6-position and their amine and acid derivatives are potent herbicides demonstrating a broad spectrum of weed control. ... | 11/06/2007 |
| 7288541 | Propylcarbamate derivatives as inhibitors of serine and cysteine proteases The present invention includes ketone derivatives (I) and (II), which are useful as cathepsin K inhibitors. The described invention also includes methods of making such ketone derivatives as well as methods of using the same in the treatment of disorders, including ... | 10/30/2007 |
| 7262209 | Carbonyloxy-cyanomethyl compounds as antiparasitic agents The invention relates to compounds of the general formula wherein Ar1, Ar2, R4, R5, R6, R7, R8, W, X, a and b have the significances gi... | 08/28/2007 |
| 7157580 | Aminopyrimidine and aminopyridine anti-inflammation agents Aminopyrimidine and aminopyridine (I) compounds, compositions and methods useful in the treatment of inflammatory, metabolic or malignant conditions, are provided herein ... | 01/02/2007 |
| 7074742 | Pyridinyl amides and imides for use as fungicides Compounds of Formula (I), their N-oxides and agriculturally suitable salts are disclosed which are useful as fungicides formula (I), (II) wherein A is a substituted pyridinyl ring; B is a substituted pyridinyl ring; W is C=L or SOn is O or S; R1 | 07/11/2006 |
| 7045631 | Substituted 2-thio-3, 5-dicyano-4-phenyl-6-aminopyridines and their use as adenosine receptor-selective ligands Compounds of the formula (I) a process for preparing them, and their use as medicaments are described. ... | 05/16/2006 |
| 6977266 | Pyridone derivatives having affinity for cannabinoid 2-type receptor It was found that the compound having a binding activity to the cannabinoid type 2 receptor represented by the formula (I): wherein R1 is a group represented by the formula: —Y1... | 12/20/2005 |
| 6953798 | β-alanine derivates Alkanoic acid derivatives of formula (1) are described: Ar1(Alka)rL1Ar2CH(R1)C(Ra)(Ra′)R (1) Ar1 is an optionally substituted aromatic or... | 10/11/2005 |
| 6927225 | Fungicidal 2-pyridyl alkyl amides and their compositions, methods of use and preparation The present invention relates to compounds of Formula I: wherein: represents a 6-membered heterocyclic aromatic ring in which X1 is N, and X2, X | 08/09/2005 |
| 6908923 | Compositions and methods for treating heart failure Certain substituted benzamide derivatives of Formula I: selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including conges... | 06/21/2005 |
| 6906195 | Pyridone dyes, a process for the preparation and their use in the production of colored plastics or polymeric color particles The present invention relates to pyridone dyes of formula (1), wherein R is a radical —(CR′H)n—W, R′ is hydrogen, C1-C2alkyl or phenyl, Y is cyano, —CONH2 or —CH2SO3H, W is hydrogen, a rad... | 06/14/2005 |
| 6893650 | N2-phenylamidine derivatives The invention provides fungicidal compounds of formula (I) and salts thereof wherein: R1 is alkyl, alkenyl, alkynyl, carbocyclyl or heterocyclyl, each of which may be substituted, or hydrogen; R2 and R3, which may be the same or diff... | 05/17/2005 |
| 6881846 | Antiproliferative agents This invention relates to certain dioxodihydropyridine derivatives and certain methacrylic acid and furan derivative precursors thereof, processes for their preparation, pharmaceutical compositions containing such compounds and their use as anti-proliferative agents... | 04/19/2005 |
| 6881736 | Vitronectin receptor antagonists Compounds of the formula (I) are disclosed which are vitronectin receptor antagonists and are useful in the treatment of osteoporosis: wherein R1 is Het or Ar ... | 04/19/2005 |
| 6872690 | Herbicidal 2-alkynyl-pyri (mi) dines The invention relates method of combating undesired plant growth at a locus, comprising application to the locus of an effective amount of at least one compound of formula (I): wherein R1 | 03/29/2005 |
| 6844295 | Benzoxazole compound, process for producing the same, and herbicide The present invention relates to benzoxazole compounds represented by the following formula (I): wherein R1 to R4 may be the same or different from each other, and each re... | 01/18/2005 |
| 6833378 | Corticotropin releasing factor antagonists Corticotropin-releasing factor (CRF) antagonists having the formulae wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 and R17 are as defined... | 12/21/2004 |
| 6825204 | N-substituted 3-hydroxy-4-pyridinones and pharmaceuticals containing thereof N-substituted 3-hydroxy-4-pyridinones and metal chelates, methods of preparing N-substituted 3-hydroxy-4-pyridinones and metal chelates, and pharmaceutical compositions containing new N-substituted 3-hydroxy-4-pyridinones and/or their metal chelates. Use of N-substi... | 11/30/2004 |
| 6794398 | Preventive/remedies for liver diseases The invention provides an agent for the prophylaxis and treatment of liver disease and an activation inhibitor of hepatic stellate cells, which contains a compound having a Rho kinase inhibitory activity. The compound having a Rho kinase inhibitory activity, such as... | 09/21/2004 |
| 6794336 | Herbicidal substituted pyridines, their preparation, and their use as herbicides and plant growth regulators The present invention relates to a compound of the formula (I) or salt thereof in which R1 is identical or different at each occurrence and is H, halogen, CN, nitro, SF5, (C1-C | 09/21/2004 |
| 6780874 | Enamine derivatives Enamine derivatives of formula (1) are described: wherein R1 is a group Ar1L2Ar2Alk- in, which Ar1 is an aromatic or heteroaromatic group, L2 is a ... | 08/24/2004 |
| 6765096 | Tricyclic compound having acyloxymethoxycarbonyl side chain There are provided a compound represented by the formula (I): wherein X and X′ are —N(COOCR3R2OCOR1)—, —O— or the like, R1 is alkyl substituted with carbamoyl, lower ... | 07/20/2004 |
| 6683186 | 2,3-Disubstituted pyridine derivative, process for the preparation thereof, pharmaceutical composition containing the same, and intermediate therefor A compound of the formula (I) ##STR1## wherein A is O, S, CHR1 or NR2, R1 and R2 are H, lower alkyl, X1 and X2 are H, halogen, nitro, cyano, etc., Y1 is H, lower alkyl, Z1 | 01/27/2004 |
| 6673745 | Herbicidal 3,5-difluoropyridines The invention relates to novel compounds of formula I: ##STR1## wherein R, A, B and X have the meaning given in claim 1; and the agronomically acceptable salts or N-oxides thereof, and to herbicidal compositions containing such compounds as active ingredi... | 01/06/2004 |
| 6670380 | Pyridone inhibitors of fatty acid binding protein and method Compounds are provided having the formula: ##STR1## wherein A, Q, and X are as described herein. A method is also provided for treating diabetes and related diseases, especially Type II diabetes, employing such compounds alone or in combination with other... | 12/30/2003 |
| 6656958 | Substituted pyridine compounds useful for controlling chemical synaptic transmission The present invention is directed to a series of substituted pyridine compounds, a method for selectively controlling neurotransmitter release in mammals using these compounds, and pharmaceutical compositions containing these compounds. Preferred compound... | 12/02/2003 |
| 6610700 | Enamine derivatives Enamine derivatives of formula (1) are described: ##STR1## wherein R1 is a group Ar1 L2 Ar2 Alk- in which Ar1 is an aromatic or heteroaromatic group, L2 is a covalent bond or a linker atom ... | 08/26/2003 |
| 6608060 | Inhibitors of p38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides... | 08/19/2003 |
| 6605625 | Ortho, meta-substituted bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them Ortho, meta-substituted bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations including their use as antiarrhythmic active compounds, for example, for the treatment and prophylaxis of atrial arrhythm... | 08/12/2003 |
| 6596863 | Medical composition containing nitroetheneamine Derivative or salt there of as active constituent Process for producing a nitroetheneamine derivative ##STR1## or its stereoisomer, its tautomer or a salt thereof comprising reacting a compound of the formula ##STR2## with a compound of the formula R6 --CH2 NO2 to obtain ... | 07/22/2003 |
| 6562750 | Catalyst for the production of olefin polymers A catalyst composition for the polymerization of olefins is provided, comprising a bis(hydroxy aromatic nitrogen ligand) transition metal catalyst precursor and an activating cocatalyst.... | 05/13/2003 |
| 6562817 | Tricyclic compound The present invention provides a compound of the formula (I): ##STR1## wherein A ring, B ring and C ring are each independently optionally substituted aromatic carbocycle or optionally substituted 5- or 6-membered heterocycle which may fuse with benzene ring, ... | 05/13/2003 |
| 6555557 | 2,3-disubstituted pyridine derivatives, process for the preparation thereof, drug compositions containing the same and intermediates for the preparation A compound of the formula (I) ##STR1## wherein A is O, S, CHR1 or NR2, R1 and R2 are H, lower alkyl, X1 and X2 are H, halogen, nitro, cyano, etc., Y1 is H, lower alkyl, Z1 | 04/29/2003 |
| 6534447 | Herbicidal pyridine compounds The invention relates to novel compounds of formula I: ##STR1## wherein E, A, X1, X2, X3, Z, m, x and y have the meaning given in claim 1, and the agronomically acceptable salts or N-oxides thereof, and to herbicidal compo... | 03/18/2003 |
| 6498172 | Prostaglandin agonists and their use to treat bone disorders This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for t... | 12/24/2002 |
| 6495571 | Pyridine compounds, use and preparation thereof New pyridine compounds are provided along with their method of preparation. The compounds are useful as intermediates in preparing new anticancer agents. A few of the pyridine compounds are also useful for treating cancer.... | 12/17/2002 |
| 6492405 | Nitric oxide donors and pharmaceutical compositions containing them The present invention provides a compound containing at least one sulfhydryl group and at least one NO donor group, wherein said compound is a) a compound containing one or more sulfhydryl groups linked to at least one aromatic ring or a heteroaromatic ri... | 12/10/2002 |
