Class 546/237 - The chalcogen, X, is in a -C(=X)- group

Subclass of Class 546 - Organic compounds -- part of the class 532-570 series
Definition: Compounds in which the chalcogen, X (i.e., oxygen, sulfur,
No. of patents: 201
Last issue date: 11/29/2011

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Number	Title	Issue Date
8067605	Process for production of piperidine derivatives Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III: The processes involve reacting a compound of formula Ia, IIa or IIIa with isobutyr...	11/29/2011
7511147	Process for manufacturing of chiral lobelin The present invention relates to a shortened process for preparing L-lobeline by rhodium-catalysed asymmetric hydrogenation on an industrial scale. ...	03/31/2009
7385060	Method for producing salts of tolperisone The invention relates to a method for producing an addition salt of 2,4′-dimethyl-3-piperidino-propiophenone (tolperisone) with a pharmaceutically acceptable acid, of formula (I). According to the invention, 4-methylpropiophenone is reacted with piperidine hydroch...	06/10/2008
7381734	Serine protease inhibitors Compounds of formula (I) where R5, R6a, each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as antiinflammatory agents. ...	06/03/2008
7365082	N-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and piperazines It has now been found that certain novel N-(substituted aryl)-4-(disubstituted methyl)piperidine and pyridine derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): wherein m, n, q, r, and s are independently sele...	04/29/2008
7307091	Deuterated 3-piperidinopropiophenone and medicaments containing said compounds The invention discloses deuterated 3-piperidinopropiophenones as well as their physiologically tolerated salts. Furthermore, the invention concerns the use of deuterated 3-piperidinopropiophenones for the treatment of muscular illnesses as well as for the preparatio...	12/11/2007
7300946	N-(substituted arylmethyl)-4-(disubstituted methyl) piperidines and pyridines It has now been found that certain novel N-(substituted aryl)-4(disubstituted methyl)piperidine and pyridine derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): wherein m, n, q, r, and s are independently selec...	11/27/2007
7294637	Method of treating addiction or dependence using a ligand for a monamine receptor or transporter One aspect of the present invention relates to a method of treating of drug addiction or drug dependence in a mammal, comprising the step of administering to a mammal in need thereof a therapuetically effective amount of a heterocyclic compound, e.g., a 3-substitute...	11/13/2007
7265226	1-alkyl-4-(3-substitutedphenyl)piperidines 8-Substituted-2,6-methano-3-benzazocines of general structure I in which A is —CH2—OH, —CH2NH2, —NHSO2CH3, and Y is O, S or NOH are useful ...	09/04/2007
7259157	N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain. ...	08/21/2007
7247730	Process for the preparation of dexmethylphenidate hydrochloride The present invention provides a new and efficient process for the preparation of the dexmethylphenidate hydrochloride with high optical purity, the process comprising: (a) reacting a solution of threo-N-Boc-ritalinic acid with (S)...	07/24/2007
RE39558	5-Substituted-6-cyclic-5,6,7,8-tetrahydronaphthalen 2-ol compounds which are useful for treating osteoporosis Compounds of this formula are useful for treating or preventing, obesity, breast cancer, osteoporosis, endometriosis, cardiovascular disease and prostatic disease. ...	04/10/2007
7115610	Substituted heterocyclic compounds Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atri...	10/03/2006
7109342	Piperidine derivatives and agent comprising the derivative as active ingredient Piperidine derivatives represented by formula (I) or nontoxic salts thereof (wherein symbols are defined in the description): Since the compound represented by formula (I) has a PDE4 inhibitory activity, it is usef...	09/19/2006
7094550	Method to determine TGF-beta A method for treating or preventing cardiovascular pathologies by administering a compound of the formula (I): wherein Z is C═O or a covalent bond; Y is H or O(C1–C4)alkyl, R1	08/22/2006
7084171	Compounds and therapies for the prevention of vascular and non-vascular pathologies The invention provides a method of treating a mammal having, or at risk of, an indication associated with a TGF-beta deficiency comprising administering one or more agents that is effective to elevate the level of TGF-beta. The invention also provides novel compound...	08/01/2006
7074934	Serine protease inhibitors Compounds of formula (I) where R2, each X, L, Y, Cy, Lp, D and n are as defined in the specification, are serine protease inhibitors useful as antithrombotic agents. ...	07/11/2006
7067501	Aryloxyphenyl and arylsulfanylphenyl derivatives The invention provides compounds of the formula wherein the substituents are as defined in the application. The compounds are valuable glycine transport inhibitors. ...	06/27/2006
7041830	Process for preparing (RS) 3-methyl-1-(2-piperidinyl phenyl) butyl amine The Present invention relates to a process for the preparation of (RS) 3-methyl-1-(2-piperidinyl phenyl) butyl amine of formula 1. (RS) 3-Methyl-1-(2-piperidinyl phenyl butyl amine having formula 1 is an important ...	05/09/2006
7030201	Bottom antireflective coatings The present invention relates to bottom antireflective coating compositions and polymers useful in making such compositions. ...	04/18/2006
7022880	Piperidine derivatives and process for their production The present invention relates to substantially pure piperidine derivative compounds of the formulae: wherein R1 is hydrogen or hydroxy;	04/04/2006
7002016	Process for the preparation of threo-methylphenidate hydrochloride The present invention provides a process for the preparation of threo-methylphenidate hydrochloride. According to a preferred embodiment, the process comprises the following steps: (a) contacting 1-(phenylglyoxylyl)piperidine arene...	02/21/2006
6992090	Substituted piperidine compounds and methods of their use Novel 3,4-disubstituted-4-aryl-piperidine compounds are disclosed. Pharmaceutical compositions containing the 3,4-disubstituted-4-aryl-piperidine compounds and methods of their pharmaceutical uses are also disclosed. The compounds disclosed are useful, inter alia, a...	01/31/2006
6974872	Process for production of piperidine derivatives The present invention discloses processes for preparing piperidine derivative compounds of the formulae: wherein n is 0 or 1; R1 is hydrogen or hydroxy;	12/13/2005
6962998	Processes for producing racemic piperidine derivative and for producing optically active piperidine derivative Disclosed are a method for producing racemic piperidine derivatives by processing optically-active piperidine derivatives in a hydrogen atmosphere in the presence of a reducing catalyst; and a method for producing optically-active piperidine derivatives or their aci...	11/08/2005
6919458	Process for production of piperidine derivatives The present invention relates to a process for preparing piperidine derivative compounds of the formulae: wherein n is 0 or 1; R1 is hydrogen or hydroxy; ...	07/19/2005
6903120	Modulators of dopamine neurotransmission New 3-substituted 4-(phenyl-N-alkyl)-piperazine and 4-(phenyl-N-alkyl)-piperidine compounds of Formula (1), wherein X N, CH, or C, however X may only be C when the compound comprises a double bond at the dotted line; R1 is OSO2CF3, O...	06/07/2005
6797826	Piperidine derivatives and process for their production The present invention relates to substantially pure piperidine derivative compounds of the formulae: wherein R1 is hydrogen or hydroxy; R2 is hydrogen; or R1 and R	09/28/2004
6743790	Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use The present invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5, R6, A, X, m and n have the meanings indicated in the claims. The...	06/01/2004
6716986	Sulfuric acid mono-[3-({1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-YL}-hydroxy-methyl)-2-methoxy-phenyl]ester The present invention is directed to sulfuric acid mono-[3-({1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-hydroxy-methyl)-2-methoxy-phenyl]ester, a metabolite of the 5HT2A antagonist (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piper...	04/06/2004
6538002	Cyclopentyl modulators of chemokine receptor activity The present in to s directed to compounds of the formula I: ##STR1## (wherein R1, R2, R3, R7, R8, X, Y, Z, x and y are defined herein) which are useful as modulators of chemokine receptor activity. In...	03/25/2003
6528529	Compounds with activity on muscarinic receptors Compounds and methods are provided for the alleviation or treatment of diseases or conditions in which modification of muscarinic m1 receptor activity has a beneficial effect. In the method, a therapeutically effective amount of a selective muscarinic m1 ...	03/04/2003
6506764	Hydroxamic and carboxylic acid derivatives Compounds of the formula B--X--(CH2)m --CR1 R2 --(CH2)n --CO--Y (I) have therapeutic utility as inhibitors of metalloproteinases etc....	01/14/2003
6506778	Acylphenylurea derivatives, a process for their preparation and their use as pharmaceuticals The invention is directed to acylphenylurea derivatives and their physiologically tolerated salts and physiologically functional derivatives. Compounds of the formula I ##STR1## in which the radicals have the stated meanings, and their physiologically ...	01/14/2003
6498255	Heterocyclic-cyclic amine derivatives as cholinesterase inhibitors Compounds of the formula ##STR1## wherein R1 R2, R7, R8, X, Y, M and L are defined as below. The compounds of formula I are cholinesterase inhibitors and are useful in enhancing memory in patients suffering from...	12/24/2002
6492400	N-ureidoalkyl-piperidines as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): ##STR1## or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases....	12/10/2002
6472397	Nitrogen-containing heterocyclic compounds having antiplatelet aggregation effect and medicinal use thereof The compounds represented by the formula (I), and pharmacologically acceptable salts and solvates thereof are disclosed. The compound is hydrolyzed in organisms into a compound represented by the formula in which W represents a hydrogen atom, and D repres...	10/29/2002
6451791	Amidoaromatic ring sulfonamide hydroxamic acid compounds An amidoaromatic ring sulfonamide hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed, as are a treatment process that comprises administering a contemplated amidoaromatic ring sulfonamide hydroxamic acid compoun...	09/17/2002
6441178	Resolution of ritalinic acid salt A process for preparing an enantiomerically-enriched form of threo-ritalinic acid, which comprises resolving a mixture of enantiomers of a salt of the acid, said salt being formed with an achiral acid or base, using a chiral resolving agent. The resolved ...	08/27/2002
6441177	Tertiary amines Tertiary amines of the formula ##STR1## wherein A1, A2, A3, A4, M, p, T and Q are as defined herein, and acid addition salts thereof, have antimycotic and cholesterol-lowering activity....	08/27/2002

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Class 546/237 - The chalcogen, X, is in a -C(=X)- group