Class 546/230 - Cyano attached indirectly to the piperidine ring by nonionic bonding

Subclass of Class 546 - Organic compounds -- part of the class 532-570 series
Definition: Compounds in which the -C N group is attached indirectly
No. of patents: 194
Last issue date: 06/03/2008

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Number	Title	Issue Date
7381721	Substituted piperidine compounds 3,4-Disubstituted-4-aryl-piperidine compounds are disclosed. Pharmaceutical compositions containing the 3,4-disubstituted-4-aryl-piperidine compounds and methods of their pharmaceutical uses are also disclosed. The compounds disclosed are useful, inter alia, as anta...	06/03/2008
7259173	Derivatives of 3-phenyl-n-(2-(4-benzyl)-piperidin-1-yl)-ethyl)-acrylamid with ccr-3-receptor antagonistic activity for use in the treatment of inflammations and allergic conditions This invention relates to organic compounds of formula I, in which Ar1 is unsubstituted phenyl substituted by one or more halogen atoms; Ar2 is unsubstituted phenyl or phenyl substituted by ...	08/21/2007
7256312	Method for producing aminoalkoxy benzylamines and aminoalkoxy benzonitriles as intermediates The invention relates to a process for preparing 4-[aminoalkoxy]benzylamines of the general formula (I) by catalytically hydrogenating 4-[aminoalkoxy]benzonitriles of the general formula (II) ...	08/14/2007
7074820	Amidino derivatives and their use as thrombin inhibitors There is provided compounds of formula I, wherein R1, R2, R3, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like protease...	07/11/2006
7015218	Amide compounds and medicinal use thereof The present invention relates to a compound of the formula wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q...	03/21/2006
6998488	Process and intermediates for the preparation of 4-aryl piperidines A novel process is provided for the preparation of 4-aryl piperidines, and the useful intermediates obtained therein. These compounds are intermediates for the synthesis of melanocortin-4 receptor (MC-4R), which are useful for the treatment of disorders such as obes...	02/14/2006
6995283	Benzophenones as inhibitors of reverse transcriptase The present invention is directed to beazophenone compounds useful in the inhibition of HIV reverse transcriptase, particularly its resistant varieties. ...	02/07/2006
6992037	Precious metal catalyst for debenzylation One aspect of the invention relates to catalyst composite containing a metal catalyst and a specifically defined carbon support containing a carbonaceous material. For example, the carbon support may have a total pore surface area of about 800 m2/g or mor...	01/31/2006
6903120	Modulators of dopamine neurotransmission New 3-substituted 4-(phenyl-N-alkyl)-piperazine and 4-(phenyl-N-alkyl)-piperidine compounds of Formula (1), wherein X N, CH, or C, however X may only be C when the compound comprises a double bond at the dotted line; R1 is OSO2CF3, O...	06/07/2005
6887889	Aryl and biaryl piperdines with MCH modulatory activity In one embodiment, this invention provides a novel class of compounds as antagonists of the MCH receptor, methods of preparing such compounds, pharmaceutical compositions containing one or more of the compounds, methods of preparing pharmaceutical formulations compr...	05/03/2005
6753336	Melanin concentrating hormone receptor ligands Disclosed are compounds of the formula: and the pharmaceutically acceptable salts thereof wherein Q, X, Y, Z, and R1 R9, and R12-R19 are defined herein. These compounds ...	06/22/2004
6642386	N-(4-carbamimidoyl-phenyl)-glycine derivatives The invention is concerned with water soluble N-(4-carbamimidoyl-phenyl)-glycine derivatives of formula (I) ##STR1## wherein R1 to R4 and n are as defined in the description and in the claims, as well as physiologically acceptable sa...	11/04/2003
6642239	Dipeptide nitrile cathepsin K inhibitors Dipeptide nitrile Cathepsin K inhibitors of formula I, and pharmaceutically acceptable salts or esters thereof: ##STR1## In which R1 and R2 are independently H or C1 -C7 lower alkyl, or R1 and R	11/04/2003
6605623	N-ureidoalkyl-piperidines as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): ##STR1## or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases....	08/12/2003
6562965	Convergent synthesis of ଱-aryl-ଲ-ketonitriles The present invention relates to processes for the production of ଱-aryl-ଲ-ketonitriles, which serve as synthetic intermediates in the preparation of a series of biologically important molecules such as corticotropin releasing factor (CRF) rece...	05/13/2003
6552022	Benzamide derivatives and their use as ApoB-100 secretion inhibitors The invention relates to therapeutic benzamide compounds of formula (I) ##STR1## wherein A, X, Z, R1, Y, R2, R3, are as defined herein, and physiologically acceptable salts, solvates or derivatives thereof. The present inv...	04/22/2003
6538137	Cyanobiphenyl derivatives Intermediates represented by the following formula: ##STR1## (wherein R1 is a hydrogen atom, an alkyl group, an aryl group, an aralkyl group or the like; X is a carboxyl group, an alkoxycarbonyl group, an aryloxycarbonyl group, an aralkoxycarbo...	03/25/2003
6486180	N-ureidoalkyl-piperidines as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): ##STR1## or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases....	11/26/2002
6458812	Muscarinic antagonists Amide derivatives of 1,4 di-substituted piperidine compounds of the formula: ##STR1## or a pharmaceutically acceptable salt, ester or solvate thereof, wherein R1 is optionally substituted cycloalkyl, cycloalkylalkyl, aryl, arylalkyl or heteroar...	10/01/2002
6441001	2-substituted-4-nitrogen heterocycles as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): ##STR1## or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases....	08/27/2002
6358979	N-cyclopentyl modulators of chemokine receptor activity The present invention is directed to compounds of the formula I: ##STR1## (wherein R1, R3, R4, R5, R6, R7, R8, X, n, x and y are defined herein) which are useful as modulators of chem...	03/19/2002
6313097	Antagonists of calcitonin gene-related peptide Compounds of the formula (I) ##STR1## wherein A, R, R1, R2, X1, X2, X3, and Y are as defined herein, and the tautomers and the pharmaceutically acceptable salts thereof, including pharmaceutical compo...	11/06/2001
6303652	BTK inhibitors and methods for their identification and use The invention provides BTK inhibitors, methods for their identification and use, and pharmaceutical compositions comprising BTK inhibitors....	10/16/2001
6303637	Heterocyclic potassium channel inhibitors The present invention relates to a class of heterocyclic compounds of Formula I that are useful as potassium channel inhibitors to treat autoimmune disorders, cardiac arrhythmias, and the like. ##STR1##...	10/16/2001
6294575	BTK inhibitors and methods for their identification and use The invention provides BTK inhibitors, methods for their identification and use, and pharmaceutical compositions comprising BTK inhibitors....	09/25/2001
6231786	Fluorinated azoles, and their use in liquid-crystalline mixtures In the fluorinated azoles of the formula (I) R1 (--A1)a --T--(A2 --)b (M--A3 --)c R2 (I) the symbols and indices have -the following meanings: T is undirected and is 4-fluorot...	05/15/2001
6221898	Amidino derivatives and their use as thrombin inhibitors There is provided compounds of formula I, ##STR1## wherein R1, R2, R3, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in partic...	04/24/2001
6160010	BTK inhibitors and methods for their identification and use The invention provides BTK inhibitors, methods for their identification and use, and pharmaceutical compositions comprising BTK inhibitors....	12/12/2000
6143896	Process for the alkylation of alkyl-or benzylcyanogen derivatives in the presence of trialkylamines or trialkylphosphines A process for the alkylation of compounds of the formula II ##STR1## where the reaction with the alkylating agent is carried out in the presence of a base and a trialkylamine and/or trialkylphosphine....	11/07/2000
6124323	4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using 4-substituted piperidine analogs are selective active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such...	09/26/2000
6107508	Convergent synthesis of ଱-aryl-ଲ-ketonitriles The present invention relates to processes for the production of ଱-aryl-ଲ-ketonitriles, which serve as synthetic intermediates in the preparation of a series of biologically important molecules such as corticotropin releasing factor (CRF) rece...	08/22/2000
6008358	Process for the preparation of piperidinylidene derivative Disclosed is a process for economic, safe and simple production of a 2-phenyl-2-(2'-piperidinylidene)acetate derivative at a reduced number of steps in a high yield, which comprises allowing 2,3,4,5-Tetrahydro-6-methoxypyridine and a benzyl cyanide deriva...	12/28/1999
6008220	Aromatic keto-acids and their derivatives as inhibitors of matrix metalloproteinases Aromatic keto-acid compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) and strome...	12/28/1999
6002009	Di-substituted 1,4-piperidine esters and amides having 5-HT4 antagonistic activity Pharmacologically active novel esters and amides of di-substituted 1,4 piperidine as 5-HT4 antagonists of formula (I) ##STR1## wherein A, X, Y and R have the meanings specified in the description, and a process for their preparation, are d...	12/14/1999
5977141	Sulfonamide inhibitors of matrix metalloproteinases Sulfonamide compounds are described which are inhibitors of matrix metalloproteinases, particularly stromelysin-1 and gelatinase A (72 kD gelatinase). Also described are methods for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aort...	11/02/1999
5932594	Muscarinic receptor antagonists A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein Y is a direct link, --(CH2 --, --(CH2)2 --, --CH2 O-- or CH2 S--; R is --CN or --CONH2 ; and R1 is a group...	08/03/1999
5922763	Biphenyl derivatives, pharmaceutical compositions containing these compounds and processes for preparing them The invention relates to biphenyl derivatives of general formula ##STR1## wherein A to E and X are defined as in claim 1, the stereoisomers thereof, including their mixtures and the salts thereof, particularly the physiologically acceptable salts the...	07/13/1999
5792769	Guanidino protease inhibitors Compounds of the formula: ##STR1## wherein R1 --R4, R7 --R8, Ra, Rb, Rc, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically ...	08/11/1998
5777123	Process for regioselective substitution of trifluorobenzoate or trifluorobenzonitrile The invention provides a process for regioselective substitution of trifluorobenzoate/trifluorobenzonitrile to afford the difluorobenzoate/difluorobenzonitrile in good yields. The resulting difluorobenzoate/difluorobenzonitrile can again be regioselective...	07/07/1998
5767151	3,3-(disubstituted) cyclohexan-1-ylidine acetate dimers and related compounds The present invention relates to novel 3,3-(disubstituted)-cyclohexan-1-ylidene acetate dimers of Formula (I): ##STR1## and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammateor...	06/16/1998

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Class 546/230 - Cyano attached indirectly to the piperidine ring by nonionic bonding