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3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Number | Title | Issue Date |
| 7858795 | Biphenyl compounds useful as muscarinic receptor antagonists This invention provides compounds of formula I: wherein a, b, c, m, p, s, t, W, Ar1, X1, R1, R2, R3, R4, R6, and R7 areas defined in th... | 12/28/2010 |
| 7816532 | Biphenyl compounds useful as muscarinic receptor antagonists This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, Ar1, R1, R2, R3, R4, R6, R7, R8, and W are as define... | 10/19/2010 |
| 7790897 | Graftable hindered amine light stabilizers The invention describes novel compound of the formula I, wherein the general symbols are as defined in claim 1, as stabilizers for protecting organic materials, in particular synthetic polymers, against oxidative, th... | 09/07/2010 |
| 7572918 | Process for preparing substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds Processes and intermediates for preparing substituted 4-amino-1-(pyridylmethyl)-piperidine and related compounds in high yield and high purity are described. The substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds prepared by the described processe... | 08/11/2009 |
| 7504510 | Graftable hindered amine light stabilizers The invention describes novel compound of the formula (I), wherein the general symbols are as defined in claim 1, as stabilizers for protecting organic materials, in particular synthetic polymers, against oxidative, thermal, dynamic, light-induced and/or ozon... | 03/17/2009 |
| 7399771 | Piperidine derivatives as CCR5 inhibitors Disclosed are compounds of formula I: wherein R1, R2, R3 and X are as defined herein, in free or salt form, which are useful as CCR5 inhibitors, e.g. in the prevention or treatment of disord... | 07/15/2008 |
| 7393861 | Derivatives of 4-aminopiperidine and their use as a medicament A subject of the present application is new derivatives of 4-aminopiperidines of formula in which R1, R2 and R3 represent various radical, and their preparation processes by synthetic method... | 07/01/2008 |
| 7326722 | N-[Phenyl(piperidin-2-yl)methyl]benzamide derivatives, their preparation and their application in therapy The present invention discloses and claims a compound of general formula (I) wherein A, X and R2 are as described herein. Also disclosed and claimed is application of this compound in a variety of ther... | 02/05/2008 |
| 7304076 | Neuropeptide Y Y5 receptor antagonists The present invention discloses compounds which, are novel receptor antagonists for NPY Y5 as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such NPY Y5 receptor antagonists as well... | 12/04/2007 |
| 7297706 | Certain glycine derivatives as factor Xa inhibitors for use in the treatment of thrombotic disorders Compounds of formula (I) in which R, R1, R2, n and X1 have the meanings given in the specification are Factor Xa inhibitors useful in the treatment of thrombotic disorders. ... | 11/20/2007 |
| 7262205 | Biphenyl compounds useful as muscarinic receptor antagonists This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, r, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the... | 08/28/2007 |
| 7259158 | Naphthaline derivatives as H3 inverse agonists The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are usef... | 08/21/2007 |
| 7256186 | Gamma secretase inhibitors This invention discloses novel gamma secretase inhibitors of the formula: wherein: R1 is a substituted aryl or substituted heteroaryl group; R2 ... | 08/14/2007 |
| 7241778 | Non-imidazole aryloxypiperidines Substituted non-imidazole aryloxypiperidine compounds, compositions containing them, and methods of making and using them to treat or prevent histamine-mediated conditions. ... | 07/10/2007 |
| 7208602 | Gamma secretase inhibitors This invention discloses novel gamma secretase inhibitors of the formula: wherein: R1 is a substituted aryl or substituted heteroaryl group; R2 ... | 04/24/2007 |
| 7205319 | N-[phenyl (piperidin-2-yl) methyl]benzamide derivatives, preparation thereof, and use thereof in therapy This invention discloses and claims a compound of general formula (I) in which R1 represents either a hydrogen atom, or an optionally substituted alkyl group, or a cycloalkylalkyl group, or an optional... | 04/17/2007 |
| 7179922 | Chemical compounds The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine ... | 02/20/2007 |
| 7166745 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the gro... | 01/23/2007 |
| 7148240 | Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same The invention relates to benzofuran or benzothiophene derivatives of general formula: These compounds are of use as medicinal products, in particular in the treatment of pathological syndromes of the cardiovascular... | 12/12/2006 |
| 7115609 | Alanyl-piperidine heterocyclic derivatives useful against cardiovascular diseases Compounds of formula (I) in which R1, R2, n and X1 have the meanings given in the specification are Factor Xa inhibitors useful in the treatment of thrombotic disorders. ... | 10/03/2006 |
| 7084196 | Flame retardant compositions Polymeric substrates, for example polyolefins such as polypropylene, can be made flame retardant by the incorporation therein of a synergistic mixture of (i.) at least one compound selected from the group consisting of nitroxyl stabilizers, hydroxylamine stabilizers... | 08/01/2006 |
| 7078415 | Certain glycine derivatives as factor Xa inhibitors for use in the treatment of thrombotic disorders Compounds of formula (I) in which R, R1, R2, n and X1 have the meanings given in the specification are Factor Xa inhibitors useful in the treatment of thrombotic disorders. ... | 07/18/2006 |
| 7022390 | Polyester and polyamide compositions of low residual aldehyde content A mixture of a polyester, such as poly(ethylene terephthalate) PET, or a polyamide, and a suitable stabilizer selected from the group consisting of hydroxylamine stabilizers, substituted hydroxylamine stabilizers, nitrone stabilizers and amine oxide stabilizers, whe... | 04/04/2006 |
| 6979566 | Method of treatment of viral infection including HIV using water soluble fullerenes—III A water soluble derivative of buckministerfullerene (C50) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is symmetrically substituted with polar organic moieties containi... | 12/27/2005 |
| 6958176 | Liquid crystal mixture Liquid crystal mixture comprising compounds of formula (I) wherein R1: is H or a linear or branched alkyl group or branched alkenyl group R2: stands for a) H... | 10/25/2005 |
| 6919456 | Catalytic compositions and methods for asymmetric aldol reactions Methods and compositions are provided for the direct catalytic asymmetric aldol reaction of aldehydes with donor molecules selected from ketones and nitroalkyl compounds. The reactions employ as catalyst a Group 2A or Group 2B metal complex of a ligand of formula I,... | 07/19/2005 |
| 6908650 | Polyester and polyamide compositions of low residual aldehyde content A mixture of a polyester, such as poly(ethylene terephthalate) PET, or a polyamide, and a suitable stabilizer selected from the group consisting of hydroxylamine stabilizers, substituted hydroxylamine stabilizers, nitrone stabilizers and amine oxide stabilizers, whe... | 06/21/2005 |
| 6894041 | Oxazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructuive pulmonary disease, of the formula: | 05/17/2005 |
| 6878723 | LTA4 hydrolase inhibitors The invention concerns compounds inhibiting LTA4 hydrolase of formula (I). The invention also concerns their therapeutic, in particular anti-inflammatory, applications. ... | 04/12/2005 |
| 6855174 | Couplers for use in oxidative hair dyeing Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): wherein X is selected from halogen and R5SO4 where the halogen is preferably Cl, Br or I; R, ... | 02/15/2005 |
| 6849631 | Semicarbazides and their uses The present invention relates to the synthesis of a new class of indeno [1,2-c]pyrazol-4-ones of formula (I): that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the ca... | 02/01/2005 |
| 6831089 | Muscarinic antagonists The present invention discloses compounds, which are novel muscarinic receptor antagonists, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such muscarinic receptor antagonists as... | 12/14/2004 |
| 6818773 | Synthesis of 4-[(Z)-4-bromophenyl)(ethoxyimino) methyl]-1'-[(2,4-dimethyl-1-oxido-3-pyridinyl)carbony)]-4'-methyl-1,4-′bipiperidine In one embodiment, the present invention describes the synthesis of 4-[(Z)-(4-bromophenyl)(ethoxyimino)methyl]-1′-[(2,4-dimethyl-1-oxido-3-pyridinyl)carbonyl]-4′-methyl-1,4′-bipiperidine, and intermediates therefor from easily available starting materials by a... | 11/16/2004 |
| 6787650 | Urea compounds, process for producing the same and use thereof A compound of the formula: [wherein R1 is a hydrocarbon group which may be substituted; R2 is a cyclic hydrocarbon group which may be substituted or a heterocyclic group which may be substitu... | 09/07/2004 |
| 6750337 | Couplers for use in oxidative hair dyeing Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): wherein X is selected from halogen and R5SO4 where the halogen is preferably Cl, Br or I; R, R | 06/15/2004 |
| 6737527 | 4-formylamino-N-methylpiperidine derivatives, the use thereof as stabilizers and organic material stabilized therewith The present invention relates to 4-formylamino-N-methylpiperidine derivatives of the formula (I) where the variables are as defined in the Description, to a process for preparing these piperidine derivatives, to the use ... | 05/18/2004 |
| 6696570 | Oligomeric hindered amine light stabilizers based on multi-functional carbonyl compounds and methods of making same Oligomeric compounds and methods of making the compound having the formula: wherein i, j, k, and l are integers from about 0 to 300 and the sum of i, j, k, and l is greater than 2, wherein the units F, F' and T are derived from one or more multi-functional car... | 02/24/2004 |
| 6683093 | Aromatic sulfone hydroxamic acids and their use as protease inhibitors This invention is directed to aromatic sulfone hydroxamates (also known as aromatic sulfone hydroxamic acids) and salts thereof that, inter alia, tend to inhibit matrix metalloproteinase (also known as matrix metalloprotease or MMP) activity and/or aggrec... | 01/27/2004 |
| 6683142 | 1-alkoxy-polyalkyl-piperidine derivatives and their use as polymerization regulators The present invention relates to 1-alkoxy-polyalkyl-piperidine derivatives containing a structural element of formula (I) ##STR1## wherein G1, G2, G3, G4 are independently C1 -C6 alkyl ... | 01/27/2004 |
| 6656954 | Sulfonyl divalent aryl or heteroaryl hydroxamic acid compounds A sulfonyl divalent aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated sulfonyl divalent aromatic or heteroa... | 12/02/2003 |
