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| Number | Title | Issue Date |
| 7951952 | Method for preparing N-aminopiperidine and its salts The invention concerns a novel method for preparing N-aminopiperidine of formula (I): ... | 05/31/2011 |
| 7786308 | Muscarinic modulators The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases. ... | 08/31/2010 |
| 7626032 | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydr... | 12/01/2009 |
| 7550599 | Water compatible sterically hindered alkoxyamines and hydroxy substituted alkoxyamines Sterically hindered alkoxyamine and hydroxy substituted alkoxyamine stabilizer compounds are made water compatible via certain backbones with affinity towards water. The sterically hindered amines are for example of the formula | 06/23/2009 |
| 7432280 | 3-aminopiperidines and 3-aminoquinuclidines as inhibitors of monoamine uptake The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, which are useful for the inhibition of the uptake of one or more physiologically active monoamines (serotonin, norepinep... | 10/07/2008 |
| 7388112 | Immunomodulation with novel pharmaceutical compositions The synthesis and use of a novel class of tumor necrosis factor (TNFα) inhibitors and immunomodulators are provided. Examples are those having the structures: wherein a, b and c are integers from 0 to 12, X equals NH or CH... | 06/17/2008 |
| 7204963 | Process for the separation of chlorosilanes from gas streams Chlorosilanes are continuously removed from a gas stream in an apparatus in which the gas stream is treated in a first stage with water vapor in the gas phase, and in a second stage with a liquid, aqueous phase. ... | 04/17/2007 |
| 7199245 | 4-imino-n-alkoxy or oxy-polyalkyl-piperidine compounds and their use as polymerization regulators The present invention relates to selected 4-imino-N-alkoxy-polyalkyl-peperidine compounds preparation, a polymerizable composition comprising a) at least one ethylenically unsaturated monomer and b) a 4-imino-N-alkoxy-polyalkyl-piperidine compound. Further aspects o... | 04/03/2007 |
| 7173022 | Bicyclic heterocycles as HIV integrase inhibitors The invention encompasses a series cyclic bicyclic heterocyclic compounds of Formula I which are inhibitors of HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also ... | 02/06/2007 |
| 7125825 | Amidoamine salt-based viscosifying agents and methods of use Viscoelastic surfactants are described for use in aqueous systems to generate thickened fluids. The surfactants are alkyl amidoamine salts of inorganic acids and/or organic acids. The fluids may also contain inorganic salts, organic salts or mixtures thereof. Additi... | 10/24/2006 |
| 7084277 | 3-Amino-piperidine derivatives and methods of manufacture This invention relates to 3-amino piperidine derivatives, their intermediates and methods of manufacture. As such, the present invention includes methods of making a compound of the formulas (Ia) and (Ib) wherein R | 08/01/2006 |
| 7045630 | Method for preparing 4-amino-4-phenylpiperidines The invention relates to a process for preparing a 4-amino-4-phenylpiperidine (I): in which R is hydrogen or a (C1–C3)alkyl group, characterized in that a 1-protected 4-piperidone (II): | 05/16/2006 |
| 7018454 | Ink jet ink and recording material The present invention relates to an ink jet ink, an ink jet recording material or an ink jet system comprising at least one sterically hindered N-hydroxylamine strong acid salt, for example 1-hydroxy-2,2,6,6-tetramethyl-4-hydroxypiperidinium chloride or bis(1-hydrox... | 03/28/2006 |
| 7015323 | Thiocarbamate inhibitors of alpha-4 integrins The invention provides novel thiocarbamate alpha-4 inhibitors of the general formula (I) that are resistant to metabolism having improved half-life and/or clearance properties compared to corresponding carbamate compounds wherein substituents L, X, Y, Z, R1 | 03/21/2006 |
| 6936717 | Tinuvin P-hindred amine light stabilizer and derivatives thereof The present invention relates to a photo-stabilizer of the general formula (I): wherein R1 is hydrogen, halogen, C1 to C12 alkyl, alkoxy (linear and branched), R2 is hydrogen... | 08/30/2005 |
| 6919483 | Immunomodulation with novel pharmaceutical compositions The synthesis and use of a novel class of tumor necrosis factor (TNFα) inhibitors and immunomodulators are provided. These compounds have pharmacological applications as well as uses in assays relating to TNFα and other involved cytokines. As pharmaceuticals, thes... | 07/19/2005 |
| 6875870 | Long chain hindered amines and compositions stabilized therewith Hindered amine compounds which are substituted by a long hydrocarbon chain are useful in a number of applications where the solubility or compatibility afforded by said substitution is needed. This is seen particularly for example with white, dyed, dipped, unscented... | 04/05/2005 |
| 6835841 | Asymmetric catalytic hydrogenation process for preparation of chiral cyclic β-aminoesters A novel process for the asymmetric synthesis of substituted cyclic β-amino-carboxylates of the type shown in the specification from appropriate β-enamino-ester starting materials is described. These compounds are useful as intermediates for MMP and TACE inhibitors... | 12/28/2004 |
| 6815458 | Azacyclic compounds Compounds and methods are provided for the treatment of disease conditions in which modification of serotonergic receptor activity has a beneficial effect. In the method, an effective amount of a compound is adminstered to a patient in need of such treatment. ... | 11/09/2004 |
| 6790845 | Fused heterocyclic inhibitors of factor Xa This invention relates generally to a novel class of fused heterocyclic compounds of the Formula (I) or Formula (II): or pharmaceutically acceptable salt forms thereof, which are inhibitors of trypsin-like serine proteas... | 09/14/2004 |
| 6755875 | Long chain hindered amines and compositions stabilized therewith Hindered amine compounds which are substituted by a long hydrocarbon chain are useful in a number of applications where the solubility or compatibility afforded by said substitution is needed. This is seen particularly for example with white, dyed, dipped, unscented... | 06/29/2004 |
| 6756393 | Azacyclic compounds Compounds and methods are provided for the treatment of disease conditions in which modification of serotonergic receptor activity has a beneficial effect. In the method, an effective amount of a compound is adminstered to a patient in need of such treatment. ... | 06/29/2004 |
| 6747044 | Neurokinin antagonists The invention relates to new compounds of formula I or the pharmaceutically acceptable salts thereof, wherein R1 denotes 3-hydroxypropyl, 1,3-dihydroxyprop-2-yl or C3-C6-cyc... | 06/08/2004 |
| 6737528 | Vinylic hindered amine light stabilizers Vinylic hindered amine light stabilizers as novel polylmerizable light stabilizers are disclosed and have the general formula (I): wherein: R1 is C1 to C8: alkyl, alkoxy, alkyl phe... | 05/18/2004 |
| 6727300 | Polymeric articles containing hindered amine light stabilizers based on multi-functional carbonyl compounds Polymeric articles containing at least one polymeric material and a sufficient amount of at least one novel hindered amine light stabilizers to inhibit at least one of photo- or thermal degradation. The hindered amine light stabilizer may be a monomeric or an oligom... | 04/27/2004 |
| 6713492 | N-acyloxylated cycloalkyl compounds, composition containing the same and methods of use therefor Drugs or reagents containing as the active ingredient N-acyloxylated cycloalkyl compounds represented by general formula (I): wherein A is optionally substituted C4 or C5 cycloalkyl which may have o... | 03/30/2004 |
| 6699298 | Long chain hindered amines and compositions stabilized therewith Hindered amine compounds which are substituted by a long hydrocarbon chain are useful in a number of applications where the solubility or compatibility afforded by said substitution is needed. This is seen particularly for example with white, dyed, dipped... | 03/02/2004 |
| 6693202 | Muscarinic receptor antagonists Disclosed are multibinding compounds which are muscarinic receptor antagonists. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a muscari... | 02/17/2004 |
| 6683151 | Supramolecular compound The invention relates to a compound comprising a reaction product of (A) an isocyanate functional compound of which at least 40 wt. %, relative to the total amount of (A), has a molecular weight of at least about 500, and (B) a nitrogen-containing compoun... | 01/27/2004 |
| 6667342 | Benzenesulfonamide-derivatives and their use as medicaments Compounds of formula (I), pharmaceutically acceptable salts or in vivo hydrolysable esters thereof, wherein: Ring X is phenyl or a six membered heteroaryl ring containing one or two ring nitrogens where said nitrogens are optionally oxidised to form the N... | 12/23/2003 |
| 6667422 | Process for the preparation of -haloketones A process for preparing an -haloketone of the formula (1) ##STR1## where R1 is an optionally heteroatom-containing and optionally substituted hydrocarbon radical, R2 is a hydrogen, alkyl, aralkyl or aryl radical, and X is a halogen... | 12/23/2003 |
| 6664248 | 2-nitromethylidene/2-cyanimino/2-nitro-imino-pyrrolidines and piperidines, intermediates, and their use as pesticides Compounds of formula ##STR1## wherein A is an unsubstituted or substituted aromatic or non-aromatic, monocyclic or bicyclic heterocyclic radical wherein a ring nitrogen atom may have been replaced by a group ##STR2## R1 is hydrogen... | 12/16/2003 |
| 6624306 | 2,2,6,6 diethyl-dimethyl-1-alkoxy-piperidine compounds and their corresponding 1-oxides The present invention relates to selected 1-alkoxy-2,2 diethyl-6,6 dimethyl piperidine and 1-alkoxy-2,6 diethyl-2,3,6 trimethyl piperidine derivatives which are substituted in the 4 position by an oxygen or nitrogen atom; a polymerizable composition compr... | 09/23/2003 |
| 6610709 | 2-n-substituted or unsubstituted-2-amino-5-methylpiperidine-3,4-diols and processes for the preparation thereof This invention relates to (2R,3S,4R,5R)-2-amino-5-methylpiperidine-3,4-diol or a (2S,3S,4R,5R)-2-N-substituted-2-amino-5-methylpiperidine-3,4-diol represented by the general formula (I): ##STR1## wherein R1 and R2 each are a hydrogen... | 08/26/2003 |
| 6596863 | Medical composition containing nitroetheneamine Derivative or salt there of as active constituent Process for producing a nitroetheneamine derivative ##STR1## or its stereoisomer, its tautomer or a salt thereof comprising reacting a compound of the formula ##STR2## with a compound of the formula R6 --CH2 NO2 to obtain ... | 07/22/2003 |
| 6593351 | Carboxylic acid substituted heterocycles, derivatives thereof and methods of use Selected novel carboxylic acid substituted heterocycle compounds are effective for prophylaxis and treatment of inflammation, tissue degradation, cancer, fibrosis and related diseases. The invention encompasses novel compounds, analogs, prodrugs and pharm... | 07/15/2003 |
| 6511991 | Nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same The present invention relates to nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions comprising such compounds, methods of using such compounds and compositions, and to a method for the preparation of nitric oxide-releasing... | 01/28/2003 |
| 6489482 | Process for the preparation of novel vinylic hindered amine light stabilizers Novel hindered amine light stabilizers of the formula ##STR1## wherein R1 is C1 to C8 alkyl, alkoxy, alkylphenyl, hydroxy alkyl, allyl, acyl, or cycloalkyl; R2 is hydrogen or methyl; R3 is vinyl or C1... | 12/03/2002 |
| 6489327 | Tryptase inhibitors The invention relates to novel inhibitors of human tryptase which are used in the pharmaceutical industry for the production of medicaments.... | 12/03/2002 |
| 6479502 | Hydroxamic acid derivatives as proteinase inhibitors Compounds of formula (I) are matrix metalloprotemase inhibitors wherein X represents a carboxylic acid group --COOH, or a hydroxamic acid group --CONHOH;R2 represents a radical of formula (II): R3 --(ALK)m --(Q)p | 11/12/2002 |
