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| Number | Title | Issue Date |
| 7705150 | Cyanine dyes The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dye... | 04/27/2010 |
| 7442732 | Hindered amine light stabilizers comprising neoalkanediol phosphites Disclosed herein are compounds of the structure: wherein R1, R2, R3, R4, R5, and R6 are independently selected alkyl groups, provided that R1 is d... | 10/28/2008 |
| 7358361 | Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as Leishmania major farnesyl di... | 04/15/2008 |
| 7354771 | Method of determining absolute configuration of chiral compound The absolute configuration of a chiral compound is determined by (i) coordinating the chiral compound to a metalloporphyrin having a carbon chain-crosslinked porphyrin dimer structure in which one of the two porphyrin rings has at least one ethyl or substituent bulk... | 04/08/2008 |
| 7332603 | Preparation of biphosphonic acids and salts thereof A process for preparing alendronate sodium includes the reaction of gammabutyric acid with phosphorous acid and phosphorus trichioride and subsequent treatment with an aqueous solution of an alkali metal hydroxide, in which the reaction is conducted in liquid ionic ... | 02/19/2008 |
| 7321828 | System of components for preparing oligonucleotides Interative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is prov... | 01/22/2008 |
| 7247434 | Methods and compositions for determining the sequence of nucleic acid molecules Methods and compounds, including compositions therefrom, are provided for determining the sequence of nucleic acid molecules. The methods permit the determination of multiple nucleic acid sequences simultaneously. The compounds are used as tags to generate tagged nu... | 07/24/2007 |
| 7217828 | Phosphinine compounds and metal complexes thereof Phosphinines of formula (I) can be combined with metal salts to prepare hydroformylation catalysts. The phosphinine complexes have two phosphorus centers that may be substituted with a variety of hetero atoms or alkyl substituents to modify the ligand characteristic... | 05/15/2007 |
| 7179905 | Nucleic acid labeling compounds Nucleic acid labeling compounds containing heterocyclic derivatives are disclosed. The heterocyclic derivative containing compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds a... | 02/20/2007 |
| 7160835 | Bisphosphine process for producing the same and use thereof Bisphosphines represented by the general formula (I) wherein Ar1 and Ar2 each represents an arylene group which may be substituted; R1 and R2 each represents an alkyl g... | 01/09/2007 |
| 7097973 | Method for monitoring molecular species within a medium Apparatus and methods for monitoring, analyzing, and/or discriminating molecular species, preferably a biomolecule, within a medium using a multisensor array (MSA) and multivariate processing. Biological compounds such as nucleotides and polynucleotides can be detec... | 08/29/2006 |
| 7052846 | Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques Tags and linkers specifically designed for a wide variety of nucleic acid reactions are disclosed, which are suitable for a wide variety of nucleic acid reactions wherein separation of nucleic acid molecules based upon size is required. ... | 05/30/2006 |
| 7030103 | Sulfonamidomethyl phosphonate inhibitors of β-lactamase The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and... | 04/18/2006 |
| 6965020 | Nucleic acid labeling compounds Nucleic acid labeling compounds containing heterocyclic derivatives are disclosed. The heterocyclic derivative containing compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds a... | 11/15/2005 |
| 6921756 | Inhibitors of β-lactamase The invention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and... | 07/26/2005 |
| 6911506 | Catalyst composition and olefin polymerization using same Novel metal complexes, particularly chromium complexes, which contain at least one tridentate ligand are disclosed and prepared. Olefins, particularly ethylene, can be reacted to form butene and/or other homo- or co-oligomers and/or polymers with high α-olefin conc... | 06/28/2005 |
| 6884791 | Inhibitors of β-lactamase The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and... | 04/26/2005 |
| 6818770 | Phosphinine compounds and metal complexes thereof Phosphinines of formula (I) can be combined with metal salts to prepare hydroformylation catalysts. The phosphinine complexes have two phosphorus centers that may be substituted with a variety of hetero atoms or alkyl substituents to modify the ligand characteristic... | 11/16/2004 |
| 6660860 | Process for the selective oxidation of alcohols using readily removable nitroxyl radicals The invention relates to a process for the selective oxidation of alcohols to ketones or to aldehydes by means of an alkali hypohalite under alkaline conditions, which comprises carrying out the oxidation in the presence of a heterogeneous oxidation catal... | 12/09/2003 |
| 6562974 | Process for making geminal bisphosphonates The present invention relates to a novel process for making geminal bisphosphonates. The process provides for bisphosphorylation using phosphorus trihalide, phosphorous acid as a reactant/solvent, and a base as an acid acceptor/solvent. The present invent... | 05/13/2003 |
| 6472406 | Sulfonamidomethyl phosphonate inhibitors of beta-lactamase The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel ଲ-lactamase inhibitors, which are structurally unrelated to the nat... | 10/29/2002 |
| 6211370 | Asymmetric cycloaddition reactions The present invention relates to a process for stereoselective cycloaddition reactions which generally comprises a cycloaddition reaction between a pair of substrates, each either chiral or prochiral, that contain reactive π-systems, in the presence of a... | 04/03/2001 |
| 6187913 | Covalently crosslinked oligonucleotides, preparation method and synthon which is of use in the method A double- or single-stranded oligonucleotide comprising one or more respectively inter- or intra-oligonucleotide covalent cross-linkages, wherein the or each covalent linkage consists of an amide bond between a primary amine group of one strand and a carb... | 02/13/2001 |
| 6172050 | Phospholipid derivatives Phospholipid derivatives of Formula X: ##STR1## wherein A is the ring system ##STR2## in which R is a linear or branched alkyl radical having 10 to 24 carbon atoms which may contain one or more double or triple bonds; R1 and R2 are independently hydr... | 01/09/2001 |
| 6130340 | Asymmetric cycloaddition reactions The present invention relates to a process for stereoselective cycloaddition reactions which generally comprises a cycloaddition reaction between a pair of chiral or prochiral substrates that contain reactive π-systems, in the present of a non-racemic ch... | 10/10/2000 |
| 6054444 | Phosphonic acid derivatives The present invention relates to phosphonic acid derivatives that inhibit N-Acetylated -Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit... | 04/25/2000 |
| 6046334 | Heterocyclic chemical compound The present application is directed to a heterocyclic compound having the structural formula: ##STR1## where R is hydrogen, C1 -C2 alkyl, cyclohexyl, phenyl, benzyl, phenylethyl, 2-hydroxyethyl, 3-hydroxypropyl, carboxymethyl, ... | 04/04/2000 |
| 5986098 | Relating to organic processes A compound of formula (I) to (III) ##STR1## in which the symbols R to R6 are organic radicals. These compounds can be used as intermediates in the production of a phosphite-HALS product.... | 11/16/1999 |
| 5958969 | Benzob!thiophene compounds, intermediates, formulations, and methods This invention relates to the field of pharmaceutical and organic chemistry and provides benzothiophene compounds, intermediates, formulations, and methods.... | 09/28/1999 |
| 5925758 | HALS phosphites and HALS phosphoramides as stabilizers The invention relates to novel compounds of the formula I in which the general symbols are as defined in claim 1, as stabilizers for organic materials against oxidative, thermal or light-induced degradation.... | 07/20/1999 |
| 5910600 | Bisphosphite compound, process for its production and hydroformylation process employing the bisphosphite compound A bisphosphite compound of the following formula (A): ##STR1## wherein --Ar--Ar-- is a bisarylene group represented by any one of the formulae (A-I) to (A-III) defined in the specification, and each of Z1 to Z4 is a C4-20 | 06/08/1999 |
| 5726185 | Acetic acid derivatives Acetic acid derivatives of the formula ##STR1## wherein L, M, T and Q have the significance given in the description, can be used for the treatment or prophylaxis of illnesses which are caused by the binding of adhesive proteins to blood platelets an... | 03/10/1998 |
| 5677432 | Immunological detection of organophosphates A compound useful for forming immunoconjugates used in the detection of organophosphate pesticides is provided. The compound has the formula ##STR1## wherein X is selected from the group consisting of R--O--, R--S-- and R--NH--, where R is an optiona... | 10/14/1997 |
| 5654430 | Oligomeric aliphatic HALS phosphites and HALS phosphonites as stabilizers The invention relates to novel oligomeric compounds of the formula I ##STR1## in which L is a group of the formula ##STR2## where the oxygen in the group L is in each case bonded to the phosphorus in the recurring structural units and the radica... | 08/05/1997 |
| 5637747 | Synthesis of 1,2-dioxetanes and intermediates therefor A compound of the formula ##STR1##... | 06/10/1997 |
| 5616636 | Phosphonite-hals and phosphite-hals compounds as stabilizers A composition comprising: a) a compound containing a phosphite or phosphonite group and at least one 2,2,6,6-tetraalkylpiperidinyl group, and b) a polyolefin which has been produced in the presence of a catalyst which is either i) a supported Zeigler catalyst ... | 04/01/1997 |
| 5442067 | Tetra-[N-alkyl-2,2,6,6,-tetramethylpiperidin-4-yl]-4,4'-diphenylbis phosphonite Tetra-[N-alkyl-2,2,6,6-tetramethylpiperidin-4-yl]-4,4'-diphenylbisphosphoni te Abstract of the Disclosure Novel compounds of formula I ##STR1## wherein R is C1 -C4 alkyl, allyl or benzyl, as stabilisers for protecting organic mat... | 08/15/1995 |
| 5401845 | Asymmetric aryl phosphites Compounds of the formula I ##STR1## in which x is 1, 2 or 3, and, if x=1, R1 is C1 -C30 alkyl, C1 -C18 alkyl substituted by halogen, --COOR2, --CN, --NR3 R4 or by... | 03/28/1995 |
| 5378694 | Acyl and alkoxy substituted quinolines Compounds useful as antiviral agents against DNA-containing viruses, such as herpes group viruses, are disclosed. The compounds are are represented by compounds of Formula 1.0: ##STR1## and their pharmaceutically acceptable salts and solvates. Pharma... | 01/03/1995 |
| 5322871 | Asymmetric aryl phosphites Compounds of the formula I ##STR1## in which x is 1, 2 or 3, and, if x=1, R1 is C1 -C30 alkyl, C1 -C18 alkyl substituted by halogen, --COOR2, --CN, --NR3 R4 or by... | 06/21/1994 |
