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| Number | Title | Issue Date |
| 7312230 | Carboxylic acid derivatives as IP antagonists This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I: wherein: R1, R2, and R3 ... | 12/25/2007 |
| 7217794 | Compounds and methods for treatment of thrombosis The present invention provides compounds that inhibit Factor XIa and methods of preventing or treating undesired thrombosis by administering a compound of the invention to a mammal. The invention also provides three-dimensional structures of Factor XIa and methods f... | 05/15/2007 |
| 7186720 | Tetrahydropyridyl-alkyl-heterocycles, method for preparing the same and pharmaceutical compositions containing the same The present invention relates to compounds of formula (I): in which X represents N or CH; R1 represents a hydrogen or halogen atom or a CF3 group; R2 and R3 independent... | 03/06/2007 |
| 7176207 | Platelet adenosine diphosphate receptor antagonists Compounds of the following formula (I): where A, a, b, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate... | 02/13/2007 |
| 7084212 | Vulcanization accelerators The present invention relates to vulcanization accelerators constituted by compounds, derived from secondary amines, belonging to the class of enamines and to a process for their preparation. ... | 08/01/2006 |
| 7026323 | Platelet adenosine diphosphate receptor antagonists Compounds of the following formula (I): where a, b, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmace... | 04/11/2006 |
| 6995156 | Platelet adenosine diphosphate receptor antagonists Compounds of the following formula (I): where a, b, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmace... | 02/07/2006 |
| 6984648 | Cyclic β-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-α The present application describes novel cyclic β-amino acid derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2 heteroatoms s... | 01/10/2006 |
| 6974813 | N-[(substituted five-membered di-or triaza diunsaturated ring) carbonyl] guanidine derivatives for the treatment of ischemia NHE-1 inhibitors, methods of using such NHE-1 inhibitors and pharmaceutical compositions containing such NHE-1 inhibitors. The NHE-1 inhibitors are useful for the reduction of tissue damage resulting from tissue ischemia. ... | 12/13/2005 |
| 6903103 | Linear cyclic ureas Compound of formula (I): wherein: V represents a single bond or an alkylene chain, M represents a single bond or an alkylene chain, A and E each repr... | 06/07/2005 |
| 6903094 | Amide derivatives and nociceptin antagonists The present invention relates to a compound of the formula [1′] wherein R2 is lower alkyl optionally substituted by hydroxy, amino and the like, ring B is phenyl, thienyl and the lik... | 06/07/2005 |
| 6864254 | Inhibitor for 20-hete-yielding enzyme An inhibitor for 20-hydroxyeicosatetraenoic acid production which comprises as the active ingredient a specific hydroxyformamidine derivative or a pharmacologically acceptable salt thereof. It is useful especially as a remedy for kidney diseases, cerebrovascular dis... | 03/08/2005 |
| 6821986 | Amino acid derivatives and their use as medicines Novel compounds of formula wherein the substituents are defined as in the specification and are useful for inhibiting neuronal NO synthase or inducible NO synthase as well as inhibiting lipidic peroxidation. ... | 11/23/2004 |
| 6818652 | Heterocyclic retinoid compounds The current invention provide novel heterocyclic retinoid compounds, methods of treating or preventing chronic obstructive pulmonary disease, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention of these disorders... | 11/16/2004 |
| 6800645 | Substituted azabicyclic compounds This invention is directed to physiologically active compounds of formula (I) wherein represents a bicyclic ring system, of about 10 to about 13 ring members, in which the ri... | 10/05/2004 |
| 6770672 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein when Y is... | 08/03/2004 |
| 6734193 | (1,2,3,4-tetrahydroquinolin-8-yl)-heptatrienoic acid derivatives having serum glucose reducing activity Compounds of the formula where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effects of reducing serum thyroxine... | 05/11/2004 |
| 6703391 | Quinoxalinedione derivatives, their preparation and use A compound having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R is hydrogen or hydroxy; R1 is hydrogen, alkyl, arylalkyl, (CH2)n OH, or (CH2)n NR7 | 03/09/2004 |
| 6605125 | Hair dye composition Provided is a hair dye composition comprising as a direct dye a compound represented by the following formula (1), (2), (3) or (4): ##STR1## [wherein, R1 and R1' each independently represents a (substituted) C1-6 alkyl or ... | 08/12/2003 |
| 6531599 | Compounds having activity as inhibitors of cytochrome P450RAI Compounds having Formula 1 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. ##STR1##... | 03/11/2003 |
| 6479436 | Hetaroyl cyclohexanedione derivatives with herbicidal effect Hetaroyl derivatives of the formula I ##STR1## where: R1 and R2 are each hydrogen, nitro, halogen, cyano, thiocyanato, hydroxyl, mercapto, C1 -C6 -alkyl, C1 -C6 -alkoxy, C1 -C | 11/12/2002 |
| 6440417 | Antibodies to argatroban derivatives and their use in therapeutic and diagnostic treatments Antibodies to a therapeutic agent and its derivatives and conjugates are disclosed, including antibodies to argatroban and its derivatives and conjugates. The antibodies are useful as reagents in assays and diagnostic kits for determining the concentratio... | 08/27/2002 |
| 6387896 | Bicyclic oxazolidinones as antibacterial agents The present invention provides compounds of formula I useful as antimicrobial agents ##STR1## wherein W, X, Y, R1, R2 and n are as defined in thereof.... | 05/14/2002 |
| 6369069 | Biphenylsulfonyl cyanamides, method for the production thereof and their utilization as a medicament The invention relates to compounds of the formula (I), ##STR1## in which the symbols have the following meaning: R(1) is 1. alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; 2. alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, in which one to all hydrogen ... | 04/09/2002 |
| 6342602 | Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thichroman and 1,2,3,4-tetrahydroquinolinecarboxlic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity Compounds of the formula ##STR1## wherein the symbols have the meaning defined in the specification have retinoid-like biological activity.... | 01/29/2002 |
| 6333337 | Potassium channel inhibitors Compounds useful as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described.... | 12/25/2001 |
| 6329389 | Amine compounds, their production and use The present invention provides a compound of the formula: ##STR1## wherein Ar represents an aromatic group which may be substituted; X represents methylene, S, SO, SO2 or CO; Y represents a spacer having a main chain of 2 to 5 atoms; n represents an inte... | 12/11/2001 |
| 6306873 | Substituted ଲ-thiocarboxylic acids This invention relates to compounds of general formula (I): ##STR1## in which Ar is a group selected from: ##STR2## A1, A2, B, C, D, E, Q1-Q3, R1-R9, Z1 and Z2 are as defined in the disclosure, and Y represents carboxy or an acid bioisostere. These c... | 10/23/2001 |
| 6303630 | Diarylsulfone non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus In accordance with the present invention, there is now provided novel anti-HIV compounds of the formulae selected from the group consisting of: ##STR1## ##STR2## wherein R1 is hydrogen or C1 -C4 alkyl; R2 is hyd... | 10/16/2001 |
| 6291677 | Compounds having activity as inhibitors of cytochrome P450RAI Compounds having Formula 7 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. ##STR1##... | 09/18/2001 |
| 6277863 | Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes Novel compounds comprising chemically reactive intermediates which can react with available reactive functionalities on blood components to form covalent linkages, where the resulting covalently-bound conjugates are found to have thrombin inhibition activ... | 08/21/2001 |
| 6228868 | Oxazoline antiproliferative agents Compounds having Formula I ##STR1## are useful for treating cancer. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of treating cancer in a mammal.... | 05/08/2001 |
| 6211196 | Benzyloxy-substituted, fused N-heterocycles, processes for their preparation, and their use as bradykinin receptor antagonists Benzyloxy-substituted, fused N-heterocycles, because of their ability to act as bradykinin receptor antagonists, have been found to be useful as therapeutics for the treatment and prevention of liver cirrhosis or Alzheimer's disease. This application desc... | 04/03/2001 |
| 6211181 | 1-Benzenesulfonyl pyrrolidine derivatives as bradykinin receptor antagonists This invention relates to compounds of the formula ##STR1## where X is halogen, R1 is H or a C1 -C3 alkyl, R2 is H or OH and R3 is one of ##STR2## in which A is a single bond or a --CO(CH2)... | 04/03/2001 |
| 6200988 | Heterocyclic derivatives and pharmaceutical use thereof A heterocyclic derivative of the formula (I) ##STR1## wherein each symbol is as defined in the specification, and pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof exhibit su... | 03/13/2001 |
| 6197959 | Piperidine derivatives Compounds of formula (I) ##STR1## wherein R1 and R2 are as defined in the description and claims and pharmaceutically acceptable salts thereof, are useful for the treating diseases associated with restenosis, glaucoma, cardiac infarc... | 03/06/2001 |
| 6166041 | 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma Novel compounds which are effective PDE IV inhibitors are disclosed. The present invention is directed to compounds having the general formula I ##STR1## wherein: X is a halogen; Q is --CH2 --CH2 --, --CH2 --, a single or ... | 12/26/2000 |
| 6150526 | Piperidine derivative having renin inhibiting activity Piperidine derivatives, their manufacture and use as medicaments, are disclosed. The invention is concerned with the piperidine derivatives of general formula I ##STR1## wherein R1, R2, R3, R4, Q, X, Z, m a... | 11/21/2000 |
| 6114533 | 2,4-pentadienoic acid derivatives having retinoid-like biological activity Compounds of Formula 1 ##STR1## wherein Z is Formula 3, ##STR2## Y is cycloalkyl or cycloalkenyl of 3 to 8 carbons optionally substituted with one or two R4 groups, or Y is phenyl, said groups being optionally substituted with on... | 09/05/2000 |
| 6110933 | Amino acid derivatives and their use as phospholipase A2 inhibitor The present invention relates to a novel fatty acid derivative of the following formula: ##STR1## wherein R1 is acyl group, etc.; R2 is acyl(lower)alkyl; R3 is lower alkyl, etc.; R4 is hydrogen, etc.; and X is -... | 08/29/2000 |
