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Penn Jillette of Penn and Teller fame has patented a "Hydro-Therapeutic Stimulator", which uses a hot tub for stimulation.
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| Number | Title | Issue Date |
| 8158800 | 4-{3-[4-(3-{4-[amino (butoxycarbonylimino) methyl] phenoxy} propyl)-1-piperidinyl] propoxy}-N'-(butoxycarbonyl) benzamidine crystals To provide novel crystals of 4-{3-[4-(3-{4-[amino(butoxycarbonylimino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy}-N′-(butoxycarbonyl)benzamidine. Means for Solving the Problems The type II crystal, the type III crystal and the type IV crystal of 4-... | 04/17/2012 |
| 7541468 | Process of preparing N-ureidoalkyl-piperidines The present application describes a process of preparing a compound of formula (IV), or salt or stereoisomer thereof: wherein Pg, at each occurrence, is independently selected from ... | 06/02/2009 |
| 7365070 | Modulators of melanocortin receptor This invention provides compounds and methods for treating melanocortin receptor associated disorders, such as weight loss disorders including cachexia resulting from cancer and other chronic illnesses. The compounds are represented by formula I: ... | 04/29/2008 |
| 7259157 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain. ... | 08/21/2007 |
| 7259138 | Anti-tumor agents A method for treating subjects with abnormal cell proliferation is provided. The method involves administering to subjects in need of such treatment an effective amount of an agent of Formula I, to inhibit cell proliferation such as that associated with tumor growth... | 08/21/2007 |
| 7214714 | 20-hydroxyeicosatetraenoic acid production inhibitors A hydroxyformamidine compound represented by the following formula or a pharmaceutically acceptable salt thereof [wherein R1 represents a substituted morpholino group, a substituted piperidino group, a... | 05/08/2007 |
| 7074820 | Amidino derivatives and their use as thrombin inhibitors There is provided compounds of formula I, wherein R1, R2, R3, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like protease... | 07/11/2006 |
| 7067489 | Hematopoietic stimulation Methods and products for stimulating hematopoiesis, preventing low levels of hematopoietic cells and producing increased numbers of hematopoietic and mature blood cells are provided. The methods and products can be used both in vivo and in vitro. The methods involve... | 06/27/2006 |
| 7064210 | Light resistant colorant and composition containing the same A light resistant colorant is obtained by coupling a dye or a pigment with a light resistant material. A light resistant colorant-containing composition has no additional light stabilizer. Therefore, side effects caused by the addition of a light stabilizer, such as... | 06/20/2006 |
| 7012098 | Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers Agents and methods for chemoprevention and treatment of neoplasia are described, the agents including a selective inhibitor of inducible nitric oxide synthase and a combination of a selective inhibitor of inducible nitric oxide synthase and an inhibitor of cylcooxyg... | 03/14/2006 |
| 6949514 | Anti-tumor agents A method for treating subjects with abnormal cell proliferation is provided. The method involves administering to subjects in need of such treatment an effective amount of an agent of Formula I, to inhibit cell proliferation such as that associated with tumor growth... | 09/27/2005 |
| 6946477 | 3-Substituted piperidines comprising urea functionality, and methods of use thereof One aspect of the present invention relates to novel heterocyclic compounds comprising urea functionality. A second aspect of the present invention relates to the use of the novel heterocyclic compounds comprising urea functionality as ligands for various cellular r... | 09/20/2005 |
| 6919356 | N-substituted heterocyclic amines as modulators of chemokine receptor activity The present application describes modulators of chemokine receptors of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases. ... | 07/19/2005 |
| 6911477 | Muscarinic receptor agonists This invention relates to a novel class of partial or full muscarinic receptor agonists intermediates for their preparation, and pharmaceutical compositions and methods of use for the treatment or prevention of diseases the treatment or prevention of which is mediat... | 06/28/2005 |
| 6906066 | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases. ... | 06/14/2005 |
| 6887872 | Propenecarboxylic acid amidoxime derivatives, a process for the preparation thereof, and pharmaceutical compositions containing the same The invention refers to novel propenecarboxylic acid amidoxime derivatives furthermore N-oxides and/or geometrical isomers and/or optical isomers and/or pharmaceutically suitable acid addition salts and/or quaternary derivatives thereof. The novel compounds are suit... | 05/03/2005 |
| 6784183 | Diphenylurea compounds Compounds of formula (I): and medicinal products containing the same which are useful as dual α2/5-HT2c antagonists. ... | 08/31/2004 |
| 6756389 | Pharmaceutically active compounds and methods of use The present invention relates to certain imine-substituted heterocyclic compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for the treatment or p... | 06/29/2004 |
| 6653312 | Amidine derivatives, their preparation and application as medicines and pharmaceutical compositions containing same Amidine compounds of the formula ##STR1## wherein the substituents are defined as in the application useful as NO-synthase enzyme inhibitors.... | 11/25/2003 |
| 6642386 | N-(4-carbamimidoyl-phenyl)-glycine derivatives The invention is concerned with water soluble N-(4-carbamimidoyl-phenyl)-glycine derivatives of formula (I) ##STR1## wherein R1 to R4 and n are as defined in the description and in the claims, as well as physiologically acceptable sa... | 11/04/2003 |
| 6638950 | Piperidine amides as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): ##STR1## or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.... | 10/28/2003 |
| 6632840 | Monoacyl-substituted guanidines, a process for their preparation, their use as a medicament or diagnostic aid, and pharmaceutical compositions containing them Monoacyl-substituted guanidines of formula III, or a salt or acid thereof, and their use as medicine or diagnostic aid: ##STR1## in which X(2) is ##STR2##... | 10/14/2003 |
| 6605623 | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): ##STR1## or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.... | 08/12/2003 |
| 6534499 | N-substituted-N'-substituted urea derivatives and the use thereof as TNF- production inhibitory agents N-Substituted-N'-substituted urea derivatives represented by the following formula, analogs thereof or pharmaceutically acceptable salts thereof are herein provided. These compounds show a TNF- production inhibitory activity. ##STR1##... | 03/18/2003 |
| 6525069 | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): ##STR1## or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.... | 02/25/2003 |
| 6525036 | Compounds and compositions as protease inhibitors The present invention relates to novel cysteine protease inhibitors of Formula I: ##STR1## the pharmaceutically acceptable salts and N-oxide derivatives thereof, their use as therapeutic agents and methods of making them.... | 02/25/2003 |
| 6500823 | Unsaturated hydroximic acid derivatives as per abstract inhibitors ##STR1## The object of the invention consists of novel unsaturated hydroximic acid derivatives, the process for their preparation and as active substance such as compounds containing pharmaceutical compositions. The novel compounds possess valuable pharma... | 12/31/2002 |
| 6486180 | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): ##STR1## or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.... | 11/26/2002 |
| 6476050 | 3-substituted piperidines comprising urea functionality, and methods of use thereof One aspect of the present invention relates to novel heterocyclic compounds comprising urea functionality. A second aspect of the present invention relates to the use of the novel heterocyclic compounds comprising urea functionality as ligands for various... | 11/05/2002 |
| 6476054 | Cyclic amine modulators of chemokine receptor activity The present invention is directed to cyclic amines of the formula I: ##STR1## (wherein R1, R2, R3, m and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds a... | 11/05/2002 |
| 6455529 | Adhesion receptor antagonists Compounds of the formula I ##STR1## in which R1, R2 and R3 have the stated meanings, and their physiologically acceptable salts, inhibit the binding of fibrinogen to the corresponding receptor and can be used for the treat... | 09/24/2002 |
| 6451801 | Compounds and methods for treatment of asthma, allergy and inflammatory disorders The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl peperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well... | 09/17/2002 |
| 6444686 | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): ##STR1## or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.... | 09/03/2002 |
| 6436999 | Diacyl-substituted guanidines, a process for their preparation, their use as medicine or diagnostic aid, and medicine containing them Diacyl-substituted guanidines of the formula I ##STR1## are described where X(1) and X(2) are ##STR2## as defined herein. The compounds are suitable for use as antiarrhythmic pharmaceuticals possessing a cardioprotective component for the prophylaxis... | 08/20/2002 |
| 6348628 | Pyridazin-3-one derivatives, their use, and intermediates for their production Novel hydrazones of formula [2] having the following structural formula ##STR1## are provided, which are useful intermediates to form active ingredients of herbicides, wherein R3 is hydrogen, alkyl, haloalkyl, or alkoxy alkyl; and Q is [Q-1], [... | 02/19/2002 |
| 6323223 | Cyclic amine derivatives- CCR-3 receptor antagonists This invention relates to certain cyclic amine derivatives of Formula (I) ##STR1## that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.... | 11/27/2001 |
| 6255301 | Amino acid derivatives and their use as thrombin inhibitors There is provided compounds of formula I, ##STR1## wherein R1, R2, R3, Rx, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin... | 07/03/2001 |
| 6242466 | Substituted phenylamidines Phenylamidines of the formula (I) ##STR1## wherein: R6 is a C5-12 -alkyloxycarbonyl group, and R7 is a hydrogen atom, or a C1-8 -alkyl, C4-7 -cycloalkyl, phenyl-C1-4 -alkyl, or R8 --C... | 06/05/2001 |
| 6239126 | Arylpiperidine and aryl-1,2,5,6-tetra-hydropyridine urea derivatives Compounds of the formula ##STR1## are useful for the treatment of disorder of the central nervous system including anxiety, depression, panic, alcohol and drug addiction, sexual dysfunction, sleep disorders, migraine, obesity, cognitive disorders and ... | 05/29/2001 |
| 6239151 | Compounds as inhibitor of tumor necrosis factor alpha release The invention provides hydrazine derivatives of the formula ##STR1## wherein R1 is lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl or aryl-lower alkyl; R2 is an acyl group derived from an -, &#... | 05/29/2001 |
