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| Number | Title | Issue Date |
| 7446204 | Amino substituted aryloxybenzylpiperidine derivatives This invention is directed to Amino substituted Aryloxybenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmac... | 11/04/2008 |
| 7351718 | Substituted pyrrolidine and related compounds This invention is directed to compounds of formula I: wherein R1-R5 and a-e are as defined in the specification; or pharmaceutically-acceptable salt or solvate or stereoisomer ... | 04/01/2008 |
| 7351717 | Substituted pyrrolidine and related compounds This invention is directed to compounds of formula I: wherein R1-R5 and a-e are as defined in the specification; or pharmaceutically-acceptable salt or solvate or stereoisomer ... | 04/01/2008 |
| 7317103 | Imaging agents for diagnosis of Parkinson's disease Generally, the present invention is directed to central nervous system dopamine transporter-imaging agents and methods of use thereof. In certain embodiments, the present invention relates to radiolabeled piperidine derivatives for use as imaging agents in the diagn... | 01/08/2008 |
| 7297793 | Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors Bis-sulfonamido hydroxyethylamino compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to retroviral protease inhibiting compounds of the formula: | 11/20/2007 |
| 7199158 | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula: wherein R1–R6, R7, R7′, R8, R30–R34, X′, Y, Y′, t,... | 04/03/2007 |
| 7196197 | Process for the preparation of Flecainide, its pharmaceutically acceptable salts and important intermediates thereof Process for the preparation of Flecainide, its pharmaceutically acceptable salts and important intermediates thereof that involves the use of the 2-halobenzoic acid and its derivatives as a starting material. The use of this process also allows for the synthesis of ... | 03/27/2007 |
| 7183292 | Substituted pyrrolidine and related compounds This invention is directed to compounds of formula I: wherein R1–R5 and a-e are as defined in the specification; or pharmaceutically-acceptable salt or solvate or ... | 02/27/2007 |
| 7129228 | Heterocyclic analgesic compounds and methods of use thereof One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various cellular receptors, including opiate receptors, other G-protein-couple... | 10/31/2006 |
| 7125825 | Amidoamine salt-based viscosifying agents and methods of use Viscoelastic surfactants are described for use in aqueous systems to generate thickened fluids. The surfactants are alkyl amidoamine salts of inorganic acids and/or organic acids. The fluids may also contain inorganic salts, organic salts or mixtures thereof. Additi... | 10/24/2006 |
| 7122551 | Metalloproteinase inhibitor compounds Compounds of the formula I useful as metalloproteinase inhibitors, especially as inhibitors of MMP 13. ... | 10/17/2006 |
| 7105575 | Methods for the treatment of neuro- disorders using aminothiol compounds The present invention relates to new uses of S-2-(3-aminopropylamino)ethyl dihydrogen phosphorothioate, (amifostine) and other aminothiol compounds to treat and reverse toxicities caused by therapeutic agents, radiation treatment or diabetes. In particular, the inve... | 09/12/2006 |
| 7049425 | Methods and compositions utilizing an alternative splice variant of the sigma-1 receptor A new variant of the sigma-1 (σ1)receptor is useful in screening compounds useful in the imaging and treatment of proliferative masses (i.e., tumors). This new variant, named sigma—1β (σ1β) finds particular use in the non-invas... | 05/23/2006 |
| 6995180 | Glycinenitrile-based inhibitors of dipeptidyl peptidase IV and methods A compound of the formula I: wherein R1, R2, R3 and R4 are as defined herein. Further provided are methods of u... | 02/07/2006 |
| 6867217 | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade The invention relates to substituted polycyclic aryl and heteroaryl pyridone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety... | 03/15/2005 |
| 6809207 | Amino acid derivatives The present invention provides certain alpha-amino acids and derivatives thereof, such as, but not limited to, esters, amides and salts. These derivatives may comprise such representative side groups as a phenyl, pyridyl, piperidinyl, tetrahydropyranyl, tetrahydroth... | 10/26/2004 |
| 6800619 | Caspase inhibitors and uses thereof Described herein are compounds that are useful as caspase inhibitors having the formula: wherein Ring A is an optionally substituted piperidine, tetrahydroquinoline or tetrahydroisoquinoline ring; R1 is hydrog... | 10/05/2004 |
| 6790854 | Diphenylalkylamine derivatives useful as opioid receptor agonists A substance having affinity for an opioid δ receptor, which is represented by the following general formula (I): wherein, X represents a group of the general formula: —CO—N(R5)(R6) (II) and the... | 09/14/2004 |
| 6787522 | Antibacterial agents Compounds of formula (I) are antibacterials: wherein: R1 represents hydrogen, or C1-C6 alkyl or C1-C6 alkyl substituted by one or more halogen atoms; R2 ... | 09/07/2004 |
| 6740741 | Diazo derivatives and process for their preparation Novel diazo derivatives useful for the deacidification of paper material and the process for their preparation comprising three steps starting from an amine and ethyl chlorocarbonate, are described. ... | 05/25/2004 |
| 6737528 | Vinylic hindered amine light stabilizers Vinylic hindered amine light stabilizers as novel polylmerizable light stabilizers are disclosed and have the general formula (I): wherein: R1 is C1 to C8: alkyl, alkoxy, alkyl phe... | 05/18/2004 |
| 6677332 | Heterocyclic analgesic compounds and methods of use thereof One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various cellular receptors, including opiate receptors, other G-pro... | 01/13/2004 |
| 6667342 | Benzenesulfonamide-derivatives and their use as medicaments Compounds of formula (I), pharmaceutically acceptable salts or in vivo hydrolysable esters thereof, wherein: Ring X is phenyl or a six membered heteroaryl ring containing one or two ring nitrogens where said nitrogens are optionally oxidised to form the N... | 12/23/2003 |
| 6653321 | Naphthylsulfonic acids and related compounds as glucose uptake agonists Methods for treating conditions associated with hyperglycemia, especially Type II diabetes, with novel naphthylsulfonic acids and related compounds. These compounds, as single stereoisomers or mixtures of stereoisomers, or their pharmaceutically acceptabl... | 11/25/2003 |
| 6538138 | Process and a novel intermediate for the preparation of Flecainide The invention relates to processes for the preparation of compounds of the formula ##STR1## wherein R is a 2-piperidyl or 2-pyridyl radical, and pharmaceutically acceptable salts thereof, the process comprising the steps of: a) reacting 2,5-bis(2,2,2-trif... | 03/25/2003 |
| 6521707 | Isocyanates containing amino groups The invention relates to novel isocyanates containing tertiary amino groups, a process for preparing them, and also their use for the synthesis and modification of polymers. The invention provides isocyanates of the formula (I) ##STR1## where R1... | 02/18/2003 |
| 6515024 | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfonyl urea derivatives are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 02/04/2003 |
| 6515124 | Dehydroamino acids Aromatic dehydroamino acids are disclosed that are active as LFA-1 arnagonists This activity enables these compounds to prevent inflammation which is a consequence of T cell activation and accordingly reduce or eliminate inflammatory skin disease psoriasi... | 02/04/2003 |
| 6506778 | Acylphenylurea derivatives, a process for their preparation and their use as pharmaceuticals The invention is directed to acylphenylurea derivatives and their physiologically tolerated salts and physiologically functional derivatives. Compounds of the formula I ##STR1## in which the radicals have the stated meanings, and their physiologically ... | 01/14/2003 |
| 6479502 | Hydroxamic acid derivatives as proteinase inhibitors Compounds of formula (I) are matrix metalloprotemase inhibitors wherein X represents a carboxylic acid group --COOH, or a hydroxamic acid group --CONHOH;R2 represents a radical of formula (II): R3 --(ALK)m --(Q)p | 11/12/2002 |
| 6458812 | Muscarinic antagonists Amide derivatives of 1,4 di-substituted piperidine compounds of the formula: ##STR1## or a pharmaceutically acceptable salt, ester or solvate thereof, wherein R1 is optionally substituted cycloalkyl, cycloalkylalkyl, aryl, arylalkyl or heteroar... | 10/01/2002 |
| 6451791 | Amidoaromatic ring sulfonamide hydroxamic acid compounds An amidoaromatic ring sulfonamide hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed, as are a treatment process that comprises administering a contemplated amidoaromatic ring sulfonamide hydroxamic acid compoun... | 09/17/2002 |
| 6387512 | Grey coloring photochromic fused pyrans A photochromic grey coloring 2H-naphtho[1,2-b]pyran of formula (1) wherein R1 is selected from mono-, di- or poly-substituted aryl groups, mono-, di- or poly-substituted naphthyl groups and mono-, di- or poly-substituted heteroaryl groups, wher... | 05/14/2002 |
| 6362183 | Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds An aromatic sulfonyl alpha-hydroxy hydroxamic acid compound that, inter alia, inhibits matrix metalloprotease activity is disclosed, as is a treatment process that comprises administering a contemplated aromatic sulfonyl alpha-hydroxy hydroxamic acid comp... | 03/26/2002 |
| 6313302 | Pyrrolidinyl and pyrrolinyl ethylamine compounds as kappa agonists A compound of the following formula: ##STR1## and the salts thereof, wherein A is hydrogen, halo, or hydroxy; the broken line represents an optional double bond with proviso that if the broken line is a double bond, then A is absent; Ar1 is opt... | 11/06/2001 |
| 6251918 | Aniline derivatives as calcium channel blockers The present invention provides compounds that block calcium channels having formula (I). The present invention also provides methods of using the compounds of formula (I) to treat stroke, cerebral ischemia, head trauma, or epilepsy and to pharmaceutical c... | 06/26/2001 |
| 6225288 | Gamma-ketoacid dipeptides as inhibitors of caspase-3 Compounds represented by formula I: ##STR1## as well as pharmaceutically acceptable salts, esters and hydrates thereof are disclosed along with pharmaceutical compositions and methods of treatment. The compounds are useful as inhibitors of caspase-3, whic... | 05/01/2001 |
| 6180759 | Process for the preparation of azacycloalkylakanoyl pseudotetrapeptides This invention is directed to a process for preparing a pseudotetrapeptide of formula I ##STR1## or a salt or prodrug thereof wherein ##STR2## is optionally nitrogen protected azaheterocyclyl; ##STR3## is a single or double bond; q is 1-5; B is alkyl... | 01/30/2001 |
| 6124333 | Metalloproteinase inhibitors Therapeutically active hydroxamic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, and the use of such compounds in medicine. The compounds are inhibitors of metalloproteinases involved in tissue degradation.... | 09/26/2000 |
| 6124332 | Metalloproteinase inhibitors Therapeutically active hydroxamic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, and the use of such compounds in medicine. The compounds are inhibitors of metalloproteinases involved in tissue degradation.... | 09/26/2000 |
