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| Number | Title | Issue Date |
| 8022220 | Process for production of piperidine derivatives The present invention discloses a process for preparing the piperidine derivative compound 4-[4-[4-hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylphenylacetic acid of formula comprising the sequential s... | 09/20/2011 |
| 7700779 | Crystalline forms of fexofenadine and its hydrochloride The present invention is related to novel polymorph of Fexofenadine and Fexofenadine hydrochloride of formula 1 and process of preparation thereof. The present invention is also directed to provide pure novel polymorphs of Fexofenadine and its hydrochloride by a sim... | 04/20/2010 |
| 7678915 | Process for production of piperidine derivatives The present invention relates to a process for preparing piperidine derivative compounds of the formulae: wherein n is 0 or 1; R1 is hydr... | 03/16/2010 |
| 7470789 | Fexofenadine polymorphs and processes of preparing the same Anhydrous crystalline fexofenadine hydrochloride Form C, crystalline fexofenadine acetate monohydrate Form D, crystalline fexofenadine acetate dihydrate Form E and crystalline fexofenadine free base monohydrate Form F, processes of preparing the same, pharmaceutical... | 12/30/2008 |
| 7396844 | Benzamidine derivatives Benzamidine derivatives of the following formulae or analogs thereof, i.e., pharmaceutically acceptable salts thereof, are provided. These compounds or salts thereof have a blood-coagulation inhibiting effect based on an excellent effect of inhibiting the action of ... | 07/08/2008 |
| 7381721 | Substituted piperidine compounds 3,4-Disubstituted-4-aryl-piperidine compounds are disclosed. Pharmaceutical compositions containing the 3,4-disubstituted-4-aryl-piperidine compounds and methods of their pharmaceutical uses are also disclosed. The compounds disclosed are useful, inter alia, as anta... | 06/03/2008 |
| 7238834 | Piperidine derivatives and process for their production The present invention relates to substantially pure piperidine derivative compounds of the formulae: wherein R1 is hydrogen or hydroxy; R2 | 07/03/2007 |
| 7235665 | Process for the production of piperidine derivatives The present invention relates to processes for preparing certain piperidine derivatives, including fexofenadine (F), the active ingredient in the non-sedating antihistamine sold in the U.S. under the designation “Allegra®”. This invention also relates to novel ... | 06/26/2007 |
| 7232908 | Process for the production of piperidine derivatives with microorganisms The present invention relates to a process for the production of piperidine derivatives with microorganisms. This is carried out by incubating starting compounds in the presence of a microorganism under conditions effective to produce piperidine derivative products.... | 06/19/2007 |
| 7220752 | Compounds active at the glucocorticoid receptor II This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in therapy and in the regulation of metabolism, especially lowering blood glucose ... | 05/22/2007 |
| 7176318 | Processes for the production of fexofenadine An improved process for the manufacture of fexofenadine is described in which a compound of formula (F): wherein R2 represents COOH, COO—C1-6 alkyl or CN; and R3 represents hydrogen, mesylate, triflate, tosylate or carboxy-C1-... | 02/13/2007 |
| 7141573 | Polypharmacophoric agents One aspect of the present invention relates to polypharmacophoric compounds. In certain embodiments, the polyphamacophore compounds comprise individual pharmacophore units selected from the group consisting of D-1 agonists, D-2 agonists, D-3 agonists, D-4 agonists, ... | 11/28/2006 |
| 7138524 | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof The present invention is related to novel processes for preparing anhydrous and hydrated forms of piperidine derivatives, polymorphs and pseudomorphs thereof of the formulas which are useful as antihistamines, an... | 11/21/2006 |
| 7135571 | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof The present invention is related to novel processes for preparing anhydrous and hydrated forms of piperidine derivatives, polymorphs and pseudomorphs thereof of the formulas which are useful as antihistamines, an... | 11/14/2006 |
| 7078402 | Aminothiol ester compounds, pharmaceutical and cosmetics compositions containing same and uses thereof The invention relates to novel aminothiol ester compounds having the general formula (I): and to a method for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary... | 07/18/2006 |
| RE39128 | Pleuromutilin derivatives as antimicrobials The present invention relates to pleuromutilin derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medical therapy, particularly antibacterial therapy. ... | 06/13/2006 |
| 7022880 | Piperidine derivatives and process for their production The present invention relates to substantially pure piperidine derivative compounds of the formulae: wherein R1 is hydrogen or hydroxy; | 04/04/2006 |
| 6992090 | Substituted piperidine compounds and methods of their use Novel 3,4-disubstituted-4-aryl-piperidine compounds are disclosed. Pharmaceutical compositions containing the 3,4-disubstituted-4-aryl-piperidine compounds and methods of their pharmaceutical uses are also disclosed. The compounds disclosed are useful, inter alia, a... | 01/31/2006 |
| 6974872 | Process for production of piperidine derivatives The present invention discloses processes for preparing piperidine derivative compounds of the formulae: wherein n is 0 or 1; R1 is hydrogen or hydroxy; | 12/13/2005 |
| 6930197 | Antihistaminic piperidine derivatives and intermediates for the preparation thereof This invention relates to a process for the preparation of compounds of the formula: wherein R1 is C1-C6alkyl and the C1-C6alkyl moiety is straight or branched. | 08/16/2005 |
| 6919458 | Process for production of piperidine derivatives The present invention relates to a process for preparing piperidine derivative compounds of the formulae: wherein n is 0 or 1; R1 is hydrogen or hydroxy; ... | 07/19/2005 |
| 6881845 | Process for preparing (±)trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidine The present invention relates to a process for preparing (±)-trans-4-p-fluorophenyl-3-hyroxymethyl-1-methylpiperdine of formula (I). The present invention also relates to novel intermediates of the formula (IX) and (IX′) methods for preparing said intermediates a... | 04/19/2005 |
| 6875775 | Triphenylalkene derivatives and their use as selective estrogen receptor modulators The invention provides novel selective estrogen receptor modulator compounds of the general formula: wherein R1 and R2, which are the same or different are a) H, halogen, OCH3 | 04/05/2005 |
| 6815549 | Process for the preparation of 4-[1-hydroxy -4-[4-(hydroxydiphenylmethly)-1-piperidinyl]-butyl]-α, α-dimethylbenzeneacetic acid A process for the preparation of 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-butyl]-α,α-dimethylbenzeneacetic acid (Fexofenadine) of formula ... | 11/09/2004 |
| 6777555 | Intermediates useful for the preparation of antihistaminic piperidine derivatives The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula wherein W represents —C(═O)— or —... | 08/17/2004 |
| 6730791 | Antihistaminic piperidine derivatives and intermediates for the preparation thereof This invention relates to novel compounds of the following formula and a process for the preparation thereof. wherein X is Cl, Br or I. ... | 05/04/2004 |
| 6723738 | Triphenylalkene derivatives and their use as selective estrogen receptor modulators The invention provides novel selective estrogen receptor modulator compounds of the general formula: wherein R1 and R2 , which are the same or different are a) H, halogen, OCH3, OH; or | 04/20/2004 |
| 6716986 | Sulfuric acid mono-[3-({1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-YL}-hydroxy-methyl)-2-methoxy-phenyl]ester The present invention is directed to sulfuric acid mono-[3-({1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-hydroxy-methyl)-2-methoxy-phenyl]ester, a metabolite of the 5HT2A antagonist (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piper... | 04/06/2004 |
| 6683094 | Antihistaminic piperidine derivatives and intermediates for the preparation thereof This invention relates to novel piperidine derivatives of formula (I) and a process for the preparation thereof. ##STR1## wherein R1 is H or C1 -C6 alkyl wherein the C1 -C6 alkyl moiety is straigh... | 01/27/2004 |
| 6673933 | Antihistaminic piperidine derivatives and intermediates for the preparation thereof This invention relates to novel compounds of formula: ##STR1## wherein R1 is H or C1 -C6 alkyl and the C1 -C6 alkyl moiety is straight or branched; R2 and R3 are each independ... | 01/06/2004 |
| 6613906 | Crystal modification A novel crystal form of ,-dimethyl-4-{1-hydroxy-4-{4-(hydroxydiphenylmethyl)-1-piperidinyl} butyl}benzeneacetic acid hydrochloride, processes for its preparation and its pharmaceutical use are disclosed.... | 09/02/2003 |
| 6613907 | Process for the production of piperidine derivatives with microorganisms The present invention relates to the production of a product compound having a structure according to Formulae IA and/or IB: ##STR1## wherein n is 0 or 1; R1 is hydrogen or hydroxy; R2 is hydrogen; or, when n is 0, R1... | 09/02/2003 |
| 6576645 | Triphenylalkene derivatives and their use as selective estrogen receptor modulators The invention provides novel selective estrogen receptor modulator compounds of the general formula: ##STR1## wherein R1 and R2, which are the same or different are a) H, halogen, OCH3, OH; or ##STR2## where X is O, NH or S; and n is an intege... | 06/10/2003 |
| 6566526 | Intermediates useful for the preparation of antihistaminic piperidine derivatives The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula ##STR1## wherein W represents --C(.dbd.O)-- or --CH(OH)--; R1 represents... | 05/20/2003 |
| 6559312 | Intermediates useful for the preparation of antihistaminic piperidine derivatives The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula ##STR1## wherein W represents --C(.dbd.O)-- or --CH(OH)--; R1 represents... | 05/06/2003 |
| 6555689 | Intermediates useful for the preparation of antihistaminic piperidine derivatives The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula ##STR1## wherein W represents --C(.dbd.O)-- or --CH(OH)--; R1 represents... | 04/29/2003 |
| 6552200 | Intermediates useful for the preparation of antihistaminic piperidine derivatives The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula ##STR1## wherein W represents --C(.dbd.O)-- or --CH(OH)--; R1 represents... | 04/22/2003 |
| 6548675 | Intermediates useful for the preparation of antihistaminic piperidine derivatives The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula ##STR1## wherein W represents --C(.dbd.O)-- or --CH(OH)--; R1 represents... | 04/15/2003 |
| 6538002 | Cyclopentyl modulators of chemokine receptor activity The present in to s directed to compounds of the formula I: ##STR1## (wherein R1, R2, R3, R7, R8, X, Y, Z, x and y are defined herein) which are useful as modulators of chemokine receptor activity. In... | 03/25/2003 |
| 6479518 | Zwitterionic tachykinin receptor antagonists The present invention is directed to certain novel compounds represented by structural formula I: ##STR1## or a pharmaceutically acceptable salt thereof, wherein R3, R5, R6, R7, R8, R11, R | 11/12/2002 |
