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| Number | Title | Issue Date |
| 8183379 | Antitumor agents The invention provides compounds of formula I: wherein Y is F or Br; or a pharmaceutically acceptable salt thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions compr... | 05/22/2012 |
| 8178679 | Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the β2 adrenergic receptors The present disclosure relates to 4-(2-amino-1-hydroxyethyl)phenol derivatives of formula (I) as well as pharmaceutical compositions comprising them, and their use in therapy as agonists of the β2 adrenergic receptor. ... | 05/15/2012 |
| 8168792 | Heterocyclic antiviral compounds Compounds having the formula A-R wherein A is a heteroaryl and R is Ia, Ib or Ic and wherein A, R, R1, R2a, R2b, R2c, R3a, R3b, R4, R5, R6, Ra, Rb | 05/01/2012 |
| 8138345 | Diamide compounds having muscarinic receptor antagonist and βadrenergic receptor agonist activity This invention relates to a compound of formula I: or a pharmaceutically acceptable salt thereof. Such compounds possess both muscarinic receptor antagonist and β2 adrenergic receptor agonist activities. The inven... | 03/20/2012 |
| 8039628 | Process for preparing (alpha S, beta R)-6-bromo-alpha-[2-(dimethylamino) ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol The present invention relates to a process for isolating (αS,βR)-6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol from a mixture of stereoisomeric forms of 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphth... | 10/18/2011 |
| 8008501 | Quinoline compounds and their uses The present invention provides quinoline compounds that inhibit the IgE receptor signaling cascade that leads to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, i... | 08/30/2011 |
| 7964730 | Amino-substituted ethylamino βadrenergic receptor agonists The invention provides novel β2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with β2 adrenergic receptor... | 06/21/2011 |
| 7825251 | Process for producing carbostyril derivatives The present invention provides a process for producing carbostyril derivatives (I) which are known to be useful as medical drug such as antithrombotic agent, cerebral circulation improver, anti-inflammatory agent, antiulcer agent, etc. in a high yield and a high pur... | 11/02/2010 |
| 7777038 | Carbostyril compound The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur at... | 08/17/2010 |
| 7723525 | Chemokine-binding heterocyclic compound salts, and methods of use thereof The present invention relates to chemokine-binding heterocyclic compound salts, methods of use thereof, and methods for preparing the same. ... | 05/25/2010 |
| 7718805 | Process for preparing rebamipide The invention provides an improved process for preparing rebamipide that is useful as a medicament, which makes it possible to prepare rebamipide with high purity and high yield. The invention is an improved process for preparing rebamipide of the formula (1), compr... | 05/18/2010 |
| 7692017 | Quinoline potassium channel inhibitors The present invention relates to compounds having the structure (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like. ... | 04/06/2010 |
| 7678912 | Process for preparation of 4-amino-1-isobutyl-1H-imidazo[4,5-C]-quinoline (Imiquimod) A process for preparation of 1-isobutyl-1H-imidazo-[4,5-c]-quinoline-5-N-oxide, comprising oxidation of 1-isobutyl-1H-imidazoquinoline with meta-chloroperbenzoic acid. ... | 03/16/2010 |
| 7626030 | Compounds and methods of use Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophyl... | 12/01/2009 |
| 7626029 | Method of selectively introducing amino substituent Provided are a technique for position-selectively introducing an amino group into a difluorobenzoic acid, a novel process for producing a quinolonecarboxylic acid derivative serving as an antibacterial agent, and intermediates in the production. The process comprise... | 12/01/2009 |
| 7605267 | Process for the preparation of 5-(halocetyl)-8-(substituted oxy)-(1h)-quinolin-2-ones The invention relates to a process for preparing 5-(α-haloacetyl)-8-substituted oxy-(1H)-quinolin-2-ones. The process involves (i) reacting (a) 8-hydroxy-(1H)-quinolin-2-one with an acylating agent and a Lewis acid to form 5-acetyl-8-hydroxy-(1H)-quinolin-2-one; or... | 10/20/2009 |
| 7582765 | Aryl aniline βadrenergic receptor agonists The invention provides novel β2 adrenergic receptor agonist compounds of formula (I): wherein R1-R13 and w have any of the values described in the specification. The invention also provides c... | 09/01/2009 |
| 7572914 | Kinase inhibitors The invention relates to compounds of the following formula that may be used to inhibits kinases, as well as compositions of matter and kits comprising these compounds. The present invention also relates to methods for inhibiting kinases, as well as treatment method... | 08/11/2009 |
| 7566785 | Amidine substituted aryl aniline compounds The invention provides novel β2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with β2 adrenergic receptor... | 07/28/2009 |
| 7550596 | Method of producing ethyl (3R, 5S, 6E)-7-[2 cyclopropyl-4-(fluorophenyl) quinoline-3-yl]-3, 5-dihydroxy-6-heptenoate A method of producing Ethyl(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-yl]-3,5-dihydroxy-6-heptenoate by means of liquid chromatography using a packing material comprising a carrier and, carried thereon, a polysaccharide derivative, wherein a part or a... | 06/23/2009 |
| 7547787 | Processes for preparing montelukast sodium The present invention provides processes for preparing montelukast. ... | 06/16/2009 |
| 7524959 | Biphenyl derivatives This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defin... | 04/28/2009 |
| 7521561 | Biphenyl derivatives This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, ... | 04/21/2009 |
| 7514558 | Biphenyl derivatives This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defin... | 04/07/2009 |
| 7511144 | Reverse hydroxamic acid derivatives Reverse hydroxamic acid derivatives having specific structure represented by a general formula (Ia): (wherein A is a hydrogen atom or the like; Ar1 is an arylene or the like; Ar2 is an optionally subst... | 03/31/2009 |
| 7495104 | Quinoline or quinazoline derivatives inhibiting auto-phosphorylation of fibroblast growth factor receptors An objective of the present invention is to provide novel compounds which have inhibitory activity against autophosphorylation of an FGF receptor family and, when orally or intraveneously administered, can suppress the growth of cancer cells. The compounds of the pr... | 02/24/2009 |
| 7482455 | Chemical compounds 3-carboxy quinoline derivatives, which are useful as YAK3 inhibitors are described herein. The described invention also includes methods of making such 3-carboxy quinoline derivatives as well as methods of using the same in the treatment of diseases mediated by inap... | 01/27/2009 |
| 7470788 | Antitumor agents The invention provides compounds of formula I: wherein Y is F, Cl or Br; or a pharmaceutically acceptable salt thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions c... | 12/30/2008 |
| 7456287 | Diastereoselective synthesis process for the preparation of imidazole compounds A diastereoselective synthesis process for the preparation of an enantiomer of 6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone which comprises the conversion of (±)-6-[chloro(4-chlomphenyl)(1-methyl-1H-imidaz... | 11/25/2008 |
| 7452995 | Aryl aniline βadrenergic receptor agonists The invention provides novel β2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with β2 adrenergic receptor... | 11/18/2008 |
| 7442798 | Autoinducer molecules and uses therefor Novel bacterial quinolone signal molecules and, more particularly, pseudomonas quinolone signal (“PQS”) molecules, e.g., 2-heptyl-3-hydroxy-4-quinolone, and analogs and derivatives thereof are described. Therapeutic compositions containing the molecules, ... | 10/28/2008 |
| 7417148 | 4-anilino-3-quinolinecarbonitriles for the treatment of chronic myelogenous leukemia (CML) Compounds of the formula: wherein: n is an integer from 1-3; X is N, CH, provided that when X is N, n is 2 or 3; R is alkyl of 1 to 3 carbon atoms; R1 is 2,4... | 08/26/2008 |
| 7402598 | Arylethanolamine β-adrenoreceptor agonist compounds The present invention relates to compounds of formula (I) as defined herein and salts or solvates thereof. Processes for preparing these compounds and pharmaceutical formulations containing them are also disclosed, as well as methods for the prophylaxis of treatment... | 07/22/2008 |
| 7399864 | Process for producing carbostyril derivatives The present invention provides a process for producing carbostyril derivatives (I) which are known to be useful as medical drug such as antithrombotic agent, cerebral circulation improver, anti-inflammatory agent, antiulcer agent, etc. in a high yield and a high pur... | 07/15/2008 |
| 7399863 | Amino-substituted ethylamino βadrenergic receptor agonists The invention provides novel β2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with β2 adrenergic receptor... | 07/15/2008 |
| 7378524 | Aminoquinoline compounds This invention relates to treating inflammatory and immune diseases with certain aminoquinoline compounds that bind to CXCR3 receptors. The aminoquinoline compounds are covered by the formula (I) shown below. Each variable is defined in the specification. | 05/27/2008 |
| 7375227 | Quinoline derivatives The invention relates to novel 1-pyridin-4-yl urea derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the com... | 05/20/2008 |
| 7348433 | Quinolinones as prostaglandin receptor ligands This invention encompasses a method for treating a prostaglandin E mediated disease or condition comprising administering to a mammalian patient in need of such treatment a compound of Formula (A) in an amount that is effective to treat the prostaglandin E mediated ... | 03/25/2008 |
| 7348434 | 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them The invention relates to 4-substituted quinoline derivatives of general formula: which are active as antimicrobials, in which: X1, X2, X3, X4 an... | 03/25/2008 |
| 7339061 | 3-(4-oxo-4H-chromen-2-yl)-(1H)-quinolin-4-one derivatives, method for preparing same and pharmaceutical compositions containing same Compound of formula (I): wherein: R1, R2, R3, R4, R6, R8, R9 and R10, which may be the same or diffe... | 03/04/2008 |
