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| Number | Title | Issue Date |
| 8163927 | Azabicyclo [3.1.0] hexane derivatives as modulators of dopamine D3 receptors The present invention relates to certain azabicyclic compounds of formula (I)′: wherein the several groups are defined herein and are modulators of dopamine D3 receptors, e.g. to treat drug dependency, as antip... | 04/24/2012 |
| 8148535 | Potassium channel inhibitors The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like. ... | 04/03/2012 |
| 8067606 | Gyrase inhibitors and uses thereof The present invention relates to methods of treating, preventing, or lessening the severity of resistant bacterial infections in mammals, utilizing compounds of formula I or formula VII or pharmaceutically salts thereof. The present invention also relates to methods... | 11/29/2011 |
| 8058444 | Heterocycle-substituted pyridine derivative's salt or crystal thereof There is provided a heterocycle-substituted pyridine derivative's salt or a crystal thereof. The present invention provides an acid addition salt of 3-(3-(4-(pyridin-2-yloxymethyl)-benzyl)-isoxazol-5-yl)-pyridin-2-yl amine or a crystal thereof as well as process for... | 11/15/2011 |
| 8039630 | Cationic compound, dye compound and method of using the same, and optical information recording medium The present invention relates to a cationic compound denoted by the general formula (I). In general formula (I), Ar1 and Ar2 each independently denote an optionally substituted aryl group or aromatic heterocyclic group, L1 denotes a ... | 10/18/2011 |
| 7989631 | Hydrate forms of AMG706 The anti-angiogenic drug AMG 706 is provided in the mono-phosphate hydrate form. Also provided is AMG 706 drug substance wherein the AMG 706 is present, in at least a detectable amount, as AMG 706 phosphate dihydrate. Also provided are processes for preparing AMG 70... | 08/02/2011 |
| 7858800 | Biaryl derivatives The present invention relates to a compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, wherein: R1 is a linear or branched alkoxy group, a cycloalkoxy group, a linear o... | 12/28/2010 |
| RE41898 | Process for halomethyl ethers of hydroxyiminomethyl quaternary pyridinium salts A halide salt of a 1-(hydroxyiminomethyl-1-pyridino)-3-(halomethyl)-2-oxapropane is prepared by adding a pyridinealdoxime to a bis-halomethylether in such a manner that the bis-halomethylether is maintained in excess throughout the addition. This procedure produces ... | 10/26/2010 |
| 7714137 | Pyridyl substituted heterocycles useful for treating or preventing HCV infection The present invention relates to pyridyl substituted heterocycles and hydro isomers thereof and pharmaceutical compositions thereof that inhibit replication and/or proliferation of HCV virus. The present invention also relates to the use of the pyridyl heterocycles ... | 05/11/2010 |
| 7560564 | Heterocyclic diamide invertebrate pest control agents This invention provides compounds of Formula (I), N-oxides and suitable salts thereof, wherein A and B are independently O or S; each J is independently a phenyl ring, a naphthyl ring system, a 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membere... | 07/14/2009 |
| 7517992 | Non-nucleoside reverse transcriptase inhibitors A compound of the formula (Y): where; R1 is O, S; R2 is a nitrogen-containing heterocycle; R3 is H, C1-C3 alkyl; X is —(CR8R8′)n-D-(CR8R8′)m | 04/14/2009 |
| 7442701 | Amino-heterocycles as VR-1 antagonists for treating pain The present invention provides a compound of formula (I): wherein V represents NR5, O, S, SO or S(O)2; W and X each independently represent CH or N; Y represents N, CH or C—Ar2, with the proviso that at least one, but no more than ... | 10/28/2008 |
| 7439258 | Viral polymerase inhibitors A compound of the formula I: wherein: X is CH or N; Y is O or S; Z is OH, NH2, NMeR3, NHR3; OR3 or 5- or 6-membered heterocycle, having 1 to 4 heteroatoms selected from O, N and S... | 10/21/2008 |
| 7429667 | Phenylamino isothiazole carboxamidines as MEK inhibitors The invention concerns compounds which inhibit MEK and which have activity as anti-neoplastic agents. These compounds include N-substituted-3-hydroxy-5-arylamino-isothiazole-4-carboxamidines. Also included are the tautomeric isothiazol-3(2H)-ones. ... | 09/30/2008 |
| 7414060 | Pyridine-2-carboxyamide derivatives The invention relates to compounds of formula I: wherein R1 to R3 are as defined in the specification, to processes for their preparation, to pharmaceutical compositions containing them, and to methods... | 08/19/2008 |
| 7414056 | Pyrazole-amide compounds useful as kinase inhibitors The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where G, X, R1, R2, R3, R4, R5, R6 | 08/19/2008 |
| 7414135 | Process for halomethyl ethers of hydroxyiminomethyl quaternary pyridinium salts A halide salt of a 1-(hydroxyiminomethyl-1-pyridino)-3-(halomethyl)-2-oxapropane is prepared by adding a pyridinealdoxime to a bis-halomethylether in such a manner that the bis-halomethylether is maintained in excess throughout the addition. This procedure produces ... | 08/19/2008 |
| 7410979 | Synergistically effective combinations of dihaloacetamide compounds and interferon or ribavirin against HCV infections The present invention relates to anti-HCV dihaloacetamide compounds in synergistic combination with an interferon and/or ribavirin and pharmaceutical compositions thereof for inhibition of the replication of HCV virus. The present invention also relates to the use o... | 08/12/2008 |
| 7407972 | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade The present invention provides compounds of Formula (I): wherein A, B, C, G, and W1 have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful to treat thro... | 08/05/2008 |
| 7407974 | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade The present invention provides compounds of Formula (I): wherein A, B, C, G, and W1 have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful to treat thro... | 08/05/2008 |
| 7402676 | Substituted dihydro 3-halo-1H-pyrazole-5-carboxylates their preparation and use This invention relates to a compound of Formula I, a method for its preparation and its use in the preparation of a compound of Formula II wherein R1, R2, R3, X and n are as defined in the d... | 07/22/2008 |
| 7399639 | Sensors, and methods of making and using the same The present invention is directed, in part, to sensors for detecting metal ions, and methods of making and using the same. ... | 07/15/2008 |
| 7399765 | Substituted diazabicycloalkane derivatives Compounds of formula (I) Z-Ar1—Ar2 (I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substitute... | 07/15/2008 |
| 7393959 | Di-aryl substituted pyrrole modulators of metabotropic glutamate receptor-5 Pyrrole compounds of Formula (I): and pharmaceutically acceptable salts thereof (where A, B, R11, R12, R13, W, X, Y and Z are as defined herein), which are substituted directly, or by a bridge, with i) a heteroaryl moiety containing ... | 07/01/2008 |
| 7393845 | Heteroaryl derivates, their preparation and use A heteroaryl derivative having the formula (I). The compounds of the invention are considered useful for the treatment of affective disorders such as general anxiety disorder, panic disorder, obsessive compulsive disorder, depression, social phobia and eating disord... | 07/01/2008 |
| 7390810 | Pyrazole-amine compounds useful as kinase inhibitors The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where G, X, R1, R2, R3, R4, R5, R6 | 06/24/2008 |
| 7388018 | 4-Piridinylmethylsulphonamide derivatives as fungicidal plant protein agents Sulfonamides of the formula I where the substituents are as follows: R1 is hydrogen, alkyl, alkoxy, alkenyl or alkynyl; and R2, R3, R4, R5 are... | 06/17/2008 |
| 7381826 | Crystalline forms of {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone The present invention provides novel crystalline forms of {2-[1-(3,5-bistrifluoromethylbenzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone, compositions thereof, intermediates thereof, methods of using the same, processes for maki... | 06/03/2008 |
| 7365205 | Diamine derivatives A compound represented by the general formula (1): Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4 (1) wherein R1 and R2 are hydrogen atoms or the li... | 04/29/2008 |
| 7361671 | Substituted heteroarylalkanoic acids Disclosed are substituted heteroarylalkanoic acids acids of the following formula D-A-C(O)R′, where D, A, and R′ are defined herein. These compounds are useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceu... | 04/22/2008 |
| 7348343 | Amides useful for treating pain The present invention relates to compounds of formula (I-VII) or a pharmaceutically acceptable salt or prodrug thereof, in which A, L, R6, R7 and R8 are defined herein. The present invention... | 03/25/2008 |
| 7329670 | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas The compounds are aryl and heteroaryl substituted heterocyclic ureas of the formula A—NH—C(O)—NH—B where A is the aryl or hetaryl substituted heterocyclic group and B is an aryl or heteroaryl moiety. The compounds inhibit raf kinase and are useful in the tre... | 02/12/2008 |
| 7323581 | Source reagent compositions and method for forming metal films on a substrate by chemical vapor deposition A metalorganic complex composition comprising a metalorganic complex selected from the group consisting of: metalorganic complexes comprising one or more metal central atoms coordinated to one or more monodentate or multidentate organic ligands, and complexed with o... | 01/29/2008 |
| 7321045 | Vitronectin receptor antagonist pharmaceuticals The present invention describes novel compounds of the formula: (Q)d-Ln-Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. Th... | 01/22/2008 |
| 7319149 | Chelants and macrocyclic metal complex radiopharmaceuticals thereof Chelants and macrocyclic metal complexes thereof, methods of preparing the chelants and macrocyclic metal complexes, and radiopharmaceutical compositions comprising the macrocyclic metal complexes are disclosed. Methods of using the macrocyclic metal complexes as ra... | 01/15/2008 |
| 7314872 | Inhibitors of cathepsin S The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides m... | 01/01/2008 |
| 7312235 | Benzamide inhibitors of factor Xa Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian Factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders. ... | 12/25/2007 |
| 7301029 | Bipyridine Derivatives The invention provides a bipyridine derivative useful as an intermediate for pharmaceutical products, agricultural chemicals, electrophotographic photosensitive materials, dyes and the like, which is a bipyridine derivative represented by the general formula (I) and... | 11/27/2007 |
| 7294716 | Process for preparing isomerically pure prodrugs of proton pump inhibitors Synthetic methods for preparing isomerically pure N-arylsulfonyl derivatives of proton pump inhibitors which include a substituted benzimidazole nucleus are shown by the synthetic schemes and experimental description. ... | 11/13/2007 |
| 7288650 | Cyclic substituted fused pyrrolocarbazoles and isoindolones The present invention is directed to cyclic substituted fused pyrrolocarbazoles and isoindolones. The invention also is directed to methods for making and using the cyclic substituted fused pyrrolocarbazoles and isoindolones. ... | 10/30/2007 |
