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| Number | Title | Issue Date |
| 7390798 | Carboxamide spirolactam CGRP receptor antagonists The present invention is directed to compounds of Formula I: I (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in... | 06/24/2008 |
| 7358220 | Alkoxylated polyol containing bleach activating terminating functional groups A polyol polymeric structure comprising a bleach activating moiety to give benefits in detergent compositions such as bleaching action, soil suspension, increased surfactant availability in the presence of free hardness. ... | 04/15/2008 |
| 7335677 | Inhibitors of dipeptidyl peptidase IV Novel compounds that are inhibitors of one or most post-proline cleaving proteases, e.g. dipeptidyl peptidase IV, according to general formula (1). R1 is H or CN, X1 is O, S, CH2, CHF, CF2, CH(CH3), C(CH3 | 02/26/2008 |
| 7250526 | Transfer hydrogenation process and catalyst A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal hydrocarbyl complex which is coordinated to defined bidentate ligands substituted with at least one group selected from an optionally substituted sulphonated hydr... | 07/31/2007 |
| 7074796 | 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives The present invention relates to substituted 4-phenyl-1-piperazinyl derivatives having the formula I wherein W is C, CH or N, and the dotted line emanating from W indicates a bond when W is C and no bond when W i... | 07/11/2006 |
| 7026485 | Retroviral protease inhibitors N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ... | 04/11/2006 |
| 6916905 | Dmt-Tic di-and tri-peptidic derivatives and related compositions and methods of use A compound of formula: wherein X is a spacer comprising one or more amino acid residues and Y comprises an aromatic group and related compositions and methods of use. ... | 07/12/2005 |
| 6903103 | Linear cyclic ureas Compound of formula (I): wherein: V represents a single bond or an alkylene chain, M represents a single bond or an alkylene chain, A and E each repr... | 06/07/2005 |
| 6753317 | Dmt-Tic di- and tri-peptide derivatives and related compositions and methods of use A compound of formula: comprising the Dmt-Tic pharmacophore and related compositions and methods of use in the inhibition of the binding of an opioid receptor-binding compound with a P-glycoprotein, specifically hMDR-... | 06/22/2004 |
| 6703391 | Quinoxalinedione derivatives, their preparation and use A compound having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R is hydrogen or hydroxy; R1 is hydrogen, alkyl, arylalkyl, (CH2)n OH, or (CH2)n NR7 | 03/09/2004 |
| 6642228 | -adrenergic receptor antagonists There are provided compounds represented by the general formula (I): ##STR1## [wherein Ar is indole etc., R1 is hydrogen etc., B is bond, or B--N--R1 forms a ring structure and is piperidine etc., n is 0, 1, etc., A is trimethylene, ... | 11/04/2003 |
| 6608082 | Treatment of erectile dysfunction using isoquinoline compound melanocortin receptor ligands Methods for treating erectile dysfunction using tetrahydroisoquinoline aromatic amines that function as melanocortin receptor ligands.... | 08/19/2003 |
| 6518264 | Azetidine derivatives, their preparation and medicaments containing them Disclosed are azetidine derivatives of formula: ##STR1## their optical isomers, their salts, their preparation and medicaments containing them.... | 02/11/2003 |
| 6509467 | Transfer hydrogenation process A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal neutral hydrocarbyl complex which is coordinated to defined bidentate ligands. Preferred metals include rhodium, ruthenium and iridium. Preferred biden... | 01/21/2003 |
| 6506759 | Retroviral protease inhibitors N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 01/14/2003 |
| 6479479 | Azetidine derivatives, their preparation and pharmaceutical compositions containing them Compounds of formula: ##STR1## in which R represents a CR1 R2, C.dbd.C(R5)SO2 R6 or C.dbd.C(R7)SO2 alk radical, their preparation and the pharmaceutical compositions containing t... | 11/12/2002 |
| 6310073 | Methods and compositions to treat glycosaminoglycan-associated molecular interactions Therapeutic compounds and methods for inhibiting a glycosaminoglycan (GAG)-associated molecular interaction in a subject, whatever its clinical setting, are described.... | 10/30/2001 |
| 6297257 | Benzazine derivatives phosphodiesterase 4 inhibitors ##STR1## Compounds of formula (I) wherein A is an orthocondensed heterocycle optionally substituted by certain substituents and necessarily substituted by a --B--Cy group where the variables are as defined in the specification and the N.fwdarw.O derivativ... | 10/02/2001 |
| 6222072 | Process for producing optically active amine A novel process for producing an optically active amine is provided. The optically active amine is adapted for use as an intermediate in synthesizing physiologically active compounds such as pharmaceuticals and agricultural chemicals, as a functional mate... | 04/24/2001 |
| 6187801 | Polycyclic thiazole systems, processes for their preparation and pharmaceuticals comprising these compounds The invention relates to polycyclic thiazole systems and their physiologically tolerated salts and physiologically functional derivatives. Compounds of the formula I, ##STR1## in which the radicals have the stated meanings, and their physiologically ... | 02/13/2001 |
| 6177445 | Substituted isoquinolines as ultra short acting neuromuscular blockers Ultra short acting neuromuscular blocking agents of Formula (I) which are useful as skeletal muscle relaxants during emergency intubation procedures, routine surgery and post-operative settings are disclosed, wherein q and t are independently from 0 to 4;... | 01/23/2001 |
| 6177443 | 4,5,6,7-tetrahydro-thieno[3, 2-C]pyridine derivatives, their preparation and use The present invention relates to pharmaceutical compositions comprising a pharmaceutically acceptable carrier or diluent and a compound of formula I ##STR1## wherein A together with the double bond of formula I is benzene or thiophene; R1 is op... | 01/23/2001 |
| 6172085 | Cyclic ether compounds as sodium channel modulators A compound of the formula: ##STR1## wherein R1 and R2 each represents hydrogen, lower alkyl which may be substituted or acyl; R3, R4 and R5 each represents lower alkyl which may be substituted or lowe... | 01/09/2001 |
| 6140339 | Monomeric and dimeric arylisoquinoline alkaloids and derivatives thereof The present invention provides new monomeric derivatives of the C-8'-7 linked naphthylisoquinoline alkaloid dioncophylline D. The invention also provides new C-4 substituted monomeric arylisoquinoline alkaloid derivatives. The present invention furthermor... | 10/31/2000 |
| 6127381 | Isoquinoline compound melanocortin receptor ligands and methods of using same The invention relates to melanocortin receptor ligands and methods of using the ligands to alter or regulate the activity of a melanocortin receptor. The invention further relates to tetrahydroisoquinoline aromatic amines that function as melanocortin rec... | 10/03/2000 |
| 6096752 | Method for the preparation of tertiary amines, a compound useful therefor and alpha-2-receptor active tetrahydroisoquinoline derivatives The invention relates to the preparation of teriatry amines of the formula (V) where R is alkyl and R6 and R7 are alkyl groups which are optionally substituted or where R6 and R7 form a ring or ring system, via ... | 08/01/2000 |
| 5968949 | Substituted hydroisoquinoline derivatives and their use as pharmaceuticals According to the present invention, there is provided a compound, or a solvate or salt thereof of formula (I): ##STR1## Substituted hydroisoquinoline derivatives are potent and selective delta opioid agonists and antagonists and are of potential ther... | 10/19/1999 |
| 5904877 | Trifluoratetrahydroisoquinoline derivatives, and the use thereof in liquid-crystalline mixtures 1,8,8-Trifluoro-5,6,7,8-tetrahydroisoquinoline derivatives, and their use in liquid-crystalline mixtures 1,8,8-Trifluoro-5,6,7,8-tetrahydroisoquinoline derivatives of the formula (I) R1 (--M1)a (--A1 --M2 | 05/18/1999 |
| 5869520 | Carbamoyloxylabdanes Novel carbamoyloxylabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure and treating cardiac failure utilizing compounds and compositions thereof are disclosed.... | 02/09/1999 |
| 5856503 | Aminoalkyl-substituted benzo-heterocyclic compounds Aminoalkyl-substituted benzo-heterocyclic compounds of the formula ##STR1## wherein M, Q, R and T are as defined in the specification, as well as acid addition salts thereof. These compounds are useful as cholesterol level lowering agents and as anti... | 01/05/1999 |
| 5817614 | Color-safe bleach boosters, compositions and laundry methods employing same Bleach boosters comprising quaternary imine zwitterions are disclosed. The bleach boosters increase bleaching effectiveness in lower temperature solutions and demonstrate superior color safety profiles. The bleach boosters are ideally suited for inclusion... | 10/06/1998 |
| 5804586 | Therapeutic agents Tetrahydroisoquinoline compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof, in which: R1 represents one or more substituents selected from H, halo, hydroxy, alkyl (optionally substituted by hydroxy), alkoxy, alkyl... | 09/08/1998 |
| 5767129 | Substituted quinolines and isoquinolines as calcium channel blockers, their preparation and the use thereof The present invention relates to novel substituted quinolines and isoquinolines and derivatives thereof useful in the treatment of neurological disorders. Methods of preparing the compounds, intermediates useful in the preparation and pharmaceutical compo... | 06/16/1998 |
| 5756516 | 1,2,3,4-tetrahydroisoquinoline derivatives and pharmaceutical composition thereof The invention relates to compounds of formula (I) ##STR1## wherein R1 is an optional substituent any position of phenyl ring and is selected from halogen, --NO2, --NH2, --OH and --O--CR1-6 alkyl; --CH2... | 05/26/1998 |
| 5686616 | Process for preparing an optically active amine A novel process for preparing an optically active amine by asymmetric hydrogenation of an imine compound, such as an imine compound prepared by condensing benzylamine and acetophenone, in the presence of a catalytic amount of an iridium-optically active p... | 11/11/1997 |
| 5665732 | Indazole derivatives A class of chemical compounds comprising a 1-H-indazole moiety and a substituted heterocyclic moiety, linked via the 3-position of the indazole moiety by a methylene group, are ligands for dopamine receptor subtypes within the body and are therefore usefu... | 09/09/1997 |
| 5641783 | Substituted amino alcohol compounds Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty. Independently, R1 and R2 are hy... | 06/24/1997 |
| 5607939 | Condensed heterocyclic compounds, their production and use The compound ##STR1## wherein ring A represents a benzene ring; Ar represents an aromatic group; R1 and R2 independently represent hydrogen, acyl or hydrocarbon group or R1 and R2 taken together with the ad... | 03/04/1997 |
| 5602236 | Metal-containing steroid mimics and ligands useful in the preparation thereof Metal-containing steroid mimic complexes are provided. Compositions containing a metal ion incorporated into a steroid skeleton structure and ligands useful in the preparation of such compositions are also provided. The metal ion is preferably a radionucl... | 02/11/1997 |
| 5576435 | Process and intermediates for the preparation of excitatory amino acid receptor antagonists The present invention provides novel intermediates which are useful for the preparation of excitatory amino acid receptor antagonists. Further provided is a process to enatioselectively prepare hydroisoquinoline compounds with central nervous system activ... | 11/19/1996 |
