Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7442793 | Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided. ... | 10/28/2008 |
| 7244731 | 6-Methylpyridine derivatives, method for preparing thereof and antiviral pharmaceutical composition comprising the same The present invention relates to 6-methylpyridine derivatives useful as an antiviral agent. More particularly, the present invention relates to novel 6-methylpyridine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV), or pha... | 07/17/2007 |
| 7226942 | 2-amino-4-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors Novel compounds are provided which are glycogen phosphorylase inhibitors which are useful in treating, preventing or slowing the progression of diseases requiring glycogen phosphorylase inhibitor therapy such as diabetes and related conditions (such as hyperglycemia... | 06/05/2007 |
| 7223761 | Salts and polymorphs of a potent antidiabetic compound Salts and polymorphs of a compound useful in the treatment of inflammatory and metabolic conditions and diseases are provided herein. In particular, the invention provides salts and polymorphs of a compound which modulates the expression and/or function of a peroxis... | 05/29/2007 |
| 7217714 | CCR5 modulators Compounds of Formula 1 [Region α]−[Region β]−[Region γ]−[Region δ] (I) which are useful as modulators of chemokine activity. The invention also provides pharmaceutical formulations and m... | 05/15/2007 |
| 7153865 | N-type calcium channel antagonists for the treatment of pain Compounds useful for the treatment of pain in accord with the following structural diagram, wherein A, R1, b, R3, d, R4, R5, R6 and R7 are any of ... | 12/26/2006 |
| 7087758 | Quinoline inhibitors of hyaki and hyak3 kinases This invention relates to novel quinoline inhibitors of hYAK1 and hYAK3 kinases and pharmaceutically acceptable salts, hydrates or solvates thereof, pharmaceutical compositions thereof, and methods of treatment of diseases in which an excessive amount of either such... | 08/08/2006 |
| 6989392 | 2-Aminoquinolines as melanin concentrating hormone receptor antagonists The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, which antagonize the effects of melanin-concentrating hormone (MCH) through the melanin concentrating ... | 01/24/2006 |
| 6969723 | Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands Compounds of general formula (I), wherein R4 and R5 stand for hydrogen atom or form together an 1,3-butadienyl group, optionally substituted by a methylenedioxy group or one or more straight or branched C1-4 alkyl group, straight or ... | 11/29/2005 |
| 6841680 | N-type calcium channel antagonists for the treatment of pain Compounds having selective action at neuronal N-type calcium channels useful for the treatment of pain in accord with the following structural diagram, wherein R1, R2 and R3 are a varie... | 01/11/2005 |
| 6770648 | Compounds for the modulation of PPARγ activity Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity. ... | 08/03/2004 |
| 6432962 | Benzophenones as inhibitors of IL-1ଲ and TNF- Heteroaryl aminobenzophenones of general formula I inhibit interleukin-1ଲ and TNF- and may therefore be useful in the therapy of inflammatory diseases and conditions.... | 08/13/2002 |
| 6369053 | 2-Aminoquinolinecarboxamides: neurokinin receptor ligands Disclosed are compounds of the formula: ##STR1## or pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof, wherein R1, R2, R3, X, Q1 and Q2 are defined herein, which compou... | 04/09/2002 |
| 6310211 | 8-hydroxy-7-substituted quinolines as anti-viral agents The present invention provides for 8-hydroxy-7-substituted quinoline compounds such as formula IA ##STR1## These compounds are useful as anti-viral agents. Specifically, these compounds have anti-viral activity against the herpes virus, cytomegalovir... | 10/30/2001 |
| 6002008 | Substituted 3-cyano quinolines This invention provides compounds having the formula: ##STR1## wherein: X is cycloalkyl which may be optionally substituted; or is a pyridinyl, pyrimidinyl, or phenyl ring; wherein the pyridinyl, pyrimidinyl, or phenyl ring may be optionally substitu... | 12/14/1999 |
| 5998437 | Benzimidazole derivatives The present invention provides novel benzimidazole derivatives or salts thereof represented by the general formula, ##STR1## wherein R1 is a hydrogen atom or a halogen atom; R2 is a phenyl-lower alkyl group; R3 is a h... | 12/07/1999 |
| 5889021 | Active Compounds The present invention relates to novel quinoline derivatives of the formula ##STR1## which inhibit exogenously or endogenously stimulated gastric acid secretion and thus can be used in the prevention and treatment of gastrointestinal inflammatory dis... | 03/30/1999 |
| 5658933 | Substituted heterocyclic carboxamide esters, their preparation and their use as pharmaceuticals The invention relates to compounds of the formula I, ##STR1## to a process for their preparation and to their use as pharmaceuticals. The compounds are employed, in particular, as ester prodrugs of prolyl hydroxylase inhibitors for inhibiting collage... | 08/19/1997 |
| 5605909 | Substituted N-heteroaryl-1,2-diaminocyclobutene-3,4-dione compounds The compounds of formula I are smooth muscle relaxants: ##STR1## wherein R1 is hydrogen, alkyl, cycloalkyl, alkanoyl, alkylsulfonyl, aroyl, arylalkenoyl, arylsulfonyl, arylalkanoyl or arylalkylsulfonyl; R2 is hydrogen, alkyl or ... | 02/25/1997 |
| 5565408 | Cyanoquinoline compounds Cyanoquinoline compounds Ia or Ib ##STR1## where R1 is CH.dbd.C(CN)2 ; CH.dbd.N--N.dbd.CH--(5-quinolyl); methylsulfonyl; CH.dbd.NOH; halogen; hydroxyl; nitro; cyano; unsubstituted or substituted C1 -C4 -alk... | 10/15/1996 |
| 5561143 | Aliphatic amino bis-aryl squalene synthase inhibitors This invention relates to a class of novel aliphatic amino bis-aryl compounds containing at least four carbon atoms and an amino group either substituted thereon or incorporated therein and is further linked or bridged to two mono- and/or bicyclic rings. ... | 10/01/1996 |
| 5556863 | Compound for gastric acid secretion inhibition The present invention relates to novel quinoline derivatives of the formula ##STR1## which inhibit exogenously or endogenously stimulated gastric acid secretion and thus can be used in the prevention and treatment of gastrointestinal inflammatory dis... | 09/17/1996 |
| 5356903 | 1-cyclopropyl-4-pyridyl-quinolines Compounds of formula ##STR1## wherein; R1 is hydrogen, lower-alkyl, or trifluoromethyl; R2 is lower-alkyl, trifluoromethyl or CH2 X where X is hydroxy, chloro, lower-alkylamino or dilower-alkylamino; R3 and R | 10/18/1994 |
| 5223517 | Heterocyclically substituted cycloalkano[b]-indolesulphonamides Heterocyclically substituted cycloalkano[b]-indolesulphonamides can be prepared by reaction of appropriate N-unsubstituted indoles with acrylonitrile, followed by hydrolysis, esterification or amidation, or by reaction of heterocyclically substituted hydr... | 06/29/1993 |
| 5216165 | N-substituted aminoquinolines as analgesic agents There are disclosed compounds of the formula ##STR1## wherein R is hydrogen, halo or trifluoromethyl; R1 is hydrogen or X; R2 is hydrogen or X; with the proviso that when R1 is X, R2 is hydrogen, and when R... | 06/01/1993 |
| 5215999 | Quinoline derivative and antiulcer agent containing said quinoline derivative The present invention discloses a quinoline derivative and salt thereof of the following general formula: ##STR1## (wherein R1, R2, R3, R4 and n have the same meanings as defined above). Such a derivative i... | 06/01/1993 |
| 5143920 | Substituted 4-aminoquinoline derivatives as gastric secretion inhibitors Substituted 4-aminoquinazoline derivatives of the formula: ##STR1## wherein R1 is hydrogen, C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy C1-6 alkyl, C3-6 cycloalkyl, C3-6 cycloalkyl C | 09/01/1992 |
| 5112837 | Quinoline derivatives having anti-tumor activity The invention relates to a quinoline of the formula: ##STR1## wherein each of R1 and R2, which may be the same or different, is hydrogen, halogeno, hydroxy, cyano, carbamoyl, nitro or amino, alkyl, alkoxy, alkylthio, alkylamino,... | 05/12/1992 |
| 5089504 | Substituted 4-aminoquinoline derivatives as gastric acid secretion inhibitors Substituted 4-aminoquinazoline derivatives of the formula: ##STR1## in which R1 is hydrogen, C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxyC1-6 alkyl, C3-6 cycloalkyl, C3-6 cycloalkylC | 02/18/1992 |
| 5089498 | Substituted 4-aminoquinoline derivatives as gastric acid secretion inhibitors Substituted 4-aminiquinazoline derivatives of the formula: ##STR1## in which R1 hydrogen, C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxyC1-6 alkyl, C3-6 cycloalkyl, C3-6 cycloalkylC1-... | 02/18/1992 |
| 5082848 | Substituted 4-aminoquinoline derivatives as gastric acid secretion inhibitors Substituted 4-aminoquinoline derivatives of the formula: ##STR1## wherein R1 is hydrogen, C1-6 alkyl, C1-6 alkoxyC1-6 alkyl; C3-6 cycloalkyl, C3-6 cycloalkyl-C1-6 alkyl, phenyl ... | 01/21/1992 |
| 5082841 | 3-carbonyl-4-amino-8-substituted quinoline compounds useful in inhibiting gastric acid secretions. Aminoquinoline derivatives are described as inhibitors of the H+ K+ ATPase enzyme useful in the treatment of gastric acidity. A compound of the invention is 3-butyryl-4-(2-methylphenylamino)-8-(3-dimethylaminopropoxy)quinoline.... | 01/21/1992 |
| 5008276 | Methyl -(2-substituted)pyrid-3-yl-ଲ-methoxyacrylates, compositions containing them and their use as fungicides Fungicidal compounds of the formula (I): ##STR1## and stereoisomers thereof, wherein K is oxygen or sulphur; Z is optionally substituted aryl or optionally substituted heteroaryl; X is O, S(O)n, NR4, CR1 R2... | 04/16/1991 |
| 4806550 | 4-Amino-3-carbonyl substituted quinolines as inhibitors of gastric acid secretion This invention relates to novel substituted 4-aminoquinoline derivatives which are inhibitors of gastric acid secretion in mammals. A compound of the invention is 3-butyryl-4-(2-methylphenylamino)-8-methoxyquinoline.... | 02/21/1989 |
| 4806549 | 4-amino-3-carbonyl substituted quinolines This invention relates to novel substituted 4-aminoquinoline derivatives which are inhibitors of gastric acid secretion in mammals. A compound of the invention is 3-butyryl-4-(2-methylphenylamino)-8-methoxyquinoline.... | 02/21/1989 |
| 4789677 | N-alkyl-[N-[N-alkyl-N-[4-(4-quinolinylamino)benzoyl]ami no]alkyl]benzenesulphonamides New compounds having the formula I ##STR1## where one of A and B is CH or N, the other of A and B is CH, Q is lower alkylene, R is lower alkyl, X1 is halogen or trifluoromethyl and X2 and X3 are independently selected... | 12/06/1988 |
| 4769461 | Quinolinyl benzene hydroxamic acids as anti-inflammatory/antiallergic agents There are disclosed compounds of the formula ##STR1## wherein W represents a covalent bond or ##STR2## X is N or CR2 ; Y is O, S, NR2 or C(R2)2 when n=0, or N or CR2 when n=1 Z is ##STR... | 09/06/1988 |
| 4767767 | 2-pyrrolidinylethyl-2-(7-trifluoromethyl-4-quinolyl-aminobenzoate having analgesic, antipyretic and anti-inflammatory activities 2-amino-benzoic acid derivatives, method for making the same as well as its use for therapeutical purposes are proposed. The general formula of 2-amino-benzoic acid derivatives is ##STR1## wherein R represents chlorine or trifluoromethyl, R' is of ge... | 08/30/1988 |
| 4735952 | Arylthio piperidinamide of (4-quinolinylamino)benzoic acid and S-oxidized derivatives This invention provides a piperidine compound of the formula: ##STR1## wherein R1 is hydrogen or trihalomethyl, R2 is hydrogen or protected carboxy, R3 is heterocyclic group or aryl which may be halogen substituted, and X is --... | 04/05/1988 |
| 4686220 | Substituted 2-[b-substituted-amino)-ethylamino]-1,4-naphthalenediones for treating asthma, allergic diseases and inflammation in warm-blooded animals This disclosure describes certain substituted piperazine-1,4-naphthalenediones useful as anti-asthmatic agents.... | 08/11/1987 |
