Class 546/235 - The chalcogen, X, is in a -C(=X)- group

Subclass of Class 546 - Organic compounds -- part of the class 532-570 series
Definition: Compounds in which the chalcogen, X (i.e., oxygen, sulfur,
No. of patents: 165
Last issue date: 04/01/2008

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Number	Title	Issue Date
7351825	Cyclopropane compounds and pharmaceutical use thereof The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1):	04/01/2008
7015348	Method for producing an optically active β-amino acid To provide a producing method of an optically active β-amino acid useful as intermediate for the production of medicines, agricultural chemicals and physiologically active substances, by means of a catalytic and asymmetric synthesis method of high performance and a...	03/21/2006
6875765	Arylsulfonamide ethers, and methods of use thereof The novel arylsulfonamide ether compounds, pharmaceutical compositions and uses thereof as inhibitors of interleukin-1β converting enzyme and other cysteine proteases in the ICE family are described. In one embodiment, the compound is described by the generalized s...	04/05/2005
6855843	Inhibitors of α4 mediated cell adhesion The present invention relates to a pharmaceutical composition comprising as an active ingredient a compound of formula (I), wherein Ring A is an aromatic or a heterocyclic ring; Q is a bond, carbonyl, lower alkylene, lower alkenylene, —O— -(lower alkylene)-, etc...	02/15/2005
6750219	Ω-amino-α-hydroxycarboxylic acid derivatives having integrin ανβ3 antagonistic activity An objective of the present invention is to provide highly water-soluble compounds having integrin αvβ3 antagonistic activity. The compounds according to the present invention are compounds represented by formula (I) and pharmaceutically acce...	06/15/2004
6747027	Thiol sulfonamide metalloprotease inhibitors This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfonamide inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors, intermediates for the syntheses of proteinase inhibitors, processes ...	06/08/2004
6642386	N-(4-carbamimidoyl-phenyl)-glycine derivatives The invention is concerned with water soluble N-(4-carbamimidoyl-phenyl)-glycine derivatives of formula (I) ##STR1## wherein R1 to R4 and n are as defined in the description and in the claims, as well as physiologically acceptable sa...	11/04/2003
6630510	Substituted succinic acid metallo-ଲ-lactamase inhibitors and their use in treating bacterial infections This invention relates to novel substituted succinic acid metallo-ଲ-lactamase inhibitors which are useful potentiators of ଲ-lactam antibiotics. Accordingly, the present invention provides a method of treating bacterial infections in animals or...	10/07/2003
6548504	Compounds The present invention therefore provides, in a first aspect, a compound of formula (I) or a salt thereof: ##STR1## in which the group D is selected from a group of formula (A), (B) or (C) below: ##STR2## in which P is a monocyclic, bicyclic or tricyc...	04/15/2003
6545022	4(3)substituted-4(3)-aminomethyl-(thio)pyran or piperidine derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders Novel amines of formulas 1D and 1E ##STR1## are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders,...	04/08/2003
6492400	N-ureidoalkyl-piperidines as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): ##STR1## or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases....	12/10/2002
6476228	Process for producing piperidinecarbinols A process for producing a piperidinecarbinol represented by the general formula (2), which comprises reducing the trans isomer of a compound represented by the general formula (1): ##STR1## wherein R1 is a hydrogen atom, a lower alkyl group or ...	11/05/2002
6420561	Amide compounds and use thereof An amide compound of the formula (I): ##STR1## wherein R is amino and the like, A is alkylene and the like, X is O, S and the like, M is arylene and the like, R1, R2, R3 and R4 are H, hydroxy and the like, R	07/16/2002
6358979	N-cyclopentyl modulators of chemokine receptor activity The present invention is directed to compounds of the formula I: ##STR1## (wherein R1, R3, R4, R5, R6, R7, R8, X, n, x and y are defined herein) which are useful as modulators of chem...	03/19/2002
6342509	Piperidine quaternary salts- CCR- 3 receptor antagonists This invention relates to certain piperidine quatemrwy salts of Formula (I): ##STR1## that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds....	01/29/2002
6329399	Antifungal amine derivatives and processing for producing the same Novel amine derivatives having an excellent antimycotic effect represented by general formula (1) below and salts thereof are provided. ##STR1## [in the formula (1, R1 represents a C1-5 alkyl group which may be halogenated, R2	12/11/2001
6303637	Heterocyclic potassium channel inhibitors The present invention relates to a class of heterocyclic compounds of Formula I that are useful as potassium channel inhibitors to treat autoimmune disorders, cardiac arrhythmias, and the like. ##STR1##...	10/16/2001
6291478	Compounds of the benzylaminodiacetamide family, compositions comprising them, preparation process and uses The present application relates to novel compounds belonging to the benzylaminodiacetamide family which have good anti-irritant and soothing properties. The invention also relates to their use in a composition comprising a physiologically acceptable mediu...	09/18/2001
6291481	N-substituted 4-(4'-aminobenzoyl)-oxymethyl)-piperidines having gastric prokinetic properties Compounds of formula I ##STR1## the N-oxide forms, the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein the substituents are as described in the specification, and process for preparing said pro...	09/18/2001
6255301	Amino acid derivatives and their use as thrombin inhibitors There is provided compounds of formula I, ##STR1## wherein R1, R2, R3, Rx, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin...	07/03/2001
6166013	Glucocortiocoid-selective agents Compounds having Formula I ##STR1## are useful for modulating the glucocorticoid receptor in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of Formula I and methods of treating immune, autoimmune, inflammatory, adrenal ...	12/26/2000
6130220	Sulfamide-metalloprotease inhibitors This invention relates to sulfamides of formula (I) ##STR1## that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds....	10/10/2000
6063816	Hydroxamic acid compounds A compound selected from those of formula (I): ##STR1## wherein: R1 represents optionally substituted alkyl, acyl, cycloalkyl, aryl, aminocarbonylalkyl, or heterocycle, R2 represents alkylene, R3 represents X or Y as defin...	05/16/2000
6008220	Aromatic keto-acids and their derivatives as inhibitors of matrix metalloproteinases Aromatic keto-acid compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) and strome...	12/28/1999
6002009	Di-substituted 1,4-piperidine esters and amides having 5-HT4 antagonistic activity Pharmacologically active novel esters and amides of di-substituted 1,4 piperidine as 5-HT4 antagonists of formula (I) ##STR1## wherein A, X, Y and R have the meanings specified in the description, and a process for their preparation, are d...	12/14/1999
5998412	Sulfamide-metalloprotease inhibitors This invention relates to sulfamides of formula (I) ##STR1## that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds....	12/07/1999
5977141	Sulfonamide inhibitors of matrix metalloproteinases Sulfonamide compounds are described which are inhibitors of matrix metalloproteinases, particularly stromelysin-1 and gelatinase A (72 kD gelatinase). Also described are methods for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aort...	11/02/1999
5962690	Benzoic acid compounds 1-Alkyl-4-benzoyl-5-hydroxy-1H-pyrazole compounds in which the benzoyl moiety is substituted in the 2-position with groups such as halo or alkyl, in the 4-position with an alkylsulfonyl group, and in the 3-position with an acyclic or cyclic derivatized am...	10/05/1999
5939438	Insecticidal oximino and hydrazono derivatives of N-benzyl-4-benzhydryl-and N-benzyl-4-benzhydrol-piperidines It has now been found that certain novel oximino and hydrazono derivatives of N-benzyl-4-benzhydryl- and 4-benhydrolpiperidines, and their corresponding N-oxides and agriculturally acceptable salts are useful as insecticides. These compounds are represent...	08/17/1999
5935585	Biaromatic amido compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active biaromatic amido compounds have the structural formula (I): ##STR1## in which Ar is a radical selected from among those of the following formulae (a)-(e): ##STR2## and are useful for the treatment ...	08/10/1999
5932595	Matrix metalloprotease inhibitors The present invention relates to compounds of Formula I: ##STR1## that are matrix metalloprotease inhibitors, pharmaceutical compositions containing them, methods for their use and methods of preparing these compounds....	08/03/1999
5929088	Cyclic amino acids as pharmaceutical agents Novel cyclic amino acids of formula (Ia) or (Ib) are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, and neuropathological d...	07/27/1999
5863903	Use of hydroxy alkyl piperidine and pyrrolidine compounds to treat diabetes The present invention relates to hydroxy alkyl piperidine compounds and pharmaceutical compositions thereof which can be used to treat diabetes....	01/26/1999
5859249	2-phenyl-2-(2'-piperidinylidene)acetate derivative, process for manufacturing the same, and process for manufacturing optically active 2-phenyl-2-(2'-piperidinyl)acetate derivative by asymmetrically hydrogenating the same Disclosed is a 2-phenyl-2-(2'-piperidinylidene)acetate derivative suitably used for a raw material of a 2-phenyl-2-(2'-piperidinyl)acetate derivative and a process for manufacturing the same. Also disclosed is a process for manufacturing an optically acti...	01/12/1999
5831114	Carbamate herbicides Substituted N-phenyl- and N-heteroarylalkylcarbamates of formula (I), in which Q is a group (1), (2) or (3); R is halogen, trifluoromethyl, cyano, nitro or C1 -C3 haloalkoxy; Z is hydrogen or halogen; or Z and R together in the 2- an...	11/03/1998
5780480	Fibrinogen receptor antagonists Fibrinogen receptor antagonists of the general formula: X-A-Y-Z-B I and which includes, for example, the compounds of formula ##STR1## are useful for inhibiting the binding of fibrinogen to blood platelets, ...	07/14/1998
5773620	Quaternary ammonium salts of aromatic amine compounds, their preparation and pharmaceutical compositions in which they are present Amine compounds of the formula (Ia): ##STR1## where m, Ar', N, T and Z are defined herein and J is a group ##STR2## are useful as precursors in the production of quaternary amines and for the treatment of pathological phenomena involving the neu...	06/30/1998
5763458	1-phenylalkanone 5-HT₄ receptor ligands The present invention relates to novel 5-HT4 receptor ligands which are 1-(5-halo-4-aminophenyl) (C2-6)alkan-1-one derivatives in which the 5-halo-4-aminophenyl group is substituted at its 2-position with (C1-4)alkyloxy or...	06/09/1998
5646144	1-acylpiperidine compounds 1-Acylpiperidine compound of the formula I ##STR1## in which R1 is an optionally substituted aralkyl, aryloxyalkyl, heteroaralkyl, aroyl, heteroaroyl, cycloalkylcarbonyl, aralkanoyl, heteroarylalkanoyl, aralkoxycarbonyl or arylcarbamoyl ra...	07/08/1997
5618825	Combinatorial sulfonamide library Combinatorial libraries are disclosed which are represented by Formula I: (T'--L)q -- S--C(O)--L'--II' I wherein: S is a solid support; T'--L-- is an identifier residue; and --L'--II' is a ligand/linker residue. Compounds which ...	04/08/1997

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Class 546/235 - The chalcogen, X, is in a -C(=X)- group