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| Number | Title | Issue Date |
| 7863453 | Tartrate salt of isofagomine and methods of use A novel tartaric acid salt of Isofagomine (Isofagomine tartrate) that can be used for the treatment of Gaucher disease is provided. The invention also provides a crystalline form of isofagomine tartrate, method for preparing the salt, a pharmaceutical composition co... | 01/04/2011 |
| 7345175 | Biphenyl derivatives This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defin... | 03/18/2008 |
| 7312332 | Chlorohydrin and cationic compounds having high affinity for pulp or paper Selected chlorohydrin and cationic compounds containing nitroxide or hydroxylamine moieties are effective in stabilizing pulp or paper, especially pulp or paper containing lignin, against yellowing and discoloration due to the adverse effects of light. These compoun... | 12/25/2007 |
| 7288613 | N-alkoxy-4,4-dioxy-polyalkyl-piperidine compounds, their corresponding N-oxides and controlled radical polymerization therewith The present invention relates to selected 1-alkoxy-2,2,6,6 tetramethyl piperidine, 1-alkoxy-2,2 diethyl-6,6 dimethyl piperidine and 1-alkoxy-2,6 diethyl-2,3,6 dimethyl piperidine derivatives which are substituted in the 4 position by two oxygen atoms forming an open... | 10/30/2007 |
| 7265227 | Piperidine derivatives useful as modulators of chemokine receptor activity The invention provides compounds of formula (I) wherein: T is C(O) or S(O)2; W is C(O) or S(O)2; X is CH2, O or NH; Y is CR11 or N; n is 0, 1 or 2; m is 1 or, when Y is CR11 m is 0; R1 is optionally s... | 09/04/2007 |
| 7259217 | Controlled-architecture polymers and use thereof as separation media Controlled architecture polymers made preferably with acrylamide type monomers are prepared in living-type or semi-living-type free radical polymerizations, with the architecture preferably being other than linear, such as star, branched, grafted or hyper-branched. ... | 08/21/2007 |
| 7199245 | 4-imino-n-alkoxy or oxy-polyalkyl-piperidine compounds and their use as polymerization regulators The present invention relates to selected 4-imino-N-alkoxy-polyalkyl-peperidine compounds preparation, a polymerizable composition comprising a) at least one ethylenically unsaturated monomer and b) a 4-imino-N-alkoxy-polyalkyl-piperidine compound. Further aspects o... | 04/03/2007 |
| 7196099 | Compounds and compositions as cathepsin inhibitors The present invention relates to novel cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making. ... | 03/27/2007 |
| 7166670 | Two-component chemical fastening systems The invention relates to two-component chemical fastening systems, the A-component containing an unsaturated polyester and a reactive diluent, and the B-component containing a peroxide and an extender, wherein the extender is either a monomeric component according t... | 01/23/2007 |
| 7144897 | Hydroxy alkyl amines Disclosed are compounds of formula X, which are useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions comprising compounds of formula X and methods of preparing the compou... | 12/05/2006 |
| 7129238 | Mandelic acid derivatives The invention is concerned with novel mandelic acid derivatives of formula (I) wherein R1 to R10, X and Y are as defined in the description and in the claims, as well as pharmaceutically acc... | 10/31/2006 |
| 7129228 | Heterocyclic analgesic compounds and methods of use thereof One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various cellular receptors, including opiate receptors, other G-protein-couple... | 10/31/2006 |
| 7122551 | Metalloproteinase inhibitor compounds Compounds of the formula I useful as metalloproteinase inhibitors, especially as inhibitors of MMP 13. ... | 10/17/2006 |
| 7109217 | Phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease Disclosed are compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is involved, such as Alzh... | 09/19/2006 |
| 7091355 | Chiral scaffolds and their preparation A crystalline salt according to formula (1): or the opposite enantiomer thereof, wherein X+ is a cation. Such salts are useful in preparing chiral scaffolds, in particular of formulae (a)–(d) ... | 08/15/2006 |
| 7087759 | Melanocortin receptor ligands Disclosed are MC-3/MC-4 receptor ligands, the ligands having the following formula: wherein A is a conformationally restricted ring system selected from the group consisting of: a) non-aromatic carbo... | 08/08/2006 |
| 7074803 | Opioid formulations The present invention provides high-concentration formulations of opioids such as fentanyl or fentanyl congeners. The formulation of the invention comprises fentanyl or a fentanyl congener in concentrations significantly in excess of conventional formulations, e.g.,... | 07/11/2006 |
| 7071184 | Protease inhibitors The present invention provides C1-6alkyl-4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel int... | 07/04/2006 |
| 7001905 | Substituted diarylamines as MEK inhibitors Diarylamines, such as 5-amide substituted diarylamines of formula (I) or formula (II) wherein A is hydroxy, C1-6 alkoxy, or NR6OR7; X is OR12, NR13R12, or NR14; inhibitors of MEK and are us... | 02/21/2006 |
| 6989449 | Chlorohydrin and cationic compounds having high affinity for pulp or paper Selected chlorohydrin and cationic compounds containing nitroxide or hydroxylamine moieties are effective in stabilizing pulp or paper, especially pulp or paper containing lignin, against yellowing and discoloration due to the adverse effects of light. These compoun... | 01/24/2006 |
| 6977260 | Piperidinyl prostaglandin E analogs The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; | 12/20/2005 |
| 6967252 | Flame retarding compounds Novel flame retarding compounds that comprise at least one sterically hindered nitroxyl, hydroxylamine or hydrocarbyloxyamine moiety and at least one conventional organohalogen or organophosphorus flame retardant moiety, represented by | 11/22/2005 |
| 6960279 | Method for stabilizing vinyl aromatic monomers using selected polymerization inhibitors and polymers prepared therewith Disclosed is the observation that 7-aryl-quinone methides and 4-tert-butylcatechol, when used in combination in a vinyl aromatic monomer to inhibit polymerization,do not inhibit polymerization to the same extend as each would if used separately. Stated another way, ... | 11/01/2005 |
| 6927295 | 1-alkoxy-polyalkyl-piperidine derivatives and their use as polymerization regulators The present invention relates to 1-alkoxy-polyalkyl-piperidine derivatives containing a structural element of formula (I) G1, G2, G3, G4 are independently C1-C | 08/09/2005 |
| 6875888 | Method for the production of esters of unsaturated carboxylic acids In a process for preparing an ester of an unsaturated carboxylic acid by reacting an ester of the unsaturated carboxylic acid and a C1-C4-alkanol with an alcohol R3OH, where R3 is a C4-C20-alkyl radic... | 04/05/2005 |
| 6872832 | Hydroxy substituted N-alkoxy hindered amines and compositions stabilized therewith Hindered amines substituted on the N-atom with an —O-E-OH moiety are particularly effective in stabilizing polyolefin and automotive coating compositions against the deleterious effects of oxidative, thermal and actinic radiation where the presence of the OH group... | 03/29/2005 |
| 6852735 | Siastatin B derivatives having a glycosidase inhibitory activity and processes for producing the same A compound of the formula (I): and a compound of the formula (V): as well as a compound of the formula (X): which are each... | 02/08/2005 |
| 6790845 | Fused heterocyclic inhibitors of factor Xa This invention relates generally to a novel class of fused heterocyclic compounds of the Formula (I) or Formula (II): or pharmaceutically acceptable salt forms thereof, which are inhibitors of trypsin-like serine proteas... | 09/14/2004 |
| 6784193 | Mutilin derivatives and their use as antibacterials A compound of formula (I) wherein R2 is arylene or heterocyclene; or R and R2 together with the nitrogen atom to which they are attached form non-aromatic heterocyclene; and the other residues have various meanings, useful as pharmaceuticals, e... | 08/31/2004 |
| 6759430 | Piperidine and pyrrolidine derivatives comprising a nitric oxide donor for treating stress The present invention relates to chemical compounds comprising a nitric oxide (NO) donor and a superoxide ion (O2−) scavenger, their preparation and their use in the treatment of conditions associated with oxidative stress or endothelial dysf... | 07/06/2004 |
| 6755875 | Long chain hindered amines and compositions stabilized therewith Hindered amine compounds which are substituted by a long hydrocarbon chain are useful in a number of applications where the solubility or compatibility afforded by said substitution is needed. This is seen particularly for example with white, dyed, dipped, unscented... | 06/29/2004 |
| 6727300 | Polymeric articles containing hindered amine light stabilizers based on multi-functional carbonyl compounds Polymeric articles containing at least one polymeric material and a sufficient amount of at least one novel hindered amine light stabilizers to inhibit at least one of photo- or thermal degradation. The hindered amine light stabilizer may be a monomeric or an oligom... | 04/27/2004 |
| 6713492 | N-acyloxylated cycloalkyl compounds, composition containing the same and methods of use therefor Drugs or reagents containing as the active ingredient N-acyloxylated cycloalkyl compounds represented by general formula (I): wherein A is optionally substituted C4 or C5 cycloalkyl which may have o... | 03/30/2004 |
| 6664411 | Heterocyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptab... | 12/16/2003 |
| 6653480 | Process for the preparation of 1,5-dideoxy-1, 5-imino hexitols from oximes or imines A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.... | 11/25/2003 |
| 6649766 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.... | 11/18/2003 |
| 6624306 | 2,2,6,6 diethyl-dimethyl-1-alkoxy-piperidine compounds and their corresponding 1-oxides The present invention relates to selected 1-alkoxy-2,2 diethyl-6,6 dimethyl piperidine and 1-alkoxy-2,6 diethyl-2,3,6 trimethyl piperidine derivatives which are substituted in the 4 position by an oxygen or nitrogen atom; a polymerizable composition compr... | 09/23/2003 |
| 6617454 | Process for the preparation of amine oxides The present invention provides a process for the preparation of amine oxide by reacting a tertiary or a secondary amine with hydrogen peroxide as an oxidant in the presence of a recyclable heterogeneous catalyst comprising a layered double hydroxide excha... | 09/09/2003 |
| 6610709 | 2-n-substituted or unsubstituted-2-amino-5-methylpiperidine-3,4-diols and processes for the preparation thereof This invention relates to (2R,3S,4R,5R)-2-amino-5-methylpiperidine-3,4-diol or a (2S,3S,4R,5R)-2-N-substituted-2-amino-5-methylpiperidine-3,4-diol represented by the general formula (I): ##STR1## wherein R1 and R2 each are a hydrogen... | 08/26/2003 |
| 6608196 | Process for solid supported synthesis of pyruvate-derived compounds Provided are processes for synthesizing structurally diverse pyruvate-derived compounds using a parallel approach on a solid phase support. Examples of such a solid phase support include resins which have also been used in solid phase peptide synthesis.... | 08/19/2003 |
