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| Number | Title | Issue Date |
| 8188285 | Purification process of Montelukast and its amine salts It comprises a process for the purification of Montelukast, or its salts or its solvates, including any stereoisomer or mixture thereof, which comprises converting Montelukast acid or a solvate thereof, including any stereoisomer or mixtures thereof, into an amine s... | 05/29/2012 |
| 8178680 | Process for the preparation of Montelukast and its pharmaceutically acceptable salts An improved process for the preparation of Montelukast and its pharmaceutically acceptable salts comprises of reacting (S) Benzenepropanol α-[3-[2-(7-chloro2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methyl ethyl)-α-methane sulfonate compound of formula (II) with ... | 05/15/2012 |
| 8163924 | Process for preparing a leukotriene antagonist and an intermediate thereof Dicyclohexylamine salt of formula (IIa) or a pharmaceutically acceptable solvate thereof, including a hydrate, and its process for preparation are provided. The invention also relates to processes for the preparation of montelukast of formula (I) or a pharmaceutical... | 04/24/2012 |
| 8115004 | Process for pure montelukast sodium through pure intermediates as well as amine salts The present invention provides an improved process for the preparation of highly pure montelukast sodium through highly pure diol intermediate compound of formula (2) and (1)-(mercapto methyl)cyclopropane acetic acid methyl ester compound of formula (4) or mercaptom... | 02/14/2012 |
| 7829716 | Process for making montelukast and intermediates therefor A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof: using a compound of formula (20) is provided. ... | 11/09/2010 |
| 7692018 | Process for producing high purity 3,5-dihydroxy-6-heptenoic acid derivative A process for producing a high purity 3,5-dihydroxy6-heptenoic acid derivative by controlling the content of impurities such as denatured substances, is provided. When a 3,5-dihydroxy-6-heptenoic acid derivative is produced by a process which comprises a step of con... | 04/06/2010 |
| 7544805 | Stable amorphous forms of montelukast sodium An amorphous form of montelukast sodium and a montelukast sodium lactose co-precipitate, processes for producing same, pharmaceutical compositions containing same and methods of treatment utilizing same are disclosed. ... | 06/09/2009 |
| 7501517 | Process for making montelukast and intermediates therefor A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof: using a compound of formula (4) is provided. ... | 03/10/2009 |
| 7417149 | Process for the preparation of Montelukast The present invention relates to a process for the preparation of Montelukast and the salts thereof comprising the following steps: (a) reaction of a compound A with a compound A2 | 08/26/2008 |
| 7388012 | (Hydrazido)(amino)thiophene compounds Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A and J are defined herein, are useful in the treatment of tumors and cancers such as mastocytosis/mast cell leukemia, ... | 06/17/2008 |
| 7339062 | Method for producing a 3,5-dihydroxy-6-heptenoate A method for producing an alkyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-6-heptenoate of the formula (1) (wherein R is a C1-4 alkyl group), which is an intermediate for a cholesterol-reducing agent (a HMG-CoA reductase inhib... | 03/04/2008 |
| 7339063 | Quinolyl organic germanium ester and the synthesis method thereof The present invention relates to compounds of quinolyl organic germanium ester having the following Formula 1 and the synthesis methods thereof. R1 and R2 are defined in the specification. Organic germanium acyl chloride and 8-hydroxylquinoline... | 03/04/2008 |
| 7335757 | Carbonyl reductase, gene encoding the same, and process for producing optically active alcohols using the same According to the present invention, there is provided a novel carbonyl reductase derived from a microbial belonging to the genus Ogataea and a DNA encoding the enzyme. By reducing ketones with the use of the carbonyl reductase, optically active alcohols, in p... | 02/26/2008 |
| 7312212 | Aminopiperidine derivatives Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man. ... | 12/25/2007 |
| 7304062 | Peroxisome proliferator activated receptor alpha agonists The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts, solvates and hydrates thereof, R1 is a substituted or unsubstituted group selected from C1-C8 alkyl, aryl-C | 12/04/2007 |
| 7265115 | Diazabicyclic CNS active agents Compounds of formula I: or pharmaceutically acceptable salts thereof, are useful for controlling synaptic transmission in mammals. ... | 09/04/2007 |
| 7241776 | Cyanoamidine P2Xantagonists for the treatment of pain Novel cyanoamidines compounds of formula (I) and (II) and their derivatives wherein R1-R12 are as defined in the specification act as antagonists of the P2X7 receptor. These compo... | 07/10/2007 |
| 7232833 | 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them The invention relates to 4-substituted quinoline compounds of general formula: which are active as antimicrobials, in which: X1, X2, X3, X4 and X5 | 06/19/2007 |
| 7232832 | Antibacterial agents Quinoline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans. ... | 06/19/2007 |
| 7205408 | Quinolines and nitrogenated derivative thereof substituted in 4-position by a piperidine-containing moiety and their use as antibacterial agents Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man. ... | 04/17/2007 |
| 7183415 | Quinoline compound A compound, which has a melanin-concentrating hormone antagonistic action and useful as an agent for preventing or treating obesity, and which is represented by the formula: wherein ... | 02/27/2007 |
| 7115543 | Aryl sulfonyl amino carbonyl triazole based selective herbicides The invention relates to novel herbicidal synergistic active compound combinations which comprise firstly arylsulphonylaminocarbonyltriazolinones and secondly herbicidally active compounds and/or safeners listed in the description, and which can be used with particu... | 10/03/2006 |
| 7071192 | Respiratory syncytial virus replication inhibitors The present invention concerns compounds of formula (I), prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof wherein -a1=a2-a3=a4-represents a radical of formu... | 07/04/2006 |
| 7071146 | Herbicidal composition A selectively herbicidal composition which comprises, besides customary inert formulation auxiliaries, as active ingredient a mixture of: a) a herbicidally active amount of a herbicide selected from the group consisting of the compounds of formula (Ia), and/or (Ib),... | 07/04/2006 |
| 7067530 | Compounds, their preparation and use Novel compounds of general formula (I), the use of these compounds as medicaments, pharmaceuticaly compositions comprising the compounds and methods of treatment employing these compounds and compostiones. The present compounds may be useful in the treatment and/or ... | 06/27/2006 |
| 7045626 | Quinoline derivatives, process for preparing them and use for the treatment of diseases mediated by s-CD23 A compound of formula (I): useful in the treatment and prophylaxis of conditions mediated by s-CD23 ... | 05/16/2006 |
| 7041829 | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states This invention provides a class of therapeutic compounds and methods for the treatment of mammals with physiological disorders, such as for example a frequently occurring type of essential hypertension, which are critically associated with the decreased binding of m... | 05/09/2006 |
| 7038056 | Method for preparing a 7-quinolinyl-3,5-dihydroxyhept-6-enoate A method for preparing a 7-quinolynyl-3,5-dihydroxyhept-6-enoate useful as an intermediate for pharmaceuticals, in high yield and in high purity, is presented. It is a method for preparing a 7-quinolinyl-3,5-dihydroxyhept-6-enoate represented by the formula (IV): | 05/02/2006 |
| 7030239 | Compounds to treat Alzheimer's disease The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases. ... | 04/18/2006 |
| 6982334 | Crystalline form of (3R,4R)-4-[3-(S)-hydroxy-3-(6-methoxyquinolin-4-yl)propyl]-1-[2-(2-thienylthio)ethyl]piperindine-3-carboxylic acid The present invention comprises crystalline forms of 3R,4R)-4-[3-(S)-hydroxy-3-(6-methoxyquinolin-4-yl)propyl]-1-[2-(2-thienylthio)ethyl]piperidine-3-carboxylic acid, represented by the structure: and as characterized h... | 01/03/2006 |
| 6960591 | Propane-1,3-dione derivative Provided is a pharmaceutical composition containing a propane-1,3-dione derivative as the active ingredient, particularly a GnRH receptor antagonist. Also, provided is a propane-1,3-dione derivative having a GnRH antagonistic effect. ... | 11/01/2005 |
| 6958349 | Heteroaryl alkylamide derivatives useful as bradykinin receptor modulators This invention is directed towards novel alkylamide derivatives as bradykinin receptor antagonists useful for the treatment of bradykinin modulated disorders such as pain, inflammation, asthma and allergy. Furthermore, the present invention is directed to novel alky... | 10/25/2005 |
| 6946557 | Process for producing optically active ethyl (3R, 5S, 6E)-7-[2-cycloproply-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-6-heptenoate The objective of this invention is to provide a process for producing an optically active isomer of ethyl 7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-6-heptenoate by optically resolving an optical isomer mixture of the compound at a high producti... | 09/20/2005 |
| 6939970 | Crystalline form of (3R,4R)-4-[3-(S)-hydroxy-3-(6 methoxyquinolin-4-propyl]-1-[2-2-thienylthio)ethyl] piperidine-3-carboxylic acid The present invention comprises monohydrated form C of (3R,4R)-4-[3-(S)-hydroxy-3-(6-methoxyquinolin-4-yl)propyl]-1-[2-(2-thienylthio)ethyl]piperidine-3-carboxylic acid, represented by the structure and as herein defin... | 09/06/2005 |
| 6911469 | Sulfonamide compounds and pharmaceutical use thereof A sulfonamide compound of the formula (I): R1—SO2NHCO—A—X—R2 (I) wherein R1 is alky, alkenyl, alkynyl and the like; A is an optionally substitutedheteropolycyclic group except benzimidazol... | 06/28/2005 |
| 6906194 | Fluorescence assay for kinase activity The present invention provides a sensor and methods for determining kinase activity. ... | 06/14/2005 |
| 6884808 | Heterocycle-containing carboxylic acid derivative and drug containing the same Described is a heterocycle-containing carboxylic acid derivative represented by the following formula (I): wherein A represents, for example, a heteroaryl group which contains at least one nitrogen atom and may have a ... | 04/26/2005 |
| 6872730 | Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists The present invention relates to novel substituted benzofurans and benzothiophenes compounds that are antagonists of alpha V (αv) integrins, for example αvβ3 and αvβ5 integrins, their pharmaceutically acceptable salts... | 03/29/2005 |
| 6867218 | Compounds, their preparation and use The present invention relates to compounds of the general formula (I) The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Act... | 03/15/2005 |
| 6855824 | Processes for preparing quinoline derivatives and intermediates thereof The present invention provides a production method of quinoline derivative (V) wherein each symbol is as defined in the Specification, which includes reacting quinolinecarbaldehyde (I) with any of the compounds (II) to... | 02/15/2005 |
