Famous Patents
The first match was accidentally discovered in 1826 when John Walker scraped a stick with chemicals on the end against a stone floor.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7790895 | Quinoline derivatives as potassium ion channel openers The present invention is directed to novel quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to ion channels such as potassium channels. ... | 09/07/2010 |
| 7265115 | Diazabicyclic CNS active agents Compounds of formula I: or pharmaceutically acceptable salts thereof, are useful for controlling synaptic transmission in mammals. ... | 09/04/2007 |
| 7223759 | Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds The invention relates to antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds and pharmaceutical compositions thereof. This invention also relates to a method of using such compounds in the treatment of bacterial infections in mammal... | 05/29/2007 |
| 7148237 | Nitrogen-containing heteroaryl compounds having HIV integrase inhibitory activity A compound of the formula (I): wherein Z4, Z5 and Z9 each is independently carbon atom or nitrogen atom; Y is hydroxy, mercapto or amino; RA is a group of the formula: ... | 12/12/2006 |
| 7129357 | Synthesis of quinoline 5-carboxamides useful for the preparation of PDE IV inhibitors In one embodiment, the present application discloses a process for making the compound of the formula: ... | 10/31/2006 |
| 7109211 | Substituted benzopyran derivatives for the treatment of inflammation A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′ wherein X, A1, A2, A | 09/19/2006 |
| 7053105 | Farnesyl transferase inhibiting quinoline and quinazoline derivatives as farnesyl transferase inhibitors This invention comprises the novel compounds of formula (I) wherein r, s, t, Y1—Y2, R1, R2, R3, R4, R5 and R7 have defined meanings, having farnesyl transferase inhibiting acti... | 05/30/2006 |
| 7053057 | Caspase inhibitors and uses thereof This invention provides caspase inhibitors having the formula: wherein Ring A is an optionally substituted piperidine, tetrahydroquinoline or tetrahydroisoquinoline ring; R1 is hydrogen, CHN2 | 05/30/2006 |
| 7019147 | Benzimidazole derivatives useful as antiproliferative agents The invention relates to compounds of formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R7, R8, R9, R10, and R11 are as defined herein. The invention als... | 03/28/2006 |
| 6943176 | Heterocyclic derivatives The present invention relates to methods for the treatment of epilepsy and irritable bowel syndrome. ... | 09/13/2005 |
| 6867299 | Oxamide IMPDH inhibitors Disclosed are compounds of the general formula which are oxamide derivatives and inhibitors of the enzyme inosine monophosphate dehydrogenase (IMPDH). ... | 03/15/2005 |
| 6852862 | Process for producing quinoline-3-carboxylic acid compound A process for producing quinoline-3-carboxylic acid represented by formula wherein R1, R2, R3, R4 and R5 have the same meanings as defined... | 02/08/2005 |
| 6844087 | Material for use in a light-emitting device and highly efficient electroluminescent device A material is provided that can be used for a light-emitting device. The base unit of said material is tris(8-quinolinolato)aluminum(III) (Alq3). This Alq3 is substituted in the said 3- or 4-position with an electron-donor group and simultaneously in the said 5-posi... | 01/18/2005 |
| 6841561 | Dihydroorotate dehydrogenase inhibitors for the treatment of viral-mediated diseases Flavivirus, rhabdovirus and paramyxovirus infections may be treated by administering an inhibitor of the enzyme dihydroorotate dehydrogenase such as 6-fluoro-2-(2′-fluoro-1,1′-biphenyl-4-yl)-3-methyl-4-quinolinearcarboxylic acid sodium salt (Brequinar). A synerg... | 01/11/2005 |
| 6825352 | Preparation and use of ortho-sulfonamido arylhydroxamic acids as matrix metalloproteinase inhibitors Ortho-sulfonamido aryl hydroxamic acids are provided which are useful, inter alia, for the inhibition of matrix metalloproteinases and the treatment of conditions associated with overexpression of MMPs. ... | 11/30/2004 |
| 6777427 | Tetrahydroquinoline compounds Tetrahydroquinoline compounds of general formula (I) or pharmacologically acceptable salts thereof, which have a specific and strong binding affinity for AR, exhibit AR agonism or antagonism, have therapeutic effects on AR-mediated diseases, particularly by not acti... | 08/17/2004 |
| 6727098 | Biaryl-type compounds, CD color fixing agent and method for determination of absolute configuration A novel achiral biaryl-type compound and a circular dichroism (CD) color fixing agent are provided. Furthermore, a method for determining an absolute configuration of a chiral compound is carried out by introducing the above achiral biaryl-type compound into the chi... | 04/27/2004 |
| 6713489 | 7-[(4′-trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoline-3-carboxylic acid amides, and methods of inhibiting the secretion of apolipoprotein B This invention relates to compounds of Formula I: that inhibit the secretion of apolipoprotein B, to pharmaceutical compositions comprising the compounds, and to methods of treating and/or preventing atherosclerosis, obe... | 03/30/2004 |
| 6596735 | Quinoline derivatives useful for inhibiting farnesyl protein transferase The invention relates to compounds of the formula: ##STR1## and to pharmaceutically acceptable salts and solvates thereof wherein Y, R1, R2, R3, R4, R5, R6, R7, R8, R | 07/22/2003 |
| 6562977 | Process for the preparation of mixed anhydrides The present invention is concerned with mixed anhydrides. The mixed anhydrides are prepared by adding an adjuvant base to a mixture of acid and reactive acid derivative. The mixed anhydrides play an role primarily in activating and coupling reactions.... | 05/13/2003 |
| 6562972 | Method for preparing heterocyclic-carboxylic acids The present invention relates to a method for preparing quinoxaline-5- and 6-carboxylic acids. The method comprises contacting an aqueous alkaline suspension of a 5- or 6-halomethyl quinoxaline with oxygen in the presence of a transition metal catalyst, t... | 05/13/2003 |
| 6559308 | Method for preparing heterocyclic-carboxylic acids The present invention relates to a method for preparing quinoxaline-5- and 6-carboxylic acids. The method comprises contacting an aqueous suspension of a 5- or 6-hydroxymethyl quinoxaline with oxygen in the presence of a transition metal catalyst, to form... | 05/06/2003 |
| 6492390 | Substituted benzopyran analogs for the treatment of inflammation A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' ##STR1## wherein X,... | 12/10/2002 |
| 6369075 | 7[4'-trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoline-3-carboxylic acid amides, and method of inhibiting the secretion of apolipoprotein B This invention relates to compounds of Formula I ##STR1## that inhibit the secretion of apolipoprotein B, to pharmaceutical compositions comprising the compounds, and to methods of treating and/or preventing atherosclerosis, obesity, diabetes, hyperlipide... | 04/09/2002 |
| 6369225 | Compounds having activity as inhibitors of cytochrome P450RAI Compounds having Formula 8 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. ##STR1##... | 04/09/2002 |
| 6340691 | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors Compounds of the formula ##STR1## are useful in treating disease conditions mediated by TNF-, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.... | 01/22/2002 |
| 6335448 | Method for the synthesis of quinoline derivatives This invention relates to novel intermediates and processes for preparing pharmaceutically active quinoline compounds, including (-)-(S)-N-(-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxamide.... | 01/01/2002 |
| 6329389 | Amine compounds, their production and use The present invention provides a compound of the formula: ##STR1## wherein Ar represents an aromatic group which may be substituted; X represents methylene, S, SO, SO2 or CO; Y represents a spacer having a main chain of 2 to 5 atoms; n represents an inte... | 12/11/2001 |
| 6310209 | Synthesis of CC-1065/duocarmycin analogs The present invention relates to a method for the synthesis of the dihydroindole C-ring found in CC-1065/duocarmycin analogs.... | 10/30/2001 |
| 6271253 | Substituted benzopyran derivatives for the treatment of inflammation A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' ##STR1## wherein X,... | 08/07/2001 |
| 6211196 | Benzyloxy-substituted, fused N-heterocycles, processes for their preparation, and their use as bradykinin receptor antagonists Benzyloxy-substituted, fused N-heterocycles, because of their ability to act as bradykinin receptor antagonists, have been found to be useful as therapeutics for the treatment and prevention of liver cirrhosis or Alzheimer's disease. This application desc... | 04/03/2001 |
| 6207667 | 1,3 diazines with platelet-derived growth factor receptor inhibitory activity 1,3 Diazines according to formula (I): ##STR1## and pharmaceutically acceptable salts thereof inhibit phosphorylation of platelet-derived growth factor receptor and thereby hinder abnormal cell growth and cell wandering. The compounds may be used to treat... | 03/27/2001 |
| 6121284 | 2,3-bridged 1,4-dihydropyridines, and their use as medicaments The present invention relates to new 2,3-bridged 1,4-dihydropyridines of the general formula (I), ##STR1## in which R, R1, R2, D and E have the meaning given in the description, processes for their preparation and their use as m... | 09/19/2000 |
| 6114349 | Substituted quinoline derivatives with antiviral action Substituted quinoline derivatives, processes for their preparation, and their use. Compounds of the formula I ##STR1## and their tautomeric forms, of the formula Ia ##STR2## in which m, n and the substituents X and R1 to R5... | 09/05/2000 |
| 6011063 | Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them Ortho-substituted benzoylguanidines of the formula I ##STR1## in which R(1) to R(5) have the meanings given in the claims, are suitable as antiarrhythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis and for infarct trea... | 01/04/2000 |
| 5990116 | Trisubstituted phenyl derivatives The invention concerns compounds of formula I ##STR1## wherein the substituents have various meanings, and their use in the prevention or treatment of inflammatory and proliferative skin diseases and cancer.... | 11/23/1999 |
| 5977074 | Inhibitors of ଲ-amyloid protein production This invention relates to compounds and pharmaceutical compositions, and methods for inhibiting or preventing the amyloid protein deposits in the brain which are associated with Alzheimer's disease and aged Down's syndrome patients. More particularly, it ... | 11/02/1999 |
| 5952345 | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities Aryl-substituted and aryl and (3-oxo-1-propenly)-substituted benzopyran, benzothiopyran, 1,2-dihydroquinoline, and 5,6-dihydronaphthalene derivatives have retinoid negative hormone and/or antagonist-like biological activities. The invented RAR antagonists... | 09/14/1999 |
| 5948778 | Difluoro statone antiviral analogs This invention relates to novel statone antiviral analogs, to the processes and intermediates useful for their preparation and to their use as antiviral agents.... | 09/07/1999 |
| 5914404 | Process for the preparation of quinargine The present invention is concerned with a novel process for the manufacture of quinargine ##STR1## (N-(2-quinolylcarbonyl)-asparagine) based on the reaction of the succinimide ester ##STR2## with asparagine or asparagine salts in an aqueous... | 06/22/1999 |
