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| Number | Title | Issue Date |
| 8163922 | Process for the preparation of 8-hydroxy-5-[(1R)-1-hydroxy-2[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone monohydrochloride 8-hydroxy-5-[(1R)-1-hydroxy-2[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone monohydrochloride of formula (I) may be conveniently prepared in a diastereomeric pure form from optically pure precursors that are readily available by simple resol... | 04/24/2012 |
| 8158797 | Oxazolidinone-quinolone hybrid antibiotics The present invention relates to compounds of the Formula (I) that are useful antimicrobial agents and effective against a variety of multi-drug resistant bacteria. ... | 04/17/2012 |
| 8158798 | Coupling process for preparing quinolone intermediates Process for making 7-cycloamino-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acids. Borate ester compounds suitable for use in such process. ... | 04/17/2012 |
| 8153801 | Process and intermediates for preparing integrase inhibitors The invention provides synthetic processes and synthetic intermediates that can be used to prepare 4-oxoquinolone compounds having useful integrase inhibiting properties. ... | 04/10/2012 |
| 8101766 | Crystalline form of a biphenyl compound The invention provides a crystalline 1,2-ethanedisulfonic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-5-methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester or a solvate thereof... | 01/24/2012 |
| 8063221 | Aminoquinolones as GSK-3 inhibitors Provided herein are aminoquinolones and pharmaceutically acceptable derivatives thereof. In certain embodiments, provided herein are compounds, compositions and methods for treating, preventing or ameliorating GSK-3 mediated diseases. ... | 11/22/2011 |
| 8022215 | Fused pyridone M1 receptor positive allosteric modulators The present invention is directed to fused pyridone compounds of formula (I) (I) that are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pa... | 09/20/2011 |
| 7915418 | Intermediates and process for the production of optically active quinolonecarboxylic acid derivatives Provision of a commercially advantageous method for producing an intermediate which is important for producing the antibacterial and which has a mother nucleus common to the antibacterial, and intermediates produced by such method. A method for producing a co... | 03/29/2011 |
| 7884208 | Crystals of laquinimod sodium, and process for the manufacture thereof Disclosed is a process for the preparation of laquinimod sodium which removes the impurities after the salt formation step, thus resulting in crystals of higher purity as well as crystals having improved crystalline characteristics. ... | 02/08/2011 |
| 7728143 | Salt and crystalline forms thereof of a drug A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed. ... | 06/01/2010 |
| 7723524 | 8-cyanoquinolonecarboxylic acid derivative To provide a quinolone antibacterial drug and a therapeutic agent for infectious diseases, which exhibit potent antibacterial activity on Gram-positive and Gram-negative bacteria and which is highly safe. A compound represented by the following formula (1): | 05/25/2010 |
| 7626028 | Use of quinaldine and naphthaline derivatives as crystallisation modifiers The invention relates to the use of compounds of general formula (I) as crystallization modifiers for organic pigments, in which formula the variables have the following designation: A represents ═N— or ═CH—; X represents methyl or a radical of formula (IIa)... | 12/01/2009 |
| 7576216 | Preparation of pyridonecarboxylic acid antibacterials A process for making 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid, and therapeutically acceptable salts thereof, and intermediates used in the process are disclosed. ... | 08/18/2009 |
| 7576215 | Quinolines and pharmaceutical compositions thereof This invention provides compounds of formula I that are useful in the treatment or inhibition of LXR mediated diseases. ... | 08/18/2009 |
| 7557213 | Substituted quinolones and methods of use Substituted quinolone compounds and compositions are provided along with methods for the use of those compounds in the treatment of diseases and disorders such as cancer. ... | 07/07/2009 |
| 7534889 | 5-HTreceptor agonist compounds The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 re... | 05/19/2009 |
| 7521560 | 2-substituted quinoline compounds and their uses The present disclosure provides 2-substituted-quinoline compounds that inhibit the IgE receptor signaling cascade that leads to the release of chemical mediators, prodrugs of the compounds, intermediates and methods of synthesizing the compounds and methods of using... | 04/21/2009 |
| 7498442 | Quinolinone-carboxamide compounds The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 re... | 03/03/2009 |
| 7495103 | Modulators of ATP-binding cassette transporters The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to metho... | 02/24/2009 |
| 7482454 | Antimicrobial quinolones, their compositions, and uses This invention relates to novel antimicrobial compounds of formula; wherein X, R1, R3, R5, R6, and R8 are defined in the claims, and to their optical isomers, diastereo... | 01/27/2009 |
| 7465799 | Methods and compositions for selectin inhibition The present invention relates to the field of anti-inflammatory substances, and more particularly to novel compounds that act as antagonists of the mammalian adhesion proteins known as selectins. In some embodiments, methods for treating selectin mediated disorders ... | 12/16/2008 |
| 7442793 | Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided. ... | 10/28/2008 |
| 7442710 | Substituted phenyl methanones The present invention relates to compounds of general formula IA or IB wherein X1 and X2 are each independently N or C—R″ and R1, R2,R3, R... | 10/28/2008 |
| 7423153 | Crystalline forms of gatifloxacin Provided are novel crystalline forms of gatifloxacin denominated forms A, B, C, D, E1, F, G, H, I, and J, and methods for their preparation. Also provided are methods for making known crystalline forms of gatifloxacin, in particular forms omega and T2RP. ... | 09/09/2008 |
| 7411067 | Crystalline forms of gatifloxacin Provided are two novel crystalline forms of gatifloxacin, denominated form O and form V, and methods for their preparation. ... | 08/12/2008 |
| 7402674 | 7-Phenylamino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments 7-Phenylamino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments The invention relates to 7-phenylamino-4-quinolone-3-carboxylic acid derivatives and to the physiologically tolerated salts and physiologically... | 07/22/2008 |
| 7399434 | Rare metal compounds and mixtures of these An article of manufacture marked with compositions comprising rare earth metal compounds which, due to their luminescence when irradiated with UV light, are suitable in particular for the marking of security-relevant items, such as documents or data carriers. ... | 07/15/2008 |
| 7399862 | 5-HTreceptor agonist compounds The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 re... | 07/15/2008 |
| 7396839 | Crystalline forms of gatifloxacin Provided are novel crystalline forms of gatifloxacin, denominated forms L, M, P, Q, S, and T1, and methods for making them. Also provided are methods of transforming the novel crystalline forms of gatifloxacin of the present invention to other crystalline forms of g... | 07/08/2008 |
| 7396933 | Quinolinone-carboxamide compounds The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 re... | 07/08/2008 |
| 7393957 | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydr... | 07/01/2008 |
| 7393958 | Triamide-substituted heterobicyclic compounds This invention relates to MTP/Apo-B secretion inhibitors of Formula (I) wherein R1-R7, X1, m and n are as defined in the specification, as well as pharmaceutical compositions comprising the ... | 07/01/2008 |
| 7378524 | Aminoquinoline compounds This invention relates to treating inflammatory and immune diseases with certain aminoquinoline compounds that bind to CXCR3 receptors. The aminoquinoline compounds are covered by the formula (I) shown below. Each variable is defined in the specification. | 05/27/2008 |
| 7368572 | Acetylene derivatives as inhibitors of histone deacetylase The present invention is directed to certain hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparin... | 05/06/2008 |
| 7354931 | Heterocyclic retinoid compounds The current invention provide novel heterocyclic retinoid compounds, methods of treating or preventing chronic obstructive pulmonary disease, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention of these disorders... | 04/08/2008 |
| 7355047 | Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof Substituted quinolone carboxylic acids and their derivatives are described. These compounds modulate the effect of γ-aminobutyric acid (GABA) via a novel site on the GABAA receptor complex in a therapeutically relevant fashion and may be used to ameliora... | 04/08/2008 |
| 7334538 | Topical medicants for aquatic animals A topical medicant for fishes, amphibians, reptiles, and aquatic macroinvertebrates applied in a site-specific manner for the localized treatment of skin wounds, lesions and diseases. The medicant comprises a hydrophilic carrier with an antimicrobial therapeutant fo... | 02/26/2008 |
| 7324236 | Discrepancy correction method and apparatus for correcting difference in levels of image signals obtained by an image sensor having a multiple output channels Image signals output from a linear image sensor which outputs charges accumulated in pixels in the right-side area and charges accumulated in pixels in the left-side area via different channels are subjected to discrepancy correction. First, a gray reference board i... | 01/29/2008 |
| 7276608 | Tetrahydroquinoline derivatives as cannabinoid receptor modulators The invention provides for compounds of formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of eating disorders, metabolic d... | 10/02/2007 |
| 7235565 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: | 06/26/2007 |
